公开(公告)号：WO2009094954A1

公开(公告)日：2009-08-06

申请号：PCT/CN2009/071048

申请日：2009-03-27

Applicant: 复旦大学 ,  株式会社岛津制作所 ,  蒋公羽 ,  罗婵 ,  丁传凡 ,  丁力

Inventor： 蒋公羽 ,  罗婵 ,  丁传凡 ,  丁力

IPC: H01J49/42

CPC classification number: H01J49/423 ,  H01J49/004 ,  H01J49/427

Abstract: A tandem mass spectrometry method with several ion traps includes generating a high-frequency trapping electric field given priority to a four poles field in a first ion trap to trap ions with multi mass-to-charge ratio, and generating a dipolar excitation electric field with a certain frequency in the first ion trap along the linear direction, which connecting the center of the first ion trap and the center of a second ion trap. The ion with a certain mass-to-charge ratio is resonated and excited and achieves relatively high amplitude of vibration along said direction in the dipolar excitation electric field. A removing pulse voltage is generated at a certain phase in the first ion trap to remove said ion with relatively high movement amplitude to the second ion trap, and ions with other mass-to-charge ratio remain in the first ion trap. The ingoing ion or other production ion is trapped by decelerating field or gas collision in the second ion trap, and is investigated and analyzed further in the second ion trap.

公开(公告)号：WO2008137481A3

公开(公告)日：2009-08-06

申请号：PCT/US2008062102

申请日：2008-04-30

Applicant: THERMO FINNIGAN LLC ,  GUCKENBERGER GEORGE B ,  QUARMBY SCOTT T

Inventor： GUCKENBERGER GEORGE B ,  QUARMBY SCOTT T

IPC: H01J49/42 ,  H01J49/00

CPC classification number: H01J49/4265 ,  H01J49/0036 ,  Y10T436/24

Abstract: A method includes: accumulating ions having a plurality of m/z values in an ion trap during a time interval; deriving from the accumulated ions a respective intensity value for each of the m/z values; and adjusting each of the intensity values as a function of the time needed by the ion trap to begin collecting ions with the corresponding m/z value. According to a different aspect, an apparatus includes a first portion with an ion trap, and a second portion. The second portion causes the ion trap to accumulate ions with a plurality of m/z values during a time interval, derives from the accumulated ions in the ion trap a respective intensity value for each of the m/z values, and adjusts each of the intensity values as a function of the time needed by the ion trap to begin collecting ions with the corresponding m/z value.

Abstract translation: 一种方法包括：在时间间隔内将离子具有多个m / z值在离子阱中累积; 从累积离子中得出每个m / z值的相应强度值; 并且根据离子阱开始收集具有相应m / z值的离子所需的时间的函数调整每个强度值。 根据不同方面，一种装置包括具有离子阱的第一部分和第二部分。 第二部分使得离子阱在时间间隔期间以多个m / z值累积离子，从离子阱中的累积离子导出每个m / z值的相应强度值，并调整每个 强度值作为离子阱开始收集具有相应m / z值的离子所需的时间的函数。

公开(公告)号：WO2008098081A3

公开(公告)日：2009-05-28

申请号：PCT/US2008053219

申请日：2008-02-06

Applicant: THERMO FINNIGAN LLC ,  SENKO MICHAEL W

Inventor： SENKO MICHAEL W

IPC: H01J49/42

CPC classification number: H01J49/423 ,  H01J49/004

Abstract: A tandem mass spectrometer includes a two-dimensional ion trap that has an elongated ion-trapping region extending along a continuously curving path between first and second opposite ends thereof. The elongated trapping region has a central axis that is defined substantially parallel to the curved path and that extends between the first and second opposite ends. The two-dimensional ion trap is configured for receiving ions through the first end and for mass selectively ejecting the ions along a direction that is orthogonal to the central axis, such that the ejected ions are directed generally toward a common point. The tandem mass spectrometer also includes a collision cell having an ion inlet that is disposed about the common point for receiving the ions that are ejected therefrom and for causing at least a portion of the ions to undergo collisions and form product ions by fragmentation. A mass analyzer in communication with the collision cell receives the product ions from the collision cell and obtains product ion mass spectra with a rapid scan rate, hi this way, a plurality of product ion spectra may be obtained for a large number of precursor ions in a sample without the need for data-dependent operation.

Abstract translation: 串联质谱仪包括二维离子阱，其具有在其第一和第二相对端之间沿着连续弯曲路径延伸的细长离子捕获区域。 细长捕获区域具有中心轴线，该中心轴线基本上平行于弯曲路径限定，并且在第一和第二相对端部之间延伸。 二维离子阱被配置用于通过第一端接收离子，并且用于沿着与中心轴正交的方向大量选择性地排出离子，使得所排出的离子大致指向公共点。 串联质谱仪还包括具有离子入口的碰撞池，该离子入口围绕公共点设置以接收从其喷出的离子，并使至少一部分离子发生碰撞并通过碎裂形成产物离子。 与碰撞单元通信的质量分析器接收来自碰撞池的产物离子，并且以快速扫描速率获得产物离子质谱。通过这种方式，可以获得大量前体离子的多个产物离子光谱 一个样本，而不需要依赖于数据的操作。

公开(公告)号：WO2008091271A3

公开(公告)日：2009-04-16

申请号：PCT/US2007012003

申请日：2007-05-18

Applicant: THERMO FINNIGAN LLC ,  SENKO MICHAEL W

Inventor： SENKO MICHAEL W

IPC: H01J49/42

CPC classification number: H01J49/4225

Abstract: A system and method are disclosed for effectively compensating for non-linear field components created by a field distortion feature in a quadrupolar ion trap, compensation provided by a geometric surface shaping which reduces the non-linear field components and creates a minimal centerline radio-frequency potential in the ion trap. The ion trap includes a centerline that passes longitudinally through a trapping volume inside of the ion trap, a pair of Y electrodes with inner Y electrode surfaces that are approximately parallel to the centerline, and a pair of X electrodes with inner X electrode surfaces that are approximately parallel to the centerline. The X electrodes have one or more ejection slots through which trapped ions are ejected from said ion trap. The inner Y electrode surfaces each have a Y radius of curvature, and the inner X electrode surfaces each have an X radius of curvature. The X radius of curvature is selected to be smaller than the Y radius of curvature. A balanced centerline potential is provided at the centerline of the ion trap.

Abstract translation: 公开了一种系统和方法，用于有效地补偿由四极离子阱中的场失真特征产生的非线性场分量，由几何表面成形提供的补偿，其减少非线性场分量并创建最小中心线射频 离子阱中的电位。 离子阱包括纵向穿过离子阱内的捕获体积的中心线，具有大致平行于中心线的内部Y电极表面的一对Y电极和具有内部X电极表面的一对X电极， 大致平行于中心线。 X电极具有一个或多个弹出槽，从所述离子阱排出被捕获的离子。 内部Y电极表面各自具有Y的曲率半径，并且内部X电极表面各自具有X的曲率半径。 选择X的曲率半径小于Y的曲率半径。 在离子阱的中心线处提供平衡的中心线电位。

公开(公告)号：WO2008063497A3

公开(公告)日：2009-02-19

申请号：PCT/US2007023834

申请日：2007-11-13

Applicant: BROOKS AUTOMATION INC ,  ERMAKOV ALEXEI VICTOROVICH ,  HINCH BARBARA JANE

Inventor： ERMAKOV ALEXEI VICTOROVICH ,  HINCH BARBARA JANE

IPC: H01J49/42

CPC classification number: H01J49/4245

Abstract: An electrostatic ion trap confines ions of different mass to charge ratios and kinetic energies within an anharmonic potential well. The ion trap is also provided with a small amplitude AC drive that excites confined ions. The mass dependent amplitudes of oscillation of the confined ions are increased as their energies increase, due to an autoresonance between the AC drive frequency and the natural oscillation frequencies of the ions, until the oscillation amplitudes of the ions exceed the physical dimensions of the trap, or the ions fragment or undergo any other physical or chemical transformation.

Abstract translation: 静电离子阱将不同质量的离子限制在非均匀势阱内的电荷比和动能。 离子阱还具有激发限制离子的小幅度交流驱动。 由于交流驱动频率与离子的固有振荡频率之间的自谐振，由于它们的能量增加，限制离子的振荡的质量依赖幅度增加，直到离子的振荡幅度超过陷阱的物理尺寸， 或离子碎片或进行任何其他物理或化学转化。

公开(公告)号：WO2008059255A3

公开(公告)日：2009-02-05

申请号：PCT/GB2007004364

申请日：2007-11-15

Applicant: MICROMASS LTD ,  BATEMAN ROBERT HAROLD ,  GILES KEVIN ,  PRINGLE STEVEN DEREK ,  WILDGOOSE JASON LEE

Inventor： BATEMAN ROBERT HAROLD ,  GILES KEVIN ,  PRINGLE STEVEN DEREK ,  WILDGOOSE JASON LEE

IPC: H01J49/42 ,  G01N27/64

CPC classification number: H01J49/4215 ,  G01N27/622 ,  H01J49/004 ,  H01J49/426

Abstract: A mass spectrometer is disclosed comprising an ion mobility spectrometer (8) and an ion gate (9). A collision cell (10) is arranged downstream of the ion gate (9). The operation of the ion mobility spectrometer (8) and the ion gate (9) are synchronised so that only ions having a particular mass to charge ratio and a desired charge state are onwardly transmitted to the collision cell (10).

Abstract translation: 公开了一种质谱仪，其包括离子迁移谱仪（8）和离子门（9）。 碰撞室（10）布置在离子门（9）的下游。 离子迁移谱仪（8）和离子浇口（9）的操作是同步的，使得只有具有特定质荷比的离子和期望的电荷状态向上传输到碰撞池（10）。

公开(公告)号：WO2008102155A2

公开(公告)日：2008-08-28

申请号：PCT/GB2008/000617

申请日：2008-02-21

Applicant: MICROMASS UK LIMITED ,  BATEMAN, Robert, Harold ,  GREEN, Martin ,  WILDGOOSE, Jason, Lee

Inventor： BATEMAN, Robert, Harold ,  GREEN, Martin ,  WILDGOOSE, Jason, Lee

IPC: H01J49/42

CPC classification number: H01J49/0095 ,  H01J49/423 ,  H01J49/424

Abstract: A mass spectrometer is disclosed comprising a 2D or 3D ion trap. The 2D ion trap comprises a quadrupole rod set ion trap wherein a slot is provided in each of the rods 1 to allow ions to be ejected radially from the ion trap. The 3D ion trap comprises a central ring electrode which is radially segmented and wherein a slot is provided in each radial segment to allow ions to be ejected radially from the ion trap. Ions having different mass to charge ratios and/or opposite polarities may be simultaneously ejected from the ion trap via different exit pathways.

Abstract translation: 公开了包括2D或3D离子阱的质谱仪。 2D离子阱包括四极棒组离子阱，其中在每个棒1中设置槽，以允许离子从离子阱径向喷射。 3D离子阱包括径向分段的中心环电极，并且其中在每个径向段中设置狭槽以允许离子从离子阱径向喷射。 具有不同质荷比和/或相反极性的离子可以通过不同的出口通道从离子阱同时喷出。

公开(公告)号：WO2008045649A3

公开(公告)日：2008-04-17

申请号：PCT/US2007/078220

申请日：2007-09-12

Applicant: GENERAL ELECTRIC COMPANY ,  LI, Xue-song, Scott

Inventor： LI, Xue-song, Scott

IPC: G01N27/64 ,  G01N35/00 ,  H01J49/42

Abstract: An ion trap mobility spectrometer calibration system and method wherein the maximum response of the spectrometer is determined. A quantity Q 0 is chosen representing a response which is a predetermined percentage of the maximum response. Input to the ion trap mobility spectrometer are at least two known quantities Q 1 and Q 2 of an analyte, which have a predetermined relationship with Q 0 . The responses corresponding to R 1 and R 2 of the ion trap mobility spectrometer are observed based on the respective inputs of quantities Q 1 and Q 2 . R 1 , R 2 , and Q 1 and Q 2 are then used to calculate the calibration constants in an equation describing a curve where the response of the ion trap mobility spectrometer is a function of the quantity of the analyte input therein. The calculated calibration constants are input to thereafter determine, from the response, the quantity of a detected analyte based on the equation.

公开(公告)号：WO2008044290A1

公开(公告)日：2008-04-17

申请号：PCT/JP2006/320290

申请日：2006-10-11

Applicant: 株式会社島津製作所 ,  奥村 大輔 ,  糸井 弘人 ,  向畑 和男 ,  三好 一生

Inventor： 奥村 大輔 ,  糸井 弘人 ,  向畑 和男 ,  三好 一生

IPC: H01J49/42

CPC classification number: H01J49/0045

Abstract: 　本願は、真空排気される分析室（１０）内に設置されるコリジョンセル（２０）の内部を、連通開口（２２）が設けられた隔壁（２１）で前方室（２３）と後方室（２４）とに区画し、前者を開裂領域（Ａ１）、後者収束領域（Ａ２）としたＭＳ／ＭＳ質量分析装置を開示する。開裂領域（Ａ１）、および収束領域（Ａ２）のそれぞれで、プリカーサイオンの開裂に最適なガス圧、およびクーリングによるイオンの収束に最適なガス圧を実現し、開裂効率およびイオン収束効率を共に高めることができる。

Abstract translation: 具有设置在抽真空分析室（10）内的碰撞室（20）的MS / MS质谱仪，其中所述碰撞室（20）的内部通过隔板（21）分隔，所述舱壁设置有连通开口（22） 23）和后室（24），前者构成切割区域（A1），后者构成会聚区域（A2）。 裂解区域（A1）和会聚区域（A2）分别实现最适合于前体离子的裂解的气体压力和通过冷却最适合离子收敛的气体压力，从而能够同时提高切割效率和离子收敛 效率。

公开(公告)号：WO2007075856A3

公开(公告)日：2008-04-17

申请号：PCT/US2006048732

申请日：2006-12-19

Applicant: MDS SCIEX INC ,  APPLERA CORP ,  COVEY THOMAS R ,  JAVAHERI HASSAN ,  SCHNEIDER BRADLEY B

Inventor： COVEY THOMAS R ,  JAVAHERI HASSAN ,  SCHNEIDER BRADLEY B

IPC: H01J49/42

CPC classification number: H01J49/063 ,  H01J49/164

Abstract: A laser desorption ion source provides enhanced ion sampling efficiency and measurement sensitivity by using one or more ion guides to effectively capture ions in a plume emitted from the ion target and guide the ions through an aperture into a downstream vacuum chamber. In one configuration using two RF multipole ion guides, a first RF multipole ion guide disposed next to the ion target is selected to be sufficiently large to capture a substantial portion of the plume, while the second RF multipole ion guide disposed between the first multipole ion guide and the aperture has a smaller dimension to assist focusing of ions into the aperture. The first RF multipole ion guides the ions in the plume into the second RF multipole ion guide, which then focuses the ions so that they pass through the aperture into the downstream vacuum chamber.

Abstract translation: 激光解吸离子源通过使用一个或多个离子引导件有效地捕获从离子靶发射的羽流中的离子并将离子引导通过孔进入下游真空室来提供增强的离子采样效率和测量灵敏度。 在使用两个RF多极离子引导件的一种配置中，选择邻近离子靶设置的第一RF多极离子导向器足够大以捕获大部分羽流，而第二射频多极离子导向器设置在第一多极离子 导向件和孔径具有较小的尺寸以辅助将离子聚焦到孔中。 第一RF多极离子将羽流中的离子引导到第二射频多极离子导向器中，然后将离子聚焦以使它们通过孔进入下游真空室。