公开(公告)号：WO2023041203A1

公开(公告)日：2023-03-23

申请号：PCT/EP2022/056412

申请日：2022-03-11

Applicant: 4D PHARMA RESEARCH LIMITED

Inventor： ADRIANI, Marsilio ,  ETTORRE, Anna ,  MULDER, Imke ,  COUTURIER, Aurelie

IPC: A61K35/744 ,  A61P35/04 ,  A61P35/00 ,  C12N1/20 ,  C12R1/46 ,  G01N33/569 ,  G01N33/574 ,  G01N33/50

Abstract: The invention is in the field of bacterial strains isolated from the mammalian digestive tract and the use of such strains, and compositions comprising these strains, in the treatment of disease.

公开(公告)号：WO2021123378A1

公开(公告)日：2021-06-24

申请号：PCT/EP2020/087317

申请日：2020-12-18

Applicant: 4D PHARMA RESEARCH LIMITED

Inventor： MULDER, Imke Elisabeth ,  REICHARDT, Nicole ,  SAVIGNAC, Helene ,  CHETAL, Sasha ,  DINAN, Ted ,  CRYAN, John

IPC: A61K35/74 ,  A61K9/00 ,  A61K9/19 ,  A61P25/00 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  A61K9/0053

Abstract: The invention provides compositions comprising bacterial strains and the use of such compositions in the treatment of disease, including in central nervous system disorders.

公开(公告)号：WO2020120714A1

公开(公告)日：2020-06-18

申请号：PCT/EP2019/084991

申请日：2019-12-12

Applicant: 4D PHARMA RESEARCH LIMITED

Inventor： MULDER, Imke Elisabeth ,  ETTORRE, Anna ,  AHMED, Suaad ,  CRYAN, John ,  DINAN, Ted

IPC: A61K35/741 ,  A61K45/06 ,  A61P25/24

Abstract: The invention provides a composition comprising a bacterial strain of the genus Megasphaera, for use in the treatment or prevention of a disorder characterised by serotonin deficiency.

公开(公告)号：WO2019141996A1

公开(公告)日：2019-07-25

申请号：PCT/GB2019/050141

申请日：2019-01-18

Applicant: 4D PHARMA RESEARCH LIMITED

Inventor： STEVENSON, Alexander

IPC: A61K35/74 ,  A61K39/395 ,  A61P35/00

CPC classification number: A61K35/74 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/507 ,  A61P35/00 ,  C07K16/2818 ,  C07K2317/76 ,  A61K2300/00

Abstract: The invention provides a combination therapy comprising a bacterial strain for treating or preventing cancer.

公开(公告)号：WO2019030411A1

公开(公告)日：2019-02-14

申请号：PCT/EP2018/071831

申请日：2018-08-10

Applicant: 4D PHARMA RESEARCH LIMITED

Inventor： MULDER, Imke Elisabeth ,  MCCLUSKEY, Seanin Marie ,  SAVIGNAC, Helene ,  JEFFERY, Ian

IPC: A61K35/744 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A23L33/135 ,  A61P1/12

Abstract: The invention provides compositions comprising bacterial strains and the use of such compositions in the treatment of disease.

公开(公告)号：WO2018229216A1

公开(公告)日：2018-12-20

申请号：PCT/EP2018/065858

申请日：2018-06-14

Applicant: 4D PHARMA RESEARCH LIMITED

Inventor： MULDER, Imke Elisabeth ,  YUILLE, Samantha ,  ETTORE, Anna ,  AHMED, Suaad ,  FOTIADOU, Parthena ,  URCIA, Joseph Roby Iringan ,  SAVIGNAC, Helene

IPC: A61K35/74 ,  A61K9/19 ,  A61P25/00 ,  A61P25/28

Abstract: The invention provides compositions comprising bacterial strains for treating and preventing neurodegenerative disorders.

公开(公告)号：WO2017089794A1

公开(公告)日：2017-06-01

申请号：PCT/GB2016/053676

申请日：2016-11-23

Applicant: 4D PHARMA RESEARCH LIMITED

Inventor： MULDER, Imke Elisabeth ,  HOLT, Amy Beth ,  MCCLUSKEY, Seanin Marie ,  LENNON, Grainne Clare ,  AHMED, Suaad

IPC: A61P19/00 ,  A61P29/00 ,  A61P11/06 ,  A61P27/02 ,  A61K39/08 ,  A61K35/74

CPC classification number: A61K35/74 ,  A23C9/152 ,  A23L33/135 ,  A23V2002/00 ,  A61K9/19 ,  A61K31/00 ,  A61K39/08 ,  A61K39/39 ,  A61K2035/11 ,  A61K2039/542 ,  A61K2039/55594 ,  A61K2039/577 ,  A61K2039/58 ,  A61K2300/00

Abstract: The invention provides compositions comprising bacterial strains for treating and preventing inflammatory and autoimmune diseases.

公开(公告)号：WO2016102950A1

公开(公告)日：2016-06-30

申请号：PCT/GB2015/054112

申请日：2015-12-22

Applicant: 4D PHARMA RESEARCH LIMITED

Inventor： PATTERSON, Angela Margaret ,  GRANT, George ,  MULDER, Imke

IPC: A61K35/74

CPC classification number: A61K35/74 ,  A23L33/135 ,  A23V2002/00 ,  A61K9/0053 ,  A61K9/19 ,  C12N1/04 ,  C12R1/01

Abstract: The present invention provides a strain of Bacteroides thetaiotaomicron and derivatives thereof, and the use of said strain or derivatives in treating inflammatory, autoimmune and allergic disorders. The invention also provides pharmaceutical compositions, nutritional supplements, feedstuffs, food products, dietary supplements, and food additives comprising said strain or derivatives.

Abstract translation: 本发明提供了拟杆菌属的三菌属和其衍生物的菌株，以及所述菌株或衍生物在治疗炎性，自身免疫性和过敏性疾病中的用途。 本发明还提供药物组合物，营养补充剂，饲料，食品，膳食补充剂和包含所述菌株或衍生物的食品添加剂。

公开(公告)号：WO2023041574A1

公开(公告)日：2023-03-23

申请号：PCT/EP2022/075514

申请日：2022-09-14

Applicant: 4D PHARMA RESEARCH LIMITED

Inventor： ADRIANI, Marsilio ,  ETTORRE, Anna ,  MULDER, Imke ,  COUTURIER, Aurelie

IPC: A61K35/744 ,  A61P35/04 ,  A61P35/00 ,  C12N1/20 ,  C12R1/46 ,  G01N33/569 ,  G01N33/574 ,  G01N33/50 ,  C12N1/00

Abstract: The invention is in the field of bacterial strains isolated from the mammalian digestive tract and the use of such strains, and compositions comprising these strains, in the treatment of disease.

公开(公告)号：WO2022003057A1

公开(公告)日：2022-01-06

申请号：PCT/EP2021/068072

申请日：2021-06-30

Applicant: 4D PHARMA RESEARCH LIMITED

Inventor： DINAN, Ted ,  CRYAN, John ,  REID, Sarah ,  AHMED, Suaad ,  ETTORRE, Anna

IPC: A61K35/74 ,  A61P25/28

Abstract: The invention provides compositions comprising one or more bacterial strains for treating or preventing a central nervous system disease or disorder.