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公开(公告)号：WO2021226444A2
公开(公告)日：2021-11-11
申请号：PCT/US2021/031271
申请日：2021-05-07
Applicant: REGENERON PHARMACEUTICALS, INC.
Inventor： OLSON, William , MARTIN, Joel , STAHL, Neil , KIM, Jee
Abstract: The present relates to VEGF traps and VEGF mini-traps that include VEGF receptor Ig-like domains, fused to a multimerizing component, which bind to VEGF and block its interaction with the VEGF receptor. Such molecules are useful for treating angiogenic eye disorders (e.g., age-related macular degeneration), cancer and for other undesired angiogenesis.
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公开(公告)号：WO2020132658A3
公开(公告)日：2020-06-25
申请号：PCT/US2019/068185
申请日：2019-12-20
Applicant: REGENERON PHARMACEUTICALS, INC.
Inventor： HAN, Amy , KELLY, Marcus , OLSON, William
Abstract: Provided herein are compounds, compositions, and methods for the treatment of diseases and disorders associated with cancer, including tubulysins and protein ( e.g. , antibody) drug conjugates thereof.
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公开(公告)号：WO2020018503A3
公开(公告)日：2020-01-23
申请号：PCT/US2019/041952
申请日：2019-07-16
Applicant: REGENERON PHARMACEUTICALS, INC.
Inventor： FAIRHURST, Jeanette , GARNOVA, Elena , OLSON, William , HAXHINASTO, Sokol
IPC: C07K16/28 , A61K39/395 , A61P37/06 , A61P17/06
Abstract: The present invention provides antibodies and antigen-binding fragments ( e.g. , human antibodies) that bind specifically to human IL-36 receptor. Methods for treating or preventing diseases mediated by IL36R ( e.g ., skin or colon inflammatory conditions such as palmo-plantar pustular psoriasis, palmoplantar pustulosis, generalized pustular psoriasis, ulcerative colitis or IBD) using the antibodies and fragments are also provided along with methods of making the antibodies and fragments.
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公开(公告)号：WO2018213082A1
公开(公告)日：2018-11-22
申请号：PCT/US2018/031910
申请日：2018-05-09
Applicant: REGENERON PHARMACEUTICALS, INC.
Inventor： HAN, Amy , MURPHY, Andrew J. , OLSON, William
IPC: C07C233/90 , A61K31/16 , A61P3/00 , A61P25/28 , A61P29/00
Abstract: Provided herein are compounds, compositions and methods for the treatment of diseases and disorders associated with the liver X receptor, including bis-octahydrophenanthrene carboxamides and protein (e.g., antibody) drug conjugates thereof.
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公开(公告)号：WO2018089373A3
公开(公告)日：2018-05-17
申请号：PCT/US2017/060434
申请日：2017-11-07
Applicant: REGENERON PHARMACEUTICALS, INC.
Inventor： HAN, Amy , OLSON, William , MURPHY J., Andrew
Abstract: Described herein protein steroid conjugates whereby a glucocorticoid compound is conjugated to a binding agent which is preferably an antibody. These are useful, for example, for the target-specific delivery of glucocorticoids (GCs) to cells.
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Patent Agency Ranking
公开(公告)号：WO2018148476A1
公开(公告)日：2018-08-16
申请号：PCT/US2018/017525
申请日：2018-02-09
Applicant: REGENERON PHARMACEUTICALS, INC.
Inventor： KELLY, Marcus , MA, Dangshe , OLSON, William , TAVARE, Richard , THURSTON, Gavin
IPC: C07K16/28 , A61K51/10 , C07C259/00 , A61K39/00
Abstract: Radiolabeled anti-LAG3 antibodies and their use in immuno-PET imaging are provided herein. Included are methods of detecting the presence of LAG3 proteins in a patient or sample.
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公开(公告)号：WO2018089373A9
公开(公告)日：2018-05-17
申请号：PCT/US2017/060434
申请日：2017-11-07
Applicant: REGENERON PHARMACEUTICALS, INC.
Inventor： HAN, Amy , OLSON, William , MURPHY J., Andrew
Abstract: Described herein protein steroid conjugates whereby a glucocorticoid compound is conjugated to a binding agent which is preferably an antibody. These are useful, for example, for the target-specific delivery of glucocorticoids (GCs) to cells.
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公开(公告)号：WO2016100807A2
公开(公告)日：2016-06-23
申请号：PCT/US2015/066654
申请日：2015-12-18
Applicant: REGENERON PHARMACEUTICALS, INC.
Inventor： PURCELL NGAMBO, Lisa, A. , VIAU, Jonathan , OLSON, William
IPC: C07K16/10 , A61K39/42 , A61K31/215
CPC classification number: C07K16/1018 , A61K31/215 , A61K39/42 , A61K2039/505 , A61K2039/507 , A61K2039/545 , A61K2300/00 , C07K2317/21 , C07K2317/33 , C07K2317/565 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C07K2317/94 , A61K39/395
Abstract: The present invention provides monoclonal antibodies, or antigen-binding fragments thereof, that bind to the influenza hemagglutinin (HA) protein, pharmaceutical compositions comprising the antibodies and methods of use. The antibodies of the invention are useful for inhibiting or neutralizing influenza virus activity, thus providing a means of treating or preventing influenza infection in humans. In some embodiments, the invention provides for use of one or more antibodies that bind to the influenza HA for preventing viral attachment and/or entry into host cells. The antibodies of the invention may be used prophylactically or therapeutically and may be used alone or in combination with one or more other anti-viral agents or vaccines.
Abstract translation: 本发明提供结合流感血凝素（HA）蛋白的单克隆抗体或其抗原结合片段，包含该抗体的药物组合物和使用方法。 本发明的抗体可用于抑制或中和流感病毒活性，从而提供治疗或预防人类流感感染的手段。 在一些实施方案中，本发明提供了一种或多种结合流感HA的抗体用于防止病毒附着和/或进入宿主细胞的用途。 本发明的抗体可以预防性或治疗性使用，并且可以单独使用或与一种或多种其他抗病毒剂或疫苗组合使用。
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公开(公告)号：WO2022240877A1
公开(公告)日：2022-11-17
申请号：PCT/US2022/028595
申请日：2022-05-10
Applicant: REGENERON PHARMACEUTICALS, INC.
Inventor： CHIN, Harvey , HATSELL, Sarah J. , LOB, Heinrich Emil , MURPHY, Andrew J. , OLSON, William , SAOTOME, Kei , ZHANG, Bojie
IPC: C07K16/28 , A61P7/00 , C07K2317/31 , C07K2317/76 , C07K2317/92
Abstract: Provided herein are monoclonal antibodies that bind to the transmembrane serine protease 6 (TMPRSS6) protein, and methods of use thereof. In various embodiments of the disclosure, the antibodies are fully human antibodies that bind to TMPRSS6. In some embodiments, the antibodies disclosed herein are useful in a method for treating or preventing a disease, disorder or condition associated with TMPRSS6 in humans.
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公开(公告)号：WO2022056276A1
公开(公告)日：2022-03-17
申请号：PCT/US2021/049887
申请日：2021-09-10
Applicant: REGENERON PHARMACEUTICALS, INC.
Inventor： LIU, Yashu , GUO, Chunguang , ZHANG, Qian , LEVENKOVA, Natasha , MURPHY, Andrew J. , OLSON, William
IPC: C07K16/00 , A01K67/027 , C07K16/28 , C07K16/46 , C12Q1/6872 , G16B30/10
Abstract: A method of obtaining a nucleotide sequence, from an immunized genetically modified non-human mammal, encoding an immunoglobulin variable domain of an antibody specific for a particular antigen is disclosed. A method for making antibodies against a particular antigen is also disclosed.
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