公开(公告)号：WO2010121700A1

公开(公告)日：2010-10-28

申请号：PCT/EP2010/002042

申请日：2010-03-31

Applicant: FIDIA FARMACEUTICI S.P.A. ,  SCHIAVINATO, Antonella ,  PARENZAN, Piera ,  GENNARI, Giovanni ,  CALLEGARO, Lanfranco

Inventor： SCHIAVINATO, Antonella ,  PARENZAN, Piera ,  GENNARI, Giovanni ,  CALLEGARO, Lanfranco

IPC: A61K31/593 ,  A61K31/728 ,  A61K31/738 ,  A61K33/06 ,  A61P19/02 ,  A61P19/08 ,  A61P19/10

CPC classification number: A61K31/728 ,  A61K31/593 ,  A61K31/738 ,  A61K33/06

Abstract: The present invention relates to compositions containing hyaluronic acid (HA) mixed with sulphated hyaluronic acid with degree of sulphation (1) (HAS1), calcium and vitamin D3, for use to prepare oral supplements for the prevention and treatment of osteoarticular and musculoskeletal disorders and osteoporosis.

Abstract translation: 本发明涉及含有与硫酸化程度的硫酸化透明质酸（1）（HAS1），钙和维生素D3混合的透明质酸（HA）的组合物，用于制备用于预防和治疗骨关节炎和肌肉骨骼疾病的口服补充剂， 骨质疏松症。

公开(公告)号：WO2009031006A2

公开(公告)日：2009-03-12

申请号：PCT/IB2008/002280

申请日：2008-09-03

Applicant: FIDIA FARMACEUTICI S.P.A. ,  CARAMELLA, Carla, Marcella ,  ROSSI, Silvia ,  SANDRI, Giuseppina ,  GENNARI, Giovanni

Inventor： CARAMELLA, Carla, Marcella ,  ROSSI, Silvia ,  SANDRI, Giuseppina ,  GENNARI, Giovanni

IPC: A61K9/06 ,  A61K31/522 ,  A61K47/32 ,  A61K47/36

CPC classification number: A61K9/0034 ,  A61K9/06 ,  A61K31/522 ,  A61K47/32 ,  A61K47/36

Abstract: The invention relates to topical formulations in the form of a bioadhesive hydrophilic gel comprising acyclovir as active ingredient, Sodium hyaluronate and an acrylic polymer. Said formulations improve the local administration of acyclovir in the treatment of herpes infections, because they possess good properties of adherence to the mucosa and high resistance to physiological removal mechanisms.

Abstract translation: 本发明涉及包含阿昔洛韦作为活性成分，透明质酸钠和丙烯酸聚合物的生物粘附亲水凝胶形式的局部制剂。 所述制剂改善了阿昔洛韦在治疗疱疹感染中的局部施用，因为它们具有粘附于粘膜的良好性质和对生理去除机制的高抗性。

公开(公告)号：WO2009003624A1

公开(公告)日：2009-01-08

申请号：PCT/EP2008/005140

申请日：2008-06-25

Applicant: FIDIA FARMACEUTICI S.P.A. ,  RENIER, Davide ,  D'ESTE, Matteo

Inventor： RENIER, Davide ,  D'ESTE, Matteo

IPC: C08B37/00 ,  C08L5/08 ,  A61K47/36 ,  A61L27/52 ,  C07C207/00

CPC classification number: A61K47/4823 ,  A61K9/0014 ,  A61K9/0021 ,  A61K31/728 ,  A61K45/06 ,  A61K47/36 ,  A61K47/61 ,  C08B37/0072

Abstract: Disclosed are hyaluronic acid derivatives functionalised with S-nitrosothiol groups of the general formula: wherein HA indicates hyaluronic acid and G indicates a suitable spacer.

Abstract translation: 本发明公开了具有以下通式的S-亚硝基硫醇官能化的透明质酸衍生物：其中HA表示透明质酸，G表示合适的间隔基。

公开(公告)号：WO2008031525A1

公开(公告)日：2008-03-20

申请号：PCT/EP2007/007758

申请日：2007-09-05

Applicant: FIDIA FARMACEUTICI S.P.A. ,  CRESCENZI, Vittorio ,  DI MEO, Chiara ,  GALESSO, Devis

Inventor： CRESCENZI, Vittorio ,  DI MEO, Chiara ,  GALESSO, Devis

IPC: C08B37/00 ,  A61L27/52 ,  A61K47/36

CPC classification number: A61L27/52 ,  A61K9/0014 ,  A61K9/06 ,  A61K47/36 ,  A61L27/20 ,  C08B37/0072 ,  C08L5/08

Abstract: Crosslinked derivatives of polycarboxylated polysaccharides are described, wherein at least one of the polysaccharide chains consists of hyaluronic acid or a derivative thereof, crosslinked by means of reactions of the "click chemistry" type and their use in the field of viscosupplementation, plastic surgery, oncologic and reconstructive surgery and also as matrices for controlled release systems of biologically and/or pharmacologically active molecules and/or macromolecules.

Abstract translation: 描述了多羧化多糖的交联衍生物，其中至少一个多糖链由透明质酸或其衍生物组成，通过“点击化学”类型的反应及其在粘弹性补充领域，整形外科，肿瘤学中的应用而交联 和重建手术，还可以作为生物和/或药理学活性分子和/或大分子的控制释放系统的基质。

公开(公告)号：WO2007137674A1

公开(公告)日：2007-12-06

申请号：PCT/EP2007/003920

申请日：2007-05-03

Applicant: FIDIA FARMACEUTICI S.P.A. ,  CALLEGARO, Lanfranco ,  RENIER, Davide

Inventor： CALLEGARO, Lanfranco ,  RENIER, Davide

IPC: A61P19/02 ,  A61K31/737

CPC classification number: A61K31/737 ,  A61K9/0019 ,  A61K9/1652 ,  A61K9/4866 ,  A61K31/726 ,  A61K38/014 ,  A61K38/39 ,  A61K45/06 ,  A61K2300/00

Abstract: This invention relates to oral and intra-articular formulations based on sulphated hyaluronic acid which are effective in the treatment of degenerative osteoarthritis.

Abstract translation: 本发明涉及基于硫酸化透明质酸的口服和关节内制剂，其有效治疗退行性骨关节炎。

公开(公告)号：WO2003057203A2

公开(公告)日：2003-07-17

申请号：PCT/EP2003/000078

申请日：2003-01-07

Applicant: FIDIA FARMACEUTICI S.P.A. ,  DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ) ,  FUSENIG, Norbert, E. ,  STARK, Hans-Jürgen ,  WILLHAUCK, Michael ,  PAVESIO, Alessandra

Inventor： FUSENIG, Norbert, E. ,  STARK, Hans-Jürgen ,  WILLHAUCK, Michael ,  PAVESIO, Alessandra

IPC: A61K31/00

CPC classification number: A61L31/042 ,  C08L5/08

Abstract: The use in the medical-surgical field of biomaterials based on hyaluronic acid derivatives, optionally in association with natural, synthetic or semisynthetic biopolymers, for suppressing the angiogenic process associated with tumour proliferation (in primary and secondary tumours) is disclosed.

Abstract translation: 公开了用于抑制与肿瘤增殖相关的血管生成过程（在原发性和继发性肿瘤中）的基于透明质酸衍生物的生物材料的医学外科领域，任选与天然的，合成的或半合成的生物聚合物结合。

公开(公告)号：WO2002064603A1

公开(公告)日：2002-08-22

申请号：PCT/EP2002/001358

申请日：2002-02-08

Applicant: FIDIA FARMACEUTICI S.P.A. ,  KIRSCHNER, Guenter ,  MENON, Giampaolo ,  VACCARO, Susanna

Inventor： KIRSCHNER, Guenter ,  MENON, Giampaolo ,  VACCARO, Susanna

IPC: C07F9/10

CPC classification number: C07F9/10 ,  A61K8/553 ,  A61Q19/00 ,  C12P9/00 ,  C12P13/06

Abstract: The present invention concerns a process for the preparation of pure phosphatides starting from mixtures of natural phosphatides, or their single components, such as soybean or egg lecithin or animal phospholipids, or from synthetic phosphatides by reacting them with phospholipase D, with transphosphatidylation activity, in aqueous medium alone in the presence of defined substrates containing a primary or secondary alcoholic group.

Abstract translation: 本发明涉及从天然磷脂或其单一组分如大豆或卵卵磷脂或动物磷脂的混合物或从合成磷脂通过与磷脂酶D反应与磷脂酰胆碱转换活性的混合物制备纯磷脂的方法， 在含有伯或仲醇基团的限定底物的存在下，单独的含水介质。

公开(公告)号：WO2021234562A1

公开(公告)日：2021-11-25

申请号：PCT/IB2021/054261

申请日：2021-05-18

Applicant: FIDIA FARMACEUTICI S.P.A.

Inventor： PIZZOCARO, Carlo

IPC: A61K9/70 ,  A61K47/10 ,  A61K47/14 ,  A61K47/32 ,  A61K31/196 ,  A61P19/02 ,  A61P21/00 ,  A61P29/00

Abstract: A slow-release medical plaster is described, based on diclofenac, specifically a medical plaster based on diclofenac sodium salt, whose formulation allows the release of the active ingredient continuously and at locally therapeutically active concentrations over 24 hours, and also the polymer adhesive matrix (PSA) for use in a medical plaster based on diclofenac sodium salt.

公开(公告)号：WO2021079303A1

公开(公告)日：2021-04-29

申请号：PCT/IB2020/059922

申请日：2020-10-22

Applicant: FIDIA FARMACEUTICI S.P.A.

Inventor： PIZZOCARO, Carlo ,  ZANELLATO, Anna Maria ,  PAVAN, Mauro

IPC: A61K9/00 ,  A61K9/08 ,  A61K31/728 ,  A61P13/10 ,  A61P31/00

Abstract: A pharmaceutical sterile composition consisting of hyaluronic acid sodium salt and Hyaffl lp50 and related use in the intravesical treatment of interstitial cystitis or Bladder Pain Syndrome (IC/BPS), of acute cystitis following bacterial infection, trauma or urolithiasis, of cystitis caused by radiation, chemotherapy, and hemorrhagic cystitis, as well as in the treatment of the bladder of patients undergoing endoscopic resection of benign or malignant bladder tumour at risk of relapse, are described.

公开(公告)号：WO2020212853A1

公开(公告)日：2020-10-22

申请号：PCT/IB2020/053530

申请日：2020-04-15

Applicant: FIDIA FARMACEUTICI S.P.A.

Inventor： BARBERA, Carlo ,  PASTORELLO, Andrea

IPC: A61K9/06 ,  A61K31/366 ,  A61K31/40 ,  A61K31/404 ,  A61P19/02 ,  A61K47/36

Abstract: The present invention relates to pharmaceutical compositions comprising mixtures of a statin and a hyaluronic acid amide derivative which are useful in the treatment of inflammation and degradation of osteoarthritic joint cartilage, in particular post-traumatic osteoarthrosis and osteoarthrosis caused by physiological joint aging, and in the treatment of other joint disorders such as rheumatoid arthritis.