TREATMENT Of RINGWORM
    6.
    发明申请
    TREATMENT Of RINGWORM 审中-公开
    RINGWORM治疗

    公开(公告)号:US20110118347A1

    公开(公告)日:2011-05-19

    申请号:US12995283

    申请日:2009-05-29

    摘要: A compound of the formula CH3(CH2)n—RA—(CH2)m-(CH═CH)q—(CH2)p—X wherein RA=(a); q=0 or 1; m and p are independently selected integers of at least 1; n=0 or an integer of at least 1; X is a polar group selected from —CO2RS, where Rs═H, Na, K, —NHRI, —NRIRII or RIII; —CH3OH; —CH3NH2; —CH3NHRI; or —CH3NRIRII; wherein RI, RII and RIII are independently selected from C1-C6 alkyl or an aryl group, preferably a hydrophilically substituted C1-C6 alkyl or aryl group, or RIII is an esterified glycol; and wherein 20>m+n+p+2q≧2; is useful for the treatment of ringworm infection caused by Trichophyton tonsurans.

    摘要翻译: 式(CH3)(CH2)n-RA-(CH2)m-(CH = CH)q-(CH2)p-X的化合物其中RA =(a) q = 0或1; m和p是独立选择的至少为1的整数; n = 0或至少为1的整数; X是选自-CO2RS的极性基团,其中Rs = H,Na,K,-NHRI,-NRIRII或RIII; -CH 3 OH; -CH 3 NH 2; -CH 3 NHRI; 或-CH 3 NRIRII; 其中RI,RII和RIII独立地选自C 1 -C 6烷基或芳基,优选亲水取代的C 1 -C 6烷基或芳基,或R III是酯化二醇; 并且其中20m + n + p +2q≥2; 用于治疗由毛癣菌引起的癣感染。