公开(公告)号：WO2014036022A1

公开(公告)日：2014-03-06

申请号：PCT/US2013/056884

申请日：2013-08-27

Applicant: AMGEN INC.

Inventor： BREGMAN, Howard ,  BUCHANAN, John L. ,  CHAKKA, Nagasree ,  DIMAURO, Erin F. ,  GUNAYDIN, Hakan ,  GUZMAN PEREZ, Angel ,  HUA, Zihao ,  HUANG, Xin

IPC: C07D403/12 ,  C07D401/14 ,  C07D413/14 ,  C07D401/12 ,  C07D239/90 ,  C07D239/95 ,  C07D413/12 ,  C07D417/14 ,  C07D471/04 ,  A61P35/00 ,  A61K31/513 ,  A61K31/517 ,  A61K31/519

CPC classification number: C07D471/02 ,  C07D239/90 ,  C07D239/95 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: Compounds of Formula I are useful inhibitors of tankyrase. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

Abstract translation: 式I化合物是阻聚酶的有用抑制剂。 式I的化合物具有以下结构：其中本文提供变量的定义。

公开(公告)号：WO2007084391A3

公开(公告)日：2007-07-26

申请号：PCT/US2007/000871

申请日：2007-01-11

Applicant: AMGEN INC. ,  ZENG, Qingping ,  ALLEN, John G. ,  BOURBEAU, Matthew P. ,  DOMINGUEZ, Celia ,  FOTSCH, Christopher H. ,  HAN, Nianhe ,  HONG, Fang-Tsao ,  HUANG, Xin ,  LEE, Matthew R. ,  LI, Aiwen ,  LIU, Qingyian ,  RIDER, James T. ,  TADESSE, Seifu ,  TASKER, Andrew S. ,  VISWANADHAN, Vellarkad N. ,  WANG, Xianghong ,  WEILER, Kurt E. ,  WOHLHIETER, George E. ,  YAO, Guomin ,  YUAN, Chester Chenguang

Inventor： ZENG, Qingping ,  ALLEN, John G. ,  BOURBEAU, Matthew P. ,  DOMINGUEZ, Celia ,  FOTSCH, Christopher H. ,  HAN, Nianhe ,  HONG, Fang-Tsao ,  HUANG, Xin ,  LEE, Matthew R. ,  LI, Aiwen ,  LIU, Qingyian ,  RIDER, James T. ,  TADESSE, Seifu ,  TASKER, Andrew S. ,  VISWANADHAN, Vellarkad N. ,  WANG, Xianghong ,  WEILER, Kurt E. ,  WOHLHIETER, George E. ,  YAO, Guomin ,  YUAN, Chester Chenguang

IPC: C07D417/04 ,  C07D417/14 ,  C07D513/04 ,  C07D471/04 ,  C07D277/54 ,  C07D495/04 ,  C07D277/42 ,  A61K31/427 ,  A61P35/00

Abstract: The invention relates to thiazole compounds of Formula (I) and Formula (II) and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

公开(公告)号：WO2011153509A1

公开(公告)日：2011-12-08

申请号：PCT/US2011/039184

申请日：2011-06-03

Applicant: AMGEN INC. ,  BARTBERGER, Michael David ,  GONZALEZ BUENROSTRO, Ana ,  BECK, Hilary Plake ,  CHEN, Xiaoqi ,  CONNORS, Richard Victor ,  DEIGNAN, Jeffery ,  DUQUETTE, Jason ,  EKSTEROWICZ, John ,  FISHER, Benjamin ,  FOX, Brian Matthew ,  FU, Jiasheng ,  FU, Zice ,  GONZALEZ LOPEZ DE TURISO, Felix ,  GRIBBLE, JR., Michael William ,  GUSTIN, Darin James ,  HEATH, Julie Anne ,  HUANG, Xin ,  JIAO, Xianyun ,  JOHNSON, Michael ,  KAYSER, Frank ,  KOPECKY, David John ,  LAI, Sujen ,  LI, Yihong ,  LI, Zhihong ,  LIU, Jiwen ,  LOW, Jonathan Dante ,  LUCAS, Brian Stuart ,  MA, Zhihua ,  MCGEE, Lawrence ,  MCINTOSH, Joel ,  MCMINN, Dustin ,  MEDINA, Julio Cesar ,  MIHALIC, Jeffrey Thomas ,  OLSON, Steven Howard ,  REW, Yosup ,  ROVETO, Philip Marley ,  SUN, Daqing ,  WANG, Xiaodong ,  WANG, Yingcai ,  YAN, Xuelei ,  YU, Ming ,  ZHU, Jiang

Inventor： BARTBERGER, Michael David ,  GONZALEZ BUENROSTRO, Ana ,  BECK, Hilary Plake ,  CHEN, Xiaoqi ,  CONNORS, Richard Victor ,  DEIGNAN, Jeffery ,  DUQUETTE, Jason ,  EKSTEROWICZ, John ,  FISHER, Benjamin ,  FOX, Brian Matthew ,  FU, Jiasheng ,  FU, Zice ,  GONZALEZ LOPEZ DE TURISO, Felix ,  GRIBBLE, JR., Michael William ,  GUSTIN, Darin James ,  HEATH, Julie Anne ,  HUANG, Xin ,  JIAO, Xianyun ,  JOHNSON, Michael ,  KAYSER, Frank ,  KOPECKY, David John ,  LAI, Sujen ,  LI, Yihong ,  LI, Zhihong ,  LIU, Jiwen ,  LOW, Jonathan Dante ,  LUCAS, Brian Stuart ,  MA, Zhihua ,  MCGEE, Lawrence ,  MCINTOSH, Joel ,  MCMINN, Dustin ,  MEDINA, Julio Cesar ,  MIHALIC, Jeffrey Thomas ,  OLSON, Steven Howard ,  REW, Yosup ,  ROVETO, Philip Marley ,  SUN, Daqing ,  WANG, Xiaodong ,  WANG, Yingcai ,  YAN, Xuelei ,  YU, Ming ,  ZHU, Jiang

IPC: C07D211/40 ,  C07D401/04 ,  C07D401/06 ,  C07D407/04 ,  C07D407/06 ,  C07D409/04 ,  C07D413/06 ,  C07D417/06 ,  C07D471/20 ,  C07D279/02 ,  C07D401/12 ,  C07D498/08 ,  C07D498/20 ,  A61K31/4412 ,  A61P35/00

CPC classification number: C07D211/76 ,  C07D221/20 ,  C07D279/02 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D407/04 ,  C07D407/06 ,  C07D409/04 ,  C07D409/12 ,  C07D413/06 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/10 ,  C07D491/08 ,  C07D491/153 ,  C07D498/08 ,  C07D498/14 ,  C07D498/20

Abstract: The present invention provides MDM2 inhibitor compounds of Formula (I), wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract translation: 本发明提供式（I）的MDM2抑制剂化合物，其中变量如上所定义，哪些化合物可用作治疗剂，特别是用于治疗癌症。 本发明还涉及含有MDM2抑制剂的药物组合物。

公开(公告)号：WO2009011871A3

公开(公告)日：2009-01-22

申请号：PCT/US2008/008690

申请日：2008-07-15

Applicant: AMGEN INC. ,  ALLEN, John, G. ,  BOURBEAU, Matthew, P. ,  DOMINGUEZ, Celia ,  FOTSCH, Christopher, H. ,  HAN, Nianhe ,  HONG, Fang-tsao ,  HUANG, Xin ,  LEE, Matthew, R. ,  LIU, Qingyian ,  REICHELT, Andreas ,  TADESSE, Seifu ,  WANG, Xianghong ,  YAO, Guomin ,  YUAN, Chester Chenguang ,  ZENG, Qingping

Inventor： ALLEN, John, G. ,  BOURBEAU, Matthew, P. ,  DOMINGUEZ, Celia ,  FOTSCH, Christopher, H. ,  HAN, Nianhe ,  HONG, Fang-tsao ,  HUANG, Xin ,  LEE, Matthew, R. ,  LIU, Qingyian ,  REICHELT, Andreas ,  TADESSE, Seifu ,  WANG, Xianghong ,  YAO, Guomin ,  YUAN, Chester Chenguang ,  ZENG, Qingping

IPC: C07D471/02 ,  C07D285/135 ,  C07D285/125 ,  A61K31/433 ,  A61P35/00 ,  A61P29/00

Abstract: The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

公开(公告)号：WO2013134079A1

公开(公告)日：2013-09-12

申请号：PCT/US2013/028751

申请日：2013-03-01

Applicant: AMGEN INC.

Inventor： BREGMAN, Howard ,  BUCHANAN, John, L. ,  CHAKKA, Nagasree ,  DIMAURO, Erin ,  GUNAYDIN, Hakan ,  GUZMAN PEREZ, Angel ,  HUA, Zihao ,  HUANG, Hongbing ,  HUANG, Xin ,  MARTIN, Matthew, W. ,  PATEL, Vinod

IPC: C07D413/14 ,  C07D413/08 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04 ,  C07D263/34 ,  C07D519/00 ,  A61K31/4166 ,  A61P35/00

CPC classification number: C07D487/04 ,  C07D263/34 ,  C07D413/08 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D519/00

Abstract: Compounds of Formula (I) and Formula (II) are useful inhibitors of tankyrase. Compounds of Formula (I) and Formula (II) have the following structure: where the definitions of the variables are provided herein.

Abstract translation: 式（I）和式（II）的化合物是阻聚酶的有用抑制剂。 式（I）和式（II）的化合物具有以下结构：其中在此提供变量的定义。