公开(公告)号：US20230373893A1

公开(公告)日：2023-11-23

申请号：US18042559

申请日：2021-08-20

申请人： University of Kansas

发明人： Mark Brandon Shiflett ,  Rajkumar Kore ,  Aaron M. Scurto

IPC分类号： C07C45/46 ,  C07D233/58

CPC分类号： C07C45/46 ,  C07D233/58

摘要： Processes for acylating an aromatic compound are provided. In embodiments, such a process comprises combining an aromatic compound, an acylating agent, and a catalyst composition under conditions to induce acylation of the aromatic compound with the acylating agent, the catalyst composition comprising components selected from the group consisting of a sulfonic acid of formula R—SO3H, wherein R is a linear alkyl group substituted with one or more halogen atoms; an ionic liquid and an acid; an acid and a base capable of forming an ionic liquid with the acid; an ionic liquid, an acid, and an aromatic; and an acid, a base capable of forming an ionic liquid with the acid, and an aromatic. The ionic liquid does not comprise a metal halide and the catalyst composition is free of a metal halide and the aromatic, if present in the catalyst composition, is not the aromatic compound being acylated.

公开(公告)号：US20230095165A1

公开(公告)日：2023-03-30

申请号：US18057394

申请日：2022-11-21

申请人： CCTEG CHINA COAL RESEARCH INSTITUTE

发明人： Xuefeng MAO ,  Heng LI ,  Fating HU ,  Jinlong ZHONG ,  Junfang LI ,  Tong WANG ,  Xiaoran ZHANG

IPC分类号： C07C45/46 ,  C07C45/84

摘要： A method for continuous synthesis of acylnaphthalene includes: mixing a raw solution containing 2-methylnaphthalene with an acylation liquid to obtain an acylation reaction liquid with a molar ratio of the 2-methylnaphthalene:the acylation agent:the Lewis catalyst of 1:1.3:1.5; adding the acylation reaction liquid into a microchannel reactor and a plurality of kettle reactors connected in series to perform acylation reaction, performing hydrolysis reaction on the acylation reaction liquid immediately after the acylation reaction liquid flows out of the plurality of kettle reactors to obtain a mixed solution, and subjecting the mixed solution to separation, rectification and crystallization, to obtain 2-methyl-6-propionylnaphthalene.

公开(公告)号：US11370742B2

公开(公告)日：2022-06-28

申请号：US17261731

申请日：2019-07-23

申请人： FAES FARMA, S.A.

发明人： Gonzalo Hernández Herrero ,  Neftalí García Domínguez ,  Pablo Morán Poladura ,  Tania González García ,  Álvaro Ganza González ,  Paloma Tato Cerdeiras

IPC分类号： C07C67/42 ,  C07C45/46 ,  C07D235/04 ,  C07D401/04 ,  C07C51/09 ,  C07C67/00

摘要： The invention relates to a process for preparing a compound of (III) wherein X is a leaving group; and R1 is C1-C6 alkyl; which comprises oxidative rearrangement of a compound of formula (II) or a solvate thereof Compounds of formula (III) are key intermediates in the synthesis of Bilastine.

公开(公告)号：US11021425B2

公开(公告)日：2021-06-01

申请号：US16158374

申请日：2018-10-12

申请人： International Business Machines Corporation

发明人： Brandon M. Kobilka ,  Scott B. King ,  Joseph Kuczynski ,  Jason T. Wertz

IPC分类号： C07C41/18 ,  C07C45/47 ,  C07C45/46 ,  C07C217/90 ,  C07C321/12 ,  C07F1/08 ,  C07D303/08 ,  C07C321/28 ,  C07C49/84 ,  C07C43/225 ,  C07C43/23

摘要： A process of forming a flame retardant material is disclosed. The process includes forming a functionalized polybrominated diphenyl-based flame retardant compound having the following structural formula: In the structural formula, X corresponds to a functional group. The process also includes forming a flame retardant material by covalently bonding the functionalized polybrominated diphenyl-based flame retardant compound into a material using the functional group.

公开(公告)号：US20200087456A1

公开(公告)日：2020-03-19

申请号：US16609790

申请日：2018-05-16

申请人： Arkema France

发明人： Guillaume LE ,  Guillaume VINCENT ,  Julien JOUANNEAU

IPC分类号： C08G65/40 ,  C07C45/46

摘要： The invention relates to a method for manufacturing 1,4-bis(4-phenoxybenzoylbenzene), comprising: providing a reactant mixture comprising terephthaloyl chloride, diphenyl ether and a Lewis acid in a solvent; reacting terephthaloyl chloride with diphenyl ether, so as to obtain a product mixture comprising a 1,4-bis(4-phenoxybenzoylbenzene)-Lewis acid complex; wherein the 1,4-bis(4-phenoxybenzoylbenzene)-Lewis acid complex is dissolved in the solvent at a 1,4-bis(4-phenoxybenzoylbenzene) weight concentration in the solvent which is higher than the saturation limit of the 1,4-bis(4-phenoxybenzoylbenzene)-Lewis acid complex during at least part of the step of reacting terephthaloyl chloride with diphenyl ether.

公开(公告)号：US20190077739A1

公开(公告)日：2019-03-14

申请号：US16186039

申请日：2018-11-09

申请人： Arkema France

发明人： Julien JOUANNEAU ,  Guillaume LE ,  Steven SCHON ,  JOHN RICHARDSON ,  Guillaume VINCENT ,  Jérôme AMSTUTZ

IPC分类号： C07C45/46 ,  C07C45/80 ,  C08G65/40

摘要： A method for manufacturing 1,4-bis(4-phenoxybenzoyl)benzene, including: reacting terephthaloyl chloride with diphenyl ether in the presence of a Lewis acid, so as to obtain a product mixture including 1,4-bis(4-phenoxybenzoyl)benzene-Lewis acid complex, wherein the 1,4-bis(4-phenoxybenzoyl)benzene-Lewis acid complex is, at least partly, in the form of a precipitate; carrying out a solid/liquid separation of the product mixture to obtain a cake comprising the 1,4-bis(4-phenoxybenzoyl)benzene-Lewis acid complex precipitate; putting the cake in contact with a decomplexing solvent, wherein the decomplexing solvent is a protic solvent, so as to dissociate the 1,4-bis(4-phenoxybenzoyl)benzene-Lewis acid complex into 1,4-bis(4-phenoxybenzoyl)benzene; and, recovering the 1,4-bis(4-phenoxybenzoyl)benzene. Also, a method for manufacturing a polyaryletherketone polymer starting from 1,4-bis(4-phenoxybenzoyl)benzene manufactured by the above method.

公开(公告)号：US10227305B2

公开(公告)日：2019-03-12

申请号：US15505760

申请日：2015-08-20

申请人： G. Pratap Reddy ,  Venkataiah Sunku ,  Sunkaraneni Suresh Babu

发明人： G. Pratap Reddy ,  Venkataiah Sunku ,  Sunkaraneni Suresh Babu

IPC分类号： C07D215/227 ,  C07D215/26 ,  C07C45/46 ,  C07C17/16 ,  C07C17/354 ,  C07B35/02 ,  C07B41/06

摘要： The present invention relates to a process for preparing indacaterol or salts thereof. The process comprises of forming compound of Formula 1 by reacting compound of Formula 2 and compound of Formula 3 in the presence of a solvent to Form compound of Formula 4, which on removal of the protecting groups forms compound of Formula 1.

公开(公告)号：US20180141882A1

公开(公告)日：2018-05-24

申请号：US15316296

申请日：2015-06-08

申请人： IGM RESINS ITALIA S.R.L.

发明人： Gabriele NORCINI ,  Angelo CASIRAGHI ,  Enzo MENEGUZZO ,  Giovanni FLORIDI ,  Giuseppe LI BASSI

IPC分类号： C07C13/465 ,  C07C17/14 ,  C07C22/04 ,  C07C45/42 ,  C07C45/46 ,  C07C45/63 ,  C07C45/64 ,  C07C45/65 ,  C07C45/72 ,  C07C45/81 ,  C07C49/788 ,  C07C49/792 ,  C07C49/794 ,  C07C49/82

CPC分类号： C07C13/465 ,  C07C17/14 ,  C07C22/04 ,  C07C45/42 ,  C07C45/46 ,  C07C45/63 ,  C07C45/64 ,  C07C45/65 ,  C07C45/72 ,  C07C45/81 ,  C07C49/788 ,  C07C49/792 ,  C07C49/794 ,  C07C49/82 ,  C07C2523/04 ,  C07C49/76 ,  C07C49/80

摘要： The present invention refers to a process for producing 5-[4-(2-hydroxy-2-methyl)-1-oxo-prop-1-yl]-3-[4-(2-hydroxy-2-methyl)-1-oxo-prop-1-yl-phenyl]-2,3-dihydro-1,1,3-trimethyl-1H-indene (dimer isomer 5) that comprises the synthesis from cumene and dimerization of 2-methyl-1-(4-(prop-1-en-2-yl)phenyl)propan-1-one in the presence of acid catalysts.

公开(公告)号：US20170253696A1

公开(公告)日：2017-09-07

申请号：US15510575

申请日：2015-09-10

申请人： KETONEX LIMITED

发明人： Ian David Henderson Towle ,  Kaylie Jane Smith

IPC分类号： C08G61/12 ,  C08G73/10 ,  C08G75/23 ,  C07C49/84 ,  C07C45/46

CPC分类号： C08G61/127 ,  C07C45/46 ,  C07C49/84 ,  C08G65/40 ,  C08G65/4012 ,  C08G73/1071 ,  C08G75/23 ,  C08G2261/122 ,  C08G2261/312 ,  C08G2261/3323 ,  C08G2261/334 ,  C08G2261/45 ,  C08G2650/40 ,  D01F6/665

摘要： The present disclosure provides a process for producing a polymer, said process comprising polymerising a monomer system comprising a compound of formula: Ar—O—Ar—C(═O)—X—C(═O)—Ar—O—Ar in a reaction medium comprising a Lewis acid where: X is an aliphatic moiety and Ar is an aromatic moiety.

公开(公告)号：US20170217865A1

公开(公告)日：2017-08-03

申请号：US15515271

申请日：2015-10-07

申请人： SYNGENTA PARTICIPATIONS AG

发明人： Denis GRIBKOV

IPC分类号： C07C45/63 ,  C07C201/08 ,  C07C205/45 ,  C07C45/46

CPC分类号： C07C45/63 ,  C07C45/46 ,  C07C201/08 ,  C07C201/12 ,  C07C205/45 ,  C07C49/80

摘要： A process for the preparation of a compound of formula (I) wherein R1 is hydrogen, fluoro or chloro; which process comprises: a) reacting a compound of formula (II) wherein R1 is hydrogen, fluoro or chloro; with a nitration agent to the compound of formula (III) wherein R1 is hydrogen, fluoro or chloro; b) reacting the compound of formula (III) with trichloroisocyanuric acid in the presence of sulfuric acid or fuming sulfuric acid to the compound of formula (IV) wherein R1 is hydrogen, fluoro or chloro; and c) reacting the compound of formula (III) with chlorine gas at a temperature from 180° C. to 250° C. to the compound of formula (I).