专利检索 ap:"I.R.A. ISTITUTO RICERCHE APPLICATE S.P.A." 第 1 页

1.

发明申请
PROCESS FOR PRODUCING A POLYNUCLEOTIDE-BASED GEL AND USE THEREOF IN THE TREATMENT OF OSTEOARTICULAR DISEASES 审中-公开

公开(公告)号：WO2022162556A1

公开(公告)日：2022-08-04

申请号：PCT/IB2022/050682

申请日：2022-01-26

申请人： I.R.A. ISTITUTO RICERCHE APPLICATE S.P.A.

发明人： CITERNESI, Ugo Raffaello , ANDOLINA, Gloria , BERETTA, Lorenzo , CIVIDINI, Andrea , CITERNESI, Lorenzo

IPC分类号： A61L27/36 , A61L27/52 , A61L27/54 , A61L31/00 , A61K9/00 , A61K35/60

摘要： The present invention concerns a process for producing an intra-articularly injectable polynucleotide-based viscous gel, wherein said polynucleotides advantageously have an average molecular weight ≥ 1000 kDa, in particular selected in the range from 2600 to 3500 kDalton. The polynucleotide-based gel finds application in the medical and veterinary fields in the treatment of osteoarticular diseases.

2.

发明申请
PEPTIDES WITH CELL DAMAGE PROTECTION ACTIVITY AND LIPOSOMIAL FORMULATIONS 审中-公开

公开(公告)号：WO2021079328A1

公开(公告)日：2021-04-29

申请号：PCT/IB2020/059968

申请日：2020-10-23

申请人： I.R.A. ISTITUTO RICERCHE APPLICATE S.P.A.

发明人： CITERNESI, Ugo Raffaello , ANDOLINA, Gloria , FORMAGGIO, Fernando , PEGGION, Cristina , DI LIDDO, Rosa , PICCIONE, Monica , BERETTA, Lorenzo , CIVIDINI, Andrea , DE MARNI, Emanuele Giuseppe , CITERNESI, Lorenzo

IPC分类号： C07K7/06 , C12N9/22 , A61K8/64 , A61K38/00

摘要： The invention relates to selected peptides which repair, by means of nucleotide excision repair (NER), cellular DNA damaged by the exposure to external agents in particular UV rays and the cosmetic or pharmaceutical use thereof in skin treatment. The invention also relates to compositions for topical application containing the peptides preferably carried in liposomes to prevent and treat skin damage caused by the exposure to UV rays in particular in subjects affected by xeroderma pigmentosum.