公开(公告)号：WO2023041275A1

公开(公告)日：2023-03-23

申请号：PCT/EP2022/072853

申请日：2022-08-16

申请人： EBERHARD KARLS UNIVERSITAET TUEBINGEN MEDIZINISCHE FAKULTAET

发明人： AVCI-ADALI, Meltem ,  CANJUGA, Denis

IPC分类号： A61L27/38 ,  A61L27/50 ,  A61L31/00 ,  A61L31/14

摘要： Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung einer mit biologischen Zellen besiedelbaren Oberfläche, eine Vorrichtung mit einer mit biologischen Zellen besiedelbaren Oberfläche, und ein Verfahren zur Besiedelung einer Oberfläche mit biologischen Zellen.

公开(公告)号：WO2023039031A2

公开(公告)日：2023-03-16

申请号：PCT/US2022/042856

申请日：2022-09-08

申请人： IANTREK, INC.

发明人： IANCHULEV, Tsontcho ,  CLAUSON, Luke ,  NELSEN, Daniel ,  ROBSON, David ,  BAKER, David ,  BUXTON, Sean

IPC分类号： A61F2/14 ,  A61F9/007 ,  A61L31/00

摘要： A system for deploying an implant cut from a biological tissue into an eye of a patient including a delivery device and a nose cone assembly, a tubular shaft projecting from the distal end region of the nose cone and comprising a lumen. Related devices, systems, and methods are provided.

公开(公告)号：WO2023281361A1

公开(公告)日：2023-01-12

申请号：PCT/IB2022/056050

申请日：2022-06-29

申请人： COVIDIEN LP

发明人： BARIL, Jacob C.

IPC分类号： A61B17/072 ,  A61L31/00

摘要： A surgical kit includes a surgical stapling device and a loading assembly. The surgical stapling device includes a tool assembly and a buttress material. The tool assembly includes first and second jaw members. The first jaw member supports a staple cartridge that includes a retention assembly. The retention assembly includes a cam block including a pair of protrusions and a spring biasing the cam block towards the second jaw member. The buttress material includes proximal and distal portions. The proximal portion defines bores laterally spaced apart and configured to receive the pair of protrusions of the cam block. The distal portion defines a cavity to be placed over a distal end portion of the staple cartridge. The loading assembly includes a housing defining a chamber configured to receive a portion of the buttress material. The housing includes a proximal portion defining a slot configured to receive the buttress material therethrough and the pair of protrusions of the cam block.

公开(公告)号：WO2022258780A1

公开(公告)日：2022-12-15

申请号：PCT/EP2022/065757

申请日：2022-06-09

申请人： FUNDACIÓ INSTITUT CATALÀ DE NANOCIÈNCIA I NANOTECNOLOGIA (ICN2) ,  CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC)

发明人： SUÁREZ GARCÍA, Salvio ,  SAIZ POSEU, Javier ,  RUIZ MOLINA, Daniel

IPC分类号： C08G12/00 ,  A61F2/00 ,  C08G65/44 ,  C08G65/48 ,  C08G73/02 ,  A61L31/00

摘要： The present invention provides a process for preparing a self-standing catecholamine-based membrane, the process comprising the steps of: (a) cross-linking a catechol derivative with an amine selected from the group consisting of: a known aliphatic amine hydrocarbon of formula (II); and an aromatic amine of formula (IIbis), in a liquid medium, wherein both the catechol and the amine are soluble, at a pH comprised from 6.5 to 10, and under appropriate agitation to create a catecholamine membrane in the air/liquid interface in the absence of any support; and b) isolating the membrane resulting from step (a) from the air/liquid interface. The resulting self-standing catecholamine-based membrane was robust, easy to handle and manipulate, highly flexible and adaptable to any kind of surface without breaking, and adhesive. In addition, the free-standing membrane of the invention shows a Janus character, with an unexpected nanopatterning in the water-contact side which endows the membranes of the invention with a higher roughness surface, something of value to promote cell adhesion.

公开(公告)号：WO2022257741A1

公开(公告)日：2022-12-15

申请号：PCT/CN2022/094367

申请日：2022-05-23

申请人： 吾奇生物医疗科技（江苏）有限公司

发明人： 董群 ,  任恒飞

IPC分类号： A61L31/00 ,  A61L31/14

摘要： 本申请提出了一种生物膜的制备方法及其产品和应用。所述生物膜的制备方法包括以下步骤：(1)采用胶原酶抑制剂处理动物腔道组织；(2)去除占动物腔道组织总脂肪含量40％以上的膜层；(3)采用第一酶溶液处理步骤(2)得到的产物；(4)采用碱溶液处理步骤(3)得到的产物；(5)采用脱细胞溶液处理步骤(4)得到的产物；(6)采用脱脂液溶液处理步骤(5)得到的产物；(7)采用第二酶溶液处理步骤(6)得到的产物；以及(8)采用超临界二氧化碳清洗步骤(7)得到的产物，得到生物膜。本申请可极大程度地保留了生物膜的多层空间结构、弹性纤维及胶原网状结构的完整性，机械强度高，能去除产品中有机物和试剂的残留，使其诱导组织再生效果更好。

公开(公告)号：WO2022253478A1

公开(公告)日：2022-12-08

申请号：PCT/EP2022/058272

申请日：2022-03-29

申请人： BIOTRONIK AG

发明人： MUELLER, Heinz ,  EHNERT, Corina ,  RZANY, Alexander

IPC分类号： A61L27/04 ,  A61L27/36 ,  A61L27/58 ,  A61L31/00 ,  A61L31/02 ,  A61L31/14

摘要： The invention relates implants (1) comprising at least one biodegradable support structure (2) and at least one covering material at least partially covering the at least one biodegradable support structure (2) already prior to implantation, wherein the covering material is selected from an autologous, xenogeneic or allogeneic material or combinations thereof, and wherein the biodegradable support structure consists of magnesium, zinc or iron; or the biodegradable support structure consists of a biodegradable magnesium-based alloy, a biodegradable zinc-based alloy or a biodegradable an iron-based alloy.

公开(公告)号：WO2022212372A1

公开(公告)日：2022-10-06

申请号：PCT/US2022/022343

申请日：2022-03-29

申请人： FORT WAYNE METALS RESEARCH PRODUCTS, LLC

发明人： GRIEBEL, Adam J. ,  CAI, Song ,  SCHAFFER, Jeremy E.

IPC分类号： A61L31/00 ,  A61L31/02 ,  A61L31/14 ,  A61M25/09 ,  A61F2/01 ,  A61K51/00

摘要： A composite wire uses a powder core to offer radiopaque enhancements without the drawbacks of a solid metal core. For example, composite wires may include highly radiopaque materials, such as tantalum and platinum, integrated into the wire core in powder form. The powder core provides high radiopacity to the finished wire while preserving mechanical properties of the shell material. The powder form of the core material also enables a wider range of candidate materials for the composite wire core, such that a desirable electrochemical profile may be maintained between the core and shell materials, including bioabsorbable shell materials.

公开(公告)号：WO2022162556A1

公开(公告)日：2022-08-04

申请号：PCT/IB2022/050682

申请日：2022-01-26

申请人： I.R.A. ISTITUTO RICERCHE APPLICATE S.P.A.

发明人： CITERNESI, Ugo Raffaello ,  ANDOLINA, Gloria ,  BERETTA, Lorenzo ,  CIVIDINI, Andrea ,  CITERNESI, Lorenzo

IPC分类号： A61L27/36 ,  A61L27/52 ,  A61L27/54 ,  A61L31/00 ,  A61K9/00 ,  A61K35/60

摘要： The present invention concerns a process for producing an intra-articularly injectable polynucleotide-based viscous gel, wherein said polynucleotides advantageously have an average molecular weight ≥ 1000 kDa, in particular selected in the range from 2600 to 3500 kDalton. The polynucleotide-based gel finds application in the medical and veterinary fields in the treatment of osteoarticular diseases.

公开(公告)号：WO2022146730A1

公开(公告)日：2022-07-07

申请号：PCT/US2021/064227

申请日：2021-12-17

申请人： ACELL, INC.

发明人： REMLINGER, Nathaniel ,  GILBERT, Thomas, W. ,  MARKS, Andrea, S. ,  YOUNG, D., Adam ,  HULEIHEL, Luai ,  REISHER, Nichol ,  TANG, Jiayu

IPC分类号： A61L31/00 ,  A61M60/00

摘要： Implantable pouch devices for encasing a cardiac implantable electronic device (CIED) or other medical device are formed from one or more bioresorbable sheets of material comprising an extracellular matrix (ECM) for maintaining and supporting a healing environment. Each bioresorbable sheet may be a medical graft assembly which comprises at least first and second sheets of ECM material layered together such that the epithelial basement membrane sides face outward.

公开(公告)号：WO2022126021A1

公开(公告)日：2022-06-16

申请号：PCT/US2021/063128

申请日：2021-12-13

申请人： THE JOHNS HOPKINS UNIVERSITY [US]/[US]

发明人： GERECHT, Sharon ,  ELLIOT, Morgan B. ,  MAO, Hai-Quan ,  CHEN, Theresa ,  PRASAD, Khyati

IPC分类号： A61F2/82 ,  A61F2/07 ,  A61L31/00 ,  A61L31/16 ,  A61L33/00

摘要： Described are methods for embedding one or more therapeutic agents into vascular grafts and other scaffold-based devices, and methods of implanting vascular grafts comprising tubular scaffolds into subjects. The tubular scaffolds comprise hydrogel nanofibers that have internally aligned polymer chains and may contain one or more therapeutic agents.