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Patent Agency Ranking1.发明申请BIOMATERIALS BASED ON HYALURONIC ACID FOR THE ANTI-ANGIOGENIC THERAPY IN THE TREATMENT OF TUMOURS 审中-公开基于静脉注射用于治疗肿瘤的抗生素治疗的生物材料
公开(公告)号：WO2003057203A2
公开(公告)日：2003-07-17
申请号：PCT/EP2003/000078
申请日：2003-01-07
Applicant: FIDIA FARMACEUTICI S.P.A. , DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ) , FUSENIG, Norbert, E. , STARK, Hans-Jürgen , WILLHAUCK, Michael , PAVESIO, Alessandra
Inventor： FUSENIG, Norbert, E. , STARK, Hans-Jürgen , WILLHAUCK, Michael , PAVESIO, Alessandra
IPC: A61K31/00
CPC classification number: A61L31/042 , C08L5/08
Abstract: The use in the medical-surgical field of biomaterials based on hyaluronic acid derivatives, optionally in association with natural, synthetic or semisynthetic biopolymers, for suppressing the angiogenic process associated with tumour proliferation (in primary and secondary tumours) is disclosed.
Abstract translation: 公开了用于抑制与肿瘤增殖相关的血管生成过程（在原发性和继发性肿瘤中）的基于透明质酸衍生物的生物材料的医学外科领域，任选与天然的，合成的或半合成的生物聚合物结合。
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2.发明申请SCAFFOLD-BASED ORGANOTYPIC CULTURE FORT THE LONG-TERM CULTIVATION OF HUMAN EPIDERMAL STEM-CELLS 审中-公开基于SCAFFOLD的有机文化长期人类干细胞的培养
公开(公告)号：WO2011117233A1
公开(公告)日：2011-09-29
申请号：PCT/EP2011/054337
申请日：2011-03-22
Applicant: DEUTSCHES KREBSFORSCHUNGSZENTRUM , LANDESSTIFTUNG BADEN-WÜRTTEMBERG GGMBH , STARK, Hans-Jürgen , FUSENIG, Norbert , BOUKAMP, Petra , BÖHNKE, Karsten
Inventor： STARK, Hans-Jürgen , FUSENIG, Norbert , BOUKAMP, Petra , BÖHNKE, Karsten
IPC: C12N5/071
CPC classification number: C12Q1/025 , C12N5/0698 , C12N2500/38 , C12N2501/01 , C12N2501/15 , C12N2501/39 , C12N2501/70 , C12N2502/094 , C12N2502/1323 , C12N2533/30 , C12N2533/56
Abstract: The present invention relates to organotypic cultures of epidermal cells and their uses for the screening of pharmaceutical and cosmetic agents. Specifically, means for the improvement of the long-term stability of said cultures are disclosed. Thus, the present invention contemplates a skin equivalent comprising (a) a dermal equivalent comprising a matrix comprising (i) nonwoven viscose fabric and (ii) fibroblasts and (b) keratinocytes. Moreover, the present invention contemplates a method for manufacturing said skin equivalent and a method for screening of agents capable of influencing skin, such as a therapeutic or cosmetic agent.
Abstract translation: 本发明涉及表皮细胞的器官型培养物及其用于筛选药物和化妆品的用途。 具体地，公开了用于改善所述培养物的长期稳定性的手段。 因此，本发明涉及皮肤等同物，其包含（a）皮肤当量，其包含基质，其包含（i）非织造粘胶织物和（ii）成纤维细胞和（b）角质形成细胞。 此外，本发明考虑了用于制造所述皮肤等效物的方法以及用于筛选能够影响皮肤的药剂如治疗剂或美容剂的方法。
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3.发明申请GENETICALLY ENGINEERED KERATINOCYTES EXPRESSING AT LEAST ONE GROWTH FACTOR AND/OR ACTIVATED EGF RECEPTOR, SKIN EQUIVALENT COMPRISING SAID KERATINOCYTES AND TOXICITY ASSAY USING SAID KERATINOCYTES 审中-公开表达至少一个生长因子和/或激活的EGF受体的基因工程化KERATINOCYTES，包含所述KERATINOCYTES的皮肤等效物质和使用所述KERATINOCYTES的毒性测定
公开(公告)号：WO2004001024A2
公开(公告)日：2003-12-31
申请号：PCT/EP2003/006475
申请日：2003-06-18
Applicant: DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTS , FUSENIG, Norbert , MAAS-SZABOWSKI, Nicole , STÄRKER, Anja , STARK, Hans-Jürgen , MARTIN, Iris , GOEDECKE, Eva
Inventor： FUSENIG, Norbert , MAAS-SZABOWSKI, Nicole , STÄRKER, Anja , STARK, Hans-Jürgen , MARTIN, Iris , GOEDECKE, Eva
IPC: C12N5/06
CPC classification number: C12N5/0629 , C12N5/0698 , C12N2501/11 , C12N2501/117 , C12N2501/148 , C12N2501/22 , C12N2502/094 , C12N2502/1323 , C12N2503/02 , C12N2510/04 , G01N33/5088
Abstract: Described is an immortalized mammalian skin keratinocyte line, preferably HaCaT, stably transfected with a vector capable of expressing a nucleic acid sequence encoding at least one growth factor and/or activated EGF receptor. Furthermore, a skin equivalent and an in vitro toxicity assay making use of this immortalized mammalian skin keratinocyte line is described.
Abstract translation: 描述了用能够表达编码至少一种生长因子和/或活化的EGF受体的核酸序列的载体稳定转染的永生化哺乳动物皮肤角质形成细胞系，优选HaCaT。 此外，描述了使用该永生化哺乳动物皮肤角质形成细胞系的皮肤等效和体外毒性测定法。
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公开(公告)号：WO2008052963A1
公开(公告)日：2008-05-08
申请号：PCT/EP2007/061610
申请日：2007-10-29
Applicant: DKFZ DEUTSCHES KREBSFORSCHUNGSZENTRUM, STIFTUNG DES ÖFFENTLICHEN RECHTS , LANDESSTIFTUNG BADEN-WÜRTTEMBERG GMBH , STARK, Hans-Jürgen , MUFFLER, Sonja , AMOROS-ALONSO, Mara , FUSENIG, Norbert , BOUKAMP, Petra
Inventor： STARK, Hans-Jürgen , MUFFLER, Sonja , AMOROS-ALONSO, Mara , FUSENIG, Norbert , BOUKAMP, Petra
CPC classification number: C12N5/0698 , C12N2502/094 , C12N2502/1323 , C12N2503/06 , C12N2533/70 , C12Q1/02 , G01N33/5073 , G01N2500/02
Abstract: The present invention provides skin equivalents comprising human epidermal stem cells which are specifically labeled. The labeling is carried out with a marker capable of labeling slowly proliferating cells, e.g. iododeoxyuridine or PKH26. Particularly, the invention provides skin equivalents comprising labeled epidermal stem cells. The invention also provides corresponding uses and methods of using such cultures, e.g. in the fields of research and medical treatment of skin diseases.
Abstract translation: 本发明提供了包含特异性标记的人表皮干细胞的皮肤等同物。 标记用能够标记慢性增殖细胞的标记进行，例如， 碘脱氧尿苷或PKH26。 特别地，本发明提供了包含标记的表皮干细胞的皮肤等同物。 本发明还提供了相应的使用和使用这些培养物的方法。 在皮肤病研究和治疗领域。
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5.发明申请
公开(公告)号：WO2003057203A3
公开(公告)日：2003-07-17
申请号：PCT/EP2003/000078
申请日：2003-01-07
Applicant: FIDIA FARMACEUTICI S.P.A. , DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ) , FUSENIG, Norbert, E. , STARK, Hans-Jürgen , WILLHAUCK, Michael , PAVESIO, Alessandra
Inventor： FUSENIG, Norbert, E. , STARK, Hans-Jürgen , WILLHAUCK, Michael , PAVESIO, Alessandra
IPC: A61L27/00
Abstract: The use in the medical-surgical field of biomaterials based on hyaluronic acid derivatives, optionally in association with natural, synthetic or semisynthetic biopolymers, for suppressing the angiogenic process associated with tumour proliferation (in primary and secondary tumours) is disclosed.
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