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    METHODS AND COMPOSITIONS FOR INCREASED PRIMING OF T-CELLS THROUGH CROSS-PRESENTATION OF EXOGENOUS ANTIGENS
    16.
    发明申请
    METHODS AND COMPOSITIONS FOR INCREASED PRIMING OF T-CELLS THROUGH CROSS-PRESENTATION OF EXOGENOUS ANTIGENS 审中-公开
    通过异源抗原交叉表达增加T细胞增殖的方法和组合物

    公开(公告)号：WO2008019366A2

    公开(公告)日：2008-02-14

    申请号：PCT/US2007075359

    申请日：2007-08-07

    申请人： LUDWIG INST CANCER RES ,  MASSACHUSETTS INST TECHNOLOGY ,  HOWLAND SHANSHAN WU ,  OLD LLOYD J ,  WITTRUP K DANE

    发明人： HOWLAND SHANSHAN WU ,  OLD LLOYD J ,  WITTRUP K DANE

    IPC分类号： A61K39/385

    CPC分类号： A61K39/385 ,  A61K39/0011 ,  A61K2039/523 ,  A61K2039/55555 ,  A61K2039/55577 ,  A61K2039/60 ,  A61K2039/6006 ,  A61K2039/6018 ,  A61K2039/6093 ,  A61K2039/627

    摘要： Methods for eliciting in an animal in need thereof a cell-mediated immune response specific to an antigen, the method comprising providing an antigen preparation comprising particles on the surface of which the antigen is attached, and administering the antigen preparation to the animal, wherein the particles are taken up by antigen presenting cells (APC) of the animal via phagocytosis, forming a phagosome inside the APC, wherein the antigen is attached to the surface of the particle in such a way that the antigen is released in the phagosome before the phagosome fuses with a late endosome or a lysosome, and wherein the antigen is cross-presented on a Class I MHC molecule. Also provided are particulate antigen preparations or particulate vaccines that can be delivered to an animal in need thereof for vaccination against, for preventing or treating, a disease related to the antigen, such as cancer and a viral infection.

    摘要翻译： 在有需要的动物中引发对抗原特异性的细胞介导的免疫应答的方法，所述方法包括提供包含其表面上附着有抗原的颗粒的抗原制剂，以及向动物施用抗原制剂，其中 颗粒被动物的抗原呈递细胞（APC）吸收，在APC内部形成噬菌体，其中抗原以这样的方式附着到颗粒表面，使得抗原在噬菌体之前被释放在吞噬体中 具有晚期内体或溶酶体的融合物，并且其中所述抗原交叉呈递在I类MHC分子上。 还提供了可以递送到有需要的动物的微粒抗原制剂或颗粒疫苗，用于预防或治疗与抗原相关的疾病如癌症和病毒感染。

    BIOACTIVE MOLECULAR MATRIX AND METHODS OF USE IN THE TREATMENT OF DISEASE
    17.
    发明申请
    BIOACTIVE MOLECULAR MATRIX AND METHODS OF USE IN THE TREATMENT OF DISEASE 审中-公开
    生物活性分子基质及其在治疗疾病中的应用

    公开(公告)号：WO2008019018A2

    公开(公告)日：2008-02-14

    申请号：PCT/US2007/017143

    申请日：2007-08-01

    申请人： SOO HOO, William

    发明人： SOO HOO, William

    IPC分类号： A61K38/19

    CPC分类号： A61K38/193 ,  A61K38/164 ,  A61K38/191 ,  A61K38/2013 ,  A61K38/208 ,  A61K38/212 ,  A61K38/217 ,  A61K39/0011 ,  A61K39/39 ,  A61K2039/5152 ,  A61K2039/55522 ,  A61K2039/55533 ,  A61K2039/55544 ,  A61K2039/55561 ,  A61K2039/55572 ,  A61K2039/60 ,  A61K2039/6093 ,  C07K16/243

    摘要： The present invention provides methods and compositions for stimulating an immune response or modulating cell signal transduction in a host by administering to said host a composition comprising at least three biomodulatory molecules connected by at least one cross-linking agent forming a chain or matrix wherein the chain or matrix functions as an immuno-stimulatory adjuvant to activate an immune accessory cell. The composition may comprise one or more types of biomodulatory molecules selected from the group consisting of cytokines, bacterial molecules, receptor ligands, antigen binding fragments of antibodies, heat shock proteins, and integrins. The composition may further comprise one or more disease- specific antigens to stimulate an immune response. The disease-specific antigens may be selected from the group consisting of tumor-associated antigens, infectious disease-associated antigens, autoimmune-associated antigens, parasitic antigens, bacterial antigens, and viral antigens. In addition the composition may further comprise a solid support to which the cross-linked biomodulatory molecules are affixed. The solid support may be selected from the group consisting of Dextran, chitosan, alginate, poly-DL lactide polyglycolide, polyglycolide, or alum.

    摘要翻译： 本发明提供了用于通过向所述宿主施用包含至少三种生物调节分子的组合物来刺激宿主中的免疫应答或调节细胞信号转导的方法和组合物，所述生物调节分子通过至少一种交联剂 形成链或基质，其中链或基质充当免疫刺激佐剂以活化免疫辅助细胞。 组合物可以包含一种或多种类型的选自细胞因子，细菌分子，受体配体，抗体的抗原结合片段，热休克蛋白和整联蛋白的生物调节分子。 该组合物可以进一步包含一种或多种疾病特异性抗原以刺激免疫应答。 疾病特异性抗原可以选自肿瘤相关抗原，传染病相关抗原，自身免疫相关抗原，寄生虫抗原，细菌抗原和病毒抗原。 此外，该组合物可以进一步包含固体载体，交联的生物调节分子附着于固体载体上。 固体载体可以选自葡聚糖，壳聚糖，藻酸盐，聚-DL丙交酯聚乙醇酸交酯，聚乙醇酸交酯或明矾。

    IMMUNOSTIMULATORY COMPOSITIONS
    18.
    发明申请
    IMMUNOSTIMULATORY COMPOSITIONS 审中-公开
    免疫组化

    公开(公告)号：WO2006116475A3

    公开(公告)日：2007-12-21

    申请号：PCT/US2006015772

    申请日：2006-04-25

    申请人： 3M INNOVATIVE PROPERTIES CO ,  GRIESGRABER GEORGE W ,  KIEPER WILLIAM C ,  MENDOZA JAMES D ,  GRAM CHRISTOPHER D

    发明人： GRIESGRABER GEORGE W ,  KIEPER WILLIAM C ,  MENDOZA JAMES D ,  GRAM CHRISTOPHER D

    IPC分类号： A61K39/395 ,  C07K16/46

    CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/39 ,  A61K2039/525 ,  A61K2039/55511 ,  A61K2039/60 ,  C12N2740/16222

    摘要： The present invention provides immunostimulatory compositions. Generally, the immunostimulatory compositions include at least partially purified conjugates that include at least one IRM moiety covalently coupled to an antigenic peptide. In some embodiments, the immunostimulatory composition includes monomeric conjugates. In other embodiments, the immunostimulatory composition includes an aggregate of a conjugate and at least one other antigenic peptide (e.g., another conjugate and/or unconjugated peptide). The present invention also provides methods of using such immunostimulatory compositions. In some embodiments, the methods include inducing an immune response by contacting the immunostimulatory composition with an immune cell. In other embodiments, the method includes treating a condition by administering an immunostimulatory composition to a subject in an amount effective to ameliorate at least one symptom or clinical sign of the condition.

    摘要翻译： 本发明提供免疫刺激组合物。 通常，免疫刺激组合物包括至少部分纯化的缀合物，其包含与抗原肽共价偶联的至少一个IRM部分。 在一些实施方案中，免疫刺激组合物包括单体缀合物。 在其它实施方案中，免疫刺激组合物包括缀合物和至少一种其它抗原肽（例如另一种缀合物和/或非共轭肽）的聚集体。 本发明还提供了使用这种免疫刺激组合物的方法。 在一些实施方案中，所述方法包括通过使免疫刺激组合物与免疫细胞接触来诱导免疫应答。 在其它实施方案中，该方法包括通过以有效改善病症的至少一种症状或临床症状的量向对象施用免疫刺激组合物来治疗病症。

    PEPTIDE MIMETOPE VACCINE OF- AND ANTIBODIES AGAINST 6B PNEUMOCOCCAL POLYSACCHARIDES
    19.
    发明申请
    PEPTIDE MIMETOPE VACCINE OF- AND ANTIBODIES AGAINST 6B PNEUMOCOCCAL POLYSACCHARIDES 审中-公开
    肽类MIMETOPE和6B抗血清多糖的抗体

    公开(公告)号：WO2007113598A3

    公开(公告)日：2007-12-06

    申请号：PCT/GB2007050181

    申请日：2007-04-05

    申请人： UNIV LEICESTER ,  ANDREW PETER ,  SMITH CLAIRE MARY ,  LOPASSO CARLA ,  BAXENDALE HELEN ,  GOLDBLATT DAVID ,  FELICI FRANCO

    发明人： ANDREW PETER ,  SMITH CLAIRE MARY ,  LOPASSO CARLA ,  BAXENDALE HELEN ,  GOLDBLATT DAVID ,  FELICI FRANCO

    IPC分类号： A61K39/395 ,  C07K9/00 ,  C07K16/12

    CPC分类号： C07K16/1275 ,  A61K2039/505 ,  A61K2039/60 ,  G01N2333/315

    摘要： The invention provides a Streptococcus pneumoniae serotype 6B pneumococcal polysaccharide (6BPP) peptide mimetope, optionally conjugated to a carrier protein, capable of stimulating a protective immune response against pneumococcal infection. The invention further provides a monoclonal antibody against a 6B pneumococcal polysaccharide, and 6BPP-binding fragments thereof, capable of conferring passive immunity against pneumococcal infection. Also provided are compositions comprising said peptide mimetope, conjugate, mAb or binding fragment thereof. Mimetic peptides, conjugates thereof, mAb and 6BPP binding fragments according to the invention are provided as medicaments and in the manufacture of medicaments for the treatment of pneumococcal infection. The invention further relates to methods for prophylactic or therapeutic treatment of pneumococcal infection.

    摘要翻译： 本发明提供了能够刺激针对肺炎球菌感染的保护性免疫应答的肺炎链球菌血清型6B肺炎球菌多糖（6BPP）肽mimetope，任选地与载体蛋白缀合。 本发明还提供了能够赋予针对肺炎球菌感染的被动免疫的针对6B型肺炎球菌多糖及其6BPP结合片段的单克隆抗体。 还提供了包含所述肽mimetope，缀合物，mAb或其结合片段的组合物。 提供本发明的模拟肽，其缀合物，mAb和6BPP结合片段作为药物和制备用于治疗肺炎球菌感染的药物。 本发明还涉及肺炎球菌感染的预防或治疗方法。