公开(公告)号：US07413898B2

公开(公告)日：2008-08-19

申请号：US11442314

申请日：2006-05-30

申请人： Seiko Yoshimura ,  Eiichi Akahoshi ,  Mitsuko Ishihara

发明人： Seiko Yoshimura ,  Eiichi Akahoshi ,  Mitsuko Ishihara

IPC分类号： C12N5/00 ,  C12N5/08 ,  C12N5/10 ,  G01N38/574 ,  C07H21/02

CPC分类号： G01N33/5058 ,  G01N33/5014 ,  G01N2333/4703

摘要： The invention provides neuron-derived cells obtained by transfecting a receptor-expressing nucleic acid having an aryl hydrocarbon receptor gene, wherein outgrowth of neurites is not observed without adding a substance for the aryl hydrocarbon receptor, and outgrowth of neurites is observed by adding the substance for the aryl hydrocarbon receptor. The invention also provides a method for determining the presence of neurotoxicity of a test substance, a method for acquiring a marker for determining the presence of neurotoxicity of the test substance, a method for acquiring a marker for neurological dysfunction, and a method for determining the effect of the test substance on neurological dysfunction using such cells.

摘要翻译： 本发明提供了通过转染具有芳基烃受体基因的受体表达核酸获得的神经元衍生细胞，其中不添加神经突的物质而不添加芳基烃受体的物质，并且通过添加物质观察到神经突的生长 用于芳基烃受体。 本发明还提供了一种测定被检物质的神经毒性的存在的方法，获得测定物质的神经毒性的存在的标记物的获取方法，获取神经功能障碍的标记物的方法， 使用这种细胞的测试物质对神经功能障碍的作用。