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公开(公告)号：US20080132573A1
公开(公告)日：2008-06-05
申请号：US11658737
申请日：2005-07-06
IPC分类号： A61K31/201 , C07C59/44 , A61P13/00
CPC分类号： C07C235/28 , C07C235/26 , C07D303/46
摘要： The compounds of the general formula (I) in which X is represents two hydrogen atoms, a π-bond, oxygen or methylene: R2 is a C6-C12 aryl, or arylalkyl residue: R3 is hydrogen, 2-hydroxyethyl or 2-aminoethyl are useful for the treatment of pathologies mediated by vanilloid receptors type I.
摘要翻译： 其中X表示两个氢原子的通式（I）的化合物，π键，氧或亚甲基：R2是C 6 -C 12 - 芳基 或芳基烷基残基：R3是氢，2-羟乙基或2-氨基乙基可用于治疗I型香草素受体介导的病理。
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公开(公告)号：US07429673B2
公开(公告)日：2008-09-30
申请号：US11658737
申请日：2005-07-06
IPC分类号： C07C69/76 , A61K31/195
CPC分类号： C07C235/28 , C07C235/26 , C07D303/46
摘要： The compounds of the general formula (I) in which X is represents two hydrogen atoms, a π-bond, oxygen or methylene: R2 is a C6-C12 aryl, or arylalkyl residue: R3 is hydrogen, 2-hydroxyethyl or 2-aminoethyl are useful for the treatment of pathologies mediated by vanilloid receptors type I.
摘要翻译： 其中X表示两个氢原子的通式（I）的化合物，π键，氧或亚甲基：R2是C 6 -C 12 - 芳基 或芳基烷基残基：R3是氢，2-羟乙基或2-氨基乙基可用于治疗I型香草素受体介导的病理。
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公开(公告)号：US20080242878A1
公开(公告)日：2008-10-02
申请号：US11886253
申请日：2006-03-13
IPC分类号： C07D305/08
CPC分类号： C07D305/14
摘要： The invention discloses novel secotaxane derivatives of general formula 1, having cytotoxic activity, which can be administered through the injective or oral route, for the therapy of tumors.
摘要翻译： 本发明公开了具有通过注射或口服途径施用的具有细胞毒活性的通式1的新型二硫代衍生物用于治疗肿瘤。
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公开(公告)号：US08524465B2
公开(公告)日：2013-09-03
申请号：US13584592
申请日：2012-08-13
IPC分类号： G01N33/567 , C07K14/705
CPC分类号： G01N33/566 , G01N2333/726 , G01N2500/04
摘要： The present invention relates to agonists of the human bitter-taste receptors hTAS2R14, hTAS2R10 and hTAS2R4 and their role in bitter taste transduction. The invention also relates to methods for identifying molecules that modulate, e.g. suppress, or enhance hTAS2R14, hTAS2R10 and hTAS2R4 bitter taste transduction or bitter taste response.
摘要翻译： 本发明涉及人苦味受体hTAS2R14，hTAS2R10和hTAS2R4的激动剂及其在苦味转导中的作用。 本发明还涉及用于鉴定调节的分子的方法。 抑制或增强hTAS2R14，hTAS2R10和hTAS2R4苦味转换或苦味反应。
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5.发明授权公开(公告)号：US08673578B2
公开(公告)日：2014-03-18
申请号：US13504750
申请日：2010-10-27
IPC分类号： G01N33/53 , G01N33/567 , C12Q1/02 , C12N1/20 , C12N15/00 , C12N5/00 , C12N5/02 , C12N15/74 , C07D307/00 , C07D407/00
CPC分类号： G01N33/566 , A23L27/86 , C07D307/93 , G01N2500/04
摘要： The present invention relates to antagonists and agonists of the human bitter-taste receptors hTAS2R40, hTAS2R43, hTAS2R44, hTAS2R46, and hTAS2R47. The invention also relates to methods for identifying further molecules that suppress or enhance bitter taste transduction or bitter taste response mediated by hTAS2R40, hTAS2R43, hTAS2R44, hTAS2R46, and/or hTAS2R47 and uses thereof.
摘要翻译： 本发明涉及人苦味受体hTAS2R40，hTAS2R43，hTAS2R44，hTAS2R46和hTAS2R47的拮抗剂和激动剂。 本发明还涉及用于鉴定抑制或增强由hTAS2R40，hTAS2R43，hTAS2R44，hTAS2R46和/或hTAS2R47介导的苦味转导或苦味反应的其它分子的方法及其用途。
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公开(公告)号：US20120283324A1
公开(公告)日：2012-11-08
申请号：US13504750
申请日：2010-10-27
IPC分类号： C07D307/93 , C12Q1/02 , A61K31/365
CPC分类号： G01N33/566 , A23L27/86 , C07D307/93 , G01N2500/04
摘要： The present invention relates to antagonists and agonists of the human bitter-taste receptors hTAS2R40, hTAS2R43, hTAS2R44, hTAS2R46, and hTAS2R47. The invention also relates to methods for identifying further molecules that suppress or enhance bitter taste transduction or bitter taste response mediated by hTAS2R40, hTAS2R43, hTAS2R44, hTAS2R46, and/or hTAS2R47 and uses thereof.
摘要翻译： 本发明涉及人苦味受体hTAS2R40，hTAS2R43，hTAS2R44，hTAS2R46和hTAS2R47的拮抗剂和激动剂。 本发明还涉及用于鉴定抑制或增强由hTAS2R40，hTAS2R43，hTAS2R44，hTAS2R46和/或hTAS2R47介导的苦味转导或苦味反应的其它分子的方法及其用途。
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7.发明授权Methods of identifying agonists and antagonists of hTASR bitter taste receptors 有权识别hTASR苦味受体的激动剂和拮抗剂的方法公开(公告)号：US08043823B2
公开(公告)日：2011-10-25
申请号：US12593398
申请日：2008-03-31
申请人： Maik Behrens , Anne Brockhoff , Christina Kuhn , Wolfgang Meyerhof , Giovanni Appendino , Valeria D'Auria
发明人： Maik Behrens , Anne Brockhoff , Christina Kuhn , Wolfgang Meyerhof , Giovanni Appendino , Valeria D'Auria
IPC分类号： G01N33/53 , G01N33/567 , C12Q1/02
CPC分类号： G01N33/566 , A23L27/86 , C07D307/60 , G01N2333/726
摘要： The present invention relates to agonists of the human bitter-taste receptors hTAS2R46, hTAS2R47 and hTAS2R50 and their role in bitter taste transduction. The invention also relates to methods for identifying molecules that modulate, e.g. suppress, or enhance hTAS2R46, hTAS2R47 and hTAS2R50 bitter taste transduction or bitter taste response.
摘要翻译： 本发明涉及人苦味受体hTAS2R46，hTAS2R47和hTAS2R50的激动剂及其在苦味转导中的作用。 本发明还涉及用于鉴定调节的分子的方法。 抑制或增强hTAS2R46，hTAS2R47和hTAS2R50苦味转换或苦味反应。
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公开(公告)号：US20130158126A1
公开(公告)日：2013-06-20
申请号：US13636214
申请日：2010-03-26
IPC分类号： C07C50/28
摘要： Cannabinoid quinone derivatives. The present invention refers to cannabinoid quinone derivatives to be used as medicaments, particularly as PPAR gamma (PPARg) agonists for treating diseases which etiology is based on an impaired PPARg function as transcription factor i.e. PPARg-related diseases.
摘要翻译： 大麻酚醌衍生物。 本发明涉及用作药物的大麻素醌衍生物，特别是作为用于治疗疾病的PPARγ（PPARg）激动剂，其病因为受损的PPARg功能为转录因子即PPARg相关疾病。
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9.发明申请COMPOSITION CONTAINING NON-PSYCHOTROPIC CANNABINOIDS FOR THE TREATMENT OF INFLAMMATORY DISEASES 审中-公开含有非光子性CANNABINOIDS用于治疗炎症疾病的组合物公开(公告)号：US20100222437A1
公开(公告)日：2010-09-02
申请号：US12681453
申请日：2008-09-29
IPC分类号： A61K31/122 , A61P29/00 , A61P35/00
CPC分类号： A61K36/185 , A61K31/05 , A61K31/352
摘要： The invention relates to a composition comprising cannabidiol and Denbinobin and its use in medicine, for example, for the prevention and treatment of gastrointestinal inflammatory diseases and for the prevention and treatment of gastrointestinal cancers.
摘要翻译： 本发明涉及包含大麻二酚和丹宁宁的组合物及其在药物中的用途，例如用于预防和治疗胃肠道炎性疾病以及预防和治疗胃肠癌。
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公开(公告)号：US08772349B2
公开(公告)日：2014-07-08
申请号：US13636214
申请日：2010-03-26
IPC分类号： C07C50/28
摘要： Cannabinoid quinone derivatives. The present invention refers to cannabinoid quinone derivatives to be used as medicaments, particularly as PPAR gamma (PPARg) agonists for treating diseases which etiology is based on an impaired PPARg function as transcription factor i.e. PPARg-related diseases.
摘要翻译： 大麻酚醌衍生物。 本发明涉及用作药物的大麻素醌衍生物，特别是作为用于治疗疾病的PPARγ（PPARg）激动剂，其病因为受损的PPARg功能为转录因子即PPARg相关疾病。
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