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    PLANT CELL LINES AND METHODS OF ISOLATING THE SAME
    11.
    发明申请
    PLANT CELL LINES AND METHODS OF ISOLATING THE SAME 审中-公开
    植物细胞系及其分离方法

    公开(公告)号：WO2012052854A2

    公开(公告)日：2012-04-26

    申请号：PCT/IB2011/003287

    申请日：2011-10-24

    Applicant: UNHWA CORPORATION ,  UNIVERSITY OF EDINBURGH ,  LEE, Eun Kyong ,  JIN, Young Woo ,  PARK, Joong Hyun ,  OH, Il Seok ,  LIM, Min Jung ,  LOAKE, Gary, John ,  YUN, Byung-Wook ,  WAIBEL, Thomas

    Inventor： LEE, Eun Kyong ,  JIN, Young Woo ,  PARK, Joong Hyun ,  OH, Il Seok ,  LIM, Min Jung ,  LOAKE, Gary, John ,  YUN, Byung-Wook ,  WAIBEL, Thomas

    CPC classification number: A01H1/04 ,  A01H4/005 ,  C12N5/04 ,  G01N33/56961

    Abstract: An isolated plant cell having increased expression of one or more of a PXY and WOL nucleic acid molecule or polypeptide, a method of isolating a plant stem cell, a method of producing a plant-derived biologically active substance using the isolated plant stem cell are disclosed. The cells are undifferentiated, undergo self-renewal, proliferate, and have the ability to differentiate. Cultures of the plant cells minimize variation of cell growth and stably produce biologically active substances, even in long-term culture. Production of biologically active substances using the plant cells solves problems of dedifferentiated plant cell cultures, including decreased cell growth and decreased productivity during long term culture.

    Abstract translation: 公开了分离的植物细胞，其具有增加PXY和WOL核酸分子或多肽中的一种或多种的表达，分离植物干细胞的方法，使用分离的植物干细胞产生植物来源的生物活性物质的方法 。 细胞未分化，经历自我更新，增殖，并具有分化能力。 植物细胞的培养物尽可能减少细胞生长的变化并稳定地生产生物活性物质，即使在长期培养中也是如此。 使用植物细胞生产生物活性物质解决了去分化植物细胞培养物的问题，包括减少细胞生长和降低长期培养中的生产力。

    COMPOSITIONS FOR DIAGNOSIS OF FUNGAL INFECTIONS
    16.
    发明申请
    COMPOSITIONS FOR DIAGNOSIS OF FUNGAL INFECTIONS 审中-公开
    用于诊断真菌感染的组合物

    公开(公告)号：WO2010104341A3

    公开(公告)日：2011-01-13

    申请号：PCT/KR2010001523

    申请日：2010-03-11

    Applicant: PUSAN NAT UNIV IND COOP FOUND ,  LEE BOK LUEL

    Inventor： LEE BOK LUEL

    IPC: A61K38/04 ,  A61K38/08 ,  A61P31/04

    CPC classification number: G01N33/56961

    Abstract: The present invention relates to a marker for diagnosis of fungal infections, which is sequentially activated in vivo in the presence of ß-1,3-glucan, which activates the Toll signaling pathway, to compositions for diagnosis of fungal infections in a specimen, and to a method for producing antibacterial substances. More particularly, the present invention has proved that a GNBP3-mediated ß-1,3-glucan recognition signal reaches pro-Spaetzle using three serine proteases as mediators, namely, modular serine protease (MSP), Spaetzle-processing enzyme activating enzyme (SAE), and Spaetzle-processing enzyme (SPE). Proteins involved with ß-1,3-glucan recognition signaling can be effectively used as compositions for detecting fungal infections in blood samples or the like.

    Abstract translation: 本发明涉及用于诊断真菌感染的标记物，其在活体Toll信号通​​路的β-1,3-葡聚糖存在下在体内依次活化成用于诊断样品中真菌感染的组合物，以及 涉及一种生产抗菌物质的方法。 更具体地说，本发明已经证明，GNBP3介导的β-1,3-葡聚糖识别信号使用三种丝氨酸蛋白酶作为介质，即模块化丝氨酸蛋白酶（MSP），温泉加工酶活化酶（SAE ）和Spaetzle加工酶（SPE）。 涉及β-1,3-葡聚糖识别信号的蛋白质可以有效地用作检测血液样品等中的真菌感染的组合物。

    DETECTION OF SECRETED ASPARTYL PROTEASES FROM CANDIDA SPECIES
    19.
    发明申请
    DETECTION OF SECRETED ASPARTYL PROTEASES FROM CANDIDA SPECIES 审中-公开
    从坎迪达物种检测分泌的ASPARTYL蛋白质

    公开(公告)号：WO2007070123A1

    公开(公告)日：2007-06-21

    申请号：PCT/US2006/032203

    申请日：2006-08-17

    Applicant: KIMBERLY-CLARK WORLDWIDE, INC. ,  PHILLIPS, Erica, M. ,  DIGAMMARINO, Enrico, L. ,  MCGRATH, Kevin, P.

    Inventor： PHILLIPS, Erica, M. ,  DIGAMMARINO, Enrico, L. ,  MCGRATH, Kevin, P.

    IPC: G01N33/558 ,  C12Q1/37

    CPC classification number: G01N33/56961 ,  C12Q1/37 ,  G01N33/558

    Abstract: Methods and devices for the detection of proteins secreted by the hyphal growth form of Candida species are disclosed. The disclosed devices may constitute a method for the diagnosis of acute or chronic infections, including candidiasis, caused by microorganisms of the species Candida, such as C. albicans, for example. The devices of the present invention incorporate antibodies specific to secreted aspartyl protease proteins whose expression is upregulated upon the conversion of the Candida species from the commensal to the pathogenic form. The antibodies may be used in assays to allow the diagnosis of candidal infections and disease conditions. Either monoclonal antibodies or polyclonal antibodies may be used, and in the case of the monoclonals, the specific epitopes of the SAP protein may be detected as well as the SAP protein itself.

    Abstract translation: 公开了用于检测由假丝酵母属菌丝生长形式分泌的蛋白质的方法和装置。 所公开的装置可以构成用于诊断例如由诸如白色念珠菌之类的假丝酵母属的微生物引起的急性或慢性感染（包括念珠菌病）的方法。 本发明的装置包含对分泌的天冬氨酰蛋白酶蛋白特异性的抗体，其在将假丝酵母菌种从共生转化为致病形式时，其表达被上调。 抗体可用于测定以允许诊断念珠菌感染和疾病状况。 可以使用单克隆抗体或多克隆抗体，并且在单克隆的情况下，可以检测SAP蛋白的特异性表位以及SAP蛋白本身。

    DRUG INDUCED EXPOSURE OF THE FUNGAL PRO-INFLAMMATORY MOLECULE BETA-GLUCAN
    20.
    发明申请
    DRUG INDUCED EXPOSURE OF THE FUNGAL PRO-INFLAMMATORY MOLECULE BETA-GLUCAN 审中-公开
    药物诱导的真菌灭活分子BETA-GLUCAN的暴露

    公开(公告)号：WO2007033315A1

    公开(公告)日：2007-03-22

    申请号：PCT/US2006/035812

    申请日：2006-09-14

    Applicant: WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH ,  WHEELER, Robert, T. ,  FINK, Gerald, R.

    Inventor： WHEELER, Robert, T. ,  FINK, Gerald, R.

    IPC: G01N33/50

    CPC classification number: G01N33/5023 ,  G01N33/56961 ,  G01N2400/24

    Abstract: Methods and reagents for screening for anti-microbial agents are provided. Diagnostic tools for assessing treatment of fungal infections are provided. Antimicrobial substances including substances useful for the treatment of fungal infections are provided. In some embodiments, the substances have antigen unmasking activity. In some embodiments the substances have fungicidal activity and surface antigen unmasking activity.

    Abstract translation: 提供了用于筛选抗微生物剂的方法和试剂。 提供了用于评估真菌感染治疗的诊断工具。 提供了包括可用于治疗真菌感染的物质的抗微生物物质。 在一些实施方案中，所述物质具有抗原暴露活性。 在一些实施方案中，所述物质具有杀真菌活性和表面抗原暴露活性。

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