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    PHOTOACOUSTIC APPARATUS
    1.
    发明申请
    PHOTOACOUSTIC APPARATUS 审中-公开
    光电设备

    公开(公告)号：WO2016153067A1

    公开(公告)日：2016-09-29

    申请号：PCT/JP2016/059787

    申请日：2016-03-18

    Applicant: CANON KABUSHIKI KAISHA

    Inventor： TAKAHASHI, Atsushi ,  FUKUI, Tatsuki ,  OGAWA, Satoshi

    IPC: A61B5/00 ,  A61B5/145 ,  A61K49/22 ,  A61M5/00

    CPC classification number: A61B5/0095 ,  A61B5/150083 ,  A61B5/7246 ,  A61B2576/02 ,  A61K49/22 ,  A61M5/007

    Abstract: A photoacoustic apparatus is used that has: a detecting unit that detects photoacoustic waves generated by an object containing contrast agent in first blood vessels of circulating blood and in second blood vessels; and a signal processing unit that generates contrast agent distribution and acquires contrast agent concentration change in the circulating blood. The signal processing unit acquires the position of the first blood vessels on the basis of a time-series change of the contrast agent distribution and the contrast agent concentration change, and lowers the concentration at the position of the first blood vessels on the basis of the contrast agent distribution.

    Abstract translation: 使用的光声装置具有：检测单元，其检测由包含造血剂的物体在循环血液的第一血管和第二血管中产生的光声; 以及产生造影剂分布并获取循环血液中的造影剂浓度变化的信号处理单元。 信号处理单元基于造影剂分布和造影剂浓度变化的时间序列变化来获取第一血管的位置，并且基于第一血管的位置降低第一血管位置的浓度 造影剂分布。

    SYSTEM AND METHOD FOR ANALYTE SAMPLING AND ANALYSIS
    3.
    发明申请
    SYSTEM AND METHOD FOR ANALYTE SAMPLING AND ANALYSIS 审中-公开
    分析采样和分析的系统和方法

    公开(公告)号：WO2006050033A9

    公开(公告)日：2007-02-01

    申请号：PCT/US2005038786

    申请日：2005-10-27

    Applicant: SONTRA MEDICAL CORP ,  KELLOGG SCOTT C ,  CHUANG HAN

    Inventor： KELLOGG SCOTT C ,  CHUANG HAN

    IPC: A61B5/05

    CPC classification number: A61B5/681 ,  A61B5/14514 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150358 ,  A61B5/150969 ,  A61B5/15134 ,  A61B5/157 ,  A61B10/0045 ,  A61B2010/0003

    Abstract: The invention relates to a transdermal analyte monitoring system comprising a medium adapted to interface with a biological membrane and to receive an analyte from the biological membrane and an electrode assembly comprising a plurality of electrodes, wherein the medium is adapted to react continuously with the analyte, an electrical signal is detected by the electrode assembly, and the electrical signal correlates to an analyte value. The analyte value may be the flux of the analyte through the biological membrane or the concentration of the analyte in a body fluid of a subject. The medium may comprise a vinyl acetate based hydrogel, an agarose based hydrogel, or a polyethylene glycol diacrylate (PEG-DA) based hydrogel, for example. The surface region of the electrode may comprise pure platinum. The system may include an interference filter located between the biological membrane and the electrode assembly for reducing interference in the system. The system may comprise a processor programmed to implement an error correction method that corrects for sensor drift.

    Abstract translation: 本发明涉及一种透皮分析物监测系统，其包括适于与生物膜接合并接收来自生物膜的分析物的介质和包含多个电极的电极组件，其中所述介质适于与分析物连续反应， 电信号由电极组件检测，电信号与分析物值相关。 分析物值可以是通过生物膜的分析物的通量或受试者的体液中分析物的浓度。 介质可以包括例如基于乙酸乙烯酯的水凝胶，基于琼脂糖的水凝胶或基于聚乙二醇二丙烯酸酯（PEG-DA）的水凝胶。 电极的表面区域可以包括纯铂。 该系统可以包括位于生物膜和电极组件之间的干涉滤波器，用于减少系统中的干扰。 系统可以包括被编程为实现校正传感器漂移的纠错方法的处理器。

    SYSTEM AND METHOD FOR ANALYTE SAMPLING AND ANALYSIS WITH HYDROGEL
    4.
    发明申请
    SYSTEM AND METHOD FOR ANALYTE SAMPLING AND ANALYSIS WITH HYDROGEL 审中-公开
    系统和方法分析采样和水凝胶分析

    公开(公告)号：WO2006050032A2

    公开(公告)日：2006-05-11

    申请号：PCT/US2005/038785

    申请日：2005-10-27

    Applicant: SONTRA MEDICAL CORPORATION ,  CHUANG, Han ,  BARMAN, Shikha, P.

    Inventor： CHUANG, Han ,  BARMAN, Shikha, P.

    IPC: A61B17/20

    CPC classification number: A61B5/681 ,  A61B5/14514 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150358 ,  A61B5/150969 ,  A61B5/15134 ,  A61B5/157 ,  A61B10/0045 ,  A61B2010/0003 ,  G06F19/00

    Abstract: The invention relates to a transdermal analyte monitoring system comprising a medium adapted to interface with a biological membrane and to receive an analyte from the biological membrane and an electrode assembly comprising a plurality of electrodes, wherein the medium is adapted to react continuously with the analyte, an electrical signal is detected by the electrode assembly, and the electrical signal correlates to an analyte value. The analyte value may be the flux of the analyte through the biological membrane or the concentration of the analyte in a body fluid of a subject. The medium may comprise a vinyl acetate based hydrogel, an agarose based hydrogel, or a polyethylene glycol diacrylate (PEG-DA) based hydrogel, for example. The surface region of the electrode may comprise pure platinum. The system may include an interference filter located between the biological membrane and the electrode assembly for reducing interference in the system. The system may comprise a processor programmed to implement an error correction method that corrects for sensor drift.

    Abstract translation: 本发明涉及一种透皮分析物监测系统，该系统包括适于与生物膜接界并接收来自生物膜的分析物的介质和包含多个电极的电极组件，其中该介质是 适于与分析物连续反应，由电极组件检测电信号，并且电信号与分析物值相关。 分析物值可以是分析物通过生物膜的通量或者受试者体液中分析物的浓度。 例如，介质可以包含基于乙酸乙烯酯的水凝胶，基于琼脂糖的水凝胶或基于聚乙二醇二丙烯酸酯（PEG-DA）的水凝胶。 电极的表面区域可以包含纯铂。 该系统可以包括位于生物膜和电极组件之间的干扰滤波器，用于减少系统中的干扰。 该系统可以包括处理器，该处理器被编程为实施校正传感器漂移的错误校正方法。

    NON-INVASIVE TRANSUDATE EXTRACTION
    5.
    发明申请
    NON-INVASIVE TRANSUDATE EXTRACTION 审中-公开
    非侵入式递送提取

    公开(公告)号：WO2002102249A1

    公开(公告)日：2002-12-27

    申请号：PCT/NZ2002/000110

    申请日：2002-06-14

    Applicant: THE HORTICULTURE AND FOOD RESEARCH INSTITUTE OF NEW ZEALAND LIMITED ,  COOK, Christian, John

    Inventor： COOK, Christian, John

    IPC: A61B5/14

    CPC classification number: A61B5/412 ,  A61B5/14514 ,  A61B5/14525 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150213 ,  A61B5/150343 ,  A61B5/150351 ,  A61B5/150755 ,  A61B5/151 ,  A61B8/00 ,  A61B2017/00765 ,  A61N7/00

    Abstract: A transudate extraction device (1) for non-invasive extraction of transudate through a target area of a skin barrier of an organism subjected to sufficient ultrasonic energy from a generator (2) to induce transudation therethrough, the device including at least: a contacting means (3) for contacting said target area to receive transudate therefrom, a transudate collection chamber (6) in open communication with said contacting means to receive transudate therefrom, circulating means for circulating transudate within said collection chamber by, for example having a fluid flow (12) through an inlet port (8) and out an outlet port (9) to thereby create and maintain a concentration gradient through the skin of a said test subject, said collection chamber having a discharge opening (9) through which exudate collected therein can be discharged.

    Abstract translation: 一种渗出物提取装置（1），用于通过来自发生器（2）的足够的超声能量的生物体的皮肤屏障的目标区域非侵入性地提取渗出物，以诱导穿过其渗出，所述装置至少包括：接触装置 （3），用于接触所述目标区域以从其接收渗出物;渗出物收集室（6），其与所述接触装置开放连通以从其接收渗出物;循环装置，用于在所述收集室内循环渗出物，例如具有流体流动 12）通过入口（8）和出口（9），从而产生并保持通过所述测试对象的皮肤的浓度梯度，所述收集室具有排出口（9），通过该排出开口收集渗出物可以 被释放

    INTEGRATED TISSUE PORATION, FLUID HARVESTING AND ANALYSIS DEVICE, AND METHOD THEREFOR
    6.
    发明申请
    INTEGRATED TISSUE PORATION, FLUID HARVESTING AND ANALYSIS DEVICE, AND METHOD THEREFOR 审中-公开
    一体化组织结构，流体收集和分析装置及其方法

    公开(公告)号：WO99044507A1

    公开(公告)日：1999-09-10

    申请号：PCT/US1999/004983

    申请日：1999-03-05

    IPC: A61M37/00 ,  A61B5/00 ,  A61B10/00 ,  A61B17/00 ,  A61K41/00 ,  A61K45/00 ,  G01N33/50

    CPC classification number: A61B5/15134 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150083 ,  A61B5/150099 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/15136 ,  A61B5/157 ,  A61B2010/008 ,  A61B2017/00172 ,  A61B2562/12 ,  A61K41/0047

    Abstract: An integrated device (100, 200, 300, 400, 600, 1000) for harvesting a biological fluid from the tissue and analysis of the biological fluid. The device comprises a layer having a porating element disposed thereon to form at least one opening in the tissue. Biological fluid is harvested from the opening of the tissue and placed in contact with a sensor incorporated in the integrated device. The sensor is responsive to the biological fluid to provide an indication of a characteristic of the biological fluid, such as the concentration of an analyte in interstitial fluid. The porating element may comprise one or more heat conducting elements that are either optically or electrically heated, or one or more mechanical porating elements.

    Abstract translation: 一种用于从组织收获生物流体并分析生物流体的整合装置（100,200,300,400,600,1000）。 该装置包括具有设置在其上以在组织中形成至少一个开口的开孔元件的层。 从组织的开口收获生物流体并将其放置在与集成装置中结合的传感器接触。 传感器响应于生物流体以提供生物流体特征的指示，例如间质液中分析物的浓度。 打孔元件可以包括一个或多个光学或电加热的导热元件，或一个或多个机械打孔元件。

    METHOD AND SYSTEM FOR HARVESTING BIOLOGICAL TISSUE
    9.
    发明申请
    METHOD AND SYSTEM FOR HARVESTING BIOLOGICAL TISSUE 审中-公开
    收集生物组织的方法和系统

    公开(公告)号：WO2016172278A1

    公开(公告)日：2016-10-27

    申请号：PCT/US2016/028542

    申请日：2016-04-21

    Applicant: GUILES, Marvin, A. ,  LABOMBARD, Denis ,  SIDOTI, Charles ,  LEVIN, Phil ,  SWYST, Thomas ,  SABIR, Sameer

    Inventor： GUILES, Marvin, A. ,  LABOMBARD, Denis ,  SIDOTI, Charles ,  LEVIN, Phil ,  SWYST, Thomas ,  SABIR, Sameer

    IPC: A61B10/02 ,  A61B5/15

    CPC classification number: A61B10/0233 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150282 ,  A61B5/150305 ,  A61B5/150396 ,  A61B5/150503 ,  A61B5/15142

    Abstract: In one aspect, the dual bevel needle can include a hollow tube having a proximal end, a distal end, a first lateral side, and a second lateral side opposite the first lateral side; a first needle point at the distal end of the hollow tube; a second point at the distal end of the hollow tube; a first bevel on each of the first lateral side and the second lateral side, the first bevel comprising a first bevel angle relative to a longitudinal axis of the tube; and a second bevel on each of the first lateral side and the second lateral side, the second bevel having a second bevel angle relative to the longitudinal axis of the tube, wherein the first and second bevels each form a portion of an ellipse, the ellipse having an inner cutting edge and terminating in the first and second needle points at the distal end of the tube, the second bevel angle being shallower than the first bevel angle, the second bevel being located adjacent the proximal end of the first bevel, and the inner cutting edge converging to a narrow heel.

    Abstract translation: 一方面，双斜针可以包括具有近端，远端，第一侧面和与第一侧面相对的第二侧面的中空管; 在中空管的远端处的第一针尖; 在中空管的远端的第二点; 所述第一横向侧和所述第二侧面中的每一个上的第一斜面，所述第一斜面包括相对于所述管的纵向轴线的第一斜角; 以及在所述第一横向侧和所述第二横向侧中的每一个上的第二斜面，所述第二斜面相对于所述管的纵向轴线具有第二斜角，其中所述第一和第二斜面各自形成椭圆的一部分，所述椭圆 具有内切割刃并终止在管的远端处的第一和第二针尖中，第二斜角比第一斜角浅，第二斜面位于第一斜面的近端附近，并且 内切割边缘收敛于窄的脚跟。

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