公开(公告)号：US20250051715A1

公开(公告)日：2025-02-13

申请号：US18720831

申请日：2022-12-08

Applicant: INTERMAG SP Z O.O.

Inventor： Hubert KARDASZ ,  Malgorzata HALAT-LAS ,  Marcin OLESZCZAK ,  Ilona KAFEL ,  Magdalena JOPEK ,  Krzysztof AMBROZIAK ,  Roksana RAKOCZY

IPC: C12N1/20 ,  A01N63/25 ,  A01P1/00 ,  A01P21/00 ,  C12R1/12

Abstract: The subject of the present invention is a novel Paenibacillus polymyxa B134 strain, PCM deposit no. B/00335, deposited in the Polish Collection of Microorganisms of the Polish Academy of Sciences in Wroclaw, and the use thereof in plant cultivation, for use against fungal pathogens and for biostimulation of plant growth and development.

公开(公告)号：US20250051713A1

公开(公告)日：2025-02-13

申请号：US18581156

申请日：2024-02-19

Applicant: CHINESE RESEARCH ACADEMY OF ENVIRONMENTAL SCIENCES

Inventor： Caihong HUANG ,  Beidou Xi ,  Wei Li ,  Yuqian Li

IPC: C12N1/20 ,  B09C1/10 ,  C02F3/34 ,  C12R1/385

Abstract: The present invention discloses an alkali-resistant microbial bacterium PDC-1 and its application. The present invention screens and isolates PDC-1 strain from the soil of a coal gangue stockpile in a coal mine in Shandong, China, which can utilize naphthalene, phenanthrene, anthracene or pyrene as the sole carbon source and has tolerance to heavy metals. The strain of the present invention is capable to degrade various PAHs with the presence of heavy metals. The strain is alkali resistant, simple to cultivate, and has a good application in the bioremediation of polycyclic aromatic hydrocarbons and heavy metal contaminated sites.

公开(公告)号：US20250043237A1

公开(公告)日：2025-02-06

申请号：US18599588

申请日：2024-03-08

Applicant: Azitra Inc

Inventor： Travis Michael Whitfill ,  Ming-De Deng ,  David Richard Dodds ,  Alexander Tikhonov

IPC: C12N1/20 ,  C12N9/10 ,  C12N9/90 ,  C12N15/00 ,  C12N15/10 ,  C12N15/74 ,  C12R1/45

Abstract: The present disclosure provides recombinant Staphylococcus bacterium (e.g. S. epidermidis) that are dependent on D-alanine for growth. In one aspect, the disclosure features a recombinant Staphylococcus bacterium comprising two inactivated alanine racemase genes (Δalr1Δalr2); and an inactivated D-alanine aminotransferase (dat) gene. In another aspect, the disclosure features a method of making the recombinant Staphylococcus bacterium.

公开(公告)号：US20250043033A1

公开(公告)日：2025-02-06

申请号：US18706846

申请日：2022-11-23

Applicant: Chr. Hansen A/S

Inventor： Vera Kuzina Poulsen ,  Paula Gaspar ,  Kristian Jensen ,  Rute Neves ,  Ahmad Zeidan

IPC: C08B37/00 ,  A23C19/032 ,  A23C19/068 ,  C12N1/20 ,  C12R1/46

Abstract: The present invention provides EPS structures, as identified by their repeating unit, the corresponding eps gene clusters and strains producing such EPS which result in the desired combination of water-holding capacity, texture and acidification speed. The invention further provides methods of using the EPS and strains producing such EPS for producing food product.

公开(公告)号：US20250032560A1

公开(公告)日：2025-01-30

申请号：US18601536

申请日：2024-03-11

Applicant: INTERNATIONAL N&H DENMARK APS

Inventor： Lotta Stenman ,  Markus Lehtinen ,  Yuejian Mao

IPC: A61K35/747 ,  A23L33/135 ,  A61K9/19 ,  A61K35/00 ,  A61P25/22 ,  A61P25/24 ,  C12R1/25

Abstract: The invention relates to novel bacteria of the species Lactobacillus plantarum and to compositions comprising Lactobacillus plantarum, and methods and uses of said compositions for preventing and/or treating mental illness, symptoms affecting mental health and/or conditions associated with chronic stress, in a mammal. The invention can be applied in restoring, maintaining, and/or promoting mental (including cognitive) health and has potential applications, inter alia, in the area of dietary and food supplements, medicaments and pharmaceuticals.

公开(公告)号：US12209227B2

公开(公告)日：2025-01-28

申请号：US17984331

申请日：2022-11-10

Applicant: Nippon Suisan Kaisha, Ltd.

Inventor： Takayoshi Sekiguchi ,  Yuji Okita ,  Yumiko Nishizawa

IPC: C11B1/10 ,  C12N1/12 ,  C12P7/6427 ,  C12P7/6434 ,  C12P7/6472 ,  C12R1/89

Abstract: Docosahexaenoic acid-containing oil containing docosahexaenoic acid in a concentration of 40 wt. % or more of the total weight of fatty acids in the oil, and having an endothermic peak temperature determined by differential scanning calorimetry (DSC) of 15° C. or lower; a biomass including the same; and a method for producing docosahexaenoic acid-containing oil including obtaining a biomass by culturing microorganisms of the genus Aurantiochytrium capable of producing this docosahexaenoic acid-containing oil, recovering the biomass after culture, and extracting the oil from the biomass after recovery.

公开(公告)号：US12208387B2

公开(公告)日：2025-01-28

申请号：US18262375

申请日：2022-01-22

Applicant: DRIZZLE HEALTH LLC

Inventor： Digvijay Singh ,  Bonolo Mathekga ,  Yukari Manabe ,  Soumyadipta Acharya ,  Hai Quan Mao

IPC: B01L3/00 ,  C12N1/20 ,  C12N11/08 ,  C12R1/32

Abstract: A device for selectively capturing mycobacteria comprises a substrate and a capture polymer layer of poly-diallyldimethyl ammonium chloride, wherein the capture polymer layer is covalently linked onto the substrate via a UV-initiated polymerization reaction of a solution comprising diallyldimethyl ammonium chloride and a photoinitiator in water purged of dissolved oxygen, and wherein the UV exposure time is 30 seconds to 4 minutes at a power density of about 20 to about 25 mW/cm2. A kit can comprise the device. A microfluidic chip comprises at least a portion of at least one channel sidewall coated with a capture polymer layer of poly-diallyldimethyl ammonium chloride. A method for manufacturing the device includes plasma treating a substrate, providing a solution comprising diallyldimethyl ammonium chloride and a photoinitiator in water purged of dissolved oxygen, and coating the plasma-treated substrate via a UV-initiated polymerization reaction.

公开(公告)号：US20250027033A1

公开(公告)日：2025-01-23

申请号：US17999955

申请日：2020-11-19

Applicant: ALGENUITY HOLDINGS LTD

Inventor： Andrew Pearce SPICER ,  Alexander Findlay PUDNEY ,  Richard Thomas SMITH ,  Jean-Charles Eric Francois ISNER ,  Gino SCHIANO DIVISCONTE

IPC: C12N1/12 ,  A23L29/00 ,  A61K8/9722 ,  C12N9/00 ,  C12N9/02 ,  C12N9/10 ,  C12N15/01 ,  C12R1/89

Abstract: Disclosed are modified strains of Chlorella vulgaris having a very low chlorophyll content. Also disclosed is a method for producing them. The method involves performing mutagenesis of a parental strain of Chlorella vulgaris. Furthermore, disclosed is a composition comprising algae biomass derived from the modified strains of Chlorella vulgaris and their use in food and/or cosmetics amongst other applications.

公开(公告)号：US12203030B2

公开(公告)日：2025-01-21

申请号：US17901913

申请日：2022-09-02

Applicant: CHINA UNIVERSITY OF GEOSCIENCES, BEIJING ,  YANGTZE UNIVERSITY

Inventor： Fan Zhang ,  Yuehui She ,  Qing Feng ,  Xiaonan Li ,  Shengsheng Li

IPC: C09K8/582 ,  C09K8/72 ,  C12N1/20 ,  C12R1/125

Abstract: Disclosed is a method for reducing pressure and increasing injection by continuous operation system of biological acid acidification and nano coating, specifically including composition and preparation method of biological acidizing agent and nano coating agent. The method for reducing pressure and increasing injection by continuous operation system of biological acid acidification and nano coating of the present disclosure is able to effectively dredge the stratum water flow channel, reduce the water flow resistance, and achieve the effect of high-efficiency pressure reduction and injection increase of the water injection well.

公开(公告)号：US12201653B2

公开(公告)日：2025-01-21

申请号：US17747689

申请日：2022-05-18

Applicant: Actym Therapeutics, Inc.

Inventor： Christopher D. Thanos ,  Laura Hix Glickman ,  Justin Skoble ,  Alexandre Charles Michel Iannello

IPC: A61K35/74 ,  A61K39/00 ,  A61K39/112 ,  A61K45/06 ,  A61P35/00 ,  C07K14/52 ,  C07K16/24 ,  C07K16/28 ,  C12N1/20 ,  C12N15/74 ,  C12R1/42

Abstract: Provided are delivery immunostimulatory bacteria that have enhanced colonization of tumors, the tumor microenvironment and/or tumor-resident immune cells, and enhanced anti-tumor activity. The immunostimulatory bacteria are modified by deletion of genes encoding the flagella, or by modification of the genes so that functional flagella are not produced, and/or are modified by deletion of pagP or modification of pagP to produce inactive PagP product. As a result, the immunostimulatory bacteria are flagellin− and/or pagP−. The immunostimulatory bacteria optionally have additional genomic modifications so that the bacteria are adenosine or purine auxotrophs. The bacteria optionally are one or more of asd−, purI−, and msbB−. The immunostimulatory bacteria, such as Salmonella species, are modified to encode immunostimulatory proteins that confer anti-tumor activity in the tumor microenvironment, and/or are modified so that the bacteria preferentially infect immune cells in the tumor microenvironment, or tumor-resident immune cells, and/or are modified to induce less cell death in immune cells than in other cells. Also provided are methods of inhibiting the growth or reducing the volume of a solid tumor by administering the immunostimulatory bacteria.