摘要:
모세관력을 이용하여 혈액으로부터 혈장을 분리하되 원치 않는 방향으로의 혈액 누수를 방지할 수 있는 혈구 분리 칩이 개시된다. 하나 이상의 에지가 비접촉되도록 멤브레인을 고정시키고, 상기 멤브레인에 의해 혈액으로부터 분리된 혈장성분이 일 방향으로 진행되도록 하는 경로를 제공하기 위한 채널의 일부가 형성된 상부기판 및 상기 상부기판과 접합하여 상기 채널을 형성하는 상기 채널의 다른 일부가 형성되고, 상기 멤브레인의 하면 일측에 대응되는 위치에 상기 혈장이 모세관력에 의해 상기 채널을 따라 진행하도록 하는 하부기판을 포함하는 혈구 분리 칩에 의하면, 멤브레인의 각 에지가 상부기판과 하부기판이 접합한 구조물에 최대한 비접촉되도록 하여 로딩된 혈액이 원치 않는 방향으로 누수되는 것을 방지할 수 있다.
摘要:
L'invention concerne un flacon de conditionnement d'un liquide à distribuer goutte à goutte comprenant un réservoir à paroi à déformation élastiquement réversible par admission d'air à l'intérieur du récipient, surmonté d'une tête de distribution du liquide comportant un embout compte-gouttes dépassant à l'extérieur du flacon et une membrane filtrante anti-bactérienne, réalisée partiellement hydrophile et partiellement hydrophobe, qui est interposée en travers de la circulation du liquide et de l'air, à la base dudit embout. La tête de distribution comporte un insert à corps évidé qui contient un tampon poreux régulateur du flux de liquide placé en aval du réservoir et en amont d'une chambre délimitée en aval par ladite membrane. A la base de cet insert du côté interne au flacon, des arches longitudinales supportant une pastille centrale ménagent des passages en étoile guidant radialement l'air qui pénètre dans le flacon après avoir traversé le tampon poreux.
摘要:
A risk of thrombogenesis is minimized in a tubular fiber membrane filter by flowing blood or other fluid through a header manifold that ensures a minimum shear rate on the wetted surfaces without flow reversal, stagnation volumes, or a shear rate that is too high. In an embodiment, fluid is conveyed into a header space and into a manifold face at a perimeter of the header space. The header space has a progressively decreasing clearance that is minimal to provide for substantial shear rate and decreasing toward a minimum clearance in a region that is remote from the perimeter and vented by openings to the micro tubular membrane fibers. Other features and embodiments are described.
摘要:
The present disclosure concerns embodiments of a microfluidic transfer device. The device mitigates risk of cross contamination between working fluids and is amenable to high-volume, low-cost manufacturing techniques. The device may be configured for mass transfer, heat transfer, or both. For instance, certain disclosed embodiments incorporate semi-permeable membranes to transfer target substances from one fluid to another. Moreover, the device may incorporate both heat and mass transfer components.
摘要:
The present invention provides a central core element for separator assemblies useful in the purification of fluids, for example separator assemblies useful for the desalination of seawater. The central core element provided by the present invention comprises at least two porous exhaust conduits (18) wherein each porous exhaust conduit comprises an exhaust channel and one or more openings which allow fluid communication between an exterior surface of the porous exhaust conduit and the exhaust channel. The central core element defines a cavity into which may be disposed a first portion of a membrane stack assembly (110,112,116). In the preparation of a separator assembly comprising the central core element provided by the present invention, a second portion of the membrane stack assembly forms a multilayer membrane assembly disposed around the central core element. Also provided are central core elements for salt separator assemblies and spiral flow reverse osmosis devices.
摘要:
The present invention generally relates to a filtration system having one or more apparatuses for filtering gases, liquids, or fluids (e.g., water) to remove particulate matter, and methods of making and using the apparatus. More particularly, embodiments relate to apparatuses and methods for applying centrifugal force(s) to push a fluid or gas to be filtered through a porous membrane or filter within the apparatus to separate particulate matter therefrom. The present invention takes advantage of the Coriolis effect within a cylindrical filter radiating out from a rotating central body. The filtration apparatus provides an energy efficient system for microfiltration (or other filtration process) to remove contaminants from gases and fluids, such as waste water.
摘要:
A reverse osmosis system in fluid communication with a fluid reservoir (114) and a method of operating the same includes a pressure vessel (102) having a membrane therein, a high pressure fluid input (108), a low pressure fluid input (110), a permeate output and a brine output. The system further includes a high pressure valve, a low pressure valve and a high pressure pump (116) in fluid communication with the high pressure input through the high pressure valve. The system also includes a low pressure pump (124) in fluid communication with the low pressure input through' the low pressure valve. The high pressure pump and the low pressure pump are in fluid communication with the fluid reservoir. The low pressure pump initially fills or rinses the pressure vessel and the high pressure pump operates during permeate production. Other embodiments use a charge reservoir instead of a low pressure pump.
摘要:
Filtration device suited for concentration of liquid samples, particularly biomolecules, and a method of concentrating, desalting, purifying and/or fractionating liquid samples. In certain embodiments the device includes a housing having a sample reservoir, and two substantially vertically oriented and spaced apart membranes disposed in the housing. An underdrain is associated with each membrane such that fluid passing through each membrane flows through a respective underdrain into a filtrate collection chamber. The fluid that does not pass through the membrane is collected in the retentate collection chamber, and can be recovered such as by a reverse spinning step, achieving recoveries greater than about 90%. The substantially vertical orientation of the membranes increases the available membrane area by at least 2.7 times the area available in a conventional filter device. The two-panel configuration also maintains more available membrane area in use during the last stages of filtration than a one-panel configuration.
摘要:
There is provided a linear device (100) for microdialysis, comprising a length of tubing (102) having at least one lumen (118) wherein at least one tubular membrane sleeve (104) is coaxiallyarranged outside the tubing periphery and extending at least partially along the peripheryofthe tubing (102). The membrane sleeve (104) is extending intermediate the ends of the tubing (102), and the tubing (102) extends at least through the tubular membrane sleeve (104). There is also provided a method of manufacturing the linear device (100) and a method wherein the linear device (100) is used.