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公开(公告)号:WO2022020545A2
公开(公告)日:2022-01-27
申请号:PCT/US2021/042692
申请日:2021-07-22
Applicant: TEXAS TECH UNIVERSITY SYSTEM
Inventor: GILL, Harvinder, Singh , JOSHI, Gaurav
IPC: A61K39/12 , A61K39/215 , A61P31/14 , C12N15/63 , C12N7/01 , A61K2039/55555 , A61K2039/55561 , A61K2039/575 , A61K2039/58 , A61K2039/70 , C07K14/00 , C12N2770/20034
Abstract: The present invention includes and immunogenic composition and methods of immunizing a mammal or avian comprising: a nanoparticle conjugated to one or more antigenic peptides or fusion polypeptides from more than one strain of virus, wherein the one or more antigenic peptides or fusion polypeptides elicit at least one of a humoral, T helper cell-1 (Th1), T helper cell-2 (Th2) or cytotoxic T cell (CTL) immune response. In certain embodiments the antigenic peptides or fusion polypeptides are selected from at least one of SEQ IN NOS: 1 to 16, 22 to 39, or any combination thereof.
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公开(公告)号:WO2021195246A1
公开(公告)日:2021-09-30
申请号:PCT/US2021/023934
申请日:2021-03-24
Applicant: TEXAS TECH UNIVERSITY SYSTEM
Inventor: MCGLONE, John J.
Abstract: In an embodiment, the present disclosure pertains to a method of repelling an animal from an object by applying a composition to the object. In some embodiments, the animal is from the felidae species. In some embodiments, the composition includes butanoic acid and 3-Mercapto-3-Methyl Butanol (MMB). In an additional embodiment, the present disclosure pertains to a composition for repelling an animal from an object. In some embodiments, the animal is from the felidae species. In some embodiments, the composition includes butanoic acid and MMB.
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公开(公告)号:WO2021173888A1
公开(公告)日:2021-09-02
申请号:PCT/US2021/019749
申请日:2021-02-25
Applicant: TEXAS TECH UNIVERSITY SYSTEM
Inventor: PALMER, Ty , BLINCH, Jarrod
Abstract: A method of analyzing a subject using a dynamo torque analyzer includes recording the force produced during an isometric contraction of the subject with a load cell, processing data associated with the isometric contraction, and calculating and displaying, via a microcomputer of the dynamo torque analyzer, peak torque, and rate of torque development values using the data associated with the isometric contraction. The dynamo torque analyzer calculates and displays the peak torque and rate of torque development values in real time.
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4.
公开(公告)号:WO2021102215A1
公开(公告)日:2021-05-27
申请号:PCT/US2020/061420
申请日:2020-11-20
Inventor: LI, Chengwen , SUTTON, R. Bryan
Abstract: The invention relates to methods and compositions for increasing introduction (e.g., transduction) efficiency. In particular, the invention relates to methods of increasing introduction (e.g., transduction) efficiency by contacting a host cell with a heterologous agent in the presence of a cell membrane fusion protein or a functional fragment or derivative thereof. The invention further relates to compositions that include a heterologous agent and a cell membrane fusion protein or a functional fragment or derivative thereof.
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公开(公告)号:WO2021026495A1
公开(公告)日:2021-02-11
申请号:PCT/US2020/045485
申请日:2020-08-07
Applicant: TEXAS TECH UNIVERSITY SYSTEM
Inventor: DHURANDHAR, Nikhil, V. , HEGDE, Vijay
Abstract: Embodiments of the present disclosure pertain to methods of treating or preventing Alzheimer's disease or symptoms of Alzheimer's disease in a subject by administering to the subject an active agent that includes an adenovirus-36 E4orf1 protein, a nucleic acid encoding an adenovirus-36 E4orfl protein, or combinations thereof. Additional embodiments of the present disclosure pertain to the active agents of the present disclosure for use in the treatment or prevention of Alzheimer's disease or symptoms of Alzheimer's disease.
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公开(公告)号:WO2020159912A1
公开(公告)日:2020-08-06
申请号:PCT/US2020/015301
申请日:2020-01-28
Applicant: TEXAS TECH UNIVERSITY SYSTEM
Inventor: FUHRMAN, Bradley P.
Abstract: The disclosure provides a way to supplement the tidal volume delivered to the patient by a leaking re-breather when the delivered volume becomes less than that set by the ventilator (in either pressure-regulated or volume modes). This may be accomplished with a shunt — a gas conduit joining the non-patient side of the re-breather to the patient side. A low-resistance, plenum or a draw-over vaporizer may also be incorporated into the gas pathway. Such a device may include a housing with a movable partition separating an actuating side from a patient side. The housing includes a ventilator orifice for pneumatic communication between a ventilator and the actuating side and a patient orifice for pneumatic communication between the patient side and a patient. A shunt defines a bypass flow path from the actuating side and to the patient side when the moveable partition is at a maximal displacement towards the patient side.
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公开(公告)号:WO2020086439A3
公开(公告)日:2020-04-30
申请号:PCT/US2019/057165
申请日:2019-10-21
Applicant: TEXAS TECH UNIVERSITY SYSTEM
Inventor: CHEN, Chau-Chyun , TUN, Hla , KAUR, Harnoor
Abstract: A method and system for adsorbed phase activity coefficients for mixed-gas adsorption includes: providing one or more processors, a memory communicably coupled to the one or more processors and an input/output device communicably coupled to the one or more processors; calculating a first gas activity coefficient γ 1 for a first gas using the one or more processors and a first equation; calculating a second gas activity coefficient y 2 for a second gas using the one or more processors and a second equation based on a bulk mole fraction of the first gas; providing the first gas activity coefficient y 1 for the first gas and the second gas activity coefficient y 2 for the second gas to the input/output device; and using the first gas activity coefficient y 1 for the first gas and the second gas activity coefficient y 2 for the second gas in the gas adsorption system.
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8.
公开(公告)号:WO2020081537A1
公开(公告)日:2020-04-23
申请号:PCT/US2019/056281
申请日:2019-10-15
Applicant: TEXAS TECH UNIVERSITY SYSTEM
Inventor: LOWE, Devin, B. , WOOSTER, Amanda, L.
Abstract: The present invention includes compositions and methods of making and using a fusion protein comprising a peptide, a first flexible linker, a β2-microglobulin domain, a second flexible linker, a soluble major histocompatibility complex (MHC) heavy chain and a peptide tag.
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公开(公告)号:WO2020018868A1
公开(公告)日:2020-01-23
申请号:PCT/US2019/042525
申请日:2019-07-19
Applicant: TEXAS TECH UNIVERSITY SYSTEM
Inventor: DAS, Hiranmoy , RUSH, Sloan, W.
Abstract: The present invention includes compositions and method of generating human corneal epithelial stem cells, a human corneal epithelial stem cell supernatant, or both, the method comprising: wetting and mincing a corneal epithelial sample in a media, drying the minced corneal epithelial sample until sample edges are adhered to a substrate, adding a growth media comprising fetal bovine serum or equivalent to the minced corneal epithelial sample without dislodging the minced corneal epithelial sample from the substrate with an amount of media that permits at least a portion of the minced corneal epithelial sample to be in contact with air, culturing the minced corneal epithelial sample for one or more days, changing the growth media to a media comprising a human corneal growth supplement (HCGS) with no fetal bovine serum, culturing the cells to grow human corneal epithelial stem cells, a human corneal epithelial stem cell supernatant, or both.
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公开(公告)号:WO2020002667A1
公开(公告)日:2020-01-02
申请号:PCT/EP2019/067458
申请日:2019-06-28
Applicant: SPECIALITES PET FOOD , TEXAS TECH UNIVERSITY SYSTEM
Inventor: HALL, Nathaniel , PERON, Franck , CAMBOU, Stéphanie
Abstract: The invention concerns a device(1) for testing sniffing of a pet, comprising a fixed casing (10) intended to be placed on the surface separately from the pet, a receptacle (2), which is rigidly attached in the first front opening (102) of the casing, an air flow sensor (3), an odor line (4), a calculator unit (6) for determination of a air flow derived databased on the air flow measured, a presence sensor (5) detecting the presence of the pet. The unit (6) is configured to command sending of the odorant stream (41) in the odor line (4) as a reaction to at least the fact that the presence sensor (5) has detected the presence of the pet.
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