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    METHOD FOR PRODUCING FACTOR H FROM A PLASMA PRECIPITATION FRACTION
    13.
    发明申请
    METHOD FOR PRODUCING FACTOR H FROM A PLASMA PRECIPITATION FRACTION 审中-公开
    用于从等离子体沉积物分级产生因子H的方法

    公开(公告)号：WO2014144764A3

    公开(公告)日：2014-11-27

    申请号：PCT/US2014029313

    申请日：2014-03-14

    Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA ,  MADLENER RUTH ,  SCHWARZ HANS-PETER ,  SVATOS SONJA ,  TESCHNER WOLFGANG ,  PLJEVLJAKOVIC AZRA ,  NITSCH LENA

    Inventor： MADLENER RUTH ,  SCHWARZ HANS-PETER ,  SVATOS SONJA ,  TESCHNER WOLFGANG ,  PLJEVLJAKOVIC AZRA ,  NITSCH LENA

    IPC: A61K38/17 ,  A61P13/12 ,  A61P27/02 ,  A61P37/00

    CPC classification number: C07K14/47 ,  A61K35/16 ,  A61K38/1725

    Abstract: The present disclosure provides, among other aspects, improved methods for the manufacture of Factor H compositions from plasma precipitation fractions. In some aspects, the methods include an improved process step for extracting Factor H from a plasma precipitate fraction with reduced co-extraction of amidolytic activities. In other aspects, the methods include a heat treatment step for reducing impurities, such as amidolytic enzymes, from a Factor H composition. In yet other aspects, the methods include improved anion exchange, heparin affinity, and/or mixed mode chromatographic enrichment of Factor H. In still other aspects, the improved methods include a combination of the individual improved process steps disclosed herein.

    Abstract translation: 本公开尤其提供了用于从等离子体沉淀组分制备因子H组合物的改进方法。 在一些方面，所述方法包括改进的工艺步骤，用于通过降解的酰胺分解活性共萃取从血浆沉淀物级分中提取因子H. 在其它方面，所述方法包括从因子H组合物中还原诸如酰胺分解酶的杂质的热处理步骤。 在其它方面，所述方法包括改进因子H的阴离子交换，肝素亲和力和/或混合模式色谱富集。在其它方面，改进的方法包括本文公开的各个改进的方法步骤的组合。

    METHOD FOR PRODUCING FACTOR H FROM A PLASMA PRECIPITATION FRACTION
    14.
    发明申请
    METHOD FOR PRODUCING FACTOR H FROM A PLASMA PRECIPITATION FRACTION 审中-公开
    从等离子体沉淀分馏产生因子H的方法

    公开(公告)号：WO2014144764A2

    公开(公告)日：2014-09-18

    申请号：PCT/US2014/029313

    申请日：2014-03-14

    Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE SA ,  MADLENER, Ruth ,  SCHWARZ, Hans-Peter ,  SVATOS, Sonja ,  TESCHNER, Wolfgang ,  PLJEVLJAKOVIC, Azra ,  NITSCH, Lena

    Inventor： MADLENER, Ruth ,  SCHWARZ, Hans-Peter ,  SVATOS, Sonja ,  TESCHNER, Wolfgang ,  PLJEVLJAKOVIC, Azra ,  NITSCH, Lena

    IPC: A61K38/17

    CPC classification number: C07K14/47 ,  A61K35/16 ,  A61K38/1725

    Abstract: The present disclosure provides, among other aspects, improved methods for the manufacture of Factor H compositions from plasma precipitation fractions. In some aspects, the methods include an improved process step for extracting Factor H from a plasma precipitate fraction with reduced co-extraction of amidolytic activities. In other aspects, the methods include a heat treatment step for reducing impurities, such as amidolytic enzymes, from a Factor H composition. In yet other aspects, the methods include improved anion exchange, heparin affinity, and/or mixed mode chromatographic enrichment of Factor H. In still other aspects, the improved methods include a combination of the individual improved process steps disclosed herein.

    Abstract translation: 除其他方面外，本公开内容提供了用于从血浆沉淀级分制造因子H组合物的改进方法。 在一些方面，所述方法包括用于从血浆沉淀级分中提取因子H并降低酰胺分解活性的共同提取的改进工艺步骤。 在其他方面，该方法包括用于从因子H组合物中减少杂质例如酰胺分解酶的热处理步骤。 在其他方面，所述方法包括因子H的改进的阴离子交换，肝素亲和力和/或混合模式色谱富集。在其他方面，改进的方法包括本文公开的各个改进的工艺步骤的组合。

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