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    Methods, software and apparati for identifying genomic regions harboring a gene associated with a detectable trait
    7.
    发明申请
    Methods, software and apparati for identifying genomic regions harboring a gene associated with a detectable trait 审中-公开
    方法，软件和装置，用于鉴定携带可检测性状相关基因的基因组区域

    公开(公告)号：US20050158788A1

    公开(公告)日：2005-07-21

    申请号：US11048148

    申请日：2005-02-01

    申请人： Nicholas Schork ,  Laurent Essioux ,  Annick Cohen-Akenine ,  Marta Blumenfeld ,  Daniel Cohen

    发明人： Nicholas Schork ,  Laurent Essioux ,  Annick Cohen-Akenine ,  Marta Blumenfeld ,  Daniel Cohen

    IPC分类号： G01N33/53 ,  C12N15/09 ,  C12Q1/68 ,  G01N33/566 ,  G06F17/30 ,  G06F19/18 ,  G06F19/22 ,  G06F19/24 ,  G06F19/00 ,  G01N33/48 ,  G01N33/50

    CPC分类号： C12Q1/6827 ,  G16B20/00 ,  G16B30/00 ,  G16B40/00

    摘要： The present invention relates to methods, software, and apparati for determining whether a genomic region harbors a gene associated with a detectable trait. In one embodiment, the present invention relates to a method of confirming that a genomic region harbors a gene associated with a detectable trait comprising the steps of identifying a candidate genomic region suspected of harboring the gene associated with the detectable trait, constructing a trait-associated distribution of association values using the biallelic markers in the candidate genomic region, identifying a plurality of biallelic markers in random genomic regions which are not suspected of harboring the gene associated with the detectable trait, constructing a random distribution of association values using the biallelic markers in the random genomic regions, comparing the trait-associated distribution of association values to the random distribution of association values, and determining whether the trait-associated distribution of association values and the random distribution of association values are significantly different from one another. In other embodiments, the present invention comprises software for performing the above method and devices comprising the software in a retrievable form.

    摘要翻译： 本发明涉及用于确定基因组区域是否包含与可检测特征相关的基因的方法，软件和装置。 在一个实施方案中，本发明涉及一种确认基因组区域包含与可检测性状相关的基因的方法，其包括以下步骤：鉴定疑似携带可检测性状相关基因的候选基因组区域，构建与性状相关 在候选基因组区域中使用双重标记的关联值的分布，鉴定不怀疑携带与可检测性状相关的基因的随机基因组区域中的多个双重标记，使用双重标记物建立关联值的随机分布 随机基因组区域，将关联值的性状相关分布与关联值的随机分布进行比较，以及确定关联值的性状相关分布和关联值的随机分布是否彼此显着不同。 在其他实施例中，本发明包括用于执行上述方法的软件和包括可检索形式的软件的装置。

    Schizophrenia associated gene, proteins and biallelic markers
    8.
    发明授权
    Schizophrenia associated gene, proteins and biallelic markers 失效
    精神分裂症相关基因，蛋白质和双重标记物

    公开(公告)号：US06555316B1

    公开(公告)日：2003-04-29

    申请号：US09679409

    申请日：2000-10-03

    申请人： Daniel Cohen ,  Marta Blumenfeld ,  Ilya Chumakov ,  Lydie Bougueleret ,  Laurent Essioux

    发明人： Daniel Cohen ,  Marta Blumenfeld ,  Ilya Chumakov ,  Lydie Bougueleret ,  Laurent Essioux

    IPC分类号： C12Q168

    CPC分类号： C12Q1/6883 ,  C07K14/47 ,  C07K16/18 ,  C12Q2600/156 ,  C12Q2600/172

    摘要： The invention concerns the human g35030 gene, polynucleotides, polypeptides biallelic markers, and human chromosome 13q31-q33 biallelic markers. The invention also concerns the association established between schizophrenia and bipolar disorder and the biallelic markers and the g35030 gene and nucleotide sequences. The invention provides means to identify compounds useful in the treatment of schizophrenia, bipolar disorder and related diseases, means to determine the predisposition of individuals to said disease as well as means for the disease diagnosis and prognosis.

    摘要翻译： 本发明涉及人g35030基因，多核苷酸，多肽双向标记和人染色体13q31-q33双重标记。 本发明还涉及精神分裂症和双相障碍与双重标记和g35030基因和核苷酸序列之间的关联。 本发明提供了鉴定用于治疗精神分裂症，双相性精神障碍和相关疾病的化合物的方法，用于确定个体对所述疾病的易感性以及疾病诊断和预后的手段。