公开(公告)号：WO2018138739A1

公开(公告)日：2018-08-02

申请号：PCT/IN2018/050040

申请日：2018-01-25

Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED

Inventor： SAMANTA, Biswajit ,  AKOLKAR, Nakul Pramodbhai ,  DESAI, Megha Shringesh ,  PATEL, Poojan Kaushikbhai ,  KALAPATAPU, Sairam V. V. M. ,  CHITTURI, Trinadha Rao

IPC: C07D413/14 ,  C07D413/04 ,  C07D498/04 ,  C07F9/09 ,  A61K31/538 ,  A61K31/5383 ,  A61P35/00

Abstract: The present invention provides novel heterocyclic compounds of Formula I wherein A, B, E, ring Z, Y, L, ring X, D, m, n, R 7 and R 8 are as defined in the specification as estrogen receptor antagonists/degraders. The compound of Formula I can be used for the treatment of cancers mediated by estrogen receptors. (Formula I ).

公开(公告)号：WO2017056115A1

公开(公告)日：2017-04-06

申请号：PCT/IN2016/050333

申请日：2016-10-01

Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED

Inventor： SAMANTA, Biswajit ,  PATEL, Poojan Kaushikbhai ,  DESAI, Megha Shringesh ,  AKOLKAR, Nakul Pramodbhai ,  ADHYAPAK, Jay Prakashchandra ,  KUMBHANI, Anil Savajibhai ,  GHOSH, Indraneel ,  CHITTURI, Trinadha Rao

IPC: C07D265/36 ,  C07D413/04 ,  C07D413/12 ,  C07D498/04

CPC classification number: C07D265/36 ,  C07D413/04 ,  C07D413/12 ,  C07D498/04

Abstract: The present invention provides novel N -aryl containing fused heterocyclic compounds as anticancer agents, especially as estrogen receptor (ER) antagonists/ degraders and process for their preparation.

Abstract translation: 本发明提供新的含N-芳基稠合杂环化合物作为抗癌剂，特别是作为雌激素受体（ER）拮抗剂/降解剂及其制备方法。