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    HEMOSTASIS SEALING DEVICE WITH CONSTRICTION RING
    2.
    发明申请
    HEMOSTASIS SEALING DEVICE WITH CONSTRICTION RING 审中-公开
    带限制环的模体密封装置

    公开(公告)号：WO2017218634A1

    公开(公告)日：2017-12-21

    申请号：PCT/US2017/037410

    申请日：2017-06-14

    Applicant: SURMODICS, INC.

    Inventor： SUTTON, Gregg Stuart

    IPC: A61M39/06 ,  A61M39/00

    Abstract: Aspects herein relate to a medical device for providing a leak-resistant seal for use in a vascular access device. In various embodiments, a device for vascular access hemostasis is included. The device can include an enclosure configured to at least partially receive a medical device, the enclosure defining a cavity. The enclosure can have a first seal portion and a second seal portion, the cavity disposed between the first seal portion and the second seal portion. The enclosure can include the second seal portion comprising a split, septum seal. The enclosure can include a barrel in structural communication with the second seal portion. The device can include a constriction ring disposed around the barrel, the constriction ring interfacing with the second seal portion to limit movement of the split, septum seal.

    Abstract translation: 本文的各方面涉及用于提供用于血管通路装置中的防漏密封件的医疗装置。 在各种实施例中，包括用于血管通路止血的装置。 该装置可以包括被配置成至少部分地接收医疗装置的外壳，该外壳限定腔体。 外壳可以具有第一密封部分和第二密封部分，该空腔设置在第一密封部分和第二密封部分之间。 该外壳可以包括第二密封部分，该第二密封部分包括分隔的隔膜密封。 外壳可以包括与第二密封部分结构连通的筒。 该装置可以包括设置在筒体周围的收缩环，该收缩环与第二密封部分连接以限制分开的隔膜密封的移动。

    COMPOSITIONS AND METHODS FOR IN VITRO DIAGNOSTIC TESTS INCLUDING SULFONIC ACID
    4.
    发明申请
    COMPOSITIONS AND METHODS FOR IN VITRO DIAGNOSTIC TESTS INCLUDING SULFONIC ACID 审中-公开
    用于体液检测的组合物和方法，包括硫酸

    公开(公告)号：WO2013142758A1

    公开(公告)日：2013-09-26

    申请号：PCT/US2013/033429

    申请日：2013-03-22

    Applicant: SURMODICS, INC. ,  OPPERMAN, Gary ,  NELSON, Wendy

    Inventor： OPPERMAN, Gary ,  NELSON, Wendy

    IPC: C12Q1/28 ,  G01N33/52 ,  G01N33/535 ,  G01N33/558 ,  G01N33/58

    CPC classification number: G01N33/581 ,  C12Q1/28 ,  G01N21/78 ,  G01N33/52 ,  G01N33/535 ,  G01N33/558

    Abstract: The invention provides compositions, kits, and methods for performing colorimetric analysis. A substrate is reacted to generate a chromogenic reaction product, and a reaction stop reagent that is a sulfonic acid is added to stop and stabilize the reaction product. The absorbance properties of the chromogenic reaction product can be maintained over significantly longer periods of time of that of conventional reagents and methods. The sulfonic acid can be used in assays such as ELISAs in order to provide a more accurate and safer detection of analytes in a biological sample.

    Abstract translation: 本发明提供用于进行比色分析的组合物，试剂盒和方法。 使底物反应生成显色反应产物，并加入作为磺酸的反应停止试剂以停止并稳定反应产物。 显色反应产物的吸光度特性可以在常规试剂和方法的显着更长的时间内保持。 磺酸可用于诸如ELISA的测定中，以便提供对生物样品中分析物的更准确和更安全的检测。

    PHOTO-VINYL LINKING AGENTS
    5.
    发明申请
    PHOTO-VINYL LINKING AGENTS 审中-公开
    紫胶连接剂

    公开(公告)号：WO2012170706A2

    公开(公告)日：2012-12-13

    申请号：PCT/US2012/041381

    申请日：2012-06-07

    Applicant: SurModics, Inc. ,  SWAN, Dale G. ,  KURDYUMOV, Aleksey V. ,  JELLE, Bruce M.

    Inventor： SWAN, Dale G. ,  KURDYUMOV, Aleksey V. ,  JELLE, Bruce M.

    IPC: C08J7/16 ,  A61L31/10

    CPC classification number: C09D4/00 ,  A61L27/34 ,  A61L27/50 ,  A61L29/085 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14 ,  A61L2420/02 ,  C07F9/4078 ,  C08J7/16 ,  Y10T428/31938

    Abstract: Embodiments of the invention include linking agents including photo groups and vinyl groups and coatings and devices that incorporate such linking agents, along with related methods. Exemplary methods herein include methods of priming substrates and methods of coating substrates using compounds having the formula R 1 - X - R 2 , wherein R 1 is a radical comprising a vinyl group, X is a radical comprising from about one to about twenty carbon atoms, and R 2 is a radical comprising a photoreactive group. Embodiments herein also include linking agents having the formula R 1 - X - R 2 , wherein R 1 is a radical comprising a vinyl group, X is a radical comprising from about one to about twenty carbon atoms, and R 2 is a radical comprising a photoreactive group. Other embodiments are also included herein.

    Abstract translation: 本发明的实施方案包括包括光学基团和乙烯基的连接剂以及包含这种连接剂的涂层和装置以及相关方法。 本文的示例性方法包括引发底物的方法和使用具有式R1-X-R2的化合物涂覆底物的方法，其中R 1是包含乙烯基的基团，X是包含约1至约20个碳原子的基团，R 2 是包含光反应性基团的基团。 本文的实施方案还包括具有式R 1 -X-R 2的连接剂，其中R 1是包含乙烯基的基团，X是包含约1至约20个碳原子的基团，R 2是包含光反应性基团的基团。 本文还包括其它实施例。

    FLUORINATED POLYMERS AND LUBRICIOUS COATINGS
    7.
    发明申请
    FLUORINATED POLYMERS AND LUBRICIOUS COATINGS 审中-公开

    公开(公告)号：WO2012006135A3

    公开(公告)日：2012-01-12

    申请号：PCT/US2011/042282

    申请日：2011-06-29

    Applicant: SURMODICS, INC. ,  ROLFES MEYERING, Emily R.

    Inventor： ROLFES MEYERING, Emily R.

    IPC: C08F226/10

    Abstract: The invention provides fluorinated polymeric articles formed a composition including a fluoropolymer. The fluoropolymer is formed using a fluorinated monomer that provides the fluoropolymer with most or all of the fluorine atoms not directly covalently attached to an atom of the fluoropolymer backbone. The fluoropolymer can also include a non-fluorinated hydrophilic monomer in a weight amount greater than the fluorinated monomer. The fluoropolymer composition also includes an ultraviolet light (UV)-reactive group capable of covalent bonding to promotes formation of the fluorinated polymeric article. The fluorinated polymeric article can be in the form of a durable lubricious coating on the surface of an implantable medical device. Coatings of the invention exhibit excellent wet/dry lubricity, durability, and controlled swelling.

    CATHETER ASSEMBLY
    8.
    发明申请
    CATHETER ASSEMBLY 审中-公开
    导管总成

    公开(公告)号：WO2012003296A1

    公开(公告)日：2012-01-05

    申请号：PCT/US2011/042556

    申请日：2011-06-30

    Applicant: SURMODICS, INC. ,  CHAPPA, Ralph, A.

    Inventor： CHAPPA, Ralph, A.

    IPC: A61M25/10

    CPC classification number: A61M25/1034 ,  A61M25/104 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2025/1075 ,  A61M2025/1086 ,  A61M2025/1093

    Abstract: A catheter assembly includes an expandable and collapsible structure (12) having an outer surface (22). The expandable and collapsible structure is adapted to expand between a contracted state and a dilated state. A coating (32) is disposed on the outer surface of the expandable and collapsible structure. The coating includes a bioactive agent. A sleeve (14) is disposed over the coating. The sleeve is adapted to expand between a compressed state and an enlarged state and to return to the compressed state. The sleeve defines a plurality of openings (150) in the compressed state. An outer diameter of the coating is less than an outer diameter of the sleeve when the expandable and collapsible structure is in the contracted state and greater than the outer diameter of the sleeve when the expandable and collapsible structure is in the dilated state.

    Abstract translation: 导管组件包括具有外表面（22）的可膨胀和可折叠结构（12）。 可膨胀和可折叠结构适于在收缩状态和膨胀状态之间膨胀。 涂层（32）设置在可膨胀和可折叠结构的外表面上。 涂层包括生物活性剂。 套管（14）设置在涂层上方。 套筒适于在压缩状态和放大状态之间膨胀并返回到压缩状态。 套筒限定了处于压缩状态的多个开口（150）。 当可膨胀和可折叠结构处于收缩状态时，当可膨胀和可折叠结构处于膨胀状态时，涂层的外径小于套筒的外径，并且大于套筒的外径。

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