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1.
公开(公告)号:US20220288175A1
公开(公告)日:2022-09-15
申请号:US17824378
申请日:2022-05-25
发明人: John R. Barta , Luc Berghman , Srichaitanya Shivaramaiah , Olivia B. Faulkner , Lisa Bielke , Billy Hargis
IPC分类号: A61K39/002 , C07K14/445 , A61K39/012 , A61K39/015
摘要: Vaccine vectors and methods of using the vaccine vectors to enhance the immune response to an Apicomplexan parasite and reduce the morbidity or mortality associated with subsequent infection are provided herein. The vaccine vectors include a polynucleotide encoding a Rhomboid polypeptide and optionally include an immune-stimulatory polypeptide suitably expressed on the surface of the vaccine vector.
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公开(公告)号:US20220265802A1
公开(公告)日:2022-08-25
申请号:US17180012
申请日:2021-02-19
申请人: Sherryll Layton , Jeffrey W. Hall
发明人: Sherryll Layton , Jeffrey W. Hall
IPC分类号: A61K39/015 , A61K39/012 , A61K39/002 , A61K39/39 , A61P33/02
摘要: A vaccine vector comprising a first polynucleotide encoding the antigenic polypeptide selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, or any combination thereof.
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3.
公开(公告)号:US11364290B2
公开(公告)日:2022-06-21
申请号:US17023795
申请日:2020-09-17
发明人: John R. Barta , Luc Berghman , Srichaitanya Shivaramaiah , Olivia B. Faulkner , Lisa Bielke , Billy Hargis
IPC分类号: A61K39/002 , C07K14/445 , A61K39/012 , A61K39/015 , A61K39/00
摘要: Vaccine vectors and methods of using the vaccine vectors to enhance the immune response to an Apicomplexan parasite and reduce the morbidity or mortality associated with subsequent infection are provided herein. The vaccine vectors include a polynucleotide encoding a Rhomboid polypeptide and optionally include an immune-stimulatory polypeptide suitably expressed on the surface of the vaccine vector.
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公开(公告)号:US11285191B2
公开(公告)日:2022-03-29
申请号:US16320586
申请日:2017-07-26
IPC分类号: A61K38/20 , A61K39/012 , A61K39/04 , A61K39/21 , A61K39/295 , C07K14/54 , A61P37/04 , A61P31/18 , A61K38/17 , A61K39/00
摘要: Disclosed are compositions and methods for stimulating immune responses. More particularly, these compositions and methods involve the use of an inhibitor of IL-25 function and an immune stimulator that stimulates an immune response to a target antigen for stimulating protective or therapeutic immune responses to a target antigen. The compositions and methods of the present invention are particularly useful in the prevention and treatment of infections and cancers.
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公开(公告)号:US20210332322A1
公开(公告)日:2021-10-28
申请号:US17367231
申请日:2021-07-02
申请人: Huvepharma Inc.
IPC分类号: C12N1/10 , A61K39/012 , C12N1/04
摘要: Compositions are provided that contain sporulated coccidial oocysts, wherein the compositions are free of antibiotics and comprise formalin at a concentration sufficient to inhibit microbial growth for at least 12 months while maintaining oocyst viability. Methods of preparing such compositions are also provided.
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公开(公告)号:US20210290761A1
公开(公告)日:2021-09-23
申请号:US17275892
申请日:2019-09-13
发明人: Paul Davis , Samer Al-Murrani
IPC分类号: A61K39/39 , A61K39/015 , A61K39/018 , A61K39/005 , A61K39/008 , A61K39/012 , A61K39/002 , A61P33/02
摘要: Anti-parasitic compounds and uses thereof. Compounds comprising a C-terminal peptide adjuvant conjugated to an N-terminal peptide antigen via a protease-cleavable linker, said peptide adjuvant comprising a peptide analog of C5a, wherein said peptide antigen comprises an antigenic epitope of a parasitic organism, such as T. gondii. Methods of therapeutic or prophylactic treatment of a parasitic infections.
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公开(公告)号:US20210213129A1
公开(公告)日:2021-07-15
申请号:US17216819
申请日:2021-03-30
申请人: Immugen Pharma LLC
发明人: Craig Travis
IPC分类号: A61K39/39 , A61K39/04 , A61K39/02 , A61K39/05 , A61K39/118 , A61K39/085 , A61K39/095 , A61K39/08 , A61K39/104 , A61K39/112 , A61K39/29 , A61K39/225 , A61K39/215 , A61K39/145 , A61K39/13 , A61K39/165 , A61K39/20 , A61K39/205 , A61K39/25 , A61K39/00 , A61K39/015 , A61K39/008 , A61K39/005 , A61K39/002 , A61K39/012
摘要: Disclosed are methods and compositions related to the use cannabinoids as adjuvants for the accelerated induction and production of an antibody based immune response.
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8.
公开(公告)号:US10792351B2
公开(公告)日:2020-10-06
申请号:US16439511
申请日:2019-06-12
发明人: John R. Barta , Luc Berghman , Srichaitanya Shivaramaiah , Olivia B. Faulkner , Lisa Bielke , Billy Hargis
IPC分类号: A61K39/002 , C07K14/445 , A61K39/012 , A61K39/015 , A61K39/00
摘要: Vaccine vectors and methods of using the vaccine vectors to enhance the immune response to an Apicomplexan parasite and reduce the morbidity or mortality associated with subsequent infection are provided herein. The vaccine vectors include a polynucleotide encoding a Rhomboid polypeptide and optionally include an immune-stimulatory polypeptide suitably expressed on the surface of the vaccine vector.
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公开(公告)号:US10744192B2
公开(公告)日:2020-08-18
申请号:US15074689
申请日:2016-03-18
发明人: Michael Christopher Fontaine , David George Emslie Smith , Julie Lydia Fitzpatrick , William Donachie , Anita Dorota Jaglarz
IPC分类号: A61K39/09 , A61K39/00 , A61K39/012 , A61K39/108 , A61K39/05 , A61K39/08 , A61K39/118 , A61K39/39 , A61K39/002 , A61K39/085 , A61K39/12 , G01N33/569
摘要: The invention is based upon the identification of a number of antigens derived from a species of the genus Streptococcus, which are cross reactive and which may serve as the basis of useful compositions and tests and procedures capable of identifying and/or detecting Streptococcus sp in samples.
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10.
公开(公告)号:US20190298815A1
公开(公告)日:2019-10-03
申请号:US16439511
申请日:2019-06-12
发明人: John R. Barta , Luc Berghman , Srichaitanya Shivaramaiah , Olivia B. Faulkner , Lisa Bielke , Billy Hargis
IPC分类号: A61K39/002 , C07K14/445 , A61K39/012 , A61K39/015
摘要: Vaccine vectors and methods of using the vaccine vectors to enhance the immune response to an Apicomplexan parasite and reduce the morbidity or mortality associated with subsequent infection are provided herein. The vaccine vectors include a polynucleotide encoding a Rhomboid polypeptide and optionally include an immune-stimulatory polypeptide suitably expressed on the surface of the vaccine vector.
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