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公开(公告)号：WO2018060437A1
公开(公告)日：2018-04-05
申请号：PCT/EP2017/074798
申请日：2017-09-29
申请人： SINTEF TTO
发明人： MØRCH, Yrr , HANSEN, Rune , SCHMID, Ruth , JOHANSEN, Heidi , STENSTAD, Per
摘要： The present invention is generally directed to improvements in the treatment of cancer and diseases in the central nervous system. A new drug delivery system is provided, method for producing it and medical uses.
摘要翻译： 本发明总体上涉及治疗中枢神经系统中的癌症和疾病的改进。 提供了新的药物输送系统，生产它的方法和医疗用途。
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公开(公告)号：WO2017184672A1
公开(公告)日：2017-10-26
申请号：PCT/US2017/028257
申请日：2017-04-19
摘要： The invention provides novel apparatus and methods for efficiently and accurately filling vials with gaseous materials such as a fluorinated gas, with or without concomitantly filling the vials with another liquid or solid material.
摘要翻译： 本发明提供了新颖的装置和方法，用于有效和准确地用气体材料例如氟化气体填充小瓶，伴随或不伴随其他液体或固体材料填充小瓶。
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公开(公告)号：WO2017087775A1
公开(公告)日：2017-05-26
申请号：PCT/US2016/062728
申请日：2016-11-18
CPC分类号： A61K9/107 , A61K9/127 , A61K41/0028 , A61K47/6925
摘要： Phase change nanodroplet conjugates and methods of making and using thereof are provided. The phase change nanodroplet conjugates include a nanodroplet having a gaseous precursor on the interior and an outer shell such as a lipid monolayer, a lipid bilayer, or a polymer layer. The phase change nanodroplet conjugates can have one or more nanoparticles attached to the outer layer, e.g. via a linker. The nanoparticles can include therapeutic, prophylactic, or diagnostic nanoparticles. The phase change nanodroplet conjugates can be used for the targeted delivery of a therapeutic, prophylactic, or diagnostic nanoparticle to a target region in a subject in need thereof. The methods can include applying an effective amount of ultrasound radiation to the target region to stimulate vaporization of the gaseous precursor followed by cavitation of the resultant bubble conjugate and release or dispersing of drug or drugs inside the liposomes. Methods of making phase change nanodroplet conjugates are also provided.
摘要翻译： 提供了相变纳米滴共轭物及其制备和使用方法。 相变纳米滴共轭物包括在内部具有气态前体并且具有外壳例如脂质单层，脂质双层或聚合物层的纳米滴。 相变纳米滴共轭物可具有一个或多个附着于外层的纳米颗粒，例如纳米颗粒。 通过链接器。 纳米颗粒可以包括治疗性，预防性或诊断性纳米颗粒。 相变纳米液滴缀合物可以用于将治疗性，预防性或诊断性纳米颗粒靶向递送至有需要的受试者中的目标区域。 该方法可以包括向目标区域施加有效量的超声波辐射以刺激气态前体的气化，接着使得到的气泡缀合物空化并且释放或分散药物或药物到脂质体内。 还提供了制备相变纳米滴共轭物的方法。
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公开(公告)号：WO2016153067A1
公开(公告)日：2016-09-29
申请号：PCT/JP2016/059787
申请日：2016-03-18
CPC分类号： A61B5/0095 , A61B5/150083 , A61B5/7246 , A61B2576/02 , A61K49/22 , A61M5/007
摘要： A photoacoustic apparatus is used that has: a detecting unit that detects photoacoustic waves generated by an object containing contrast agent in first blood vessels of circulating blood and in second blood vessels; and a signal processing unit that generates contrast agent distribution and acquires contrast agent concentration change in the circulating blood. The signal processing unit acquires the position of the first blood vessels on the basis of a time-series change of the contrast agent distribution and the contrast agent concentration change, and lowers the concentration at the position of the first blood vessels on the basis of the contrast agent distribution.
摘要翻译： 使用的光声装置具有：检测单元，其检测由包含造血剂的物体在循环血液的第一血管和第二血管中产生的光声; 以及产生造影剂分布并获取循环血液中的造影剂浓度变化的信号处理单元。 信号处理单元基于造影剂分布和造影剂浓度变化的时间序列变化来获取第一血管的位置，并且基于第一血管的位置降低第一血管位置的浓度 造影剂分布。
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公开(公告)号：WO2015150354A1
公开(公告)日：2015-10-08
申请号：PCT/EP2015/056954
申请日：2015-03-31
申请人： GE HEALTHCARE AS
发明人： HENRIKSEN, Ingrid , KVALE, Svein , TOKERUD, Ole, Johannes , PER, Sontum , SWAERD-NORDMO KISERUD, Marit
IPC分类号： A61K49/22
CPC分类号： A61K49/223
摘要： The present invention relates to a method of preparation of ultrasound contrast agent precursors comprising phospholipid- stabilised perfluorobutane microbubbles. The method is amenable to commercial scale manufacture, and provides more consistent vial-to-vial yields and size distribution of said microbubbles. Also provided are methods of preparing kits and ultrasound contrast agents using the method of the invention.
摘要翻译： 本发明涉及包含磷脂稳定的全氟丁烷微泡的超声造影剂前体的制备方法。 该方法适于商业规模的制造，并且提供更一致的小瓶与小瓶的产量和所述微泡的尺寸分布。 还提供了使用本发明的方法制备试剂盒和超声造影剂的方法。
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公开(公告)号：WO2015095734A1
公开(公告)日：2015-06-25
申请号：PCT/US2014/071549
申请日：2014-12-19
申请人： NAIMCO, INC. , MORGAN, G., Chad
发明人： MORGAN, G., Chad
IPC分类号： A61K49/22
CPC分类号： A61K49/222 , A61B8/4281 , A61B2017/2253 , A61N7/00
摘要： Embodiments associated with an ultrasound conductive medium are described. In one embodiment, an ultrasound conductive substance (500) is formed into a solidified shape and includes a locking element (505) for connecting to a device.
摘要翻译： 描述了与超声波导电介质相关的实施例。 在一个实施例中，超声导电物质（500）形成为固化形状，并且包括用于连接到装置的锁定元件（505）。
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公开(公告)号：WO2014117253A1
公开(公告)日：2014-08-07
申请号：PCT/CA2014/000062
申请日：2014-01-28
发明人： GANG, Zheng , HUYNH, Elizabeth , NG, Kenneth , SHAKIBA, Mojdeh , WEERSINK, Robert , WILSON, Brian
CPC分类号： A61K49/227 , A61K49/0036 , A61K49/0052 , A61K49/0084 , A61K49/221
摘要： There is provided herein a nanovesicle having a bilayer comprising a saturated first phospholipid and no more than about 15 molar % of a second phospholipid covalently conjugated to a J-aggregate forming dye.
摘要翻译： 本文提供了具有包含饱和第一磷脂和不超过约15摩尔％的与J-骨料形成染料共价缀合的第二磷脂的双层的纳米囊。
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公开(公告)号：WO2013001309A3
公开(公告)日：2014-01-09
申请号：PCT/GB2012051524
申请日：2012-06-29
CPC分类号： B01F3/04985 , A61K9/1271 , A61K9/5015 , B01J13/04 , B05B1/06 , B05B7/0458
摘要： This invention relates to bubble generation, in particular to microbubble generation in a microfluidic device, which bubbles may be useful as contrasting agents or drug delivery vehicles. The invention further relates to apparatuses, systemsand methods for manufacturing said microbubbles, microbubbles produced by such methods and to their uses, e.g. in medical, diagnostic and other such applications. The microbubbles are preferentially formed using a microspray regime.
摘要翻译： 本发明涉及气泡产生，特别涉及微流体装置中的微泡生成，该气泡可用作对比剂或药物递送载体。 本发明还涉及用于制造所述微泡的装置，系统和方法，通过这些方法产生的微泡及其用途，例如， 在医疗，诊断和其他此类应用中。 使用微阵列优先形成微泡。
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29.发明申请
公开(公告)号：WO2013188470A1
公开(公告)日：2013-12-19
申请号：PCT/US2013/045274
申请日：2013-06-11
发明人： MATTREY, Robert , WU, Zhe , OLSON, Emilia , WANG, Joseph , GAO, Wei , MALONE, Chris
IPC分类号： A61B5/0215 , A61B5/0245 , A61B5/042 , A61B5/04 , A61B8/00 , A61K49/22
CPC分类号： A61B8/481 , A61B8/0841 , A61B8/4483 , A61B90/39 , A61B2090/3925 , A61F2/0063 , A61F2/02 , A61F2250/0096 , A61K49/223 , A61K49/225 , A61M25/0108
摘要： A method and system are provided for detection of localized hydrogen peroxide within tissue by introducing a catalase-containing material into at location of interest, positioning an ultrasound transducer over the location, and generating an ultrasound image to detect microbubbles, where the presence of microbubbles indicate the presence of localized hydrogen peroxide. The catalase-coated surface may be the inner surface of a microtube, on the surface of or incorporated within a nanosphere or microsphere, or an implantable device.
摘要翻译： 提供了一种方法和系统，用于通过将含有过氧化氢酶的材料引入感兴趣的位置来检测组织内的局部过氧化氢，将超声换能器定位在该位置上，并产生超声图像以检测微泡，其中微泡的存在指示 局部过氧化氢的存在。 过氧化氢酶涂覆的表面可以是微管的内表面，在纳米球或微球体的表面或纳入微球体或可植入装置中。
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公开(公告)号：WO2013158895A1
公开(公告)日：2013-10-24
申请号：PCT/US2013/037194
申请日：2013-04-18
发明人： PEASE, Leonard, F. , SAFFARI, Hedieh , PETERSON, Kathryn , GLEICH, Gerald , LEIFERMAN, Kristin , KENNEDY, Anne , CONDIE, Russell, Morris
CPC分类号： A61K49/221 , A61K49/22
摘要： Disclosed are compositions and methods for related to echogenic contrast agents. Also disclosed are methods and compositions for diagnosing eosinophilic esophagitis in a subject. Also disclosed are methods for producing a medical image of a tissue. Also disclosed are methods of monitoring the progression of eosinophilic esophagitis in a subject before, during, and after treatment.
摘要翻译： 公开了与回声造影剂相关的组合物和方法。 还公开了用于诊断受试者嗜酸粒细胞性食管炎的方法和组合物。 还公开了用于生产组织的医学图像的方法。 还公开了监测治疗前，治疗期间和治疗后受试者嗜酸粒细胞性食管炎进展的方法。
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