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    Combined assay for current glucose level and intermediate or long-term glycemic control
    2.
    发明授权
    Combined assay for current glucose level and intermediate or long-term glycemic control 失效
    用于当前葡萄糖水平和中期或长期血糖控制的联合测定

    公开(公告)号：US5695949A

    公开(公告)日：1997-12-09

    申请号：US418495

    申请日：1995-04-07

    申请人： Robert S. Galen ,  John F. Burd ,  Talei Hoblitzell ,  Gebhard Neyer

    发明人： Robert S. Galen ,  John F. Burd ,  Talei Hoblitzell ,  Gebhard Neyer

    IPC分类号： C12Q1/34 ,  C12Q1/54 ,  G01N33/52 ,  G01N33/66 ,  G01N31/22

    CPC分类号： C12Q1/34 ,  C12Q1/54 ,  G01N33/526 ,  G01N33/66 ,  C12Q2326/12 ,  C12Q2326/14 ,  C12Q2326/92 ,  G01N21/645 ,  G01N2333/42 ,  Y10S435/97 ,  Y10S436/828 ,  Y10T436/144444

    摘要： The present invention is directed to a single test system and method for determining the integrated glycemic condition of a subject by measuring the concentration of glucose and the level of protein-bound glucose in a subject's body fluid, such as whole blood. The glucose concentration is indicative of the subject's immediate glycemic condition, whereas the protein-bound glucose concentration is indicative of either intermediate or long-term glycemic condition. Optionally, other analytes indicative of glycemic condition, such as ketone bodies or fatty acid derivatives, can also be measured. The present invention also provides a method of diagnosing diabetes. The invention additionally provides a method for analyzing the concentration of fructosamine in less than or equal to five minutes without the use of a reaction accelerator.

    摘要翻译： 本发明涉及用于通过测量受试者体液（例如全血）中葡萄糖浓度和蛋白质结合葡萄糖水平来测定受试者的综合血糖状况的单一测试系统和方法。 葡萄糖浓度表示受试者的立即血糖状况，而蛋白质结合的葡萄糖浓度则指示中度或长期血糖状态。 任选地，还可以测量指示血糖状况的其它分析物，例如酮体或脂肪酸衍生物。 本发明还提供了诊断糖尿病的方法。 本发明另外提供了一种在不使用反应促进剂的情况下分析小于或等于五分钟的果糖胺浓度的方法。

    Combined assay for current glucose level and intermediate or long-term glycemic control
    3.
    发明授权
    Combined assay for current glucose level and intermediate or long-term glycemic control 失效
    用于当前葡萄糖水平和中期或长期血糖控制的联合测定

    公开(公告)号：US06958129B2

    公开(公告)日：2005-10-25

    申请号：US10666364

    申请日：2003-09-19

    申请人： Robert S. Galen ,  John F. Burd ,  Talei Hoblitzell ,  Gebhard Neyer

    发明人： Robert S. Galen ,  John F. Burd ,  Talei Hoblitzell ,  Gebhard Neyer

    IPC分类号： C12Q1/34 ,  C12Q1/54 ,  G01N33/52 ,  G01N33/66 ,  G01N31/22

    CPC分类号： C12Q1/34 ,  C12Q1/54 ,  C12Q2326/12 ,  C12Q2326/14 ,  C12Q2326/92 ,  G01N21/645 ,  G01N33/526 ,  G01N33/66 ,  G01N2333/42 ,  Y10S435/97 ,  Y10S436/828 ,  Y10T436/144444

    摘要： The present invention is directed to a single test system and method for determining the integrated glycemic condition of a subject by measuring the concentration of glucose and the level of protein-bound glucose in a subject's body fluid, such as whole blood. The glucose concentration is indicative of the subject's immediate glycemic condition, whereas the protein-bound glucose concentration is indicative of either intermediate or long-term glycemic condition. Optionally, other analytes indicative of glycemic condition, such as ketone bodies or fatty acid derivatives, can also be measured. The present invention also provides a method of diagnosing diabetes. The invention additionally provides a method for analyzing the concentration of fructosamine in less than or equal to five minutes without the use of a reaction accelerator.

    摘要翻译： 本发明涉及一种用于通过测量受试者体液（例如全血）中葡萄糖浓度和蛋白质结合葡萄糖水平来测定受试者的综合血糖状况的单一测试系统和方法。 葡萄糖浓度表示受试者的立即血糖状况，而蛋白质结合的葡萄糖浓度则指示中度或长期血糖状态。 任选地，还可以测量指示血糖状况的其它分析物，例如酮体或脂肪酸衍生物。 本发明还提供了诊断糖尿病的方法。 本发明另外提供了一种在不使用反应促进剂的情况下分析小于或等于五分钟的果糖胺浓度的方法。

    Apparatus for combined assay for current glucose level and intermediate or long-term glycemic control
    4.
    发明授权
    Apparatus for combined assay for current glucose level and intermediate or long-term glycemic control 失效
    用于当前葡萄糖水平和中期或长期血糖控制的联合测定的装置

    公开(公告)号：US06670192B1

    公开(公告)日：2003-12-30

    申请号：US09477900

    申请日：2000-01-05

    申请人： Robert S. Galen ,  John F. Burd ,  Talei Hoblitzell ,  Gebhard Neyer

    发明人： Robert S. Galen ,  John F. Burd ,  Talei Hoblitzell ,  Gebhard Neyer

    IPC分类号： G01D3372

    CPC分类号： C12Q1/34 ,  C12Q1/54 ,  C12Q2326/12 ,  C12Q2326/14 ,  C12Q2326/92 ,  G01N21/645 ,  G01N33/526 ,  G01N33/66 ,  G01N2333/42 ,  Y10S435/97 ,  Y10S436/828 ,  Y10T436/144444

    摘要： The present invention is directed to a single test system and method for determining the integrated glycemic condition of a subject by measuring the concentration of glucose and the level of protein-bound glucose in a subject's body fluid, such as whole blood. The glucose concentration is indicative of the subject's immediate glycemic condition, whereas the protein-bound glucose concentration is indicative of either intermediate or long-term glycemic condition. Optionally, other analytes indicative of glycemic condition, such as ketone bodies or fatty acid derivatives, can also be measured. The present invention also provides a method of diagnosing diabetes. The invention additionally provides a method for analyzing the concentration of fructosamine in less than or equal to five minutes without the use of a reaction accelerator.

    摘要翻译： 本发明涉及用于通过测量受试者体液（例如全血）中葡萄糖浓度和蛋白质结合葡萄糖水平来测定受试者的综合血糖状况的单一测试系统和方法。 葡萄糖浓度表示受试者的立即血糖状况，而蛋白质结合的葡萄糖浓度则指示中度或长期血糖状态。 任选地，还可以测量指示血糖状况的其它分析物，例如酮体或脂肪酸衍生物。 本发明还提供了诊断糖尿病的方法。 本发明另外提供了一种在不使用反应促进剂的情况下分析小于或等于五分钟的果糖胺浓度的方法。

    Multi-layer devices and methods of assaying for fructosamine
    5.
    发明授权
    Multi-layer devices and methods of assaying for fructosamine 失效
    多层装置和果糖胺测定方法

    公开(公告)号：US5470752A

    公开(公告)日：1995-11-28

    申请号：US269351

    申请日：1994-06-29

    申请人： John F. Burd ,  Talei Hoblitzell ,  Gebhard Neyer

    发明人： John F. Burd ,  Talei Hoblitzell ,  Gebhard Neyer

    IPC分类号： G01N31/00 ,  G01N31/22 ,  G01N33/487 ,  G01N33/52 ,  G01N33/66

    CPC分类号： G01N33/526 ,  Y10S435/805 ,  Y10S436/825 ,  Y10T436/255

    摘要： The present invention is directed to a multi-layer test device and method for analyzing the concentration of fructosamine in a liquid sample. The multi-layer test device has a buffer layer containing a buffer having a pH value of at least 9 which is either superposed above or juxtaposed to an indicator layer containing an indicator capable of being reduced by fructosamine. Supporting the buffer layer, the indicator layer, and any additional layers in the multi-layer device is at least one support member which optionally has a detection aperture for analyzing the concentration of fructosamine on the indicator layer. An additional support member having a sample aperture can be used. Where two support members are used the multi-layers are sandwiched between the first support member having a sample aperture and the second support member optionally having a detection aperture.

    摘要翻译： 本发明涉及用于分析液体样品中果糖胺浓度的多层测试装置和方法。 多层测试装置具有缓冲层，该缓冲层含有pH值至少为9的缓冲液，该缓冲层叠加在含有能够被果糖胺还原的指示剂的指示剂层上方或并置。 支撑缓冲层，指示层和多层装置中的任何附加层是至少一个支撑构件，其任选地具有用于分析指示剂层上果糖胺浓度的检测孔。 可以使用具有样品孔的另外的支撑构件。 在使用两个支撑构件的情况下，多层夹在具有样品孔的第一支撑构件和可选地具有检测孔的第二支撑构件之间。