公开(公告)号：WO2008027371A2

公开(公告)日：2008-03-06

申请号：PCT/US2007018906

申请日：2007-08-29

Applicant: SURMODICS INC ,  ERICKSON SIGNE R ,  LAWIN LAURIE R

Inventor： ERICKSON SIGNE R ,  LAWIN LAURIE R

IPC: A61F9/00

CPC classification number: A61F9/0017 ,  A61K9/0051

Abstract: Disclosed are implantable devices that are configured for implantation through tissue or membrane and into an implantation site comprising viscoelastic fluid or non-osseous tissue. In embodiments of the invention, the implantable devices comprise: (a) a nonlinear body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal portion and a distal portion, wherein at least a portion of the body member deviates from the direction of extension, (b) a retention element at the proximal portion of the body member, the retention element configured to retain the implantable device at the implantation site, the retention element presenting an external profile of no greater than 0.5 mm when the device is implanted in a patient; and (c) a bioactive agent delivery system at the distal portion of the body member, the bioactive agent delivery system comprising one or more bioactive agents. Also disclosed are methods of delivering a bioactive agent to a patient using the devices.

Abstract translation: 公开了被配置用于通过组织或膜植入并植入包括粘弹性流体或非骨组织的植入部位中的可植入装置。 在本发明的实施例中，可植入装置包括：（a）具有延伸方向的非线性主体构件，沿延伸方向的纵向轴线以及近端部分和远端部分，其中主体的至少一部分 构件从所述延伸方向偏离，（b）在所述主体构件的所述近侧部分处的保持元件，所述保持元件构造成将所述可植入装置保持在所述植入部位处，所述保持元件呈现不大于0.5mm 当该装置植入患者体内时; 和（c）位于身体构件远端部分的生物活性剂递送系统，生物活性剂递送系统包含一种或多种生物活性剂。 还公开了使用这些装置将生物活性剂递送给患者的方法。

公开(公告)号：WO2008006083A3

公开(公告)日：2008-01-10

申请号：PCT/US2007/072983

申请日：2007-07-06

Applicant: SURMODICS, INC. ,  KLOKE, Tim, M. ,  KEOUGH, Steven, J. ,  LOCKWOOD, Nathan ,  GARDNER, Margaret, R.

Inventor： KLOKE, Tim, M. ,  KEOUGH, Steven, J. ,  LOCKWOOD, Nathan ,  GARDNER, Margaret, R.

IPC: A61L31/16 ,  A61L31/10

Abstract: A wound spacer device comprising multiple beads connected by non-absorbable suture material is disclosed. The device can be applied, for example, by a first responder to an injured individual, or can be applied by a trauma treatment facility, such as a Level 2 medical unit. In typical embodiments the device allows for site-specific controlled elution of an antimicrobial agent, such as Tobramycin, including defined elution over a period of time, such as 48 or 72 hours.

公开(公告)号：WO2008003043A2

公开(公告)日：2008-01-03

申请号：PCT/US2007/072357

申请日：2007-06-28

Applicant: SURMODICS, INC. ,  CHAPPA, Ralph, A. ,  HERGENROTHER, Robert, W. ,  BUSHENDORF, Paula ,  SLAGER, Joram

Inventor： CHAPPA, Ralph, A. ,  HERGENROTHER, Robert, W. ,  BUSHENDORF, Paula ,  SLAGER, Joram

IPC: A61K9/00 ,  A61L27/48 ,  A61L27/54 ,  A61L27/58 ,  C08L33/06

CPC classification number: A61L27/58 ,  A61L27/48 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/256 ,  A61L2300/604 ,  C08L23/0853 ,  C08L23/0869 ,  C08L33/08 ,  C08L71/02 ,  C08L2201/06 ,  C08L2666/22

Abstract: The present invention relates to relates to combination degradable and non- degradable matrices and related methods. In an embodiment, the invention includes an active agent delivery matrix including a degradable polymer network, a non-degradable polymer network, the non-degradable polymer network interspersed within the degradable polymer network, and an active agent. In an embodiment, the invention includes an active agent elution control matrix including a degradable polymer; and a non-degradable polymer interspersed with the degradable polymer. In an embodiment, the invention includes a method of making an active agent delivery matrix including mixing a degradable polymer with a first solvent to form a degradable polymer solution; mixing a non-degradable polymer with a second solvent to form a non-degradable polymer solution; and simultaneously depositing the degradable polymer solution and the non-degradable polymer solution onto a substrate.

Abstract translation: 本发明涉及可降解和不可降解的组合和相关方法。 在一个实施方案中，本发明包括活性剂递送基质，其包括可降解聚合物网络，不可降解聚合物网络，散布在可降解聚合物网络内的不可降解聚合物网络和活性剂。 在一个实施方案中，本发明包括包含可降解聚合物的活性剂洗脱控制基质; 和散布有可降解聚合物的不可降解聚合物。 在一个实施方案中，本发明包括制备活性剂递送基质的方法，包括将可降解聚合物与第一溶剂混合以形成可降解聚合物溶液; 将不可降解的聚合物与第二溶剂混合以形成不可降解的聚合物溶液; 同时将可降解聚合物溶液和不可降解聚合物溶液沉积在基材上。

公开(公告)号：WO2006099470A3

公开(公告)日：2007-05-10

申请号：PCT/US2006009277

申请日：2006-03-14

Applicant: SURMODICS INC ,  FINLEY MICHAEL J

Inventor： FINLEY MICHAEL J

IPC: A61F2/01 ,  A61L27/34 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16

CPC classification number: A61L27/34 ,  A61F2/88 ,  A61F2002/30067 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/608 ,  A61L2420/08 ,  Y10T428/13 ,  Y10T428/1334 ,  Y10T428/1338 ,  Y10T428/1341 ,  Y10T428/1352 ,  Y10T428/1355 ,  Y10T428/1379 ,  Y10T428/1386 ,  Y10T428/1393 ,  Y10T428/31678 ,  Y10T428/31931

Abstract: Compliant coatings for insertable medical articles are provided. In some aspects, the coating includes a diene polymer-containing layer, and a second coated layer that includes another polymer. The coating can be formed by coupling the polymer of the second coated layer to the first coated layer via latent reactive groups, such as photoreactive groups. In other aspects, the insertable medical article has a coating that provides different functional features to different surfaces of the article. The medical article can have a cylindrical shape with an interior surface having a first coating, and an exterior surface with a second coating, wherein the article also includes a plurality of openings.

Abstract translation: 提供了可插入医疗用品的合适涂层。 在一些方面，涂层包括含二烯聚合物的层和包含另一种聚合物的第二涂层。 可以通过将潜在的反应性基团如光反应性基团将第二涂层的聚合物偶联到第一涂层来形成涂层。 在其它方面，可插入医疗制品具有向制品的不同表面提供不同功能特征的涂层。 医疗制品可以具有带有第一涂层的内表面和具有第二涂层的外表面的圆柱形形状，其中该制品还包括多个开口。

公开(公告)号：WO2007016405A2

公开(公告)日：2007-02-08

申请号：PCT/US2006/029555

申请日：2006-07-27

Applicant: SURMODICS, INC. ,  KLOKE, Timothy, M. ,  HERGENROTHER, Bob ,  LAWIN, Laurie, R.

Inventor： KLOKE, Timothy, M. ,  HERGENROTHER, Bob ,  LAWIN, Laurie, R.

CPC classification number: C09D133/14 ,  A61K31/785 ,  A61L15/44 ,  A61L27/34 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L33/064 ,  A61L2300/80 ,  C08L33/26

Abstract: The present invention relates to devices, articles, coatings, and methods for controlled active agent release and/or for providing a hemocompatible surface. More specifically, the present invention relates to copolymer compositions and devices, articles, and methods regarding the same for controlled active agent release. In an embodiment, the present invention includes a copolymer composition. The copolymer composition can include a copolymer and an active agent. In an embodiment, the copolymer includes an effective portion of a monomelic unit including a polar moiety. The active agent can be polar. The active agent can be charged. The active agent can be non-polar. In an embodiment, the copolymer composition includes a random copolymer. In an embodiment, the random copolymer includes butyl methacrylate-co-acrylamido-methyl-propane sulfonate copolymer, which can provide reduced platelet adhesion.

Abstract translation: 本发明涉及用于控制的活性剂释放和/或用于提供血液相容性表面的装置，制品，涂层和方法。 更具体地说，本发明涉及与受控活性剂释放相同的共聚物组合物和装置，制品和方法。 在一个实施方案中，本发明包括共聚物组合物。 共聚物组合物可以包括共聚物和活性剂。 在一个实施方案中，共聚物包括包含极性部分的单体单元的有效部分。 活性剂可以是极性的。 活性剂可以充电。 活性剂可以是非极性的。 在一个实施方案中，共聚物组合物包括无规共聚物。 在一个实施方案中，无规共聚物包括可提供降低的血小板粘附的甲基丙烯酸丁酯 - 共 - 丙烯酰氨基 - 甲基 - 丙烷磺酸共聚物。

公开(公告)号：WO2006107336A1

公开(公告)日：2006-10-12

申请号：PCT/US2005/035957

申请日：2005-10-06

Applicant: SURMODICS, INC. ,  DEWITT, David, M. ,  FINLEY, Michael, J. ,  LAWIN, Laurie, R.

Inventor： DEWITT, David, M. ,  FINLEY, Michael, J. ,  LAWIN, Laurie, R.

IPC: A61L31/10 ,  A61L31/16

CPC classification number: A61L27/50

Abstract: A coating composition and related method for use in applying a bioactive agent to a surface in a manner that will permit the bioactive agent to be released from the coating in vivo. The composition is particularly well suited for coating the surface of implantable medical device, such as a stent or catheter, in order to permit the device to release bioactive agent to the surrounding tissue over time. The composition includes a plurality of compatible polymers having different properties that can permit them to be combined together to provide an optimal combination of such properties as durability, biocompatibility, and release kinetics.

Abstract translation: 一种用于将生物活性剂施用于表面的涂料组合物和相关方法，其方式将允许生物活性剂在体内从涂层中释放。 组合物特别适用于涂覆可植入医疗装置（例如支架或导管）的表面，以便允许装置随着时间的推移向周围组织释放生物活性剂。 该组合物包括具有不同性质的多种相容性聚合物，其可以将它们组合在一起，以提供诸如耐久性，生物相容性和释放动力学之类的最佳组合。

公开(公告)号：WO2006091675A2

公开(公告)日：2006-08-31

申请号：PCT/US2006/006294

申请日：2006-02-23

Applicant: SURMODICS, INC. ,  WILLIAMS, Stuart, K. ,  BABCOCK, David, E. ,  CHINN, Joseph, A. ,  CLAPPER, David, L.

Inventor： WILLIAMS, Stuart, K. ,  BABCOCK, David, E. ,  CHINN, Joseph, A. ,  CLAPPER, David, L.

CPC classification number: A61K38/39 ,  A61K38/10 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L31/10 ,  A61L2300/25 ,  A61L2300/254 ,  A61L2300/606 ,  C08L89/00 ,  C08L89/06

Abstract: Laminin-containing coatings for the surfaces of implantable medical devices are disclosed. The coatings promote the formation of vessels in association with the coated surfaces with minimal fibrotic resonse.

Abstract translation: 公开了用于可植入医疗装置的表面的含层粘蛋白的涂层。 涂层促进与涂层表面相关联的血管的形成，具有最小的纤维化反应。

公开(公告)号：WO2006014484A3

公开(公告)日：2006-06-22

申请号：PCT/US2005023972

申请日：2005-07-05

Applicant: SURMODICS INC ,  DE JUAN EUGENE ,  VARNER SIGNE E ,  LAWIN LAURIE R

Inventor： DE JUAN EUGENE ,  VARNER SIGNE E ,  LAWIN LAURIE R

IPC: A61F9/00 ,  A61K9/00

CPC classification number: A61K9/0051 ,  A61F9/0017 ,  A61L27/54 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/43 ,  A61L2300/602 ,  A61L2430/16

Abstract: Featured is a method for instilling one or more bioactive agents into ocular tissue within an eye of a patient for the treatment of an ocular condition, the method comprising concurrently using at least two of the following bioactive agent delivery methods (A)-(C): (A) implanting a sustained release delivery device comprising one or more bioactive agents in a posterior region of the eye so that it delivers the one or more bioactive agents into the vitreous humor of the eye; (B) instilling (e.g., injecting or implanting) one or more bioactive agents subretinally; and (C) instilling (e.g., injecting or delivering by ocular iontophoresis) one or more bioactive agents into the vitreous humor of the eye.

Abstract translation: 特征是一种将一种或多种生物活性剂滴入患者眼睛内用于治疗眼部病症的眼组织的方法，所述方法包括同时使用以下生物活性剂递送方法中的至少两种（A） - （C） （A）将包含一种或多种生物活性剂的持续释放递送装置植入眼睛的后部区域，使得其将一种或多种生物活性剂递送至眼睛的玻璃体液中; （B）将一种或多种生物活性剂灌注（例如注射或植入） 和（C）将眼睛离子电渗疗法中的一种或多种生物活性剂灌注（例如，注射或递送）到眼睛的玻璃体液中。

公开(公告)号：WO2006063021A2

公开(公告)日：2006-06-15

申请号：PCT/US2005/044198

申请日：2005-12-06

Applicant: SURMODICS, INC. ,  CHAPPA, Ralph A. ,  LINDSOE, Kim

Inventor： CHAPPA, Ralph A. ,  LINDSOE, Kim

IPC: A61L27/34 ,  A61L27/54 ,  A61L27/50 ,  A61L31/10 ,  A61L31/16 ,  A61L31/14

CPC classification number: A61L31/16 ,  A61K6/0017 ,  A61K31/56 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L31/10 ,  A61L31/14 ,  A61L2300/216 ,  A61L2300/222 ,  A61L2300/43 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/63 ,  A61L2420/02 ,  A61L2420/06

Abstract: The present invention relates to coatings with crystallized active agent(s) and related methods. In an embodiment, the invention includes a method for coating a medical device including selecting a solvent and a polymer, selecting a concentration of an active agent of at least a certain amount of saturation, forming a coating composition having the selected concentration of the active agent, and applying the coating composition to the medical device. In an embodiment, the invention includes an elution control coating disposed on a medical device, the elution control coating including a polymer, and an active agent, wherein the active agent is at least about 80% crystallized within one week of being disposed on the medical device. In an embodiment, the invention includes a method for enhancing the formation of active agent crystals within a coating layer including forming a coating solution and adjusting the concentration of the active agent in the coating solution to reach some percentage of the active agent saturation point. In an embodiment, the invention includes a method of enhancing crystallization of an active agent, the method including forming a coating solution comprising a polymer, an active agent, and a solvent; applying the coating solution to a substrate; and increasing the rate of active agent nucleation within the coating.

Abstract translation: 本发明涉及具有结晶活性剂的涂层和相关方法。 在一个实施方案中，本发明包括用于涂覆医疗装置的方法，包括选择溶剂和聚合物，选择至少一定量饱和度的活性剂的浓度，形成具有选定浓度的活性剂的涂料组合物 ，并将所述涂料组合物施用于所述医疗装置。 在一个实施方案中，本发明包括设置在医疗装置上的洗脱控制涂层，洗脱控制涂层包括聚合物和活性剂，其中活性剂在被放置在医疗上的一周内至少约80％结晶 设备。 在一个实施方案中，本发明包括一种用于增强涂层内活性剂晶体形成的方法，包括形成涂层溶液并调节涂层溶液中活性剂的浓度达到活性剂饱和点的一定百分比。 在一个实施方案中，本发明包括增强活性剂结晶的方法，所述方法包括形成包含聚合物，活性剂和溶剂的涂布溶液; 将涂布溶液涂布到基材上; 并增加涂层内活性剂成核的速率。

公开(公告)号：WO2006047617A1

公开(公告)日：2006-05-04

申请号：PCT/US2005/038628

申请日：2005-10-26

Applicant: SURMODICS, INC. ,  CHAPPA, Ralph, A.

Inventor： CHAPPA, Ralph, A.

IPC: B05B13/02 ,  B05C13/02

CPC classification number: B05B13/0228

Abstract: The invention relates to methods and apparatus for a medical device having a cylindrical shape like a stent. The invention includes a coating solution supply member having a major axis oriented parallel to a gap between rollers on a coating apparatus on which gap the sent is placed and rotated. The method includes removing a static charge from the small diameter medical device.

Abstract translation: 本发明涉及一种具有圆柱形状的支架的医疗装置的方法和装置。 本发明包括涂层溶液供应构件，该涂层溶液供应构件具有平行于涂覆装置上的辊之间的间隙的主轴，所述涂覆装置在其上放置并旋转所发送的间隙。 该方法包括从小直径医疗装置中去除静电荷。