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公开(公告)号：US06262254B1
公开(公告)日：2001-07-17
申请号：US09199975
申请日：1998-11-25
IPC分类号： C07H19167
CPC分类号： C07D473/00
摘要： An efficient, regiocontrolled approach to the synthesis of 8-fluoropurines by direct fluorination of purines with dilute elemental fluorine, or acetyl hypofluorite, is provided. In a preferred embodiment, a purine compound is dissolved in a polar solvent and reacted with a dilute mixture of F2 in He or other inert gas.
摘要翻译： 提供了通过用稀释的元素氟或乙酰基次氟酸直接氟化嘌呤来合成8-氟嘌呤的有效的区域控制方法。 在一个优选的实施方案中，将嘌呤化合物溶解在极性溶剂中并与F 2在He或其它惰性气体中的稀混合物反应。
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公开(公告)号：US06596858B2
公开(公告)日：2003-07-22
申请号：US09803765
申请日：2001-03-12
IPC分类号： C07H19167
CPC分类号： C07D473/00 , C07D473/40 , C07F9/65616 , C07F9/657181 , C07H19/16
摘要： A novel process for preparing 2-halo-6-aminopurine derivatives and their analogs is disclosed. The method comprises halogenation of 2,6-diaminopurine derivatives at the C-2 position in a specific combination of aprotic polar and nonpolar organic solvents to give the corresponding halogenated derivatives.
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公开(公告)号：US06576620B2
公开(公告)日：2003-06-10
申请号：US09728555
申请日：2000-12-01
申请人： Luiz Belardinelli , Zhenhai Gao
发明人： Luiz Belardinelli , Zhenhai Gao
IPC分类号： C07H19167
CPC分类号： C07H19/16
摘要： The present invention provides a method for identifying partial adenosine A1 receptor agonists that are useful in the treatment of arrhythmias. Partial adenosine A1 receptor agonists and methods for using partial adenosine A1 receptor agonists to treat arrhythmias in mammals.
摘要翻译： 本发明提供了用于鉴定可用于治疗心律失常的部分腺苷A1受体激动剂的方法。 部分腺苷A1受体激动剂和使用部分腺苷A1受体激动剂治疗哺乳动物心律失常的方法。
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4.发明授权Stable salts of S-adenosyl-L-methionine (SAMe) and the process for their preparation 失效S-腺苷-L-甲硫氨酸（SAMe）的稳定盐及其制备方法公开(公告)号：US06649753B2
公开(公告)日：2003-11-18
申请号：US09875006
申请日：2001-06-07
IPC分类号： C07H19167
CPC分类号： C07H19/16
摘要： This invention relates to the production of new & stable salts of S-adenosyl-L-methionine SAMe). The source of SAMe used in the salt formation is from chemical process wherein stereoselective methylation of S-adenosyl-L-homocysteine is achieved. The process for the salt preparation is simple, efficient & reproducible on large scale. The new salts were found to be stable at accelerated temperature for minimum 3 months.
摘要翻译： 本发明涉及S-腺苷-L-甲硫氨酸SAMe的新稳定盐的生产。 在盐形成中使用的SAMe的来源是其化学过程，其中实现了S-腺苷-L-高半胱氨酸的立体选择性甲基化。 盐的制备过程简单，高效，可重复性大。 发现新盐在加速温度下稳定至少3个月。
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公开(公告)号：US06455690B1
公开(公告)日：2002-09-24
申请号：US09594647
申请日：2000-06-15
申请人： Robert Tam , Devron Averett , Guangyi Wang , Kanda Ramasamy
发明人： Robert Tam , Devron Averett , Guangyi Wang , Kanda Ramasamy
IPC分类号： C07H19167
CPC分类号： C07H19/16 , A61K31/52 , A61K31/522 , A61K31/70 , A61K31/7076 , A61K31/7115 , C07H19/052 , C07H19/056 , C07H19/24
摘要： Novel nucleosides having the structure of Formula 1 and Formula 2 are contemplated. In one aspect of the invention, controlled release dosage forms are particularly contemplated. Further, alternative routes of administration of the nucleosides having the structure of Formula 1 or Formula 2 are contemplated.
摘要翻译： 考虑了具有式1和式2结构的新型核苷。 在本发明的一个方面，特别考虑了控释剂型。 此外，考虑了具有式1或式2结构的核苷的替代的给药途径。
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公开(公告)号：US06252061B1
公开(公告)日：2001-06-26
申请号：US09274518
申请日：1999-03-23
IPC分类号： C07H19167
CPC分类号： C07D473/00 , C07D473/40 , C07F9/65616 , C07F9/657181 , C07H19/16
摘要： A novel process for preparing 2-halo-6-aminopurine derivatives and their analogs is disclosed. The method comprises halogenation of 2,6-diaminopurine derivatives at the C-2 position in a specific combination of aprotic polar and nonpolar organic solvents to give the corresponding halogenated derivatives.
摘要翻译： 公开了一种制备2-卤代-6-氨基嘌呤衍生物及其类似物的新方法。 该方法包括在非质子极性和非极性有机溶剂的特定组合中在C-2位上卤化2,6-二氨基嘌呤衍生物，得到相应的卤代衍生物。
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