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公开(公告)号：WO2019067383A1
公开(公告)日：2019-04-04
申请号：PCT/US2018/052525
申请日：2018-09-25
Inventor： WEI, Alexander , YUAN, Chongli
IPC: C12Q1/68 , C12N15/115 , C40B40/06
CPC classification number: C12N15/1093 , C12N15/111 , C12N2310/16 , C12N2320/13 , C12Q1/6811 , C40B40/06 , C12Q2525/205 , C12Q2563/149
Abstract: The present disclosure relates to aptamers for detection of an analyte in a sample; a substrate having attached thereto the aptamers according to the invention; a kit of parts for the detection of an analyte in a sample; and a method for the detection of an analyte in a sample comprising the use of said aptamers.
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公开(公告)号：WO2018136526A1
公开(公告)日：2018-07-26
申请号：PCT/US2018/014068
申请日：2018-01-17
Applicant: COUNSYL, INC.
Inventor： BEAUCHAMP, Kyle , MUZZEY, Dale , WELKER, Noah , MAGUIRE, Jared, Robert
CPC classification number: C12Q1/6869 , B01J19/0046 , B01J2219/00572 , B01J2219/00722 , C12N15/1093 , C12Q1/6806 , C12Q1/6811 , C12Q1/6883 , C40B40/06 , C40B50/14 , G16B30/00 , C12Q2545/10 , C12Q2565/519
Abstract: Capture probe libraries can be used to enrich a region of interest in a sequencing library for high-depth sequencing. The capture probes within the capture probe libraries often do not function in a predictable or uniform manner. Described herein are balanced capture probe libraries and methods of balancing capture probe libraries. A sequencing library can be enriched using balanced capture probe libraries, and the enriched sequencing library can be sequenced to obtain a sequencing depth closer to a desired sequencing depth.
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公开(公告)号：WO2017209575A1
公开(公告)日：2017-12-07
申请号：PCT/KR2017/005818
申请日：2017-06-02
Applicant: SEEGENE, INC.
Inventor： CHUN, Jong Yoon , YOON, Gi-Seok
CPC classification number: C12Q1/68 , C12Q1/6811 , G16B30/00 , G16B30/10 , G16B50/00
Abstract: The present invention relates to a method for evaluating specificity of oligonucleotides represented by 5'-X-Y-Z-3'. The present invention comprises comparing the complete or a partial sequence of the oligonucleotide of Formula (I) against at least one database of nucleotide sequences, and extracting reference nucleotide sequences comprising a region homologous to the complete or a partial sequence of the oligonucleotide of Formula (I) from the database; and analyzing portion-by-portion match/mismatch between the oligonucleotide of Formula (I) and each of the reference nucleotide sequences to provide (i) the number or ratio of matched or mismatched bases between the portion X of the oligonucleotide of Formula (I) and each of the reference nucleotide sequences and individually (ii) the number or ratio of matched or mismatched bases between the portion Z of the oligonucleotide of Formula (I) and each of the reference nucleotide sequences.
Abstract translation: 本发明涉及用于评估由5'-X-Y-Z-3'表示的寡核苷酸的特异性的方法。 本发明包括将式（I）寡核苷酸的完整或部分序列与至少一个核苷酸序列数据库进行比较，并提取包含与式（I）寡核苷酸的完整或部分序列同源的区域的参考核苷酸序列 我）从数据库中; （I）的寡核苷酸与每个参考核苷酸序列之间的部分 - 部分匹配/错配以提供（i）式（I）的寡核苷酸的部分X之间的匹配或错配碱基的数目或比例 ）和每个参考核苷酸序列并且单独（ii）式（I）的寡核苷酸的部分Z与每个参考核苷酸序列之间匹配的或错配的碱基的数目或比例。
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公开(公告)号：WO2017180549A1
公开(公告)日：2017-10-19
申请号：PCT/US2017/026892
申请日：2017-04-11
Applicant: DOTS TECHNOLOGY CORP.
Inventor： GILBOA-GEFFEN, Adi , BABU BROWN, Renuka
CPC classification number: C12N15/10 , C12Q1/6811 , G01N33/53 , G01N33/54326 , C12Q2525/205 , C12Q2563/143 , C12Q2563/149
Abstract: The present invention relates to assays and methods for target analyte (e.g., allergen) detection in a sample using aptamer-magnetic particle complexes.
Abstract translation: 本发明涉及使用适体 - 磁性颗粒复合物在样品中检测靶分析物（例如过敏原）的测定和方法。
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公开(公告)号：WO2017143317A1
公开(公告)日：2017-08-24
申请号：PCT/US2017/018569
申请日：2017-02-20
Applicant: BASHKIROV, Vladimir I. , KOTSEROGLOU, Theofilos
Inventor： BASHKIROV, Vladimir I. , KOTSEROGLOU, Theofilos
CPC classification number: C12Q1/6811 , C07H21/04 , C12N15/09 , C12Q1/68 , C12Q1/6816 , C12Q1/682 , C12Q1/6832 , C12Q1/6834 , C12Q1/6883 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2521/301 , C12Q2523/31 , C12Q2563/116 , C12Q2565/632 , C12Q2521/327 , C12Q2525/307 , C12Q2531/125 , C12Q2565/601
Abstract: The present invention provides methods and systems for nucleic acid detection and identification.
Abstract translation: 本发明提供了用于核酸检测和鉴定的方法和系统。
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Patent Agency Ranking
公开(公告)号：WO2017072330A2
公开(公告)日：2017-05-04
申请号：PCT/EP2016/076148
申请日：2016-10-28
Applicant: QUERDENKER APS
Inventor： MOELLER, Thorleif
IPC: C12N15/10
CPC classification number: A61J1/10 , A61J1/1475 , A61J1/2024 , A61J1/2031 , A61J1/2093 , C12N15/1068 , C12Q1/6811 , C12Q1/6832 , C12Q2525/205 , C12Q2531/113 , C12Q2537/143 , C12Q2545/114 , C12Q2563/179 , C12Q2525/155 , C12Q2525/161 , C12Q2533/101
Abstract: The present invention discloses methods for identification of oligonucleotides by manipulation of the information content a plurality of oligonucleotides. A main object of the methods is the identification of new molecular activity such as new ligands of interest for the development of therapeutics or in the field of nanotechnology.
Abstract translation: 本发明公开了通过操纵多个寡核苷酸的信息含量来鉴定寡核苷酸的方法。 这些方法的主要目标是识别新的分子活性，例如用于开发治疗剂或纳米技术领域的新兴配体。
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公开(公告)号：WO2017048709A1
公开(公告)日：2017-03-23
申请号：PCT/US2016/051514
申请日：2016-09-13
Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Inventor： LABAER, Joshua , GORMAN, Kevin , KAY, Brian , WANG, Jie , QIU, Ji
CPC classification number: C12Q1/6811 , C12N15/1037 , C12N15/1041 , C12N15/1062 , C12Q2565/501 , C12Q2565/515
Abstract: Methods for screening of affinity reagents for many target proteins of interest simultaneously. Arrayed targets (e.g., peptide, protein, RNA, cell, etc.) are used in affinity selection experiments to reduce the amount of target needed and to improve the throughput of discovering recombinant affinity reagents to a large collection of targets.
Abstract translation: 同时筛选许多目标蛋白质的亲和试剂的方法。 在亲和力选择实验中使用阵列靶（例如肽，蛋白质，RNA，细胞等）以减少所需靶标的量并提高向大量靶标发现重组亲和试剂的通过量。
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公开(公告)号：WO2017020023A3
公开(公告)日：2017-03-09
申请号：PCT/US2016044914
申请日：2016-07-29
Applicant: PROGENITY INC , MANN TOBIAS , WANG HENG , KIM JUNG H , SEKEDAT MATTHEW
Inventor： MANN TOBIAS , WANG HENG , KIM JUNG H , SEKEDAT MATTHEW
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , C12Q1/6811 , C12Q1/6816 , C12Q1/6827 , C12Q2600/156 , C12Q2600/158 , G06F19/20 , G06F19/22 , G06F19/345 , G16H50/20 , C12Q2521/319 , C12Q2525/307 , C12Q2531/113 , C12Q2535/122 , C12Q2537/165
Abstract: Methods and nucleic acid molecules for detecting chromosomal abnormalities such as aneuploidy. Methods for selecting nucleic acid molecules for use in the methods of the disclosure.
Abstract translation: 用于检测染色体异常例如非整倍性的方法和核酸分子。 选择用于本公开方法的核酸分子的方法。
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公开(公告)号：WO2017020023A2
公开(公告)日：2017-02-02
申请号：PCT/US2016/044914
申请日：2016-07-29
Applicant: PROGENITY, INC. , MANN, Tobias , WANG, Heng , KIM, Jung H. , SEKEDAT, Matthew
Inventor： MANN, Tobias , WANG, Heng , KIM, Jung H. , SEKEDAT, Matthew
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , C12Q1/6811 , C12Q1/6816 , C12Q1/6827 , C12Q2600/156 , C12Q2600/158 , G06F19/00 , G06F19/20 , G06F19/22 , G16H50/20 , C12Q2521/319 , C12Q2525/307 , C12Q2531/113 , C12Q2535/122 , C12Q2537/165
Abstract: Methods and nucleic acid molecules for detecting chromosomal abnormalities such as aneuploidy. Methods for selecting nucleic acid molecules for use in the methods of the disclosure.
Abstract translation: 用于检测染色体异常（如非整倍体）的方法和核酸分子。 用于选择用于本公开的方法的核酸分子的方法。
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10.发明申请
公开(公告)号：WO2016210448A1
公开(公告)日：2016-12-29
申请号：PCT/US2016/039671
申请日：2016-06-27
Inventor： HEEMSTRA, Jennifer , JAHNKE, Frank , PETERSON, Amberlyn
IPC: C12N15/115 , C12Q1/68
CPC classification number: C12N15/115 , C12N2310/16 , C12N2330/31 , C12Q1/6811 , C12Q2525/205
Abstract: Methods for preparing nucleic acid aptamers in the presence of a surfactant are described, as are methods for using nucleic acid aptamers to separate a target molecule from a sample. The methods may be used to separate abundant proteins including HSA from a biological sample such as serum.
Abstract translation: 描述了在表面活性剂存在下制备核酸适体的方法，以及使用核酸适配子从样品中分离靶分子的方法。 该方法可用于从生物样品例如血清中分离包括HSA的丰富蛋白质。
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