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    MECHANICAL FINGER FOR GRIPPER
    2.
    发明申请
    MECHANICAL FINGER FOR GRIPPER 审中-公开

    公开(公告)号：WO2021146811A1

    公开(公告)日：2021-07-29

    申请号：PCT/CA2021/050067

    申请日：2021-01-22

    Applicant: UNIVERSITE LAVAL

    Inventor： BABIN, Vincent ,  GOSSELIN, Clément ,  LALIBERTE, Thierry

    IPC: B25J15/08

    Abstract: A mechanical finger has a base. A proximal phalanx and a distal phalanx is provided with a first epicyclic joint between the base and proximal phalanx, and a second epicyclic joint between the proximal phalanx and the distal phalanx. A distal four-bar mechanism includes the proximal phalanx, the distal four-bar mechanism coupled to the distal phalanx. A nail is optionally provided and has a joint mechanism movably connecting the nail to the distal most one of the phalanges between a stowed position in which a grasping tip of the nail is concealed in the distal most one of the phalanges, and a deployed configuration in which the grasping tip projects out of the distal most one of the phalanges.

    ORGANOSOLV PROCESS FOR THE EXTRACTION OF HIGHLY PURE LIGNIN AND PRODUCTS COMPRISING THE SAME
    4.
    发明申请
    ORGANOSOLV PROCESS FOR THE EXTRACTION OF HIGHLY PURE LIGNIN AND PRODUCTS COMPRISING THE SAME 审中-公开
    用于提取高纯度木质素和包含其的产品的有机溶剂方法

    公开(公告)号：WO2016197233A1

    公开(公告)日：2016-12-15

    申请号：PCT/CA2016/000169

    申请日：2016-06-09

    Applicant: UNIVERSITE LAVAL

    Inventor： STEVANOVIC, Tatjana ,  KOUMBA YOYA, Georges

    IPC: C08H7/00 ,  C08H8/00 ,  D21C1/00

    CPC classification number: C08H8/00 ,  C08L97/005 ,  D21C1/04 ,  D21C3/04 ,  D21C3/20 ,  D21C11/0007

    Abstract: A highly pure lignin comprising a lignin content of at least 97% and characterized by a low carbohydrate content and substantially no sulfur content is disclosed herein. An organosolv process for extracting the highly pure lignin is also disclosed herein. The process comprises pretreating a lignocellulosic material in a first polar protic solvent, to remove extractive compounds and to provide a pretreated lignocellulosic material; and treating the pretreated lignocellulosic material with a Lewis acid in a second polar protic solvent.

    Abstract translation: 本文公开了包含至少97％的木质素含量并且特征在于低碳水化合物含量且基本上不含硫含量的高纯度木质素。 本文还公开了用于提取高纯度木质素的有机溶剂法。 该方法包括在第一极性质子溶剂中预处理木质纤维素材料，以除去萃取化合物并提供预处理的木质纤维素材料; 并用路易斯酸在第二极性质子溶剂中处理预处理的木质纤维素材料。

    MODIFYING PROTEIN PRODUCTION IN PLANTS
    5.
    发明申请
    MODIFYING PROTEIN PRODUCTION IN PLANTS 审中-公开
    修改植物中的蛋白质生产

    公开(公告)号：WO2016004536A1

    公开(公告)日：2016-01-14

    申请号：PCT/CA2015/050644

    申请日：2015-07-10

    Applicant: MEDICAGO INC. ,  UNIVERSITE LAVAL

    Inventor： MICHAUD, Dominique ,  PEPIN, Steeve ,  ETHIER, Gilbert ,  GOULET, Marie-Claire ,  GAUDREAU, Linda ,  GAGNE, Marielle ,  MARTEL, Michele ,  BECHTOLD, Nicole ,  D'AOUST, Marc-Andre ,  GOSSELIN, Andre

    IPC: C12N15/00 ,  A01H3/00 ,  A01H5/00 ,  C12N15/82 ,  C12P21/00

    CPC classification number: C12N15/8251 ,  A01H3/00 ,  A01H3/02 ,  A01H3/04 ,  C12N15/8258

    Abstract: A method for synthesizing a protein of interest within a plant or a portion of a plant is provided. The method involves treating the plant to increase secondary leaf biomass production, followed by introducing one or more than one nucleic acid sequence encoding a protein of interest operatively linked with a regulatory region that is active in the plant, into the plant. The plant is then maintained under conditions that permit the nucleic acid sequence encoding the protein of interest to be expressed in the plant or the portion of the plant. Optionally, the plant or portion of the plant may be harvested and the protein of interest extracted.

    Abstract translation: 提供了在植物或植物的一部分内合成感兴趣的蛋白质的方法。 该方法包括处理植物以增加次生叶生物量的产生，随后将编码目的蛋白质的一种或多于一种的核酸序列与在植物中具有活性的调节区域可操作地连接到植物中。 然后将植物保持在允许编码目的蛋白质的核酸序列在植物或植物部分中表达的条件下。 任选地，可以收获植物或植物的一部分，并提取目的蛋白质。

    OPTOGENETIC PROBE
    6.
    发明申请
    OPTOGENETIC PROBE 审中-公开

    公开(公告)号：WO2013188973A1

    公开(公告)日：2013-12-27

    申请号：PCT/CA2013/050467

    申请日：2013-06-18

    Applicant: UNIVERSITE LAVAL

    Inventor： VIENS, Jean-François ,  GRAVEL, Jean-François ,  MESSADDEQ, Younès ,  LEDEMI, Yannick ,  RIOUX, Maxime

    IPC: A61B5/04 ,  A61B5/00 ,  B82Y30/00

    CPC classification number: A61B1/0017 ,  A61B1/00114 ,  A61B1/015 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0476 ,  A61B5/6847 ,  B82Y30/00 ,  C03B37/01211 ,  C03B37/026 ,  C03B37/02763 ,  C03B37/02781 ,  C03B2203/16 ,  C03B2203/34 ,  G02B6/4274 ,  G02B6/43

    Abstract: An optogenetic probe, an optogenetic system, and a method for fabricating an optogenetic probe are provided. The optogenetic probe has a proximal and a distal end, and includes an elongated body made of a body glass material and extending longitudinally between the proximal and distal ends. The optogenetic probe also includes at least one optical channel, each including an optical channel glass material having a refractive index larger than a refractive index of the body glass material, so as to guide light therealong. The optogenetic probes also includes at least one electrical channel, each including an electrical channel structure having an electrical conductivity larger than the electrical conductivity of the body glass material, so as to conduct electricity therealong. The optogenetic probe further includes at least one fluidic channel, each adapted for transporting fluid therealong. Each optical, electrical and fluidic channel extends longitudinally within the elongated body.

    Abstract translation: 提供了一种光发射探针，一种光遗传系统和一种制造光发射探针的方法。 光发射探针具有近端和远端，并且包括由主体玻璃材料制成并在近端和远端之间纵向延伸的细长主体。 光发射探针还包括至少一个光学通道，每个光学通道包括具有大于体玻璃材料的折射率的折射率的光学通道玻璃材料，以便沿着其引导光。 光发射探针还包括至少一个电通道，每个电通道包括电导率大于体玻璃材料的电导率的电通道结构，从而沿其导电。 光发射探针还包括至少一个流体通道，每个流体通道适于在其上输送流体。 每个光学，电气和流体通道在细长体内纵向延伸。

    PROGNOSTIC MARKERS OF INHERITED VARIATIONS IN THE UGT2B GENES FOR PROSTATE CANCER RECURRENCE
    7.
    发明申请
    PROGNOSTIC MARKERS OF INHERITED VARIATIONS IN THE UGT2B GENES FOR PROSTATE CANCER RECURRENCE 审中-公开
    UGT2B基因中前列腺癌复发的入选标记

    公开(公告)号：WO2012071665A1

    公开(公告)日：2012-06-07

    申请号：PCT/CA2011/001338

    申请日：2011-12-02

    Applicant: UNIVERSITE LAVAL ,  LEVESQUE, Eric ,  GUILLEMETTE, Chantal ,  FRADET, Yves ,  LACOMBE, Louis

    Inventor： LEVESQUE, Eric ,  GUILLEMETTE, Chantal ,  FRADET, Yves ,  LACOMBE, Louis

    IPC: C12Q1/68 ,  C07H21/00 ,  C40B30/04

    CPC classification number: C12Q1/6886 ,  C12Q2600/156

    Abstract: The present application discloses that reduced copy number variations (CNVs) in UGT2B17 and UGT2B28 were significantly associated with bRFS while no significant association was observed for additional UGT variants tested. The co-occurrence of two or more deletions of UGT2B17 and UGT2B28 genes resulted in an HR of 1.377 (95% CI [1.105; 1.716]; p=0.004) for Caucasians and 2.151 (95% CI [1.239; 3.372]; p=0.006) for Asians. In all studied men, risk of BCR was 1.510; 95% CI [1.178 - 1.950]; p=0.001 ). The addition of the UGT2B CNV status in the D'Amico risk classification further enhanced the risk prediction mainly for the low and intermediate risk categories (Log-rank test, p=0.022 and 0.011, respectively). In addition, after adjusting for all clinicopathologic risk factors, we found a strong association between the risk of BCR and 7 SNPs in SRD5A genes. The combination of 2 SNPs respectively in SRD5A1 and SRD5A2 were highly favourable, reducing drastically the risk of BCR for carriers of 3-4 alleles (HR=0.34; 95% CN0.18- 0.64; P=9x10"4). Other variations in the SRD5A2 gene were associated with an increased rate of BCR, namely the coding SNPs rs523349 with a HR of 2.12 (95% CI, 1.21 -3.75; P=0.009) and reaching 4.97 when combined with deleted copies of UGT2B genes (95% CI, 2.38-10.36; P=0.00002). Further, BCR-free survival rate was significantly reduced to 27% in patients with unfavourable genotypes compared to 75% for patients with favourable genotypes (P=7x10 -6 ). This study is the first to recognize CNV in genes at the end of the androgenic signal as significant and independent predictors of PCa recurrence after prostatectomy. In addition, inherited polymorphisms in the SRD5A and UGT2B genes are independent predictors of biochemical recurrence after radical prostatectomy.

    Abstract translation: 本申请公开了UGT2B17和UGT2B28中的减少的拷贝数变异（CNV）与bRFS显着相关，而对于另外的测试的UGT变体，没有观察到显着的关联。 UGT2B17和UGT2B28基因的两个或多个缺失的共同发生导致白种人的HR为1.377（95％CI [1.105; 1.716]; p = 0.004），而2.151（95％CI [1.239; 3.372]; p = 0.006）亚洲人。 在所有研究的男性中，BCR的风险为1.510; 95％CI [1.178 - 1.950]; p = 0.001）。 在D'Amico风险分类中增加UGT2B CNV状态进一步增强了风险预测，主要针对中低风险类别（Log-rank检验，分别为p = 0.022和0.011）。 此外，在调整所有临床病理危险因素后，我们发现BCR和SRD5A基因中7个SNP的风险之间存在很强的相关性。 SRD5A1和SRD5A2中2个SNP的组合非常有利，大大降低了3-4个等位基因携带者的BCR风险（HR = 0.34; 95％CN0.18-0.64; P = 9×10-4），其他变异 SRD5A2基因与BCR的增加率相关，即编码SNPs rs523349，HR为2.12（95％CI，1.21〜3.75; P = 0.009），与UGT2B基因缺失拷贝（95％CI）组合时达到4.97 ，2.38-10.36; P = 0.00002），而不良基因型患者BCR无生存率显着降低至27％，而有良好基因型患者为75％（P = 7×10-6），本研究首次 在雄激素信号结束时将基因中的CNV识别为前列腺切除术后PCa复发的重要和独立预测因子，此外，SRD5A和UGT2B基因的遗传多态性是根治性前列腺切除术后生化复发的独立预测因子。

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