公开(公告)号：WO2014093591A1

公开(公告)日：2014-06-19

申请号：PCT/US2013/074604

申请日：2013-12-12

Applicant: DOW AGROSCIENCES LLC ,  JOHNSON, Peter Lee ,  RENGA, James M. ,  GIAMPIETRO, Natalie C. ,  WHITEKER, Gregory T. ,  GALLIFORD, Christopher

Inventor： JOHNSON, Peter Lee ,  RENGA, James M. ,  GIAMPIETRO, Natalie C. ,  WHITEKER, Gregory T. ,  GALLIFORD, Christopher

IPC: A01N43/40

CPC classification number: C07D213/74 ,  C07C251/12 ,  C07D213/73 ,  C07D251/12 ,  Y02P20/55

Abstract: 4-Amino-3-chloro-6-(substituted)picolinates are prepared from difluoroacetic acid or trifluoroacetic acid, tritylamine or t-butylamine as a protecting group, a 3,3-dialkoxyprop-1-yne and a substituted methylene amine by a series of steps. Provided herein are processes for the preparation of 4-amino-5-fluoro-3-halo-6-(substituted)picolinates and 4-amino-3-halo-6-(substituted)picolinates. More particularly, provided herein are processes for the preparation of 4-amino-5-fluoro-3-halo-6-(substituted)picolinates and 4-amino-3-halo-6- (substituted)picolinates from a non-pyridine source. These picolinates are useful as herbicides.

Abstract translation: 4-氨基-3-氯-6-（取代的）吡啶甲酸盐由二氟乙酸或三氟乙酸，三苯甲基胺或叔丁胺作为保护基团制备，3,3-二烷氧基丙-1-炔和取代的亚甲基胺 一系列步骤。 本文提供了制备4-氨基-5-氟-3-卤代-6-（取代的）吡啶甲酸盐和4-氨基-3-卤代-6-（取代的）吡啶甲酸盐的方法。 更具体地，本文提供的是从非吡啶源制备4-氨基-5-氟-3-卤代-6-（取代的）吡啶甲酸盐和4-氨基-3-卤代-6-（取代的）吡啶甲酸盐的方法 。 这些吡啶甲酸盐作为除草剂是有用的。

公开(公告)号：WO2014093580A1

公开(公告)日：2014-06-19

申请号：PCT/US2013/074575

申请日：2013-12-12

Applicant: DOW AGROSCIENCES LLC ,  GIAMPIETRO, Natalie C. ,  RENGA, James M.

Inventor： GIAMPIETRO, Natalie C. ,  RENGA, James M.

IPC: A01N43/40

CPC classification number: C07D213/79 ,  C07C251/12 ,  C07D213/803

Abstract: 4-Amino-5-fluoro-3-chloro-6-(substituted)picolinates are prepared from trifluoroacetic acid, p-methoxyaniline, a C1-C4 alkyl propiolate and a substituted methylene amine by a series of steps. In particular, provided herein are processes for the preparation of 4-amino-5-fluoro-3-chloro-6-(substituted)picolinates from a non-pyridine source without a metal assisted coupling and without fluorination with an expensive fluorinating agent. These picolinates are useful as herbicides.

Abstract translation: 4-氨基-5-氟-3-氯-6-（取代的）吡啶甲酸盐通过一系列步骤由三氟乙酸，对甲氧基苯胺，C 1 -C 4烷基丙炔酸酯和取代的亚甲基胺制备。 特别地，本文提供的是从非吡啶源制备4-氨基-5-氟-3-氯-6-（取代的）吡啶甲酸盐的方法，没有金属辅助偶合而不用昂贵的氟化剂氟化。 这些吡啶甲酸盐作为除草剂是有用的。

公开(公告)号：WO2014093588A1

公开(公告)日：2014-06-19

申请号：PCT/US2013/074600

申请日：2013-12-12

Applicant: DOW AGROSCIENCES LLC ,  RENGA, James M. ,  WHITEKER, Gregory T. ,  JOHNSON, Peter Lee ,  GALLIFORD, Christopher

Inventor： RENGA, James M. ,  WHITEKER, Gregory T. ,  JOHNSON, Peter Lee ,  GALLIFORD, Christopher

IPC: A01N43/40

CPC classification number: C07D213/803 ,  C07C251/12 ,  C07D213/72 ,  C07D213/73 ,  C07D213/74 ,  C07D213/79

Abstract: 4-Amino-5-fIuoro-3 -chloro-6-( substituted)picolinates are prepared from trifluoroacetic acid, p-methoxyaniline, a 3,3-dialkoxyprop-1-yne and a substituted methylene amine by a series of steps. In particular, provided herein are processes for the preparation of 4-amino-5-fluoro-3-chloro-6-(substituted)picolinates from a non-pyridine source without a metal assisted coupling and without fluorination with an expensive fluorinating agent. These picolinates are useful as herbicides.

Abstract translation: 4-氨基-5-氟-3-氯-6-（取代的）吡啶甲酸盐通过一系列步骤由三氟乙酸，对甲氧基苯胺，3,3-二烷氧基丙-1-炔和取代的亚甲基胺制备。 特别地，本文提供的是从非吡啶源制备4-氨基-5-氟-3-氯-6-（取代的）吡啶甲酸盐的方法，没有金属辅助偶合而不用昂贵的氟化剂氟化。 这些吡啶甲酸盐作为除草剂是有用的。

公开(公告)号：WO2012103044A1

公开(公告)日：2012-08-02

申请号：PCT/US2012/022288

申请日：2012-01-24

Applicant: DOW AGROSCIENCES LLC ,  ZHU, Yuanming ,  WHITEKER, Gregory T. ,  ARNDT, Kim E. ,  RENGA, James M. ,  FROESE, Robert D.

Inventor： ZHU, Yuanming ,  WHITEKER, Gregory T. ,  ARNDT, Kim E. ,  RENGA, James M. ,  FROESE, Robert D.

IPC: A01N43/40 ,  A61K31/435

CPC classification number: C07D213/807 ,  C07D213/79 ,  C07D213/803 ,  C07D213/84

Abstract: 4-Amino-3-chloro-5-fluoro-6-(substituted)picolinates are conveniently prepared from 3,4,5,6-tetrachloropicolinonitrile by a series of steps involving fluorine exchange, amination, reaction with hydrazine, halogenation, hydrolysis and esterification, and transition metal assisted coupling.

Abstract translation: 通过一系列涉及氟交换，胺化，与肼反应，卤化反应，水解和水解的步骤，可以方便地从3,4,5,6-四氯吡啶腈制备4-氨基-3-氯-5-氟-6-（取代的）吡啶甲酸盐 酯化和过渡金属辅助偶联。

公开(公告)号：WO2016099929A1

公开(公告)日：2016-06-23

申请号：PCT/US2015/063720

申请日：2015-12-03

Applicant: DOW AGROSCIENCES LLC

Inventor： GIAMPIETRO, Natalie C. ,  BAUM, Erich W. ,  FISCHER, Lindsey G. ,  GOLDSMITH, Miriam E. ,  CROUSE, Gary D. ,  RENGA, James M. ,  SPARKS, Thomas C.

IPC: A01N43/653

CPC classification number: A01N47/36 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, compositions containing such molecules, and processes of using such molecules and compositions against such pests. These molecules and compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula ("Formula One").

Abstract translation: 本公开涉及具有杀虫效果的分子领域，其中包括节肢动物，软体动物和线虫中的害虫，产生此类分子的方法，用于此类方法的中间体，含有这些分子的组合物，以及使用此类分子的方法和抗这种害虫的组合物 。 这些分子和组合物可以用作例如杀螨剂，杀虫剂，杀螨剂，杀软体动物剂和杀线虫剂。 该文献公开了具有下式（“一级方程式”）的分子。

公开(公告)号：WO2016007638A1

公开(公告)日：2016-01-14

申请号：PCT/US2015/039569

申请日：2015-07-08

Applicant: DOW AGROSCIENCES LLC

Inventor： RENGA, James M. ,  ZHU, Yuanming ,  WHITEKER, Gregory T. ,  CHOY, Nakyen

IPC: C07D213/65 ,  C07D213/79 ,  C07D213/84

CPC classification number: C07D213/803 ,  C07D213/79 ,  C07D213/84 ,  C07D307/54

Abstract: 4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and bromination-rearrangement. 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 4,6-dibromo-3-hydroxypicolinonitrile in a series of chemical steps selected from bromo substitution, nitrile hydrolysis and halogen reduction.

Abstract translation: 4,6-二溴-3-羟基吡啶-2-腈可以由选自氰基胺化，胺盐形成和溴化重排的一系列化学步骤中的糠醛制备。 在一系列选自溴取代，腈水解和卤素还原的化学步骤中，可以方便地从4,6-二溴-3-羟基吡啶-2-腈制备4-烷氧基-3-羟基吡啶甲酸。

公开(公告)号：WO2016007637A1

公开(公告)日：2016-01-14

申请号：PCT/US2015/039568

申请日：2015-07-08

Applicant: DOW AGROSCIENCES LLC

Inventor： RENGA, James M. ,  ZHU, Yuanming ,  WHITEKER, Gregory T. ,  CHOY, Nakyen

IPC: A61K31/535

CPC classification number: C07D213/803 ,  C07D213/79 ,  C07D213/84 ,  C07D307/54

Abstract: 4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and bromination-rearrangement.

Abstract translation: 4,6-二溴-3-羟基吡啶腈可以从选自氰基胺化，胺盐形成和溴化重排的一系列化学步骤中由糠醛制备。

公开(公告)号：WO2016022623A1

公开(公告)日：2016-02-11

申请号：PCT/US2015/043707

申请日：2015-08-05

Applicant: DOW AGROSCIENCES LLC

Inventor： GRANDBOIS, Matthew L. ,  LAITAR, David S. ,  RENGA, James M. ,  WHITEKER, Gregory T.

IPC: C07D213/79

CPC classification number: C07D213/803 ,  B01J31/1815 ,  B01J2531/847

Abstract: 4,5,6-Trichloropicolinic acid is prepared by selectively dechlonnating 3,4,5,6- tetrachloropicolinic acid with zinc and a catalyst prepared from a nickel compound and a bidentate ligand in a polar solvent. A process for the preparation of 4,5,6-trichloro-picolinic acid by the regioselective reductive dechlorination of 3,4,5,6-tetrachloropicolinic acid is provided. More particularly, the process is described for the preparation of 4,5,6-trichloropicolinic acid (Formula I) which comprises selectively dechlonnating 3,4,5,6-tetrachloropicolinic acid (Formula II) with zinc and a catalyst prepared from a nickel compound and a bidentate ligand in a polar solvent.

Abstract translation: 通过选择性地将3,4,5,6-四氯吡啶甲酸与锌和由极性溶剂中的镍化合物和二齿配体制备的催化剂进行选择性脱除制备4,5,6-三氯吡啶甲酸。 提供了通过区域选择性还原脱氯3,4,5,6-四氯吡啶甲酸制备4,5,6-三氯吡啶甲酸的方法。 更具体地，描述了用于制备4,5,6-三氯吡啶甲酸（式I）的方法，其包括选择性地使3,4,5,6-四氯吡啶甲酸（式II）与锌和由镍制备的催化剂 化合物和二齿配体在极性溶剂中。

公开(公告)号：WO2016014664A1

公开(公告)日：2016-01-28

申请号：PCT/US2015/041528

申请日：2015-07-22

Applicant: DOW AGROSCIENCES LLC

Inventor： BAUM, Erich W. ,  FISCHER, Lindsey G. ,  CROUSE, Gary D. ,  SPARKS, Thomas C. ,  GIAMPIETRO, Natalie C. ,  DENT III, William ,  NIYAZ, Noormohamed M. ,  PETKUS, Jeff ,  DEMETER, David A. ,  LAMBERT, William Thomas ,  MCLEOD, CaSandra L. ,  RIGSBEE, Emily Marie ,  RENGA, James M.

IPC: A01N43/00

CPC classification number: A01N43/653 ,  A01N43/82 ,  A01N43/84 ,  A01N47/30 ,  A01N47/36 ,  C07D249/08 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12

Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Nematoda, Arthropoda, and/or Mollusca, processes to produce such molecules and intermediates used in such processes, compositions containing such molecules, and processes of using such molecules against such pests. These molecules may be used, for example, as nematicides, acaricides, insecticides, miticides, and/or molluscicides. This document discloses molecules having the following formula ("Formula One").

Abstract translation: 本公开涉及具有杀虫效力的分子领域，用于在叶螨（Phyla Nematoda），节肢动物（Arthropoda）和/或软体动物（Mollusca）中的害虫，产生这种分子的方法和用于该方法的中间体，含有这些分子的组合物，以及使用这种分子对这种害虫 。 这些分子可以用作例如杀线虫剂，杀螨剂，杀虫剂，杀螨剂和/或杀软体动物剂。 该文献公开了具有下式（“一级方程式”）的分子。

公开(公告)号：WO2016007532A1

公开(公告)日：2016-01-14

申请号：PCT/US2015/039411

申请日：2015-07-07

Applicant: DOW AGROSCIENCES LLC

Inventor： RENGA, James M.

IPC: C07D213/803 ,  C07D307/54

CPC classification number: C07D213/803 ,  C07D307/54

Abstract: 4,6-Dibromo-3-hydroxypicolinate esters are prepared from furan-2-yl aminoacetates in one chemical step by use of a bromination-rearrangement reaction.

Abstract translation: 通过使用溴化 - 重排反应，在一个化学步骤中由呋喃-2-基氨基乙酸酯制备4,6-二溴-3-羟基吡啶甲酸酯。