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    Ionene polymers and their use as antimicrobial agents
    6.
    发明授权
    Ionene polymers and their use as antimicrobial agents 有权
    紫罗烯聚合物及其作为抗微生物剂的用途

    公开(公告)号：US06955806B2

    公开(公告)日：2005-10-18

    申请号：US10051765

    申请日：2002-01-17

    申请人： Richard J. Fitzpatrick ,  Keith K. Shackett ,  Jeffrey D. Klinger

    发明人： Richard J. Fitzpatrick ,  Keith K. Shackett ,  Jeffrey D. Klinger

    IPC分类号： A01N25/10 ,  A01N33/12 ,  A01N47/44 ,  A01N57/34 ,  A61K31/74 ,  A61K31/785 ,  A61K31/787 ,  A61K31/80 ,  A61P1/00 ,  A61P1/02 ,  A61P31/04 ,  C08G61/12 ,  C08G73/00 ,  C08G73/02 ,  C08G73/06 ,  C08G79/06 ,  A61F13/00

    CPC分类号： C08G73/0627 ,  A61K31/74 ,  A61K31/785 ,  A61K31/787 ,  A61K31/80 ,  C08G61/12 ,  C08G73/00 ,  C08G73/0226

    摘要： Disclosed are ionene polymers having antimicrobial activity. “Ionene polymers” as used in this invention are cationic polymers in which a substantial proportion of the atoms providing the positive charge are quaternized nitrogens located in the main polymeric chain or backbone of the polymer rather than in pendant groups. Also disclosed are antimicrobial compositions comprising ionene polymers and methods for treating microbial infections in mammals comprising the step of administering to a mammal, a therapeutically effective amount of at least one antimicrobial composition of the invention. Also disclosed are antimicrobial compositions comprising at least one ionene polymer and methods for preventing, inhibiting or eliminating the growth, dissemination, and/or the accumulation of microorganisms on a susceptible surface (including, but not limited to, the formation of biofilms on a susceptible surface) comprising the step of contacting such surface with a composition of the invention.

    摘要翻译： 公开了具有抗微生物活性的紫罗烯聚合物。 本发明中使用的“紫罗烯聚合物”是阳离子聚合物，其中提供正电荷的大部分原子是位于聚合物的主要聚合物链或骨架中而不是侧基的季铵化氮。 还公开了包含紫罗烯聚合物和用于治疗哺乳动物微生物感染的方法的抗微生物组合物，其包括向哺乳动物施用治疗有效量的本发明的至少一种抗微生物组合物的步骤。 还公开了包含至少一种紫罗烯聚合物的抗微生物组合物和用于预防，抑制或消除微生物在易感表面上的生长，扩散和/或积累的方法（包括但不限于在易感的表面上形成生物膜 包括使这种表面与本发明的组合物接触的步骤。

    Antimicrobial surfaces
    7.
    发明申请
    Antimicrobial surfaces 有权
    抗菌面

    公开(公告)号：US20050181006A1

    公开(公告)日：2005-08-18

    申请号：US10117311

    申请日：2002-04-05

    申请人： Robert Engel ,  JaimeLee Cohen ,  Karin Fincher

    发明人： Robert Engel ,  JaimeLee Cohen ,  Karin Fincher

    IPC分类号： A01N25/34 ,  A01N33/12 ,  A01N43/24 ,  A01N43/32 ,  A01N43/90 ,  A01N57/34 ,  D06M13/285 ,  D06M13/338 ,  D06M13/46 ,  D06M13/467 ,  D21H21/36 ,  A61K9/70

    CPC分类号： D06M13/338 ,  A01N25/34 ,  A01N33/12 ,  A01N43/32 ,  A01N57/34 ,  D06M13/285 ,  D06M13/46 ,  D21H21/36 ,  A01N25/10 ,  A01N2300/00

    摘要： These and other objectives will be apparent to those having ordinary skill in the art have been achieved by providing an antimicrobial surface having formula 1: SS—(Ua—V+b1—W)b2dX−e  formula 1 wherein: SS represents a modified solid surface that comprises a hydroxyl group in the unmodified state thereof; a represents 0 or 1; U represents —Y1T-; Y1 represents —O—, —S—, or —NQ-; Q represents H; a saturated or unsaturated hydrocarbon group having 1-24 atoms; phenyl; or benzyl; T represents a saturated or unsaturated hydrocarbon chain having 1-24 atoms; V represents a positively charged moiety; b1 represents 1 or 2; b2 represents 1-3; W represents LZ; L represents a saturated or unsaturated hydrocarbon chain having 10-24 atoms; Z represents —H, —OH, —SH, —F, —Cl, —Br, —I, —OR, —HN(O)CQ, or —O(O)CQ; R represents a saturated or unsaturated hydrocarbon group having 1-24 carbon atoms; phenyl; or benzyl; X represents an anion; d represents 1 or 2; and e represents 1-3; wherein b1×b2=d×e.

    摘要翻译： 通过提供具有式1的抗微生物表面已经实现了本领域普通技术人员的这些和其它目的：<？in-line-formula description =“In-line formula”end =“lead”？> SS 式（1）式（1）其中，式（1）其中， -formulae description =“In-line Formulas”end =“tail”？>其中：SS表示包含未改性状态的羟基的改性固体表面; a表示0或1; U表示-Y 1→T; Y 1表示-O - ， - S-或-NQ-; Q表示H; 具有1-24个原子的饱和或不饱和烃基; 苯基; 或苄基; T表示具有1-24个原子的饱和或不饱和烃链; V表示带正电的部分; b1表示1或2; b2表示1-3; W表示LZ; L表示具有10-24个原子的饱和或不饱和烃链; Z表示-H，-OH，-SH，-F，-Cl，-Br，-I，-OR，-HN（O）CQ或-O（O） R表示具有1-24个碳原子的饱和或不饱和烃基; 苯基; 或苄基; X表示阴离子; d表示1或2; e表示1-3; 其中b1xb2 = dxe。

    Biocidal compositions and use thereof containing a synergistic mixture of diiodomethyl-p-tolylsulfone and n-tributyl tetradecyl phosphonium chloride
    8.
    发明授权
    Biocidal compositions and use thereof containing a synergistic mixture of diiodomethyl-p-tolylsulfone and n-tributyl tetradecyl phosphonium chloride 失效
    含有二碘甲基对甲苯砜和正丁基十四烷基氯化鏻的协同混合物的杀菌组合物及其用途

    公开(公告)号：US5089484A

    公开(公告)日：1992-02-18

    申请号：US683210

    申请日：1991-04-10

    申请人： Deborah K. Donofrio ,  Wilson K. Whitekettle

    发明人： Deborah K. Donofrio ,  Wilson K. Whitekettle

    IPC分类号： A01N57/34

    CPC分类号： A01N57/34

    摘要： A bactericidal composition and method for inhibiting and controlling the growth of the capsulated, facultative bacterium, Klebsiella pneumoniae, are disclosed. The composition comprises an amount, effective for the intended purpose of diiodomethyl-p-tolylsulfone and N-tributyl tetradecyl phosphonium chloride. The method comprises administering between about 0.1 to about 200 parts of this combined treatment (based on one million parts of the desired aqueous system) to the particular water containing system for which treatment is desired.

    摘要翻译： 公开了一种用于抑制和控制包裹的兼性细菌肺炎克雷伯杆菌生长的杀菌组合物和方法。 组合物包含对于二碘甲基对甲苯砜和N-三丁基十四烷基氯化鏻的预期目的有效的量。 该方法包括将约0.1至约200份的该组合处理（基于一百万份所需的水性体系）施用于需要治疗的具体含水系统。

    Biocidal compositions and use thereof containing a synergistic mixture of n-tributyl tetradecyl phosphonium chloride and a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiozolin-3-one
    10.
    发明授权
    Biocidal compositions and use thereof containing a synergistic mixture of n-tributyl tetradecyl phosphonium chloride and a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiozolin-3-one 失效
    含有N-三丁基十四烷基氯化鏻和5-氯-2-甲基-4-异噻唑啉-3-酮和2-甲基-4-异硫代唑啉-3-酮的混合物的协同混合物的杀生物组合物及其用途

    公开(公告)号：US5063217A

    公开(公告)日：1991-11-05

    申请号：US566957

    申请日：1990-08-13

    申请人： Wilson K. Whitekettle ,  Deborah K. Donofrio

    发明人： Wilson K. Whitekettle ,  Deborah K. Donofrio

    IPC分类号： A01N57/34 ,  C02F1/50

    CPC分类号： C02F1/50 ,  A01N57/34

    摘要： A bactericidal composition and method for inhibiting and controlling the growth of the capsulated, facultative bacterium, Klebsiella pneumoniae, are disclosed. The composition comprises an amount, effective for the intended purpose of "Belclene 350" and a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one ("Kathon 886F"). The active biocidal component of the "Belclene 350" product is tri n-butyl tetradecyl phosphonium chloride. The method comprises administering between about 0.1 to about 200 parts of this combined treatment (based on one million parts of the desired aqueous system) to the particular water containing system for which treatment is desired.

    摘要翻译： 公开了一种用于抑制和控制包裹的兼性细菌肺炎克雷伯杆菌生长的杀菌组合物和方法。 组合物包含对于“Belclene 350”和5-氯-2-甲基-4-异噻唑啉-3-酮和2-甲基-4-异噻唑啉-3-酮（“Kathon”）的混合物的预期目的有效的量 886F“）。 “Belclene 350”产品的活性杀生物成分是三正丁基十四烷基氯化鏻。 该方法包括将约0.1至约200份的该组合处理（基于一百万份所需的水性体系）施用于需要治疗的具体含水系统。