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    DOXORUBICIN ADJUVANTS TO REDUCE TOXICITY AND METHODS FOR USING THE SAME
    11.
    发明申请
    DOXORUBICIN ADJUVANTS TO REDUCE TOXICITY AND METHODS FOR USING THE SAME 审中-公开
    DOXORUBICIN ADJUVANTS减少毒性及使用方法

    公开(公告)号：WO2009102808A2

    公开(公告)日：2009-08-20

    申请号：PCT/US2009/033825

    申请日：2009-02-11

    Applicant: TOSK, INCORPORATED ,  GARLAND, William A. ,  FRENZEL, Brian D.

    Inventor： GARLAND, William A. ,  FRENZEL, Brian D.

    IPC: A61K31/704 ,  A61P35/00 ,  C07C251/00 ,  C07C321/00

    CPC classification number: A61K31/15 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  C07C251/30 ,  C07C321/22 ,  C07C321/24 ,  C07C321/26 ,  C07C323/47 ,  A61K2300/00

    Abstract: Methods are provided for using doxorubicin active agents in which reduced host toxicity is observed. Aspects of the methods including administering to a subject an effective amount of a doxorubicin active agent in conjunction with a doxorubicin toxicity-reducing adjuvant, e.g., a nitrone compound, or a nitrone compound in combination with a bisdioxopiperazine compound. Also provided are compositions for use in practicing the subject methods. The methods and compositions find use in a variety of different applications, including in the treatment of a variety of different disease conditions.

    Abstract translation: 提供了使用观察到降低的宿主毒性的多柔比星活性剂的方法。 所述方法的方面包括给予受试者有效量的多柔比星活性剂与多柔比星毒性降低佐剂，例如硝酮化合物或硝酮化合物与双二氧代哌嗪化合物的组合。 还提供了用于实践本发明方法的组合物。 所述方法和组合物可用于各种不同的应用，包括治疗各种不同的疾病状况。

    ポリメルカプトポリフェニルおよびその合成方法
    12.
    发明申请
    ポリメルカプトポリフェニルおよびその合成方法 审中-公开
    聚合物的合成及其合成方法

    公开(公告)号：WO2002085846A1

    公开(公告)日：2002-10-31

    申请号：PCT/JP2002/003736

    申请日：2002-04-15

    Applicant: 科学技術振興事業団 ,  佐藤 瀏

    Inventor： 佐藤 瀏

    IPC: C07C321/26

    CPC classification number: C07C321/26

    Abstract: Novel di-, tri- or tetra- thiols or thiolates of biphenyl, biphenyl derivatives, terphenyl or terphenyl derivatives, as represented by the general formula (A), wherein M1 and M2 are each independently selected from the group consisting of H, Na, Li, and K, and R1 to R7 are each H or an organic group, with the proviso that M1, M2, and R1 to R7 may be the same or different from each other; E1 and E2 are SM3 and SM4 (wherein M3 and M4 are each selected from the same group as defined above for M1 or M2) or each a group selected from among those as defined above for R1 to R7; and n is 1 or 0, with the proviso that when n is 0, E1 and E2 are SM3 and SM4.

    Abstract translation: 由通式（A）表示的联苯，联苯衍生物，三联苯或三联苯衍生物的新型二，三或四硫醇或硫醇盐，其中M1和M2各自独立地选自H，Na， Li和K，且R 1至R 7各自为H或有机基团，条件是M 1，M 2和R 1至R 7可以彼此相同或不同; E1和E2是SM3和SM4（其中M3和M4各自选自与上述M1或M2所定义的相同的基团），或每个选自如上对于R 1至R 7的那些基团; n为1或0，条件是当n为0时，E1和E2为SM3和SM4。

    NOVEL SYNTHETIC ASPIRIN-MIMICS AND INNOVATIVE ANTIOXIDANTS AND THEIR USES
    16.
    发明申请
    NOVEL SYNTHETIC ASPIRIN-MIMICS AND INNOVATIVE ANTIOXIDANTS AND THEIR USES 审中-公开
    新型合成阿司匹林和创新抗氧化剂及其用途

    公开(公告)号：WO2015053797A2

    公开(公告)日：2015-04-16

    申请号：PCT/US2013/071629

    申请日：2013-11-25

    Applicant: LU, Yansong

    Inventor： LU, Yansong

    IPC: C07C323/22 ,  A61K31/60

    CPC classification number: C07C327/06 ,  C07C321/26 ,  C07C327/18 ,  C07C327/26 ,  C07C327/48 ,  C07D213/65 ,  C07D213/83 ,  C07D239/38 ,  C07D241/24 ,  C07D487/04

    Abstract: The present invention relates to novel synthetic aspirin-mimics that mimic the molecular structure of aspirin, with sulfur to replace oxygen in the key functional groups of aspirin. The novel synthetic aspirin-mimics in this invention integrate multiple features/functions: 1. they are considered as "druggable", as they resemble aspirin in structure; 2. they possess the strongest possible capability as scavengers for free radicals; 3. they could reinstate some damaged proteins/enzymes via the mechanism of thiol-disulfide exchange; 4. they are better chelators to heavy metals and could efficiently remove heavy metals out of body, compared to aspirin. This invention is also directed to novel aspirin-mimics as both drugs and prodrugs, their rational design, their feasible preparation routes by means of synthetic organic chemistry, and their potential therapeutic uses including but not limited to, in treatment and/or prevention of major diseases associated with oxidative stress, such as Alzheimer's disease, Parkinson's disease, cancers, diabetes, cardiovascular disease, renal disease, HIV, pain, hypertension, hypercholesterolemia, hyperlipidemia, rheumatoid arthritis, inflammation, aging, stroke, cataract, glaucoma, age-related macular degeneration, depression, acne, etc.

    Abstract translation: 本发明涉及模拟阿司匹林分子结构的新型合成阿司匹林模拟物，其中硫代替阿司匹林的关键官能团中的氧。 本发明中的新型合成阿司匹林模拟物整合了多种特征/功能：1.它们被认为是“可药用的”，因为它们与结构上的阿司匹林相似; 他们具有最强的自由基清除剂的能力; 他们可以通过硫醇 - 二硫化物交换的机制恢复一些受损的蛋白质/酶; 4.与阿司匹林相比，它们是重金属的螯合剂，可以有效去除重金属。 本发明还涉及作为药物和前药的新型阿司匹林模仿物，其合理设计，其通过合成有机化学的可行制备途径及其潜在的治疗用途，包括但不限于治疗和/或预防主要 与氧化应激相关的疾病，如阿尔茨海默病，帕金森病，癌症，糖尿病，心血管疾病，肾病，艾滋病病毒，疼痛，高血压，高胆固醇血症，高脂血症，类风湿性关节炎，炎症，老化，中风，白内障，青光眼，年龄相关 黄斑变性，抑郁，粉刺等

    NOVEL SYNTHETIC ANTIOXIDANTS AND THEIR USES
    17.
    发明申请
    NOVEL SYNTHETIC ANTIOXIDANTS AND THEIR USES 审中-公开
    新型合成抗氧化剂及其用途

    公开(公告)号：WO2014084898A1

    公开(公告)日：2014-06-05

    申请号：PCT/US2013/037038

    申请日：2013-04-18

    Applicant: LU, Yansong

    Inventor： LU, Yansong

    IPC: C07C321/28

    CPC classification number: C07C327/06 ,  C07C321/26 ,  C07C327/18 ,  C07C327/26 ,  C07C327/48 ,  C07D213/65 ,  C07D213/83 ,  C07D239/38 ,  C07D241/24 ,  C07D487/04

    Abstract: The present invention relates to synthetic organic antioxidants of small molecules. The novel dithiol-containing compounds in this invention possess strongest possible capability as both scavenger for free radicals and antioxidant. This invention is directed to novel molecules as prodrugs of the novel dithiol-containing compounds, their rational design, their feasible preparation route by means of synthetic organic chemistry, and their potential uses in application to treatment and/or prevention of major diseases associated with oxidative stress, such as Alzheimer's disease, Parkinson's disease, cancer, diabetes, HIV, acne, cardiovascular disease, renal disease, hypertension, hypercholesterolemia, hyperlipidemia, rheumatoid arthritis, inflammation, pain, aging, stroke, cataract, glaucoma, age-related macular degeneration, etc.

    Abstract translation: 本发明涉及小分子的合成有机抗氧化剂。 本发明的新型二硫醇化合物作为自由基和抗氧化剂的清除剂具有最强的可能性。 本发明涉及新型分子作为新二硫醇化合物的前药，其合理设计，其通过合成有机化学的可行制备途径及其在治疗和/或预防与氧化性相关的主要疾病中的潜在用途 压力，如阿尔茨海默病，帕金森病，癌症，糖尿病，艾滋病毒，痤疮，心血管疾病，肾病，高血压，高胆固醇血症，高脂血症，类风湿性关节炎，炎症，疼痛，老年，中风，白内障，青光眼，年龄相关性黄斑变性 等等

    PROCESS FOR PRODUCING BIS(4-ALKYLTHIOPHENYL) DISULFIDE
    20.
    发明申请
    PROCESS FOR PRODUCING BIS(4-ALKYLTHIOPHENYL) DISULFIDE 审中-公开
    生产双（4-羟基乙基）二胺的方法

    公开(公告)号：WO1996019448A1

    公开(公告)日：1996-06-27

    申请号：PCT/JP1995002645

    申请日：1995-12-22

    Applicant: TORAY INDUSTRIES, INC. ,  UCHIRO, Hiromi ,  KAWABE, Norio ,  KAWANO, Teiji ,  TSURUTA, Kouichi

    Inventor： TORAY INDUSTRIES, INC.

    IPC: C07C321/28

    CPC classification number: C07C319/24 ,  C07C319/02 ,  C07C321/28 ,  C07C321/26

    Abstract: A process for producing a bis(4-alkylthiophenyl) disulfide comprising: (a) directly reducing a 4-alkylthiobenzenesulfonyl chloride or (b) reducing a 4-alkylthiobenzenesulfonyl chloride and oxidizing the obtained 4-alkylthiobenzenethiol, whereby the compound represented by formula (I), which is useful as an intermediate of medicines, can be produced on an industrial scale.

    Abstract translation: 一种制备双（4-烷硫基苯基）二硫化物的方法，包括：（a）直接还原4-烷硫基苯磺酰氯或（b）还原4-烷硫基苯磺酰氯并氧化所得4-烷硫基苯硫醇，由此将式 ）作为药物中间体是有用的，可以在工业规模上生产。

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