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1.发明申请
公开(公告)号：WO2022201104A1
公开(公告)日：2022-09-29
申请号：PCT/IB2022/052729
申请日：2022-03-24
发明人： SCHMEING, Thomas Martin , PELLETIER, Gerard , SHEN, Leo Liyuan , TREMPE, Jean-François , BAYNE, Andrew Norman , MCKEAGUE, Maureen
IPC分类号： C12Q1/686 , C12P19/34 , C12Q1/70 , C12Q1/6851
摘要： The invention provides reagents, methods and kits for improving nucleic acids amplification and detection. Described herein are compositions and ready-to-use reagent mixtures comprising, among other things, Polyinosinic acid (Poly(I)). Also described are kits and methods for increasing sensitivity of polymerase chain reaction (PCR) and/or for increasing sensitivity of reverse transcription polymerase chain reaction (RT-PCR).
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2.发明申请
公开(公告)号：WO2022193020A1
公开(公告)日：2022-09-22
申请号：PCT/CA2022/050403
申请日：2022-03-17
发明人： ZHAO, Songrui , ZHANG, Qihua
摘要： There is described a substrate for a semiconductor device. The substrate generally has a semiconductor wafer; an intermediate nanowire layer having a plurality of nanowires each having in succession a base portion mounted to the semiconductor wafer, an elongated body portion extending away from the semiconductor wafer, and a tip portion; and a buffer layer of aluminum nitride being made integral to the tip portions of the plurality of nanowires.
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公开(公告)号：WO2022170419A1
公开(公告)日：2022-08-18
申请号：PCT/CA2022/050160
申请日：2022-02-04
摘要： The present disclosure relates to improvements in the field of water treatment, and more particularly to the separation step in a water treatment process. There is provided a method of separating contaminants from contaminated water. A fibrous treatment agent is provided into the contaminated water. The fibrous treatment agent has a length of about 100 pm and a diameter of at least 5 pm. The fibrous treatment agent is allowed to associate with the contaminants forming floes comprising a size of at least 1000 pm. The floes are physically separated from the contaminated water.
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公开(公告)号：WO2022011466A1
公开(公告)日：2022-01-20
申请号：PCT/CA2021/050968
申请日：2021-07-14
发明人： A. HOESLI, Corinne , BASHTH, Omar Salem Ahmed , ELKHODIRY ABOELEELA MOHAMED, Mohamed Aly , LAROCHE, Gaétan
IPC分类号： C07K17/00 , A61L27/54 , C12N11/00 , C12N5/071 , C12N5/09 , G01N1/40 , G01N33/543 , C07K16/00 , C07K16/18 , C07K16/28
摘要： There is provided a surface functionalized with cross linking groups adapted to receive antibodies and/or fragments thereof. The surface has an antibody binding biomolecule having a linker region which is covalently crosslinked to functional groups and an antibody binding region. The surface also has a cell interacting biomolecule having a linker region which is covalently crosslinked to functional groups of the surface and a cell interacting region that imparts functional attributes including cell adhesion, spreading, proliferation, differentiation and/or a functional response. The two biomolecules are present in independently controlled concentrations and have similar small molecular weights.
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5.发明申请
公开(公告)号：WO2021163802A1
公开(公告)日：2021-08-26
申请号：PCT/CA2021/050183
申请日：2021-02-19
申请人： THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY , CENTRE HOSPITALIER DE L'UNIVERSITÉ DE MONTRÉAL , UNIVERSITÉ LAVAL
IPC分类号： A61K31/37 , A61K36/61 , A61K9/48 , A61P35/00 , A61P37/02 , C07D493/22 , A61K39/395
摘要： Methods and uses for enhancing or restoring the antitumor response, such as the antitumor immune mediated by immune checkpoint inhibitors, in cancer patients, are described. These methods are based on the administration of castalagin or analogs thereof, and are particularly useful for the treatment of tumors resistant to immunotherapy such as immune checkpoint inhibitor therapy. The castalagin or analog thereof may be administered in any suitable form, for example in a crude plant or fruit extract such as a Myrciaria dubia extract, or in a pharmaceutical composition.
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公开(公告)号：WO2021158792A1
公开(公告)日：2021-08-12
申请号：PCT/US2021/016618
申请日：2021-02-04
申请人： AGIOS PHARMACEUTICALS, INC. , THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY
发明人： HAYES, Sebastian , CHUBUKOV, Victor , RODDY, Thomas, P. , KINGSBURY, Gillian , JONES, Russell, Graham
IPC分类号： A61K31/4178 , C07D233/88 , A61P35/00
摘要： The disclosure is directed to methods of treating autoimmune and inflammatory diseases or disorders using inhibitors of the MAT2A enzyme.
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公开(公告)号：WO2021022371A1
公开(公告)日：2021-02-11
申请号：PCT/CA2020/051067
申请日：2020-08-05
申请人： THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY , CENTRE HOSPITALIER DE L'UNIVERSITÉ DE MONTRÉAL , NEXPLASMAGEN INC.
IPC分类号： H05H1/24
摘要： A plasma source comprising a first hollow electrode and a second hollow electrode separated by a gap and a dielectric barrier of a constant width; wherein the plasma source is configured to selectively produce a plasma in either one of a first configuration and a second configuration; wherein, i) in the first configuration, a plasma-forming gas flows in the gap while a non plasma-forming gas flows within the first hollow electrode; and ii) in the second configuration, a plasma-forming gas flows within the first hollow electrode and a non plasma-forming gas flows within the gap. The method comprises selecting at least two gases of different breakdown voltages, injecting a first gas in a first electrode separated from a second hollow electrode by a gas gap of a constant width, injecting a second gas in the gas gap under an applied power.
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公开(公告)号：WO2020237361A1
公开(公告)日：2020-12-03
申请号：PCT/CA2020/050706
申请日：2020-05-25
发明人： DEMOPOULOS, George
摘要： This invention relates to safe immobilization and disposal of arsenic found in industrial waste streams and residues in the form of clean and compact well grown scorodite solids.
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公开(公告)号：WO2020146952A1
公开(公告)日：2020-07-23
申请号：PCT/CA2020/050051
申请日：2020-01-17
摘要： A system and method for stereo vision measurement are provided. A three- dimensional visual stimulus is generated. The visual stimulus is composed of a plurality of spatially filtered dot elements configured to isolate stereo function. The visual stimulus is then presented to a user via a display device and input data is received in response to the user viewing the visual stimulus as presented. A stereo performance of the user is then determined from the input data.
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公开(公告)号：WO2020061357A1
公开(公告)日：2020-03-26
申请号：PCT/US2019/051996
申请日：2019-09-19
申请人： THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY , AVIEX TECHNOLOGIES LLC
发明人： WARD, Brian , WINTER, Kaitlin
IPC分类号： A61K39/112 , C12N1/21 , A61P31/04 , C12N15/863
摘要： An attenuated Salmonella enterica serovar Typhimurium strain (YS1646) is repurposed to produce a vaccine. Plasmid-based candidates expressing either the TcdA or TcdB RBD were screened. Different vaccine routes and schedules were tested to achieve detectable serum and mucosal antibody titers in C57BL/6J mice. When given in a multi-modality schedule over 1 week (day 0 IM+PO, days 2 and 4 PO), several candidates provided 100% protection against lethal challenge. Substantial protection (82%) was achieved with combined PO TcdA/TcdB vaccination alone (d0, 2 and 4). These data demonstrate the potential of the YS1646-based vaccines for C. difficile .
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