公开(公告)号：US20250057895A1

公开(公告)日：2025-02-20

申请号：US18611944

申请日：2024-03-21

Applicant: VALVET CARE CO., LTD.

Inventor： Yong Min KIM ,  Ju Hyun JEON

IPC: A61K35/744 ,  A61K47/14 ,  A61K47/44 ,  A61P25/32

Abstract: A gastric acid-stable probiotic formulation the lactic acid bacteria formulation of the present invention strongly exerts an excellent and advanced effect than the previously known lactic acid bacteria formulation through various experiments, for examples, (1) an experiment for the preparation of an emulsion solution by heating temperature (Experimental Example 1); Alcohol dehydrogenase (ADH) and Aldehyde dehydrogenase (ALDH) activity measurement experiment (Experimental Example 2); Lactobacillus viability experiment in artificial gastric juice (pH 2) (Experimental Example 3); Effect of inventive lactic acid bacteria formulation on the relieving hangover symptoms (simple clinical test 1); measurement on the alcohol concentration (%) in exhalation (simple clinical test 2), and it showed an excellent and advanced effect than the previously known lactic acid bacteria preparation in terms of hangover relief effect and liver function improvement effect as well as taste than the previously known lactic acid bacteria preparation.

公开(公告)号：US20250032558A1

公开(公告)日：2025-01-30

申请号：US18787463

申请日：2024-07-29

Applicant: ACADEMIA SINICA

Inventor： Yin-Ru CHIANG ,  Mei-Jou CHEN ,  Tsun-Hsien HSIAO ,  Chia-Hung CHOU

IPC: A61K35/744 ,  A61K35/742 ,  A61P5/26 ,  A61P17/14

Abstract: The present disclosure relates to a probiotic composition for use in a method for regulating hyperactivity of a serum androgen level and/or increasing hair re-growth. The present disclosure also relates to a method for treating or preventing a disease, disorder or condition caused by hyperactivity of a serum androgen level.

公开(公告)号：US20250025516A1

公开(公告)日：2025-01-23

申请号：US18713947

申请日：2022-12-02

Applicant: The Regents of the University of California

Inventor： Elaine Y Hsiao ,  Gregory Lum

IPC: A61K35/744 ,  A61K35/742 ,  A61K45/06 ,  A61P25/08

Abstract: Provided herein are methods and compositions related to treating or preventing seizures.

公开(公告)号：US20250017988A1

公开(公告)日：2025-01-16

申请号：US18744457

申请日：2024-06-14

Applicant: ProbioTech LLC

Inventor： Deborah L. Lynch

IPC: A61K35/747 ,  A23L33/135 ,  A61K9/00 ,  A61K9/02 ,  A61K9/48 ,  A61K35/741 ,  A61K35/744 ,  A61K35/745 ,  A61K36/53 ,  A61K36/63 ,  A61K36/87 ,  A61K38/06 ,  A61K45/06 ,  A61K47/02 ,  A61K47/12 ,  A61K47/44 ,  A61K47/46

Abstract: Suppository compositions are provided combining a pharmaceutically acceptable matrix material that is solid outside of the human body and in a dry environment, but which melts at body temperature; and apple cider vinegar and one or more species of probiotic bacteria dispersed within the matrix material; wherein the matrix material contains a mixture of fatty acids that are solid at room temperature. Methods for supplementing and nourishing the microbiome of the rectum of a male or female and the microbiome of the vagina of a female are also disclosed. Oral dosage forms of the compositions of the present invention are also provided.

公开(公告)号：US20250009814A1

公开(公告)日：2025-01-09

申请号：US18744111

申请日：2024-06-14

Applicant: Solarea Bio, Inc.

Inventor： Gerardo V. Toledo ,  Maria Juliana Soto-Giron ,  Jinwoo Kim ,  Julie E. Button ,  Eric Michael Schott

IPC: A61K35/741 ,  A23L33/125 ,  A23L33/135 ,  A23L33/14 ,  A61K31/702 ,  A61K35/744 ,  A61K36/062 ,  A61K45/06 ,  A61P19/08 ,  A61P19/10

Abstract: Described herein are methods and compositions for using microbial agents (probiotics) and agents that promote growth of certain microbes (prebiotics) for management (including prevention and treatment) of musculoskeletal disorders, including osteoporosis, osteopenia, Paget's disease, stunting, osteoarthritis, osteomyelitis, and delayed or non-union fractures.

公开(公告)号：US20250009669A1

公开(公告)日：2025-01-09

申请号：US18219623

申请日：2023-07-07

Applicant: UNITED ARAB EMIRATES UNIVERSITY

Inventor： BASIM ABU-JDAYIL ,  MUTAMED AYYASH ,  ASMAA SAMIR ALHAMAYDA

IPC: A61K9/48 ,  A61K35/744

Abstract: An encapsulated probiotic is provided. The encapsulated probiotic includes one or more beneficial bacteria encapsulated in a capsule comprising ground date seeds (pits) and sodium alginate.

公开(公告)号：US20240424034A1

公开(公告)日：2024-12-26

申请号：US18766499

申请日：2024-07-08

Applicant: Shayne Morris ,  Michael Benson

Inventor： Shayne Morris ,  Michael Benson

IPC: A61K35/742 ,  A61K9/19 ,  A61K35/744 ,  C12N1/20

Abstract: A method for growing probiotic organisms wherein the growth media includes prebiotics especially selected and prepared to be paired with the probiotic organisms being grown. The prebiotic formula is optimized to grow the desired probiotic organisms, as well as important byproducts of the growth process. Specialized freeze-drying buffers may also be paired with certain probiotic organisms for the freeze-drying process. Specific products may utilize selected probiotic organisms grown and supported with paired prebiotic formulas to promote and maintain physiological health in a subject.

公开(公告)号：US20240408154A1

公开(公告)日：2024-12-12

申请号：US18705636

申请日：2022-10-28

Applicant: KABUSHIKI KAISHA YAKULT HONSHA

Inventor： Ayaka MAKI ,  Tomoaki NAITO ,  Saya TAJIMA ,  Tetsuji HORI ,  Satoshi MATSUMOTO

IPC: A61K35/744 ,  A23L33/135 ,  A61P37/04 ,  C12N1/20

Abstract: Provided is an enhancer of number of TCR clones containing live lactic acid bacteria as an active ingredient. Provided is an enhancer of number of TCR clones, containing live lactic acid bacteria as an active ingredient, wherein after vaccination with CD4 carrying TRBV19 such as vaccination with IEV or a virus carrying an epitope recognized by CD8 positive T cells, the number of TCR clones carrying TRBV19 is enhanced.

公开(公告)号：US20240408151A1

公开(公告)日：2024-12-12

申请号：US18583667

申请日：2024-02-21

Applicant: Seres Therapeutics, Inc.

Inventor： Noubar B. AFEYAN ,  Mary-Jane LOMBARDO-MCKENZIE ,  Kevin Daniel LITCOFSKY ,  David N. COOK ,  Matthew R. HENN ,  Geoffrey VON MALTZAHN

IPC: A61K35/744 ,  A61K35/00 ,  A61K35/741 ,  A61K35/742

Abstract: Provided are defined bacterial compositions for the maintenance or restoration of a healthy microbiota in the gastrointestinal tract of a mammalian subject, and methods for populating the gastrointestinal tract of a subject. Provided also are bacterial formulations for oral or gastric administration to a mammalian subject in an effective amount for prevention or treatment of a gastrointestinal disease, disorder or condition.

公开(公告)号：US12156893B2

公开(公告)日：2024-12-03

申请号：US18130118

申请日：2023-04-03

Applicant: The Regents of the University of California

Inventor： Anahid Jewett

IPC: A61K35/744 ,  A61K31/198 ,  A61K31/337 ,  A61K33/243 ,  A61K35/17 ,  A61K35/32 ,  A61K35/745 ,  A61K35/747 ,  A61K45/06 ,  A61P35/00 ,  C12N5/077 ,  C12N5/0783 ,  C12N5/09 ,  A61K35/00

Abstract: The present application relates to probiotic compositions, e.g., comprising at least one bacterial strain selected from: Streptococcus thermophilus, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium infantis, Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus paracasei, KE99, and Lactobacillus bulgaricus, optionally wherein the at least one bacterial strain is either alive or sonicated.