公开(公告)号：US06239272B1

公开(公告)日：2001-05-29

申请号：US09098694

申请日：1998-06-17

申请人： Leonid Beigelman ,  Alex Karpeisky

发明人： Leonid Beigelman ,  Alex Karpeisky

IPC分类号： C07M2102

CPC分类号： C12N15/1137 ,  C07H19/06 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20 ,  C07H21/00 ,  C12N15/1138 ,  C12N2310/121 ,  C12N2310/315 ,  C12N2310/32 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/33 ,  C12N2310/332 ,  C12N2310/346 ,  C12Y304/24017 ,  C12N2310/3521

摘要： A compound having the formula: wherein, R1 represents 2′-O-R3-thio-R3 and/or 2′-C-R3-thio-R3, wherein R3 is a compound independently selected from a group consisting of alkyl, alkenyl, alkynyl, aryl, alkylaryl, carbocyclic aryl, heterocyclic aryl, amide and ester, X represents a base or H; Y represents a phosphorus-containing group; and R2 represents H, DMT or a phosphorus-containing group.

摘要翻译： 具有下式的化合物：其中R1表示2'-O-R3-thio-R3和/或2'-C-R3-硫代-R3，其中R3是独立地选自烷基，烯基， 炔基，芳基，烷基芳基，碳环芳基，杂环芳基，酰胺和酯，X表示碱或H; Y表示含磷基团; R2代表H，DMT或含磷基团。

公开(公告)号：US06548657B1

公开(公告)日：2003-04-15

申请号：US09216584

申请日：1998-12-18

申请人： Alex Burgin ,  Leonid Beigelman ,  Laurent Bellon

发明人： Alex Burgin ,  Leonid Beigelman ,  Laurent Bellon

IPC分类号： C07M2102

CPC分类号： C12N15/113 ,  A61K38/00 ,  C12N15/1135 ,  C12N15/1137 ,  C12N15/1138 ,  C12N2310/111 ,  C12N2310/12 ,  C12N2310/121 ,  C12N2310/122 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/332 ,  C12N2310/3519 ,  C12Y204/02001 ,  C12Y207/01037 ,  C12N2310/3521

摘要： Nucleic acid catalysts, method of screening for variants of nucleic acid catalysts, synthesis of ribozyme libraries and discovery of gene sequences are described.

公开(公告)号：US06476208B1

公开(公告)日：2002-11-05

申请号：US09539333

申请日：2000-03-30

申请人： Daniel Cohen ,  Marta Blumenfeld ,  Ilya Chumakov ,  Lydie Bougueleret ,  Bernard Bihain ,  Laurent Essioux

发明人： Daniel Cohen ,  Marta Blumenfeld ,  Ilya Chumakov ,  Lydie Bougueleret ,  Bernard Bihain ,  Laurent Essioux

IPC分类号： C07M2102

CPC分类号： C07K14/47 ,  A01K2217/075 ,  C12Q1/6883 ,  C12Q2600/156

摘要： The invention concerns the human sbg1, g34665, sbg2, g35017 and g35018 genes, polynucleotides, polypeptides biallelic markers, and human chromosome 13q31-q33 biallelic markers. The invention also concerns the association established between schizophrenia and bipolar disorder and the biallelic markers and the sbg1, g34665, sbg2, g35017 and g35018 genes and nucleotide sequences. The invention provides means to identify compounds useful in the treatment of schizophrenia, bipolar disorder and related diseases, means to determine the predisposition of individuals to said disease as well as means for the disease diagnosis and prognosis.

摘要翻译： 本发明涉及人sbg1，g34665，sbg2，g35017和g35018基因，多核苷酸，多肽双重标记和人染色体13q31-q33双重标记。 本发明还涉及精神分裂症和双相情感障碍与双重标记和sbg1，g34665，sbg2，g35017和g35018基因和核苷酸序列之间建立的关联。 本发明提供了鉴定用于治疗精神分裂症，双相性精神障碍和相关疾病的化合物的方法，用于确定个体对所述疾病的倾向以及疾病诊断和预后的手段。