公开(公告)号：WO2007130304A2

公开(公告)日：2007-11-15

申请号：PCT/US2007/010132

申请日：2007-04-23

Applicant: THERMO FINNIGAN LLC ,  SENKO, Michael, W. ,  QUARMBY, Scott, T. ,  GUCKENBERGER, George, B.

Inventor： SENKO, Michael, W. ,  QUARMBY, Scott, T. ,  GUCKENBERGER, George, B.

IPC: G01N30/72

CPC classification number: H01J49/427 ,  H01J43/02 ,  H01J49/0095 ,  H01J49/025

Abstract: An apparatus and method are disclosed for efficient detection of ions ejected from a quadrupolar ion trap, in which the ions are ejected as first and second groups of ions having different directions. The first and second groups of ions are received by a conversion dynode structure, which responsively emits secondary particles that are directed to a shared detector, such as an electron multiplier. The conversion dynode structure may be implemented as a common dynode or as two dynodes (or sets of dynodes), with each dynode positioned to receive one of the groups of ions.

Abstract translation: 公开了一种用于有效检测从四极离子阱排出的离子的装置和方法，其中离子作为具有不同方向的第一和第二组离子喷射。 第一组和第二组离子由转换倍增极结构接收，转换倍增器结构响应地发射被引导到诸如电子倍增器的共享检测器的次级粒子。 转换倍增极结构可以被实现为公共倍增电极或者作为两个倍增电极（或者一组倍增极），其中每个倍增极定位成接收一组离子。

公开(公告)号：WO2009018231A3

公开(公告)日：2009-10-29

申请号：PCT/US2008071386

申请日：2008-07-28

Applicant: THERMO FINNIGAN LLC ,  QUARMBY SCOTT T ,  GUCKENBERGER GEORGE B

Inventor： QUARMBY SCOTT T ,  GUCKENBERGER GEORGE B

IPC: H01J49/08

CPC classification number: H01J49/147 ,  H01J27/205

Abstract: An electron source can selectively provide a first stream of electrons that travels in a direction along an imaginary line to a location remote from the electron source, or a second stream of electrons that travels in the direction along the line to the location. The electron source includes a first electron emitter for selectively emitting electrons for the first stream, and a second electron emitter for selectively emitting electrons for the second stream. A different aspect relates to a method for operating an apparatus having an electron source that includes first and second electron emitters. The method includes selectively producing a first stream of electrons that travels from the first electron emitter in a direction along an imaginary line to a location remote from the electron source, or a second stream of electrons that travels from the second electron emitter in the direction along the line to the location.

Abstract translation: 电子源可以选择性地提供沿着虚线的方向行进到远离电子源的位置的第一电子流，或者沿着线的方向行进到该位置的第二电子流。 电子源包括用于选择性地发射第一流的电子的第一电子发射器和用于选择性地发射第二流的电子的第二电子发射器。 一个不同的方面涉及一种用于操作具有包括第一和第二电子发射器的电子源的装置的方法。 该方法包括选择性地产生从第一电子发射器沿着虚线向远离电子源的位置行进的第一电子流或从第二电子发射器沿第一电子发射器方向行进的第二电子流 到该位置的线路。

公开(公告)号：WO2009100073A3

公开(公告)日：2009-11-19

申请号：PCT/US2009032977

申请日：2009-02-03

Applicant: THERMO FINNIGAN LLC ,  QUARMBY SCOTT T ,  GUCKENBERGER GEORGE B ,  MCCAULEY EDWARD B

Inventor： QUARMBY SCOTT T ,  GUCKENBERGER GEORGE B ,  MCCAULEY EDWARD B

IPC: H01J49/14 ,  H01J27/20

CPC classification number: H01J27/20 ,  H01J49/147

Abstract: A method for operating a mass spectrometer includes determining a first performance characteristic while operating the mass spectrometer with a first electron emitter, storing first information relating to the first performance characteristic, determining a second performance characteristic while operating the mass spectrometer with a second electron emitter, storing second information relating to the second performance characteristic, and thereafter switching from operation using the first electron emitter to operation using the second electron emitter. The switching includes using the first and second information to normalize performance of the second electron emitter after the switching relative to performance of the first electron emitter before the switching.

Abstract translation: 一种用于操作质谱仪的方法包括：确定第一性能特性，同时用第一电子发射器操作质谱仪;存储与第一性能特性有关的第一信息;确定第二性能特性，同时用第二电子发射器操作质谱仪; 存储与第二性能特性相关的第二信息，然后从使用第一电子发射器的操作切换到使用第二电子发射器的操作。 切换包括使用第一和第二信息来相对于切换之前的第一电子发射器的性能来标准化在切换之后的第二电子发射器的性能。

公开(公告)号：WO2009018231A2

公开(公告)日：2009-02-05

申请号：PCT/US2008/071386

申请日：2008-07-28

Applicant: THERMO FINNIGAN LLC ,  QUARMBY, Scott, T. ,  GUCKENBERGER, George, B.

Inventor： QUARMBY, Scott, T. ,  GUCKENBERGER, George, B.

CPC classification number: H01J49/147 ,  H01J27/205

Abstract: An electron source can selectively provide a first stream of electrons that travels in a direction along an imaginary line to a location remote from the electron source, or a second stream of electrons that travels in the direction along the line to the location. The electron source includes a first electron emitter for selectively emitting electrons for the first stream, and a second electron emitter for selectively emitting electrons for the second stream. A different aspect relates to a method for operating an apparatus having an electron source that includes first and second electron emitters. The method includes selectively producing a first stream of electrons that travels from the first electron emitter in a direction along an imaginary line to a location remote from the electron source, or a second stream of electrons that travels from the second electron emitter in the direction along the line to the location.

Abstract translation: 电子源可以选择性地提供在沿着假想线的方向上行进到远离电子源的位置的电子的第一电子流或沿着线的方向行进到位置的第二电子流。 电子源包括用于选择性地为第一流发射电子的第一电子发射器和用于为第二流选择性地发射电子的第二电子发射器。 不同的方面涉及一种用于操作具有包括第一和第二电子发射器的电子源的装置的方法。 该方法包括选择性地产生沿着沿着假想线的方向从第一电子发射器行进到远离电子源的位置的电子的第一电子流，或者从第二电子发射器沿着沿着方向行进的第二电子流 行到位置。

公开(公告)号：WO2008137481A3

公开(公告)日：2009-08-06

申请号：PCT/US2008062102

申请日：2008-04-30

Applicant: THERMO FINNIGAN LLC ,  GUCKENBERGER GEORGE B ,  QUARMBY SCOTT T

Inventor： GUCKENBERGER GEORGE B ,  QUARMBY SCOTT T

IPC: H01J49/42 ,  H01J49/00

CPC classification number: H01J49/4265 ,  H01J49/0036 ,  Y10T436/24

Abstract: A method includes: accumulating ions having a plurality of m/z values in an ion trap during a time interval; deriving from the accumulated ions a respective intensity value for each of the m/z values; and adjusting each of the intensity values as a function of the time needed by the ion trap to begin collecting ions with the corresponding m/z value. According to a different aspect, an apparatus includes a first portion with an ion trap, and a second portion. The second portion causes the ion trap to accumulate ions with a plurality of m/z values during a time interval, derives from the accumulated ions in the ion trap a respective intensity value for each of the m/z values, and adjusts each of the intensity values as a function of the time needed by the ion trap to begin collecting ions with the corresponding m/z value.

Abstract translation: 一种方法包括：在时间间隔内将离子具有多个m / z值在离子阱中累积; 从累积离子中得出每个m / z值的相应强度值; 并且根据离子阱开始收集具有相应m / z值的离子所需的时间的函数调整每个强度值。 根据不同方面，一种装置包括具有离子阱的第一部分和第二部分。 第二部分使得离子阱在时间间隔期间以多个m / z值累积离子，从离子阱中的累积离子导出每个m / z值的相应强度值，并调整每个 强度值作为离子阱开始收集具有相应m / z值的离子所需的时间的函数。

公开(公告)号：WO2007130304A3

公开(公告)日：2008-04-10

申请号：PCT/US2007010132

申请日：2007-04-23

Applicant: THERMO FINNIGAN LLC ,  SENKO MICHAEL W ,  QUARMBY SCOTT T ,  GUCKENBERGER GEORGE B

Inventor： SENKO MICHAEL W ,  QUARMBY SCOTT T ,  GUCKENBERGER GEORGE B

IPC: B01D59/44

CPC classification number: H01J49/427 ,  H01J43/02 ,  H01J49/0095 ,  H01J49/025

Abstract: An apparatus and method are disclosed for efficient detection of ions ejected from a quadrupolar ion trap, in which the ions are ejected as first and second groups of ions having different directions. The first and second groups of ions are received by a conversion dynode structure, which responsively emits secondary particles that are directed to a shared detector, such as an electron multiplier. The conversion dynode structure may be implemented as a common dynode or as two dynodes (or sets of dynodes), with each dynode positioned to receive one of the groups of ions.

Abstract translation: 公开了一种用于有效检测从四极离子阱排出的离子的装置和方法，其中离子作为具有不同方向的第一和第二组离子喷射。 第一组和第二组离子由转换倍增极结构接收，转换倍增器结构响应地发射被引导到诸如电子倍增器的共享检测器的次级粒子。 转换倍增极结构可以被实现为公共倍增电极或者作为两个倍增电极（或者一组倍增极），其中每个倍增极定位成接收一组离子。

公开(公告)号：WO2006014285A3

公开(公告)日：2007-03-22

申请号：PCT/US2005023074

申请日：2005-06-30

Applicant: THERMO FINNIGAN LLC ,  MCCAULEY EDWARD B ,  QUARMBY SCOTT T ,  GUCKENBERGER GEORGE B

Inventor： MCCAULEY EDWARD B ,  QUARMBY SCOTT T ,  GUCKENBERGER GEORGE B

IPC: H01J49/42

CPC classification number: H01J49/147 ,  H01J49/429

Abstract: A variable duty cycle ion source assembly is coupled to a continuous beam mass spectrometer. The duty cycle can be adjusted based on previous scan data or real time sampling of ion intensities during mass analysis. This provides the ability to control the total number of ions formed, mass analyzed and detected for each ion mass of interest. The frequency of the ion source can be sufficiently high (kHz range) so as to maintain accurate peak centroiding. The ion source assembly can be used for both electron ionization (El) or chemical ionization (CI) modes of operation.

Abstract translation: 可变占空比离子源组件耦合到连续光束质谱仪。 可以根据先前的扫描数据或质谱分析中离子强度的实时采样来调整占空比。 这提供了控制每个离子质量所形成的离子总数，质量分析和检测的能力。 离子源的频率可以足够高（kHz范围），以保持准确的峰值重心。 离子源组件可用于电子电离（El）或化学电离（CI）操作模式。

公开(公告)号：WO2009123914A1

公开(公告)日：2009-10-08

申请号：PCT/US2009/038452

申请日：2009-03-26

Applicant: THERMO FINNIGAN LLC ,  GUCKENBERGER, George, B. ,  WIECK, Joseph, B. ,  MCCAULEY, Edward, B. ,  QUARMBY, Scott, T.

Inventor： GUCKENBERGER, George, B. ,  WIECK, Joseph, B. ,  MCCAULEY, Edward, B. ,  QUARMBY, Scott, T.

IPC: H01J49/10 ,  H01J49/04 ,  H01J49/02 ,  H01J49/00

CPC classification number: H01J49/107 ,  H01J49/04

Abstract: A method and apparatus of combining an ion volume, a lens stack, and an ion optic that similarly cooperates with a detached multipole ion guide is herein incorporated into a single sub-assembly that can be removed from a mass spectrometer instrument without venting. Such an arrangement allows an operator to clean all parts of the ion path that get contaminated in normal operation, reassemble and reinsert in a timely manner and then pump down to an acceptable vacuum without having to vent the system.

Abstract translation: 将离子体体积，透镜组和与分离的多极离子导向器相配合的离子光学器件组合在一起的方法和装置结合到单个子组件中，该组件可以从质谱仪器中取出而不进行排气。 这种布置允许操作者清洁在正常操作中被污染的离子路径的所有部分，重新​​组装并重新插入，然后泵送到可接受的真空而不必排放系统。

公开(公告)号：WO2009100073A2

公开(公告)日：2009-08-13

申请号：PCT/US2009/032977

申请日：2009-02-03

Applicant: THERMO FINNIGAN LLC ,  QUARMBY, Scott, T. ,  GUCKENBERGER, George, B. ,  MCCAULEY, Edward, B.

Inventor： QUARMBY, Scott, T. ,  GUCKENBERGER, George, B. ,  MCCAULEY, Edward, B.

IPC: H01J49/00 ,  B01D59/44

CPC classification number: H01J27/20 ,  H01J49/147

Abstract: A method for operating a mass spectrometer includes determining a first performance characteristic while operating the mass spectrometer with a first electron emitter, storing first information relating to the first performance characteristic, determining a second performance characteristic while operating the mass spectrometer with a second electron emitter, storing second information relating to the second performance characteristic, and thereafter switching from operation using the first electron emitter to operation using the second electron emitter. The switching includes using the first and second information to normalize performance of the second electron emitter after the switching relative to performance of the first electron emitter before the switching.

Abstract translation: 用于操作质谱仪的方法包括：在用第一电子发射器操作质谱仪的同时确定第一性能特征，存储与第一性能特征相关的第一信息，在用第二电子发射器操作质谱仪时确定第二性能特征， 存储与第二性能特征相关的第二信息，然后从使用第一电子发射器的操作切换到使用第二电子发射器的操作。 切换包括在切换之前相对于第一电子发射器的性能，使用第一和第二信息来规范第二电子发射器的性能。

公开(公告)号：WO2008137481A2

公开(公告)日：2008-11-13

申请号：PCT/US2008/062102

申请日：2008-04-30

Applicant: THERMO FINNIGAN LLC ,  GUCKENBERGER, George, B. ,  QUARMBY, Scott, T.

Inventor： GUCKENBERGER, George, B. ,  QUARMBY, Scott, T.

IPC: H01J49/42

CPC classification number: H01J49/4265 ,  H01J49/0036 ,  Y10T436/24

Abstract: A method includes: accumulating ions having a plurality of m/z values in an ion trap during a time interval; deriving from the accumulated ions a respective intensity value for each of the m/z values; and adjusting each of the intensity values as a function of the time needed by the ion trap to begin collecting ions with the corresponding m/z value. According to a different aspect, an apparatus includes a first portion with an ion trap, and a second portion. The second portion causes the ion trap to accumulate ions with a plurality of m/z values during a time interval, derives from the accumulated ions in the ion trap a respective intensity value for each of the m/z values, and adjusts each of the intensity values as a function of the time needed by the ion trap to begin collecting ions with the corresponding m/z value.

Abstract translation: 一种方法包括：在时间间隔内将离子具有多个m / z值在离子阱中累积; 从累积离子中得出每个m / z值的相应强度值; 并且根据离子阱开始收集具有相应m / z值的离子所需的时间的函数调整每个强度值。 根据不同方面，一种装置包括具有离子阱的第一部分和第二部分。 第二部分使得离子阱在时间间隔期间以多个m / z值累积离子，从离子阱中的累积离子导出每个m / z值的相应强度值，并且调整每个 强度值作为离子阱开始收集具有相应m / z值的离子所需的时间的函数。