公开(公告)号：US20240316018A1

公开(公告)日：2024-09-26

申请号：US18588730

申请日：2024-02-27

申请人： Gilead Sciences, Inc.

发明人： Laura Elizabeth Bauer ,  Anna Chiu ,  Eric M. Gorman ,  Andrew Stephen Mulato ,  Martin Sunkwang Rhee ,  Charles William Rowe ,  Scott P. Sellers ,  Dimitrios Stefanidis ,  Winston C. Tse ,  Stephen R. Yant ,  Dana J. Levine

IPC分类号： A61K31/4439 ,  A61K9/00 ,  A61K9/48 ,  A61K31/34 ,  A61K31/4418 ,  A61K31/536 ,  A61K31/5365 ,  A61K31/685 ,  A61P31/18

CPC分类号： A61K31/4439 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/4825 ,  A61K31/34 ,  A61K31/4418 ,  A61K31/536 ,  A61K31/5365 ,  A61K31/685 ,  A61P31/18

摘要： The present disclosure relates to compounds of Formula (Ia) and (Ib):




or a pharmaceutically acceptable salt thereof, which are useful in the treatment of an HIV infection in heavily treatment-experienced patients with multidrug resistant HIV infection.

公开(公告)号：US20240261295A1

公开(公告)日：2024-08-08

申请号：US18634055

申请日：2024-04-12

申请人： Recurium IP Holdings, LLC

发明人： Fernando Donate ,  Hooman Izadi ,  Ahmed Abdi Samatar ,  Brant Clayton Boren ,  Kevin Duane Bunker ,  Peter Qinhua Huang

IPC分类号： A61K31/5365 ,  A61K31/519 ,  A61K39/00 ,  A61P35/00 ,  C07K16/28

CPC分类号： A61K31/5365 ,  A61K31/519 ,  A61P35/00 ,  C07K16/2803 ,  A61K2039/505

摘要： Disclosed herein are combinations of compounds for treating a disease or condition, such as cancer.

公开(公告)号：US12016853B2

公开(公告)日：2024-06-25

申请号：US17228590

申请日：2021-04-12

申请人： Belite Bio, Inc ,  THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Yu-Hsin Tom Lin ,  Cheng-Chi Irene Wang ,  Konstantin Petrukhin

IPC分类号： A61K31/4545 ,  A61K9/00 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/5365 ,  A61K31/5383 ,  A61P3/04 ,  A61P3/10

CPC分类号： A61K31/4545 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/5365 ,  A61K31/5383 ,  A61P3/04 ,  A61P3/10

摘要： Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for the treatment of retinal binding protein (RBP4) related diseases, such as obesity and the like.

公开(公告)号：US20240059772A1

公开(公告)日：2024-02-22

申请号：US18339837

申请日：2023-06-22

申请人： BioNTech AG ,  Astellas Pharma Inc. ,  TRON - Translationle Onkologie an der Universitatsmedizin der Johannes Gutenberg-Universitat Mainz

发明人： Ugur Sahin ,  Ozlem Tureci ,  Korden Walter ,  Meike Wagner ,  Maria Kreuzberg ,  Sabine Hacker ,  Stefan Jacobs

IPC分类号： C07K16/28 ,  G01N33/574 ,  A61K47/68 ,  A61K33/243 ,  A61K31/337 ,  A61K31/5365 ,  A61K31/7048 ,  A61K31/7064 ,  A61K39/395 ,  A61N5/10 ,  C07K16/30

CPC分类号： C07K16/28 ,  G01N33/57484 ,  A61K47/6851 ,  A61K33/243 ,  A61K31/337 ,  A61K31/5365 ,  A61K31/7048 ,  A61K31/7064 ,  A61K39/39558 ,  A61N5/10 ,  C07K16/30 ,  G01N33/57492 ,  G01N2800/52 ,  C07K2317/73 ,  A61K2039/505

摘要： The present invention provides methods for diagnosis or treatment of cancer diseases involving cancer stem cells comprising targeting CLDN6. In particular, the present invention provides a method of determining cancer stem cells comprising detecting cells expressing CLDN6. Furthermore, the present invention provides a method of treating or preventing cancer comprising inhibiting and/or eliminating cancer stem cells by administering an antibody having the ability of binding to CLDN6 to a cancer patient.

公开(公告)号：US11865183B2

公开(公告)日：2024-01-09

申请号：US17591621

申请日：2022-02-03

申请人： POLYTHERICS LIMITED

发明人： Antony Godwin ,  Andrew Kyle ,  Nicholas Evans

IPC分类号： A61K47/68 ,  A61K31/404 ,  A61K31/5365 ,  A61K47/65 ,  A61K47/54 ,  A61K47/60 ,  A61K31/10 ,  A61K31/407 ,  C07K16/28 ,  C07K16/40 ,  A61K39/00 ,  A61K31/40

CPC分类号： A61K47/6803 ,  A61K31/40 ,  A61K31/407 ,  A61K47/54 ,  A61K47/545 ,  A61K47/60 ,  A61K47/65 ,  A61K47/6867 ,  A61K47/6871 ,  C07K16/2878 ,  C07K16/40 ,  A61K2039/505 ,  C07K2317/24

摘要： A conjugate comprising a protein or peptide conjugated to a therapeutic, diagnostic or labelling agent via a linker, characterised in that the linker includes at least two ˜(CH2—CH2—O—)˜ units within a ring, said ring being attached via a single tethering atom within the ring to the rest of the linker, or said ring being attached via two or more tethering atoms within the ring to the rest of the linker at a single point.

公开(公告)号：US20230414625A1

公开(公告)日：2023-12-28

申请号：US18242560

申请日：2023-09-06

申请人： The Global Alliance for TB Drug Development, Inc.

发明人： Khisimuzi Mdluli, JR. ,  Cari M. Mendel ,  Eric Nuermberger

IPC分类号： A61K31/5377 ,  A61K31/47 ,  A61K31/4965 ,  A61K31/5365 ,  C07D498/04 ,  C07D263/20 ,  C07D215/227 ,  C07D241/24 ,  A61P31/04

CPC分类号： A61K31/5377 ,  A61K31/47 ,  A61K31/4965 ,  A61K31/5365 ,  A61P31/04 ,  C07D263/20 ,  C07D215/227 ,  C07D241/24 ,  C07D498/04

摘要： The present invention relates to therapeutic combinations of anti-bacterial agents linezolid, bedaquiline and pretomanid, and optionally with pyrazinamide, in a short-course oral dosage regimen for the treatment of tuberculosis.

公开(公告)号：US20230390318A1

公开(公告)日：2023-12-07

申请号：US18233959

申请日：2023-08-15

申请人： The Scripps Research Institute

发明人： Arnab K. Chatterjee ,  Anil K. Gupta ,  Anders M. Eliasen ,  Sean B. Joseph

IPC分类号： A61K31/7076 ,  A61P31/20 ,  A61P31/18 ,  A61K9/00 ,  A61K47/26 ,  A61K47/38 ,  A61K9/10 ,  A61K31/4439 ,  A61K31/4985 ,  A61K31/513 ,  A61K31/5365 ,  A61K31/675 ,  C07H19/16

CPC分类号： A61K31/7076 ,  A61P31/20 ,  A61P31/18 ,  A61K9/0019 ,  A61K47/26 ,  A61K47/38 ,  A61K9/10 ,  A61K31/4439 ,  A61K31/4985 ,  A61K31/513 ,  A61K31/5365 ,  A61K31/675 ,  C07H19/16

摘要： Diesters of 4′-ethynyl-2-fluoro-2′-deoxyadenosine and aqueous parenteral suspensions thereof provide extended in vivo viral suppression of human immunodeficiency virus (HIV).

公开(公告)号：US11834498B2

公开(公告)日：2023-12-05

申请号：US17838016

申请日：2022-06-10

申请人： ImmunoGen, Inc.

发明人： Olga Ab ,  Neeraj Kohli ,  Thomas Chittenden ,  Julianto Setiady

IPC分类号： C07K16/28 ,  A61K31/5365 ,  A61P35/00 ,  A61K47/68

CPC分类号： C07K16/28 ,  A61K31/5365 ,  A61K47/6803 ,  A61P35/00 ,  C07K2317/31 ,  C07K2317/569

摘要： The present disclosure provides biparatopic antibodies comprising polypeptides that bind to folate receptor alpha (FRα) compositions comprising such biparatopic antibodies. In a specific aspect, the biparatopic antibodies bind to FRα and modulate FRα activity. The present disclosure also provides methods for treating disorders, such as cancer, by administering a biparatopic antibody that specifically binds to FRα and modulates FRα activity.

公开(公告)号：US20230364053A1

公开(公告)日：2023-11-16

申请号：US18246522

申请日：2021-04-20

申请人： TOKYO METROPOLITAN GERIATRIC HOSPITAL AND INSTITUTE OF GERONTOLOGY

发明人： Satoshi INOUE ,  Ken-ichi TAKAYAMA ,  Hiroyuki OSADA ,  Yasumitsu KONDOH

IPC分类号： A61K31/37 ,  A61K31/405 ,  A61K31/5365 ,  A61P35/00 ,  A61K31/453

CPC分类号： A61K31/37 ,  A61K31/405 ,  A61K31/5365 ,  A61P35/00 ,  A61K31/453

摘要： The object of the present invention is to provide a therapeutic agent for treating hormone therapy-resistant, treatment-resistant cancers, and a method of the treatment of hormone therapy-resistant, treatment-resistant cancers. The problem can be solved by a pharmaceutical composition including a compound represented by the formula (1) or a salt thereof or a compound represented by the formula (2) or (3) or a salt thereof, as an active ingredient for treating prostate cancer. Furthermore, the pharmaceutical composition of the present invention can effectively treat not only hormone therapy-resistant prostate cancer or breast cancer but also non-hormone therapy-resistant prostate cancer or breast cancer and Castration-resistant prostate cancer or treatment-resistant breast cancer caused by other mechanisms.

公开(公告)号：US20230255973A1

公开(公告)日：2023-08-17

申请号：US18005300

申请日：2021-07-20

申请人： Eli Lilly and Company

发明人： David Michael HYMAN

IPC分类号： A61K31/5365 ,  A61K31/7068 ,  A61K33/243 ,  A61K31/282 ,  A61P1/16 ,  A61P35/00

CPC分类号： A61K31/5365 ,  A61K31/7068 ,  A61K33/243 ,  A61K31/282 ,  A61P1/16 ,  A61P35/00

摘要： The present invention relates to combination therapy with (a) a mutant IDH1 inhibitor, or a pharmaceutically acceptable salt thereof, (b) a deoxyadenosine analog, or a pharmaceutically acceptable salt thereof, and (c) a platinum agent, for the treatment of a solid tumor cancer.