公开(公告)号：US11634540B2

公开(公告)日：2023-04-25

申请号：US17538885

申请日：2021-11-30

申请人： Nektar Therapeutics

发明人： Sean M. Culbertson ,  Xiaoming Shen ,  Antoni Kozlowski ,  Samuel P. McManus

IPC分类号： A61K47/60 ,  C08G65/26 ,  C08L71/02 ,  C07K1/00 ,  C07K17/08 ,  C08G65/331 ,  C08G65/333 ,  C08G65/332 ,  A61K38/00

摘要： Provided herein are polymeric α-hydroxy aldehyde or α-hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable conjugates in a single-step reaction. In selected embodiments, the polymeric reagent itself incorporates an internal proton-abstracting (basic) functional group, to promote more efficient reaction. The substituent is appropriately situated, via a linker if necessary, to position the group for proton abstraction, preferably providing a 4- or 5-bond spacing between the abstracting atom and the hydrogen atom on the α-carbon. Also provided are methods of using the reagents and stable, solubilized conjugates of the reagents with biologically active compounds. In preferred embodiments, the polymeric component of the reagent or conjugate is a polyethylene glycol.

公开(公告)号：US20230090239A1

公开(公告)日：2023-03-23

申请号：US17788075

申请日：2020-12-22

申请人： SHOWA DENKO K.K.

发明人： Masaki NANKO

IPC分类号： C08G65/00 ,  C08G65/331 ,  C08G65/333 ,  C10M107/38 ,  G11B5/725

摘要： The present invention provides a fluorine-containing ether compound represented by the following formula: R1—R2—CH2—R3—CH2—R4—R5 (in the formula, R3 represents a perfluoropolyether chain; R1 and R5 each independently represent any of an alkyl group which may have a substituent, an organic group having a double bond or a triple bond, and a hydrogen atom; —R2—CH2—R3 is represented by -[A]-[B]—O—CH2—R3; R3—CH2—R4— is represented by R3—CH2—O—[C]-[D]-; [A] is represented by Formula (4), [B] is represented by Formula (5), [C] is represented by Formula (6), and [D] is represented by Formula (7)):

公开(公告)号：US11530295B2

公开(公告)日：2022-12-20

申请号：US16887081

申请日：2020-05-29

申请人： NOF CORPORATION

发明人： Takuma Tsubusaki ,  Yuji Yamamoto

IPC分类号： A61K47/60 ,  C08G65/333 ,  C07D405/06 ,  C08G65/329 ,  C07D317/22 ,  C07D317/28 ,  C08G65/331 ,  C08G65/337 ,  C08G65/334 ,  C07D317/20 ,  C07D317/24

摘要： A hydrophilic polymer derivative having a cyclic benzylidene acetal linker represented by the following formula (1): wherein R1 and R6 are each independently a hydrogen atom or a hydrocarbon group; R2, R3, R4 and R5 are each independently an electron-withdrawing or electron-donating substituent or a hydrogen atom; X1 is a chemically reactive functional group; P is a hydrophilic polymer; s is 1 or 2, t is 0 or 1, and s+t is 1 or 2; w is an integer of 1 to 8; and Z1 and Z2 are each independently a selected divalent spacer.

公开(公告)号：US11427680B2

公开(公告)日：2022-08-30

申请号：US16469636

申请日：2017-12-12

申请人： SOLVAY SPECIALTY POLYMERS ITALY S.P.A.

发明人： Cristiano Monzani ,  Vito Tortelli ,  Marco Galimberti ,  Roberto Valsecchi ,  Patrizia Maccone

IPC分类号： C08G65/00 ,  C08G65/323 ,  C08G65/331 ,  G11B5/71 ,  C10M107/38

摘要： The present invention relates to a novel process for the synthesis of (per)fluoropolyether polymers, to certain novel (per)fluoropolyether polymers. The present invention also relates to the use of the (per)fluoropolyether polymers thus obtained as intermediate compounds for the manufacture of further polymers suitable for use as lubricants, notably for magnetic recording media (MRM).

公开(公告)号：US20220118100A1

公开(公告)日：2022-04-21

申请号：US17561342

申请日：2021-12-23

申请人： Xiamen Sinopeg Biotech Co., Ltd.

发明人： WenGui WENG ,  Chao LIU ,  JinCheng LIAO ,  JinChun YUAN

IPC分类号： A61K47/60 ,  C08G65/08 ,  C08G65/331 ,  C08G65/26

摘要： The monofunctional branched poly(ethylene glycol) (PEG) has a general formula shown in formula (1), and the bio-related substance modified by the monofunctional branched PEG has a general formula shown in formula (2), wherein X1 and X2 are each independently a hydrocarbon group having 1 to 20 carbon atoms, n1 and n2 are each independently an integer selected from 1 to 1000, n3 is an integer selected from 11 to 1000, L1, L2 are each independently a linking group, p is 0 or 1, q is 0 or 1, R1 is a hydrogen atom or a hydrocarbon group having 1 to 20 carbon atoms, D is a bio-related substance, Z is a linking group, and Z can react with the bio-related substance to form a residue group L3. The PEG-modified bio-related substance maintains good biological activity, and has better solubility and a longer half-life in vivo.

公开(公告)号：US11220649B2

公开(公告)日：2022-01-11

申请号：US16480464

申请日：2017-12-04

申请人： SHOWA DENKO K.K.

发明人： Naoya Fukumoto ,  Daisuke Yagyu ,  Yuta Yamaguchi ,  Shoko Uetake ,  Tsuyoshi Kato ,  Hiroyuki Tomita ,  Ryuuta Miyasaka ,  Katsumi Murofushi

IPC分类号： C10M105/54 ,  C07C43/178 ,  G11B5/725 ,  C08G65/331 ,  C10M107/38 ,  C10N20/04 ,  C10N30/06 ,  C10N50/00 ,  C10N40/18

摘要： A fluorine-containing ether compound represented by Formula (1) is provided; R1—R2—CH2—R3—CH2—R4—R5  (1) (In Formula (1), R1 and R5 may be the same as or different from each other and each represents an alkenyl group having 2 to 8 carbon atoms or an alkynyl group having 3 to 8 carbon atoms, R2 and R4 may be the same as or different from each other and each represents a divalent linking group having a polar group, and R3 represents a perfluoropolyether chain, with a proviso that R1 and R2 are, and R4 and R5 are divided due to the presence of an atom other than the carbon atom such as an oxygen atom).

公开(公告)号：US11124712B2

公开(公告)日：2021-09-21

申请号：US16763839

申请日：2018-11-13

申请人： Dow Global Technologies LLC

发明人： Thiago V. Alonso ,  Callie M. Ayers ,  Stephen M. Hoyles

IPC分类号： C10G33/04 ,  B01D17/04 ,  C08G65/331

摘要： A method of demulsifying crude oil, said method comprising the step of reacting an amount of crude oil with a polyester demulsifier, therein the demulsifier is used in quantities from 0.0001% to 5% (1-50,000 ppm), preferably 0.0005% to 2% (5-20,000 ppm), more preferably 0.0008% to 1% (8-10,000 ppm) and most preferably 0.001 to 0.1 wt. % polymer (10-1,000 ppm) related to the oil fraction of the utilized emulsion.

公开(公告)号：US11040009B2

公开(公告)日：2021-06-22

申请号：US16809118

申请日：2020-03-04

申请人： Mayo Foundation for Medical Education and Research

发明人： Xifeng Liu ,  Michael J. Yaszemski ,  Lichun Lu

IPC分类号： C07D319/06 ,  A61K31/704 ,  A61K9/127 ,  C08G65/332 ,  A61K9/00 ,  C08G65/331 ,  C08G65/337

摘要： This disclosure relates to polymersomes comprising a crosslinked polymer and their use as drug delivery vehicles. Specifically, polymersomes comprising a polymer of Formula I: wherein each R is independently C1-6 alkyl; and n is an integer between 1 and 50.

公开(公告)号：US20210024778A1

公开(公告)日：2021-01-28

申请号：US17066295

申请日：2020-10-08

申请人： SOLVAY SPECIALTY POLYMERS ITALY S.P.A.

发明人： Roberto Valsecchi ,  Simonetta Antonella Fontana ,  Fabrizio Mutta ,  Alberto Zompatori

IPC分类号： C09D183/12 ,  C08G77/46 ,  C09D5/00 ,  C09D187/00 ,  C08G65/00 ,  C08G65/336 ,  C08G65/331

摘要： The present invention relates to novel (per)fluoropolyether (PFPE) polymer derivatives, a method for their manufacture and their use for providing an anti-soiling coating.

公开(公告)号：US20210024692A1

公开(公告)日：2021-01-28

申请号：US17041102

申请日：2019-03-27

申请人： NOF CORPORATION

发明人： Akihide ONOZAWA ,  Hiroki YOSHIOKA ,  Masaki KAMIYA

IPC分类号： C08G65/324 ,  C08G65/325 ,  C08G65/326 ,  C08G65/331 ,  C08G65/333 ,  C08G65/334 ,  A61K47/60

摘要： A method for producing a multi-arm type polyethylene glycol derivative, which includes carrying out the following in order: Step (A): protecting an even number of hydroxyl groups, while leaving only the hydroxyl group at the 1-position of a polyhydric alcohol having an odd number of hydroxyl groups, other than the hydroxyl group at the 1-position by cyclic benzylidene acetalization, Step (B): linking two molecules of the compound obtained in step (A) to a compound for introducing a specific linker by etherification reaction, Step (C): deprotecting the cyclic benzylidene acetal structure at the terminal of the compound obtained in step (B), Step (D): polymerizing 3 to 600 mol of ethylene oxide to each hydroxyl group of the compound obtained in step (C) to obtain a multi-arm type polyethylene glycol derivative, and Step (E): functionalizing the hydroxyl group at the terminal of the multi-arm type polyethylene glycol derivative obtained in step (D).