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公开(公告)号：WO2020024058A1
公开(公告)日：2020-02-06
申请号：PCT/CA2019/051055
申请日：2019-08-01
发明人： CARRIER-VALLIERES, Martin , CHATTERJEE, Avishek , LEVESQUE, Ives R. , REINHOLD, Caroline , SEUNTJENS, Jan
摘要： There is described herein methods and systems for generating universal models, normalizing patient features, combining normalized clinical datasets, and predicting patient outcomes from universal models. Clinical datasets may be combined from different institutions, and patient outcomes may be predicted from data collected from institutions not included in the original clinical datasets. One or more medical imaging datasets representing a patient anatomy are acquired. A set of features is extracted from each of medical imaging dataset and normalized to generate one or more normalized datasets. A universal model is then generated from the one or more normalized datasets.
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公开(公告)号：WO2019227202A1
公开(公告)日：2019-12-05
申请号：PCT/CA2019/050719
申请日：2019-05-27
发明人： CODERRE, Terence J. , FULAS, Oli Abate , LAFERRIÈRE, André , AYOUB, Ghada , FRICIC, Tomislav , GANDRATH, Dayaker , MOTTILLO, Cristina
IPC分类号： C07D473/04 , A61K31/192 , A61K31/385 , A61K31/4168 , A61K31/4245 , A61K31/522 , A61P25/04 , C07C59/52 , C07C65/03 , C07D233/50 , C07D271/04 , C07D339/04
摘要： Disclosed are pharmaceutical salts and co-crystals of pentoxifylline, clonidine and linsidomine with caffeic acid, protocatechuic acid or α-lipoic acid, and method for preparing thereof. Also disclosed are topical compositions comprising said salts or co-crystals and use thereof for treating pain.
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公开(公告)号：WO2019183717A1
公开(公告)日：2019-10-03
申请号：PCT/CA2019/050356
申请日：2019-03-22
发明人： LEFSRUD, Mark , REDDY, Srinivasa , SCHWALB, Michael , WU, Bo-Sen
摘要： There is described a method of growing a plant having at least one light absorbing pigment where the at least one light absorbing pigment absorbing optical energy at absorbing wavelengths. The method generally includes a step of illuminating the plant with at least one light beam. The at least one light beam having optical energy within at least two spectral regions each encompassing a given wavelength, the given wavelengths being away from the absorbing wavelengths of the at least one light absorbing pigment. The at least two spectral regions including at least both a first spectral region at about 430 nm and a second spectral region at about 595 nm.
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公开(公告)号：WO2019148282A1
公开(公告)日：2019-08-08
申请号：PCT/CA2019/050120
申请日：2019-01-31
发明人： HEKIMI, Siegfried , WANG, Ying
IPC分类号： C12N5/10 , A01K67/027 , A61K31/122 , A61K31/337 , A61K47/34 , A61K47/42 , A61K9/08 , A61K9/107 , A61P35/00 , A61P39/06 , C07C50/28 , C07D305/14 , C07K7/56 , C12N15/53 , C12N15/54 , C12Q1/02
摘要： The present disclosure concerns methods and formulations for delivery of hydrophobic agents (such as ubiquinone or poorly soluble drugs) for therapeutic and bioanalytical use. It further concerns use of lipopeptides (e.g. caspofungin) or surfactants to solubilize hydrophobic agents and thus increase their bioavailability. Also described are therapeutic methods for the treatment of conditions that benefit from such hydrophobic agents. The present disclosure further relates to methods of identifying drug candidates for treatment of ubiquinone deficiency.
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15.发明申请
公开(公告)号：WO2018218361A1
公开(公告)日：2018-12-06
申请号：PCT/CA2018/050644
申请日：2018-05-31
IPC分类号： G01T1/29 , G01T1/164 , G01R33/563
摘要： Methods and systems for establishing a kinetic model input function (IF) in positron emission tomography and single-photon emission computed tomography are provided. A position of interaction along a scintillating fiber coil is determined by: detecting a first plurality and second plurality of photons at first and second ends of the scintillating fiber coil; associating the first plurality of photons and the second plurality of photons with the interaction event based on a timing parameter; and determining a position of interaction for the interaction event based on a comparison between a first parameter of the first plurality of photons and a second parameter of the photons in the second plurality of photons.
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公开(公告)号：WO2018102931A1
公开(公告)日：2018-06-14
申请号：PCT/CA2017/051489
申请日：2017-12-08
发明人： SHAO, Yixin , MAHOUTIAN, Mehrdad
摘要： The present subject-matter relates to landscaping product comprising steel slag and optionally cement, compositions and processes for preparing same.
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公开(公告)号：WO2018083523A8
公开(公告)日：2018-05-11
申请号：PCT/IB2017/000555
申请日：2017-04-20
IPC分类号： B82B1/00 , B82Y15/00 , B82Y5/00 , G01N1/00 , G01N33/557
摘要： Provided herein are devices for manipulating and visualizing molecular interactions in customized nanoscale spaces.
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公开(公告)号：WO2018053648A1
公开(公告)日：2018-03-29
申请号：PCT/CA2017/051127
申请日：2017-09-25
摘要： There is described herein methods and systems for generating a treatment plan for delivery of a radiation dose to a subject based on a plurality of radiation modalities, each radiation modality having a delivery element and an associated weight associated thereto. The treatment plan is constructed iteratively by considering the different radiation modalities and different delivery elements and selecting those that meet one or more goals regarding a target dose distribution.
摘要翻译： 本文中描述了用于基于多个辐射模态来生成用于向对象传递辐射剂量的治疗计划的方法和系统，每个辐射模态具有递送元件和与其相关联的相关联的重量 。 通过考虑不同的辐射形式和不同的递送元素并选择满足关于目标剂量分布的一个或多个目标的治疗计划来迭代地构建治疗计划。
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公开(公告)号：WO2018035600A1
公开(公告)日：2018-03-01
申请号：PCT/CA2017/050771
申请日：2017-06-23
发明人： SAVADJIEV, Peter , SIDDIQI, Kaleem
摘要： The present disclosure provides methods and systems for determining heart fiber geometry from ultrasound images. Ultrasound images of a heart model are generated. Then, a probability of accuracy of the model ultrasound images is determined based at least in part on one or more ultrasound image of an actual heart. When the probability of accuracy is above a given threshold, the heart model is applied to the ultrasound images of the actual heart in order to determine heart fiber geometry for the actual heart.
摘要翻译： 本公开提供了用于根据超声图像确定心脏纤维几何形状的方法和系统。 生成心脏模型的超声图像。 然后，至少部分地基于实际心脏的一个或多个超声图像来确定模型超声图像的准确性的概率。 当准确性的概率高于给定阈值时，将心脏模型应用于实际心脏的超声图像，以确定实际心脏的心脏纤维几何形状。
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20.发明申请USE OF CRANBERRY DERIVED PHENOLIC COMPOUNDS AS ANTIBIOTIC SYNERGIZING AGENT AGAINST PATHOGENIC BACTERIA 审中-公开CRANBERRY派生的酚类化合物作为抗菌协同剂对致病菌的应用
公开(公告)号：WO2017096484A1
公开(公告)日：2017-06-15
申请号：PCT/CA2016/051447
申请日：2016-12-09
IPC分类号： A61K36/45 , A61K31/505 , A61K31/635 , A61K31/04 , C07D239/49 , C07D261/16
CPC分类号： A61K31/04 , A61K31/505 , A61K31/635 , A61K36/45 , Y02A50/473 , A61K2300/00
摘要： This present disclosure relates to the use of a cranberry extract rich in proanthocyanidins as antibiotic synergizing agent to mitigate multidrug resistance and biofilm formation in different pathogenic bacteria. The synergistic combination of antibiotic and cranberry extract could treat bacterial infections using a lower dose of antibiotics to prevent biofilm formation and proliferation of microorganisms, with defined modes of action.
摘要翻译： 本公开涉及富含原花色素的蔓越莓提取物作为抗生素增效剂用于减轻不同致病细菌中的多药物抗性和生物膜形成的用途。 抗生素和蔓越莓提取物的协同组合可以使用较低剂量的抗生素来治疗细菌感染，以防止微生物的生物膜形成和增殖，并具有确定的作用模式。
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