公开(公告)号：WO2010145017A1

公开(公告)日：2010-12-23

申请号：PCT/CA2010/000917

申请日：2010-06-15

Applicant: UNIVERSITE LAVAL ,  CORMIER, Yvon ,  GIRARD, Mélissa ,  ISRAËL-ASSAYAG, Evelyne

Inventor： CORMIER, Yvon ,  GIRARD, Mélissa ,  ISRAËL-ASSAYAG, Evelyne

IPC: A61K39/02 ,  A61K9/72 ,  A61P11/00 ,  A61P31/12 ,  A61P37/04

CPC classification number: C12N1/06 ,  A61K9/0043 ,  A61K39/39 ,  A61K2039/55594

Abstract: There is provided a method of attenuating a respiratory infection in a subject, use of a composition for the manufacture of a medicament and a composition for treating respiratory infections comprising a preparation of Saccharopolyspora rectivirgula (SR), a non pathogenic thermophilic actinomycetes , which can stimulate the innate pulmonary immune response. This invention thus presents a novel preventive measure for acute viral or bacterial lung infections.

Abstract translation: 提供了减轻受试者呼吸道感染的方法，用于制备药物的组合物的用途和用于治疗呼吸道感染的组合物，其包括可致癌的非致病嗜热放线菌（Saccharopolyspora rectivirgula） 先天性肺部免疫反应。 因此，本发明提出了一种用于急性病毒或细菌肺感染的新型预防措施。

公开(公告)号：WO2009143614A1

公开(公告)日：2009-12-03

申请号：PCT/CA2009/000724

申请日：2009-05-26

Applicant: UNIVERSITE LAVAL ,  QUELLETTE, Marc ,  FENG, Jie

Inventor： QUELLETTE, Marc ,  FENG, Jie

IPC: C12N9/10 ,  C07K14/31 ,  C07K14/315 ,  C12N1/21 ,  C12N15/31 ,  C12N15/54 ,  C12Q1/68 ,  G01N33/53

CPC classification number: C07K14/31 ,  C07K14/3156 ,  C12Q1/6883 ,  C12Q1/689 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158

Abstract: Linezolid is a member of a novel class of antibiotics, with resistance already being reported. We used whole-genome sequencing on three independent Streptococcus pneumoniae strains made resistant to linezolid in vitro in a step-by-step fashion. Analysis of the genome assemblies revealed mutations in the 23S rRNA gene in all mutants including, notably, G2576T, a previously recognized resistance mutation. Mutations in an additional 31 genes were also found in at least one of the three sequenced genomes. We concentrated our efforts on three new mutations that were found in at least two independent mutants. All three mutations were experimentally confirmed to be involved in antibiotic resistance. Mutations upstream of the ABC transporter genes SP_1114 and SP_2075 were correlated with increased expression of these genes and neighboring genes of the same operon. The hypothetical protein SP_0373 contains an RNA methyltransferase domain, and mutations within that domain were found in all S. pneumoniae linezolid-resistant strains. Interestingly, the SP_0373 ortholog was also mutated in a linezolid-resistant clinical Staphylococcus aureus isolate.

Abstract translation: 利奈唑德是一类新型抗生素的成员，其抗药性已被报道。 我们使用全基因组测序在三个独立的肺炎链球菌菌株上，以一系列的方式在体外对利奈唑胺耐药。 基因组装置的分析显示所有突变体中23S rRNA基因的突变，特别是G2576T，一种以前识别的抗性突变。 另外31个基因的突变也在三个测序基因组中的至少一个中发现。 我们集中力量在至少两个独立突变体中发现的三个新突变。 所有三个突变都被实验证实参与抗生素耐药。 ABC转运基因SP_1114和SP_2075上游的突变与这些基因和相同操纵子的相邻基因的表达增加相关。 假想蛋白SP_0373含有RNA甲基转移酶结构域，并且在所有肺炎链球菌耐药菌株中都发现了该结构域内的突变。 有趣的是，SP0373直向同源物也在耐利奈唑胺耐药临床金黄色葡萄球菌分离株中突变。

公开(公告)号：WO2009039653A1

公开(公告)日：2009-04-02

申请号：PCT/CA2008/001710

申请日：2008-10-22

Applicant: UNIVERSITE LAVAL ,  BAZINET, Laurent ,  LIN TENG SHEE, Fabrice

Inventor： BAZINET, Laurent ,  LIN TENG SHEE, Fabrice

IPC: C07H3/06 ,  B01D61/42 ,  B01D61/52 ,  C08B37/08 ,  C12P19/00 ,  C25B9/00

CPC classification number: C07H3/06 ,  B01D61/445 ,  C08B37/003 ,  C12P19/14

Abstract: In accordance with the present invention, there is provided a new method for producing oligosaccharides using bipolar membrane electrodialysis (BMED) in an electrodialysis cell. The method allow for the simultaneous transformation of polysaccharides into oligosaccharides and the demineralization of the resulting oligosaccharides.

Abstract translation: 根据本发明，提供了一种在电渗析池中使用双极膜电渗析（BMED）制备寡糖的新方法。 该方法允许将多糖同时转化成寡糖和所得寡糖的脱矿质。

公开(公告)号：WO2008116309A1

公开(公告)日：2008-10-02

申请号：PCT/CA2008/000571

申请日：2008-03-26

Applicant: UNIVERSITE LAVAL ,  FATHALLAH, Habib ,  RUSCH, Leslie, Ann

Inventor： FATHALLAH, Habib ,  RUSCH, Leslie, Ann

IPC: H04B10/08

CPC classification number: H04B10/071

Abstract: A method and system for testing an optical network for defects in multiple light paths are presented. A pulsed monitoring light signal is transmitted in the network, and reflected by encoders in each light path. The encoders encode the light signal according to encoding functions having a low cross-correlation to each other. The return light signal from all light paths is decoded, either optically or electronically, according to decoding functions correlated to each of the encoding functions, and analysed to determine if a defect is present in any given light path. According to some embodiments, the location of the defect along the light path may also be determined.

Abstract translation: 提出了一种用于测试光网络中用于多个光路中的缺陷的方法和系统。 脉冲监测光信号在网络中传输，并由每个光路中的编码器反射。 编码器根据彼此具有低互相关的编码功能对光信号进行编码。 根据与每个编码功能相关的解码功能，来自所有光路的返回光信号被光学地或电子地解码，并且被分析以确定在任何给定光路中是否存在缺陷。 根据一些实施例，还可以确定缺陷沿着光路的位置。

公开(公告)号：WO2008043185A1

公开(公告)日：2008-04-17

申请号：PCT/CA2007/001852

申请日：2007-10-12

Applicant: UNIVERSITE LAVAL ,  DRUMMELSMITH, Jolyne ,  OUELLETTE, Marc

Inventor： DRUMMELSMITH, Jolyne ,  OUELLETTE, Marc

IPC: C12Q1/68 ,  C12Q1/04 ,  G01N33/569 ,  C12N15/31 ,  C07K14/31

CPC classification number: G01N33/56938 ,  C07K14/31 ,  C12Q1/6851 ,  C12Q1/689 ,  G01N2469/10

Abstract: The present invention relates to a method for identifying a VISA strain in a sample comprising measuring SAV2095 expression levels, a kit and use of SAV2095 for same. The present invention also relates to a method for facilitating the development of an individualized treatment regimen comprising measuring the expression level of SAV2095. The present invention further relates to a method for monitoring the progression of a vancomycin treatment of an infection comprising measuring the expression level of SAV2095. The present invention also relates to the detection of Staphylococcus aureus in a sample.

Abstract translation: 本发明涉及用于鉴定样品中VISA菌株的方法，包括测量SAV2095表达水平，试剂盒和SAV2095的用途。 本发明还涉及促进个体化治疗方案发展的方法，其包括测量SAV2095的表达水平。 本发明还涉及用于监测万古霉素治疗感染进展的方法，包括测量SAV2095的表达水平。 本发明还涉及样品中金黄色葡萄球菌的检测。

公开(公告)号：WO2006026850A1

公开(公告)日：2006-03-16

申请号：PCT/CA2005/001337

申请日：2005-09-01

Applicant: UNIVERSITE LAVAL ,  GUERTIN, Pierre

Inventor： GUERTIN, Pierre

IPC: A61K31/506

CPC classification number: A61K31/135 ,  A61K31/15 ,  A61K31/198 ,  A61K31/473 ,  A61K31/506 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention relates to the field of neuropathological disorders involving impaired locomotor functions. More specifically, the present invention relates to a composition and method for inducing and restoring locomotor functions, such as basic walking movements in the lower extremities of chronic spinal cord injured animals, such as paraplegic or tetraplegic individuals.

Abstract translation: 本发明涉及涉及运动功能受损的神经病理学障碍的领域。 更具体地，本发明涉及诱导和恢复运动功能的组合物和方法，例如慢性脊髓损伤动物的下肢的基本步行运动，例如截瘫或四肢个体。

公开(公告)号：WO2004012359A2

公开(公告)日：2004-02-05

申请号：PCT/CA2003/001127

申请日：2003-07-30

Applicant: UNIVERSITE LAVAL

Inventor： ROY, Sébastien, Joseph, Armand

IPC: H04B7/00

CPC classification number: H04B7/0874 ,  H04B7/0854

Abstract: An array antenna system comprising an array of antenna elements (22/1,...,22/10) and a receiver (12 0 ,..., 12 7 ) which uses a subset of the signals from the antenna elements, the selection of the subset of signals which should be used for a particular user being made on the basis of measurements of potential performance of the receiver with each subset of signals, combined, rather than of each individual signal.

Abstract translation: 一种阵列天线系统，包括天线元件阵列（22/1，...，22/10）和使用来自天线元件的信号子集的接收器（120，...，127），选择 基于接收机的潜在性能的测量而对特定用户应该使用的信号子集，每个子​​信号的组合而不是每个单独的信号。

公开(公告)号：WO2003043769A3

公开(公告)日：2003-05-30

申请号：PCT/CA2002/001787

申请日：2002-11-19

Applicant: UNIVERSITE LAVAL ,  CURODEAU, Alain ,  GUIDOIN, Marie-France

Inventor： CURODEAU, Alain ,  GUIDOIN, Marie-France

IPC: B23H1/06

Abstract: A method for electric discharge machining (EDM) with a ductile carbonaceous electrode, to automate roughing, finishing, polishing and texturing operations on a electrically conductive material. The EDM method comprises using a ductile electrically conductive electrode made of carbon-polymer composite material. Prior to electric discharge machining, the electrode is made by heating uniformly a prescribed volume of said ductile electrode material, at a temperature close to the melting point temperature of the polymer matrix. The composite material is then molded into the desired electrode shape by pressing the soft material against a template, a mold model, a replicate of the workpiece or part of the workpiece. The formed electrode is then used to machine the desired shape and surface finish on the said workpiece using proper electric discharge machining techniques. When the dimensions and surface of the electrode are altered by wear, the same electrode can be rectified quickly and repetitively, by following the initial procedure of softening and pressing until the workpiece is complete.

公开(公告)号：WO2002081697A1

公开(公告)日：2002-10-17

申请号：PCT/CA2002/000503

申请日：2002-04-05

Applicant: UNIVERSITE LAVAL ,  MOINEAU, Sylvain ,  BOUCHARD, Julie ,  DION, Éric

Inventor： MOINEAU, Sylvain ,  BOUCHARD, Julie ,  DION, Éric

IPC: C12N15/31

CPC classification number: C07K14/315 ,  C12N15/746

Abstract: The present invention relates to a 2227-bp DNA fragment that confers antiphage activity. Two proteins encoded by this DNA sequence are responsible for the phage resistance phenotype. When introduced in Lactococcus lactis phage-sensitive strain, this DNA fragment aborts infection of phages of the 936 and P335 species.

Abstract translation: 本发明涉及赋予抗噬菌素活性的2227bp的DNA片段。 由该DNA序列编码的两种蛋白质负责噬菌体抗性表型。 当引入乳酸乳球菌噬菌体敏感菌株时，该DNA片段中止936和P335物种的噬菌体感染。

公开(公告)号：WO1997027321A1

公开(公告)日：1997-07-31

申请号：PCT/CA1997000047

申请日：1997-01-23

Applicant: UNIVERSITE LAVAL

Inventor： UNIVERSITE LAVAL ,  ROUSSEAU, François

IPC: C12Q01/68

CPC classification number: C12Q1/6883 ,  C12Q2600/156

Abstract: The present invention relates to a method of determining predisposition to low or high bone mineral density and to development of osteoporosis of a patient, which comprises determining estrogen receptor polymorphism in linkage disequilibrium in a biological sample of said patient, wherein heterozygosity is associated with high bone density and homozygosity is associated with low bone density.

Abstract translation: 本发明涉及一种确定低或高骨矿物质密度倾向和患者骨质疏松症发展的方法，其包括确定所述患者生物样品中连锁不平衡中的雌激素受体多态性，其中杂合性与高骨相关 密度和纯合性与低骨密度相关。