公开(公告)号：US3890302A

公开(公告)日：1975-06-17

申请号：US25983972

申请日：1972-06-05

Applicant: KOTERA KATSUMI ,  KITAHONOKI KEIZO ,  KIDO RYONOSUKE

Inventor： KOTERA KATSUMI ,  KITAHONOKI KEIZO ,  KIDO RYONOSUKE

IPC: C07D203/08 ,  C07D23/06

CPC classification number: C07D203/08

Abstract: Racemic 1-methyl-2-(2-naphthyl)aziridine, being useful as a tranquilizer, is prepared via three routes: (a) halogenation of the corresponding aminoalcohol and treatment of the resulting haloamine with an alkali; (b) treatment of the corresponding aminoalcohol with sulfuric acid and treatment of the resulting hydrogen sulfate with an alkali; and (c) treatment of 2-(2naphthyl)aziridine with an oxonium methylating agent. Dextro-1methyl-2-(2-naphthyl)aziridine, being more potent in the tranquilizing activity than the racemate, is prepared by optical resolution of racemic 2-(2-naphthyl)-2-methylaminoethanol with levo-tartaric acid, treatment of the resulting dextro-2-(2naphthyl)-2-methylaminoethanol levo-tartrate with an alkali, treatment of the resulting dextro-2-(2-naphthyl)-2methylaminoethanol with a halogenating agent and treatment of the resulting levo-N-methyl-2-halogeno-1-(2-naphthyl)ethylamine with an alkali.

Abstract translation: 通过三种途径制备用作镇定剂的外消旋1-甲基-2-（2-萘基）氮丙啶：（a）卤化相应的氨基醇并用碱处理得到的卤代胺; （b）用硫酸处理相应的氨基醇，用碱处理得到的硫酸氢盐; 和（c）用氧代甲基化剂处理2-（2-萘基）氮丙啶。 通过用左旋酒石酸旋光拆分外消旋的2-（2-萘基）-2-甲基氨基乙醇，制备了比外消旋物更有效的镇痛活性的右旋-1-甲基-2-（2-萘基）氮丙啶， 用碱处理得到的右旋-2-（2-萘基）-2-甲基氨基乙醇左旋酒石酸盐，用卤化剂处理所得的右旋-2-（2-萘基）-2-甲基氨基乙醇，并处理所得的 左旋-N-甲基-2-卤代-1-（2-萘基）乙胺与碱反应。

公开(公告)号：US3855217A

公开(公告)日：1974-12-17

申请号：US24687372

申请日：1972-04-24

Applicant: DOW CHEMICAL CO

Inventor： THILL B

IPC: C07D203/08 ,  C07D23/06

CPC classification number: C07D203/08

Abstract: N-Benzylically substituted aziridines are conventionally prepared by reacting a benzyl halide with aziridine (or other non-N-substituted aziridine) in the presence of an acid acceptor. Product yields are considerably improved by conducting the above process in a liquid aromatic hydrocarbon reaction medium. E.g., N-benzylaziridine is prepared in excellent yields by reacting benzyl chloride with aziridine in the presence of powdered KOH and benzene.

Abstract translation: N-苄基取代的氮丙啶通常在酸受体存在下使苄基卤与氮丙啶（或其它非N-取代的氮丙啶）反应制备。 通过在液体芳族烃反应介质中进行上述方法，产物产率显着提高。 例如，通过苄基氯与氮丙啶在粉末状KOH​​和苯的存在下反应制得N-苄基氮丙啶。

公开(公告)号：US3719698A

公开(公告)日：1973-03-06

申请号：US3719698D

申请日：1967-11-27

Applicant: STEVENS & CO INC J P

Inventor： TESORO G ,  RING R

IPC: C07D203/08 ,  C07D213/20 ,  C07F7/18 ,  D06M13/342 ,  D06M13/493 ,  C07C101/20 ,  C07D23/06

CPC classification number: C07D203/08 ,  C07D213/20 ,  C07F7/1836 ,  D06M13/342 ,  D06M13/493

Abstract: Polyfluorinated esters of the formula WHEREIN Rf is a polyfluorinated hydrocarbon radical containing at least three fluorine atoms and up to 20 carbon atoms, A is an alkylene radical of up to six carbon atoms, Z is the residue of an amine component selected from the group consisting of amines and amine slats which have had at least one hydrogen atom removed, and q is an integer selected from 1 and 2, useful as textile finishing agents.

公开(公告)号：US3629239A

公开(公告)日：1971-12-21

申请号：US3629239D

申请日：1969-09-03

Applicant: SHIONOGI & CO

Inventor： KITAHONOKI KEIZO ,  KOTERA KATSUMI

IPC: C07D203/08 ,  C07D203/18 ,  C07D203/20 ,  C07D203/22 ,  C07D203/26 ,  C07D277/16 ,  C07D23/02 ,  C07D23/06 ,  C07D31/42

CPC classification number: C07D203/08 ,  C07D203/18 ,  C07D203/20 ,  C07D203/22 ,  C07D203/26 ,  C07D277/16

Abstract: NOVEL PROCESS FOR PREPARING AZIRIDINE DERIVATIVE WHICH COMPRISES REDUCING AN OXIME COMPOUND WITH A METALLIC HYDRIDE COMPLEX IN AN INERT SOLVENT.

公开(公告)号：US3440242A

公开(公告)日：1969-04-22

申请号：US3440242D

申请日：1963-09-12

Applicant: MINNESOTA MINING & MFG

Inventor： SMITH GEORGE H

IPC: C07D203/18 ,  C07D23/06

CPC classification number: C07D203/18

公开(公告)号：US3751395A

公开(公告)日：1973-08-07

申请号：US3751395D

申请日：1971-08-18

Applicant: ESPE PHARM PRAEP

Inventor： SCHMITT W ,  ZAHLER W ,  PURRMANN R ,  JOCHUM P

IPC: A61C9/00 ,  A61K6/087 ,  C07D203/18 ,  C08G73/02 ,  C07D23/06

CPC classification number: A61K6/087 ,  A61C9/00 ,  C07D203/18 ,  C08G73/024 ,  Y10S528/92

Abstract: THE PRESENT INVENTION RELATES TO MATERIAL FOR MAKING CASTS FOR DENTAL PURPOSES, WHICH MATERIAL SUBSTANTIALLY COMPRISES BIS-ETHYLENE-IMINE COMPOUNDS CAPABLE OF BEING CROSS-LINKED AND HAVING THE FORMULA

((-(CH2)2-)>N-Y-O-R''-O-(1,4-CYCLOHEXYLENE))2-R

WHEREIN R IS AN ALKYLIDENE RADICAL WITH 1-6 CARBON ATOMS, A CYCLOALKYLIDENE RADICAL OR AN SO2 RADICAL; R'' AN ALKYLENE RADICAL HAVING 2-6 CARBON ATOMS OR A CYCLOALKYLENE RADICAL, AND Y AN ACYL RADICAL OF A CARBOXYLIC ACID WITH 2-6 CARBON ATOMS, WHICH MAY ALSO BE SUBSTITUTED BY AN AROMATIC SUBSTITUENT.

公开(公告)号：US3634400A

公开(公告)日：1972-01-11

申请号：US3634400D

申请日：1967-07-03

Applicant: ESPE PHARM PRAEP

Inventor： SCHMITT WERNER ,  PURRMANN ROBERT ,  JOCHUM PETER ,  ZAHLER WOLF-DIETRICH

IPC: A61C9/00 ,  A61C13/00 ,  A61K6/087 ,  C07D203/18 ,  C08G73/02 ,  C08G73/04 ,  C07D23/06

CPC classification number: A61C9/00 ,  A61C13/00 ,  A61K6/087 ,  C07D203/18 ,  C08G73/024 ,  Y10S528/92

Abstract: THE PRESENT INVENTION RELATES TO MATERIAL FOR MAKING CASTS FOR DENTAL PURPOSES, WHICH MATERIAL SUBSTANTIALLY COMPRISES BIS-ETHYLENE-IMINIE COMPOUNDS CAPABLE OF BEING CROSS-LINKED AND HAVING THE FORMULA

1-((4-((AZIRIDIN-1-YL)-Y-O-R''-O-)PHENYL)-R-),4-((AZIRIDIN-

1-YL)-Y-O-R''-O-)BENZENE

WHEREIN R IS AN ALKYLIDENE RADICAL WITH 1-6 CARBON ATOMS, A CYCLOKALKYLIDENE RADICAL OR AN SO2 RADICAL; R'' AN ALKYLENE RADICAL HAVING 2-6 CARBON ATOMS OR A CYCLOALKYLENE RADICAL, AND Y AN ACYL RADICAL OF A CARBOXYLIC ACID WITH 2-6 CARBON ATOMS, WHICH MAY ALSO BE SUBSTITUTED BY AN AROMATIC SUBSTITUENT.

公开(公告)号：US3583977A

公开(公告)日：1971-06-08

申请号：US3583977D

申请日：1968-06-18

Applicant: GEN TIRE & RUBBER CO

Inventor： UELZMANN HEINZ

IPC: C07D203/10 ,  C08G18/10 ,  C08G18/50 ,  C08G18/64 ,  C08G59/10 ,  C08G59/50 ,  C08G65/22 ,  C08G65/26 ,  C08G73/02 ,  C08K5/3412 ,  C08L63/00 ,  C08L101/08 ,  C07D23/02 ,  C07D23/06

CPC classification number: C08L63/00 ,  C07D203/10 ,  C08G18/10 ,  C08G18/5057 ,  C08G18/6423 ,  C08G59/10 ,  C08G59/5066 ,  C08G65/22 ,  C08G65/263 ,  C08G73/0206 ,  C08G73/0226 ,  C08K5/3412 ,  C08L101/08 ,  Y10S516/06 ,  C08G18/3293 ,  C08L2666/20 ,  C08L2666/02

Abstract: AZIRIDINYL COMPOUNDS OF THE FORMULA:

AZ-CH2-CH(-O-R'')-CH2-O-R

WHEREIN

AZ IS AN AZIRIDINO GROUP, R IS HYDROGEN, OR AN ALKENYL, ALKENYL CYCLO ALIPHATIC, ALKENYLARYL, HYDROXYPOLYOXYALKYLENE, OR A HYDROXY POLYOXYALKYLENE (OXYALKYENYL) GROUP, AND R'' IS HYDROGEN, OR A HYDROXYPOLYOXALKYLENE, OR A HYDROXY POLYOXYALKYLENE (OXYALKENYL) GROUP

ARE PREPARED ACCORDING TO THE REACTION ILLUSTRATED BY THE FOLLOWING TYPICAL PREPARATION:

2-(HO-CH2-)-OXIRANE + AZIRIDINE ---->

1-(HO-CH2-CH(-OH)-CH2-)-AZIRIDINE

THE NEW COMPOUNDS CAN BE USED IN FORMING ADHESIVES, COATINGS FOR FABRICS, FOAMS AND SPONGES, BINDERS, EMULSIFIERS AND SURFACTANTS AND AS CROSS-LINKERS FOR POLYMERS.

公开(公告)号：US3520875A

公开(公告)日：1970-07-21

申请号：US3520875D

申请日：1966-08-25

Applicant: DOW CHEMICAL CO

Inventor： ASHBY THEODORE L ,  LANE ROBERT E JR

IPC: C07D203/08 ,  C07D23/06 ,  C07D23/02

CPC classification number: C07D203/08

公开(公告)号：US3449323A

公开(公告)日：1969-06-10

申请号：US3449323D

申请日：1965-10-04

Applicant: DOW CHEMICAL CO

Inventor： DUNBAR JOSEPH E

IPC: C07D295/26 ,  C07D87/46 ,  C07C149/24 ,  C07D23/06

CPC classification number: C07D295/26