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公开(公告)号：US07125667B2
公开(公告)日：2006-10-24
申请号：US10214684
申请日：2002-08-07
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C07K14/715 , C12Q2600/156
摘要： The invention provides novel LSR genomic sequences, polypeptides, antibodies, and polynucleotides including biallelic markers derived from the LSR locus. Primers hybridizing to regions flanking these biallelic markers are also provided. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype.
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公开(公告)号：US20060148690A1
公开(公告)日：2006-07-06
申请号：US10521005
申请日：2003-06-30
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4723 , G01N33/6893
摘要： This invention provides secreted active peptides, methods and compositions for making such peptides, and methods of using the peptides in detection assays, for disease diagnosis, for disease treatment and for drug development, in particular for microbial or viral infections.
摘要翻译： 本发明提供分泌的活性肽，用于制备这些肽的方法和组合物，以及在检测测定中使用肽，疾病诊断，疾病治疗和药物开发，特别是微生物或病毒感染的方法。
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公开(公告)号：US07067627B2
公开(公告)日：2006-06-27
申请号：US10147603
申请日：2002-05-16
申请人： Daniel Cohen , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Bernard Bihain , Laurent Essioux
发明人： Daniel Cohen , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Bernard Bihain , Laurent Essioux
CPC分类号： C12Q1/6883 , A01K2217/075 , C07K14/47 , C12Q2600/156
摘要： The invention concerns the human sbg1, g34665, sbg2, g35017 and g35018 genes, polynucleotides, polypeptides biallelic markers, and human chromosome 13q31-q33 biallelic markers. The invention also concerns the association established between schizophrenia and bipolar disorder and the biallelic markers and the sbg1, g34665, sbg2, g35017 and g35018 genes and nucleotide sequences. The invention provides means to identify compounds useful in the treatment of schizophrenia, bipolar disorder and related diseases, means to determine the predisposition of individuals to said disease as well as means for the disease diagnosis and prognosis.
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公开(公告)号：US07041454B2
公开(公告)日：2006-05-09
申请号：US10376893
申请日：2003-02-27
CPC分类号： C12N9/10 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172 , G01N2500/10
摘要： The invention concerns the genomic sequence of the purH gene. The invention also concerns biallelic markers of a purH gene and the association established between these markers and cancer, particularly prostate cancer. The invention provides means to determine the predisposition of individuals to cancer as well as means for the diagnosis of cancer and for the prognosis/detection of an eventual treatment response to agents acting on cancer.
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公开(公告)号：US06908988B2
公开(公告)日：2005-06-21
申请号：US10071179
申请日：2002-03-19
申请人： Lydie Bougueleret
发明人： Lydie Bougueleret
IPC分类号： A01K67/027 , A61K38/00 , C07H21/04 , C07K14/47 , C07K14/82 , C07K16/18 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/68 , G01N33/53 , G01N33/566 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： C12Q1/6886 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07H21/04 , C07K14/47 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
摘要： The present invention is directed to a polynucleotide comprising open reading frames defining a coding region encoding a retinoblastoma binding protein (RBP-7) as well as regulatory regions located both at the 5′ end and the 3′ end of said coding region. The present invention also pertains to a polynucleotide carrying the natural regulation signals of the RBP-7 gene which is useful in order to express a heterologous nucleic acid in host cells or host organisms as well as functionally active regulatory polynucleotides derived from said regulatory region. The invention also concerns polypeptides encoded by the coding region of the RBP-7 gene. The invention also deals with antibodies directed specifically against such polypeptides that are useful as diagnostic reagents. The invention also comprises genetic markers, namely biallelic markers, that are means that may be useful for the diagnosis of diseases related to an alteration in the regulation or in the coding regions of the RBP-7 gene and for the prognosis/diagnosis of an eventual treatment with therapeutic agents, especially agents acting on pathologies involving abnormal cell proliferation and/or abnormal cell differentiation.
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6.发明申请Biallelic markers derived from genomic regions carrying genes involved in arachidonic acid metabolism 失效衍生自携带花生四烯酸代谢基因的基因组区域的双基因标记公开(公告)号：US20050014190A1
公开(公告)日：2005-01-20
申请号：US10926684
申请日：2004-08-25
CPC分类号： G06F19/18 , C12Q1/6858
摘要： The invention provides polynucleotides including biallelic markers derived from genes involved in arachidonic acid metabolism and from genomic regions flanking those genes. Primers hybridizing to regions flanking these biallelic markers are also provided. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype.
摘要翻译： 本发明提供了多核苷酸，包括衍生自花生四烯酸代谢参与的基因的双重标记和来自这些基因侧翼的基因组区域。 还提供了与这些双重标记物侧翼的区域杂交的引物。 本发明还提供了适用于对本发明的一种或多种双重标记物的含有核酸的样品进行基因分型的多核苷酸和方法。 此外，本发明提供了检测双标记等位基因和表型之间和/或双重标记单倍型和表型之间的统计学相关性的方法。
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公开(公告)号：US06476208B1
公开(公告)日：2002-11-05
申请号：US09539333
申请日：2000-03-30
申请人： Daniel Cohen , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Bernard Bihain , Laurent Essioux
发明人： Daniel Cohen , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Bernard Bihain , Laurent Essioux
IPC分类号： C07M2102
CPC分类号： C07K14/47 , A01K2217/075 , C12Q1/6883 , C12Q2600/156
摘要： The invention concerns the human sbg1, g34665, sbg2, g35017 and g35018 genes, polynucleotides, polypeptides biallelic markers, and human chromosome 13q31-q33 biallelic markers. The invention also concerns the association established between schizophrenia and bipolar disorder and the biallelic markers and the sbg1, g34665, sbg2, g35017 and g35018 genes and nucleotide sequences. The invention provides means to identify compounds useful in the treatment of schizophrenia, bipolar disorder and related diseases, means to determine the predisposition of individuals to said disease as well as means for the disease diagnosis and prognosis.
摘要翻译： 本发明涉及人sbg1，g34665，sbg2，g35017和g35018基因，多核苷酸，多肽双重标记和人染色体13q31-q33双重标记。 本发明还涉及精神分裂症和双相情感障碍与双重标记和sbg1，g34665，sbg2，g35017和g35018基因和核苷酸序列之间建立的关联。 本发明提供了鉴定用于治疗精神分裂症，双相性精神障碍和相关疾病的化合物的方法，用于确定个体对所述疾病的倾向以及疾病诊断和预后的手段。
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公开(公告)号：US06455280B1
公开(公告)日：2002-09-24
申请号：US09750580
申请日：2000-12-28
IPC分类号： C07K100
CPC分类号： C07K16/30 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K14/47 , C07K14/4747 , C07K2319/02 , C07K2319/21 , C07K2319/32 , C12N15/625
摘要： The invention provides the genomic sequence of GSSP-2, GSSP-2 cDNAs and GSSP-2 polypeptides. Further the invention provides polynucleotides including biallelic markers derived from the GSSP-2 gene and from genomic regions flanking the gene. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid molecule containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype. The invention also concerns methods and compositions for killing neoplastic cells or inhibiting neoplastic cell growth. In particular, the present invention concerns cell proliferation arresting/inhibiting and apoptosis/necrosis inducing compositions and methods for the treatment of tumors. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides.
摘要翻译： 本发明提供GSSP-2，GSSP-2 cDNA和GSSP-2多肽的基因组序列。 此外，本发明提供了多核苷酸，其包括衍生自GSSP-2基因的双重标记和来自该基因侧翼的基因组区域。 本发明还提供适用于对含有本发明的一种或多种双重标记物的含有核酸分子的样品进行基因分型的多核苷酸和方法。 此外，本发明提供了检测双标记等位基因和表型之间和/或双重标记单倍型和表型之间的统计学相关性的方法。 本发明还涉及用于杀死肿瘤细胞或抑制肿瘤细胞生长的方法和组合物。 特别地，本发明涉及细胞增殖阻滞/抑制和凋亡/坏死诱导组合物和治疗肿瘤的方法。 本发明涉及新型多肽和编码那些多肽的核酸分子。
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9.发明授权Biallelic markers derived from genomic regions carrying genes involved in arachidonic acid metabolism 失效衍生自携带花生四烯酸代谢基因的基因组区域的双基因标记公开(公告)号：US06432648B1
公开(公告)日：2002-08-13
申请号：US09641638
申请日：2000-08-16
IPC分类号： C12Q168
CPC分类号： G06F19/18 , C12Q1/6858
摘要： The invention provides polynucleotides including biallelic markers derived from genes involved in arachidonic acid metabolism and from genomic regions flanking those genes. Primers hybridizing to regions flanking these biallelic markers are also provided. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype.
摘要翻译： 本发明提供了多核苷酸，包括衍生自花生四烯酸代谢参与的基因的双重标记和来自这些基因侧翼的基因组区域。 还提供了与这些双重标记物侧翼的区域杂交的引物。 本发明还提供了适用于对本发明的一种或多种双重标记物的含有核酸的样品进行基因分型的多核苷酸和方法。 此外，本发明提供了检测双标记等位基因和表型之间和/或双重标记单倍型和表型之间的统计学相关性的方法。
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10.发明授权Genomic sequence of the 5-lipoxygenase-activating protein (FLAP), polymorphic markers thereof and methods for detection of asthma 失效5-脂氧合酶活化蛋白（FLAP）的基因组序列及其多态性标记及哮喘检测方法公开(公告)号：US07494777B2
公开(公告)日：2009-02-24
申请号：US11512789
申请日：2006-08-29
CPC分类号： C12Q1/6883 , A01K2217/05 , A01K2217/075 , C07K14/4705 , C12Q1/6827 , C12Q2600/156
摘要： The invention concerns the genomic sequence of the FLAP gene. The invention also concerns biallelic markers of a FLAP gene and the association established between these markers and diseases involving the leukotriene pathway such as asthma. The invention provides means to determine the predisposition of individuals to diseases involving the leukotriene pathway as well as means for the diagnosis of such diseases and for the prognosis/detection of an eventual treatment response to agents acting on the leukotriene pathway.
摘要翻译： 本发明涉及FLAP基因的基因组序列。 本发明还涉及FLAP基因的双重标记和这些标记与涉及白细胞三烯途径如哮喘的疾病之间建立的关联。 本发明提供了确定个体对涉及白细胞三烯途径的疾病的易感性以及用于诊断这些疾病的手段以及对作用于白三烯途径的药剂的最终治疗反应的预后/检测的手段。
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