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公开(公告)号：US09763982B2
公开(公告)日：2017-09-19
申请号：US14637235
申请日：2015-03-03
发明人： Anahid Jewett
IPC分类号： A61K35/00 , A61K35/17 , A61K31/337 , A61K31/198 , A61K45/06 , C12N5/0783 , A61K38/20 , A61K38/21 , A61K39/395 , C07K16/28 , A61K35/12 , A61K39/00
CPC分类号： A61K35/17 , A61K31/198 , A61K31/337 , A61K35/12 , A61K38/2013 , A61K38/212 , A61K39/3955 , A61K45/06 , A61K2039/577 , C07K16/283 , C12N5/0646 , A61K2300/00
摘要： Compositions and methods are provided for killing of cancer stem cells, and for the transplantation of pluripotent stem cells and differentiated cells derived therefrom.
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公开(公告)号：US11617771B2
公开(公告)日：2023-04-04
申请号：US16470040
申请日：2017-12-15
发明人： Anahid Jewett
IPC分类号： A61K35/744 , A61P35/00 , A61K33/243 , A61K31/198 , A61K31/337 , A61K35/17 , A61K35/32 , A61K35/745 , A61K35/747 , A61K45/06 , C12N5/0783 , C12N5/077 , C12N5/09 , A61K35/00
摘要： The present application relates to probiotic compositions, e.g., comprising at least one bacterial strain selected from: Streptococcus thermophiles, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium infantis, Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus paracasei, KE99, and Lactobacillus bulgaricus, optionally wherein the at least one bacterial strain is either alive or sonicated.
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3.发明申请公开(公告)号：US20200009201A1
公开(公告)日：2020-01-09
申请号：US16470040
申请日：2017-12-15
发明人： Anahid Jewett
IPC分类号： A61K35/744 , A61K35/745 , A61K35/747 , A61K35/32 , A61K45/06 , A61K35/17 , A61P35/00 , C12N5/0783 , C12N5/077 , C12N5/09 , A61K33/243 , A61K31/337 , A61K31/198
摘要： The present application relates to probiotic compositions, e.g., comprising at least one bacterial strain selected from: Streptococcus thermophiles, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium infantis, Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus paracasei, KE99, and Lactobacillus bulgaricus, optionally wherein the at least one bacterial strain is either alive or sonicated.
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公开(公告)号：US20150238530A1
公开(公告)日：2015-08-27
申请号：US14637235
申请日：2015-03-03
发明人： Anahid Jewett
IPC分类号： A61K35/17 , C12N5/0783 , A61K45/06 , A61K31/337 , A61K31/198
CPC分类号： A61K35/17 , A61K31/198 , A61K31/337 , A61K35/12 , A61K38/2013 , A61K38/212 , A61K39/3955 , A61K45/06 , A61K2039/577 , C07K16/283 , C12N5/0646 , A61K2300/00
摘要： Compositions and methods are provided for killing of cancer stem cells, and for the transplantation of pluripotent stem cells and differentiated cells derived therefrom.
摘要翻译： 提供组合物和方法用于杀死癌症干细胞，以及用于移植多能干细胞和由其衍生的分化细胞。
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公开(公告)号：US20240148809A1
公开(公告)日：2024-05-09
申请号：US18025499
申请日：2021-09-09
发明人： Anahid Jewett , Tracy Ryan
CPC分类号： A61K36/185 , A61K45/06 , A61P35/00 , A61P37/04 , C07K14/54 , C07K16/2809 , C07K16/2818 , C07K16/283 , A61K2039/507
摘要： The present invention provides methods for increasing NK cytotoxicity of natural killer (NK) cells by administering to a subject in need thereof a composition comprising cannabis in an amount effective to induce apoptosis of a tumor cell. This invention also provides methods for increasing or restoring secretion of interferon gamma (IFN-γ) by a peripheral blood mononuclear cell (PMBC), in particular an NK cell, by administering to a subject in need thereof a composition comprising cannabis. The present invention further provides methods for preventing or reversing inactivation of cytotoxicity of an NK cell by administering to a subject in need thereof a composition comprising cannabis in an amount effective to induce apoptosis of a tumor cell. Methods for treating a subject having cancer or a tumor by administering a composition comprising cannabis are provided.
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公开(公告)号：US20240131130A1
公开(公告)日：2024-04-25
申请号：US18277897
申请日：2022-02-17
发明人： Anahid Jewett
CPC分类号： A61K39/0011 , C12N5/0693 , C12N15/86 , A61K2039/5152 , A61K2039/572 , C12N2529/00 , C12N2710/16143
摘要： The present invention is based, in part, on cancer vaccine compositions or pharmaceutical compositions comprising cancer cells, monocytes, and/or osteoclasts that activate NK cells, and methods for using same to prevent and/or treat diseases such as cancer.
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公开(公告)号：US20200306300A1
公开(公告)日：2020-10-01
申请号：US16486123
申请日：2018-02-15
发明人： Anahid Jewett
IPC分类号： A61K35/17 , A61K35/32 , A61K35/741 , C12N5/078
摘要： The present application relates to methods of activating a NK cells in vitro, ex vivo, and/or in vivo by an osteoclast cell (OC) and/or a dendritic cell, and methods of treating disease using these activated NK cells.
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公开(公告)号：US20240245770A1
公开(公告)日：2024-07-25
申请号：US17784145
申请日：2020-12-16
发明人： Anahid Jewett
IPC分类号： A61K39/395 , A61K31/198 , A61K31/4152 , A61K31/428 , A61P25/28
CPC分类号： A61K39/3955 , A61K31/198 , A61K31/4152 , A61K31/428 , A61P25/28
摘要： The present invention relates to compositions and methods that reduce the level of pro-inflammatory cytokines, chemokines, and growth factors for inhibiting motor neuron degeneration and treating neurodegenerative disorders.
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公开(公告)号：US20240226255A9
公开(公告)日：2024-07-11
申请号：US18277897
申请日：2022-02-17
发明人： Anahid Jewett
CPC分类号： A61K39/0011 , C12N5/0693 , C12N15/86 , A61K2039/5152 , A61K2039/572 , C12N2529/00 , C12N2710/16143
摘要： The present invention is based, in part, on cancer vaccine compositions or pharmaceutical compositions comprising cancer cells, monocytes, and/or osteoclasts that activate NK cells, and methods for using same to prevent and/or treat diseases such as cancer.
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公开(公告)号：US20220381772A1
公开(公告)日：2022-12-01
申请号：US17629948
申请日：2020-07-31
发明人： Anahid Jewett
IPC分类号： G01N33/50 , G01N33/543 , G01N33/68
摘要： The present application relates to natural killer (NK) cell-specific tests that are useful in determining the expansion potential and function of NK cells.
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