公开(公告)号：US06670192B1

公开(公告)日：2003-12-30

申请号：US09477900

申请日：2000-01-05

申请人： Robert S. Galen ,  John F. Burd ,  Talei Hoblitzell ,  Gebhard Neyer

发明人： Robert S. Galen ,  John F. Burd ,  Talei Hoblitzell ,  Gebhard Neyer

IPC分类号： G01D3372

CPC分类号： C12Q1/34 ,  C12Q1/54 ,  C12Q2326/12 ,  C12Q2326/14 ,  C12Q2326/92 ,  G01N21/645 ,  G01N33/526 ,  G01N33/66 ,  G01N2333/42 ,  Y10S435/97 ,  Y10S436/828 ,  Y10T436/144444

摘要： The present invention is directed to a single test system and method for determining the integrated glycemic condition of a subject by measuring the concentration of glucose and the level of protein-bound glucose in a subject's body fluid, such as whole blood. The glucose concentration is indicative of the subject's immediate glycemic condition, whereas the protein-bound glucose concentration is indicative of either intermediate or long-term glycemic condition. Optionally, other analytes indicative of glycemic condition, such as ketone bodies or fatty acid derivatives, can also be measured. The present invention also provides a method of diagnosing diabetes. The invention additionally provides a method for analyzing the concentration of fructosamine in less than or equal to five minutes without the use of a reaction accelerator.

摘要翻译： 本发明涉及用于通过测量受试者体液（例如全血）中葡萄糖浓度和蛋白质结合葡萄糖水平来测定受试者的综合血糖状况的单一测试系统和方法。 葡萄糖浓度表示受试者的立即血糖状况，而蛋白质结合的葡萄糖浓度则指示中度或长期血糖状态。 任选地，还可以测量指示血糖状况的其它分析物，例如酮体或脂肪酸衍生物。 本发明还提供了诊断糖尿病的方法。 本发明另外提供了一种在不使用反应促进剂的情况下分析小于或等于五分钟的果糖胺浓度的方法。