公开(公告)号：WO2011028987A3

公开(公告)日：2011-09-01

申请号：PCT/US2010047788

申请日：2010-09-03

Applicant: UNIV TENNESSEE RES FOUNDATION ,  ARMEL GREGORY RUSSELL ,  KOPSELL DEAN ADAM ,  BROSNAN JAMES T ,  HORVARTH BRANDON J ,  SOROCHAN JOHN CHARLES

Inventor： ARMEL GREGORY RUSSELL ,  KOPSELL DEAN ADAM ,  BROSNAN JAMES T ,  HORVARTH BRANDON J ,  SOROCHAN JOHN CHARLES

IPC: A01G7/06 ,  A01H1/06 ,  A01N25/00

CPC classification number: A01N43/70 ,  A01N37/34 ,  A01N37/40 ,  A01N41/10 ,  A01N43/16 ,  A01N43/40 ,  A01N43/653 ,  A01N43/707 ,  A01N43/80 ,  A01N43/88 ,  A01N47/30 ,  A01N47/36 ,  A01N57/16 ,  A01N2300/00

Abstract: The subject application provides methods for the direct or indirect improvement of levels of key phytonutrients and/or stress tolerance in plants. Methods of providing for the improvement in key phytonutrient levels and/or stress tolerance in plants are provided through the application of safeners, herbicides, fungicides, insecticides, nematicides, miticides, defoliants/desiccants. antibiotics, and/or plant growth regulators to plants. Agricultural products arising from the disclosed methods are also provided.

Abstract translation: 本申请提供了用于直接或间接改善植物中关键植物营养素水平和/或胁迫耐受性的方法。 通过施用安全剂，除草剂，杀真菌剂，杀虫剂，杀线虫剂，杀螨剂，脱叶剂/干燥剂来提供改善植物中关键植物营养素水平和/或胁迫耐受性的方法。 抗生素和/或植物生长调节剂。 还提供了从所公开的方法产生的农产品。

公开(公告)号：WO2011028912A3

公开(公告)日：2011-07-14

申请号：PCT/US2010047690

申请日：2010-09-02

Applicant: UNIV TENNESSEE RES FOUNDATION ,  LEVIN MICHAEL C ,  LEE SANGMIN

Inventor： LEVIN MICHAEL C ,  LEE SANGMIN

IPC: G01N33/53 ,  C40B40/10 ,  G01N33/68

CPC classification number: G01N33/564 ,  A61K39/00 ,  C07K14/4713 ,  C07K2319/00 ,  G01N33/6896 ,  G01N2800/2814 ,  G01N2800/2821 ,  G01N2800/2828 ,  G01N2800/2835 ,  G01N2800/285

Abstract: The present invention provides a method of detecting or diagnosing a neurodegenerative disease or condition in a subject. Further aspects of the invention provide a method of monitoring a subject over a period of time to detect the development or progress of a neurodegenerative disease or condition. Methods of treating, detecting or diagnosing a neurodegenerative disease or condition in a subject are also provided.

Abstract translation: 本发明提供了检测或诊断受试者中的神经退行性疾病或病症的方法。 本发明的其他方面提供了在一段时间内监测受试者以检测神经退行性疾病或病症的发展或进展的方法。 还提供了治疗，检测或诊断受试者的神经退行性疾病或病症的方法。

公开(公告)号：WO2011022692A3

公开(公告)日：2011-06-16

申请号：PCT/US2010046222

申请日：2010-08-20

Applicant: UNIV TENNESSEE RES FOUNDATION ,  MOORE BOB M II ,  GURLEY STEVEN ,  MUSTAFA SUNI

Inventor： MOORE BOB M II ,  GURLEY STEVEN ,  MUSTAFA SUNI

IPC: C07D491/048 ,  A61K31/4355 ,  A61P35/00 ,  C07D213/02 ,  C07D409/04

CPC classification number: C07D491/04 ,  A61K31/4355

Abstract: Furanopyridine cannabinoid analog compounds of the formula (I) are disclosed. The compounds are useful to modify the activity of CB 1 and CB2 receptors and treat conditions mediated by these receptors.

Abstract translation: 公开了式（I）的呋喃并吡啶大麻素类似物。 该化合物可用于改变CB 1和CB 2受体的活性并治疗由这些受体介导的病症。

公开(公告)号：WO2011022679A3

公开(公告)日：2011-06-16

申请号：PCT/US2010046208

申请日：2010-08-20

Applicant: UNIV TENNESSEE RES FOUNDATION ,  MOORE BOB M II ,  GURLEY STEVEN ,  MUSTAFA SUNI

Inventor： MOORE BOB M II ,  GURLEY STEVEN ,  MUSTAFA SUNI

IPC: C07D407/04 ,  A61K31/343 ,  A61P35/00 ,  C07D307/83 ,  C07D409/04

CPC classification number: C07D409/04 ,  A61K31/381 ,  A61K31/4192 ,  A61K31/4406 ,  C07D307/79 ,  C07D491/04

Abstract: Furanopyridine cannabinoid analog compounds of the formula I are disclosed. The compounds are useful to modify the activity of CB 1 and CB2 receptors and treat conditions mediated by these receptors.

Abstract translation: 公开了式I的呋喃并吡啶大麻素类似物。 该化合物可用于改变CB 1和CB 2受体的活性并治疗由这些受体介导的病症。

公开(公告)号：WO2010091353A3

公开(公告)日：2010-11-25

申请号：PCT/US2010023485

申请日：2010-02-08

Applicant: UNIV TENNESSEE RES FOUNDATION ,  CHEN FENG ,  ZHAO NAN ,  ARMEL GREGORY RUSSELL

Inventor： CHEN FENG ,  ZHAO NAN ,  ARMEL GREGORY RUSSELL

IPC: A01H5/00 ,  C12N15/54 ,  C12N15/82

CPC classification number: C12N9/1007 ,  A01N39/02 ,  A01N39/04 ,  C12N9/1003 ,  C12N15/8274

Abstract: The subject invention provides novel polynucleotides and polypeptides encoding a methyltransferase. The subject invention provides novel plants that express the methyltrasferase disclosed herein and are resistant to auxin-based herbicides. The subject invention also provides transgenic plants that have been transformed with one or more other herbicide resistance genes such that the plants are resistant to the application of auxin-based herbicides and one or more other herbicides.

Abstract translation: 本发明提供了编码甲基转移酶的新型多核苷酸和多肽。 本发明提供了表达本文公开的甲基转移酶并且对生长素基除草剂具有抗性的新型植物。 本发明还提供已经用一种或多种其它除草剂抗性基因转化的转基因植物，使得植物对施用生长素基除草剂和一种或多种其它除草剂具有抗性。

公开(公告)号：WO2010074776A3

公开(公告)日：2010-08-19

申请号：PCT/US2009047572

申请日：2009-06-16

Applicant: UNIV TENNESSEE RES FOUNDATION ,  UNIV OHIO STATE RES FOUND ,  MILLER DUANE D ,  LI WEI ,  WANG ZHAO ,  LU YAN ,  CHEN JIANJUN ,  DALTON JAMES T ,  LI CHIEN-MING

Inventor： MILLER DUANE D ,  LI WEI ,  WANG ZHAO ,  LU YAN ,  CHEN JIANJUN ,  DALTON JAMES T ,  LI CHIEN-MING

IPC: A01N43/64 ,  A61K31/41

CPC classification number: C07D403/04 ,  A61K31/421 ,  A61K31/426

Abstract: Compounds according to formula (I) are disclosed, (I), where Q is S, N, or O; X is optional, and can be O=, S=, =N-NH2, =N-OH, or -OH; Y is optional and can be -N(H)-, O, or C1 to C20 hydrocarbon; and R1 and R2 are each independently substituted or unsubstituted single-, fused- or multiple-ring aryl or (hetero)cyclic ring systems. Methods of making these compounds, pharmaceutical compositions containing the compounds, and their use, particularly for treating or preventing cancer, are also disclosed.

Abstract translation: 公开了根据式（I）的化合物，（I），其中Q是S，N或O; X是可选的，并且可以是O =，S =，= N-NH 2，= N-OH或-OH; Y是任选的并且可以是-N（H） - ，O或C1至C20烃; 并且R 1和R 2各自独立地为取代或未取代的单环，稠环或多环芳基或（杂）环系。 还公开了制备这些化合物的方法，含有该化合物的药物组合物及其用途，特别是用于治疗或预防癌症的用途。

公开(公告)号：WO2010045379A3

公开(公告)日：2010-07-22

申请号：PCT/US2009060706

申请日：2009-10-14

Applicant: UNIV TENNESSEE RES FOUNDATION ,  GURLEY STEVEN ,  MUSTAFA SUNI ,  MOORE BOB M

Inventor： GURLEY STEVEN ,  MUSTAFA SUNI ,  MOORE BOB M

IPC: C07D239/52 ,  A61K31/44 ,  A61K31/505 ,  A61P35/00 ,  C07D213/69

CPC classification number: C07D409/06 ,  A61K31/44 ,  A61K31/505 ,  C07D213/69

Abstract: Disclosed are compounds of the formula (I): wherein R1, R2, V, W, X, Y and Z can be as defined herein. The compounds can be used in the treatment of disorders mediated by the cannabinoid receptors.

Abstract translation: 公开了式（I）化合物：其中R 1，R 2，V，W，X，Y和Z可以如本文所定义。 这些化合物可用于治疗由大麻素受体介导的病症。

公开(公告)号：WO2010060048A2

公开(公告)日：2010-05-27

申请号：PCT/US2009065558

申请日：2009-11-23

Applicant: UNIV TENNESSEE RES FOUNDATION ,  ADCOCK JAMIE L ,  COLVIN ANDREW J

Inventor： ADCOCK JAMIE L ,  COLVIN ANDREW J

IPC: C07C43/12 ,  C07C41/22 ,  C08G65/332

CPC classification number: C07C43/313 ,  C07C41/48 ,  C08G65/007

Abstract: Compounds of Formula (I): R1-O-(CF2-O)n-R1, wherein: n is an integer from 2 to 100; and R1 is perfluorinated alkyl or substituted perfluorinated alkyl are described. Also described are methods of preparing the compounds of Formula (I). For example, compounds of Formula (I) can be prepared by providing a poly(oxymethylene) compound and fluohnating the poly(oxymethylene) compound, for instance, via direct aerosol fluorination.

Abstract translation: 式（I）化合物：R1-O-（CF2-O）n-R1，其中：n是2至100的整数; 并描述了R1是全氟化烷基或取代的全氟化烷基。 还描述了制备式（I）化合物的方法。 例如，式（I）化合物可以通过提供聚（氧化亚甲基）化合物并例如通过直接气溶胶氟化氟化聚（氧化亚甲基）化合物来制备。

公开(公告)号：WO2009038779A3

公开(公告)日：2009-11-12

申请号：PCT/US2008010924

申请日：2008-09-19

Applicant: UNIV TENNESSEE RES FOUNDATION ,  DIVI MURALI KRISHNA ,  WOOD GEORGE C ,  GABER M WALEED ,  THOMA LAURA

Inventor： DIVI MURALI KRISHNA ,  WOOD GEORGE C ,  GABER M WALEED ,  THOMA LAURA

IPC: A61K47/48 ,  A61K49/00 ,  A61P35/00

CPC classification number: A61K49/0047 ,  A61K47/6911 ,  A61K49/0032 ,  A61K49/0084

Abstract: Provided are methods for inhibiting undesirable proliferation of a tumor cell or a tumor in a subject including administering to the subject a composition that includes an effective amount of an active agent, wherein the active agent is entrapped by one or more liposomes, the active agent has activity in inhibiting undesirable proliferation of the tumor cell or the tumor, and the one or more liposomes include one or more targeting agents that preferentially or specifically bind to a binding molecule expressed by the tumor cell or the tumor, present on the tumor cell or the tumor, present in the tumor cell or the tumor, or combinations thereof. Also provided are compositions for treating tumors, particularly gliomas, in a subject in need thereof.

Abstract translation: 提供了用于抑制受试者中肿瘤细胞或肿瘤的不良增殖的方法，其包括向受试者施用包含有效量的活性剂的组合物，其中活性剂被一种或多种脂质体包埋，活性剂具有 抑制肿瘤细胞或肿瘤的不良增殖的活性，并且一种或多种脂质体包括优选或特异性结合肿瘤细胞或肿瘤表达的结合分子的一种或多种靶向剂，存在于肿瘤细胞或肿瘤细胞上 存在于肿瘤细胞或肿瘤中的肿瘤，或其组合。 还提供了用于在有需要的受试者中治疗肿瘤，特别是神经胶质瘤的组合物。

公开(公告)号：WO2009086141A2

公开(公告)日：2009-07-09

申请号：PCT/US2008087740

申请日：2008-12-19

Applicant: UNIV TENNESSEE RES FOUNDATION ,  WANG SIQUN ,  XING CHENG

Inventor： WANG SIQUN ,  XING CHENG

IPC: C09J11/06

CPC classification number: C09J101/02 ,  C08J3/203 ,  C08J2461/10 ,  C08K3/346 ,  C08K7/04 ,  C09J11/04 ,  C09J11/08 ,  C09J161/06 ,  C09J2461/00 ,  E04C2/16 ,  Y10T428/249925

Abstract: The present disclosure relates to additives used in conjunction with adhesives to give enhanced performance. Engineered composite wood materials and methods of making such materials are also provided by the subject application. A reinforced adhesive includes an adhesive and an additive material comprising nanoscopic and microscopic materials.

Abstract translation: 本公开涉及与粘合剂结合使用以增强性能的添加剂。 本发明还提供了工程复合木材以及制造这种材料的方法。 增强型粘合剂包括粘合剂和包含纳米和微观材料的添加剂材料。