公开(公告)号：WO2004012602A2

公开(公告)日：2004-02-12

申请号：PCT/EP0308246

申请日：2003-07-25

Applicant: ABBOTT LAB VASCULAR ENTPR LTD ,  MICHLITSCH KENNETH J

Inventor： MICHLITSCH KENNETH J

IPC: A61B17/12 ,  A61B17/00

CPC classification number: A61B17/0057 ,  A61B17/00491 ,  A61B2017/00637 ,  A61B2017/00654 ,  A61B2017/00659 ,  A61B2017/00672

Abstract: Apparatus (10) is provided for sealing a vascular puncture tract by forming the autologous plug within the puncture tract, and extruding that plug into the puncture tract. The apparatus of the present invention forms an autologous blood plug by drawing blood into the apparatus from a vessel, mixing a blood congealing agent with the drawn blood, and ejecting a plug formed from the clotted blood within the puncture tract. Also provided are various closure elements (22) to isolate the drawn blood from the vessel during mixture with the blood congealing agent, and to facilitate placement of the apparatus relative to the vessel.

Abstract translation: 设置装置（10），用于通过在穿刺道内形成自体塞子来密封血管穿刺管道，并将该塞子挤压到穿刺管道中。 本发明的装置通过从血管中将血液吸入装置，将血液凝固剂与抽取的血液混合，并在穿刺管内喷出由凝血血液形成的塞子，形成自体血栓。 还提供了各种封闭元件（22），以在与血液凝固剂混合期间将抽出的血液与血管隔离，并且便于相对于血管的装置放置。

公开(公告)号：WO2003024299A2

公开(公告)日：2003-03-27

申请号：PCT/US2002/029167

申请日：2002-09-12

Applicant: JOMED GMBH ,  JOERGENSEN, Erling, Ib. ,  SEIBOLD, Gerd ,  QUINT, Bodo, Stefan, Josef ,  MICHLITSCH, Kenneth, J. ,  BREMSER, Martina ,  VON OEPEN, Randolf

Inventor： JOERGENSEN, Erling, Ib. ,  SEIBOLD, Gerd ,  QUINT, Bodo, Stefan, Josef ,  MICHLITSCH, Kenneth, J. ,  BREMSER, Martina ,  VON OEPEN, Randolf

IPC: A61B

CPC classification number: A61M25/104 ,  A61F2/013 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0069

Abstract: Apparatus and methods for providing distal protection during a medical procedure comprising a vascular filter having a self-expanding, porous foam body that conformably seals against a vessel wall and capture emboli within one or more recesses. The filter is coupled to a distal region of an elongated member, such as a guide wire. Delivery systems for use with filters of the present invention and methods of using the apparatus of the present invention also are provided.

Abstract translation: 一种用于在医疗过程中提供远端保护的装置和方法，包括具有自膨胀多孔泡沫体的血管过滤器，所述自扩张多孔泡沫体适形地密封血管壁并在一个或多个凹部内捕获栓塞。 过滤器联接到诸如导丝的细长构件的远侧区域。 还提供了与本发明的过滤器一起使用的输送系统和使用本发明的装置的方法。

公开(公告)号：WO2005122914A3

公开(公告)日：2006-02-23

申请号：PCT/US2005020349

申请日：2005-06-08

Applicant: USGI MEDICAL INC ,  SAADAT VAHID ,  EWERS RICHARD C ,  MAAHS TRACY D ,  KHAIRKHAHAN ALEX ,  MICHLITSCH KENNETH J

Inventor： SAADAT VAHID ,  EWERS RICHARD C ,  MAAHS TRACY D ,  KHAIRKHAHAN ALEX ,  MICHLITSCH KENNETH J

IPC: A61B17/04 ,  A61B17/00 ,  A61B17/06 ,  A61B17/064 ,  A61B17/08 ,  A61B19/00

CPC classification number: A61B17/0644 ,  A61B17/0401 ,  A61B17/0469 ,  A61B17/0482 ,  A61B2017/00867 ,  A61B2017/0454 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2090/037

Abstract: Systems for optimizing anchoring force are described herein. In securing tissue folds, over-compression of the tissue directly underlying the anchors is avoided by utilizing tissue anchors having expandable arms configured to minimize contact area between the anchor and tissue. When the anchor is in its expanded configuration, a load is applied to the anchor until it is optimally configured to accommodate a range of deflections while the anchor itself exerts a substantially constant force against the tissue. Various devices, e.g., stops, spring members, fuses, strain gauges, etc., can be used to indicate when the anchor has been deflected to a predetermined level within the optimal range. Moreover, other factors to affect the anchor characteristics include, e.g., varying the number of arms or struts of the anchor, positioning of the arms, configuration of the arms, the length of the collars, etc.

Abstract translation: 这里描述了用于优化锚固力的系统。 在固定组织褶皱时，通过利用具有可扩张臂的组织锚来避免直接位于锚固件正下方的组织的过度压缩，所述组织锚构造成使锚和组织之间的接触面积最小化。 当锚固件处于其膨胀构型时，将负载施加到锚固件，直到其被最佳地构造成适应一定范围的偏转，同时锚固件本身对组织施加基本恒定的力。 可以使用各种装置，例如止动件，弹簧构件，保险丝，应变计等来指示锚固件何时被偏转到最佳范围内的预定水平。 此外，影响锚固特征的其他因素包括例如改变锚的臂或支柱的数量，臂的定位，臂的构型，套环的长度等。

公开(公告)号：WO2005065585A1

公开(公告)日：2005-07-21

申请号：PCT/US2004/041513

申请日：2004-12-10

Applicant: SADRA MEDICAL, INC. ,  SALAHIEH, Amr ,  BRANDT, Brian ,  MOREJOHN, Dwight, P. ,  MICHLITSCH, Kenneth, J. ,  SAUL, Tom

Inventor： SALAHIEH, Amr ,  BRANDT, Brian ,  MOREJOHN, Dwight, P. ,  MICHLITSCH, Kenneth, J. ,  SAUL, Tom

IPC: A61F2/06

CPC classification number: A61F2/013 ,  A61F2/2418 ,  A61F2/2439 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/008

Abstract: Apparatus (10) for protecting a patient against embolization during endovascular replacementduring endvascular replacement of the patient's heart valve is provided, the apparatus including a replacement valve (20) configured for endovascular delivery and deployment, and an embolic filter configured for disposal downstream of the replacement valve (20) during deployment of the valve. Apparatus including a delivery catheter having an expandable replacement valve (20) disposed therein, and an embolic filter advanceable along the delivery catheter for diverting emboli released during endovascular deployment of the replacement valve (20) is also provided. Furthermore, methods for protecting a patient against embolization during endovascular replacement of the patient's heart valve are provided, the methods including the steps of endovascularly deploying an embolic filter downstream of the heart valve, and endovascularly deploying the replacement valve.

Abstract translation: 提供了一种用于在血管内置换期间保护患者免受栓塞的装置（10），其中，所述装置包括构造成用于血管内递送和展开的置换瓣膜（20），以及构造成用于在所述置换 阀门（20）在展开阀门期间。 还提供了包括具有设置在其中的可扩张置换瓣膜（20）的递送导管的装置，以及沿输送导管可推进的栓塞过滤器，用于在置换瓣膜（20）的血管内展开期间释放栓塞。 此外，提供了用于在患者心脏瓣膜的血管内置换期间保护患者免受栓塞的方法，所述方法包括在心脏瓣膜下游血管内部署栓塞过滤器并且血管内部署替换瓣膜的步骤。

公开(公告)号：WO2004012605A1

公开(公告)日：2004-02-12

申请号：PCT/EP2003/008247

申请日：2003-07-25

Applicant: ABBOTT LABORATORIES VASCULAR ENTERPRISES, LIMITED ,  NIELSEN, Stevan ,  QUINT, Bodo ,  VON OEPEN, Randolf ,  MICHLITSCH, Kenneth, J. ,  SEIBOLD, Gerd ,  CONZELMANN, Tommy ,  JOERGENSEN, Ib Erling

Inventor： NIELSEN, Stevan ,  QUINT, Bodo ,  VON OEPEN, Randolf ,  MICHLITSCH, Kenneth, J. ,  SEIBOLD, Gerd ,  CONZELMANN, Tommy ,  JOERGENSEN, Ib Erling

IPC: A61B17/03

CPC classification number: A61B17/00491 ,  A61B17/0057 ,  A61B2017/00654 ,  A61B2017/0472

Abstract: Apparatus is provided for sealing a vascular puncture by causing a reduction in the circumference of the puncture tract through delivery of a closure agent into tissue surrounding the puncture tract. A resultant inflammatory response and volumetric increase cause the tissue to swell into the puncture tract, thereby sealing it.

Abstract translation: 提供了用于通过将封闭剂递送到穿刺道周围的组织中引起穿刺道周围的减少来密封血管穿刺的装置。 产生的炎症反应和体积增加导致组织溶胀到穿刺道中，从而将其密封。

公开(公告)号：WO2004012603A2

公开(公告)日：2004-02-12

申请号：PCT/EP2003/008248

申请日：2003-07-25

Applicant: ABBOTT LABORATORIES VASCULAR ENTERPRISES, LIMITED ,  SEIBOLD, Gerd ,  MICHLITSCH, Kenneth, J. ,  VON OEPEN, Randolf ,  QUINT, Bodo ,  JOERGENSEN, Ib, Erling ,  NIELSEN, Stevan ,  CONZELMANN, Tommy

Inventor： SEIBOLD, Gerd ,  MICHLITSCH, Kenneth, J. ,  VON OEPEN, Randolf ,  QUINT, Bodo ,  JOERGENSEN, Ib, Erling ,  NIELSEN, Stevan ,  CONZELMANN, Tommy

IPC: A61B17/00

CPC classification number: A61B17/0057 ,  A61B17/0643 ,  A61B2017/00004 ,  A61B2017/00477 ,  A61B2017/00659

Abstract: Apparatus is provided for sealing a puncture within a vessel or tissue to provide hemostasis, comprising a first disk coupled to either a second disk or a spring, and sealingly engaged to the vessel or tissue surrounding the puncture. At least the first disk is preferably configured to substantially conform to the profile of the vessel or tissue when deployed. In one embodiment, the disks may be released from engagement with the vessel or tissue to reposition the disks after deployment.

Abstract translation: 提供了用于密封容器或组织内的穿刺以提供止血的装置，包括联接到第二盘或弹簧的第一盘，并密封地接合到围绕穿刺的容器或组织。 至少第一盘优选地构造成在展开时基本上符合血管或组织的轮廓。 在一个实施例中，盘可以从与血管或组织的接合中释放，以在部署之后重新定位椎间盘。

公开(公告)号：WO03024299A3

公开(公告)日：2003-08-07

申请号：PCT/US0229167

申请日：2002-09-12

Applicant: JOMED GMBH ,  JOERGENSEN ERLING IB ,  SEIBOLD GERD ,  QUINT BODO STEFAN JOSEF ,  MICHLITSCH KENNETH J ,  BREMSER MARTINA ,  VON OEPEN RANDOLF

Inventor： JOERGENSEN ERLING IB ,  SEIBOLD GERD ,  QUINT BODO STEFAN JOSEF ,  MICHLITSCH KENNETH J ,  BREMSER MARTINA ,  VON OEPEN RANDOLF

IPC: A61F2/01 ,  A61M29/02 ,  A61M29/00

CPC classification number: A61M25/104 ,  A61F2/013 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0069

Abstract: Apparatus and methods for providing distal protection during a medical procedure comprising a vascular filter (10) having a self-expanding, porous foam body (12) that conformably seals against a vessel wall and captures emboli within one or more recesses (14). The filter is coupled to a distal region of an elongated member (18), such as a guide wire. Delivery systems for use with filters of the present invention and methods of using the apparatus of the present invention also are provided.

Abstract translation: 一种用于在医疗过程中提供远端保护的装置和方法，包括具有自膨胀多孔泡沫体（12）的血管过滤器（10），所述自扩张多孔泡沫体（12）可顺应地密封血管壁并在一个或多个凹槽（14）内捕获栓塞。 过滤器联接到诸如导丝的细长构件（18）的远侧区域。 还提供了与本发明的过滤器一起使用的输送系统和使用本发明的装置的方法。