公开(公告)号：WO0055194A2

公开(公告)日：2000-09-21

申请号：PCT/US0007196

申请日：2000-03-17

Applicant: CORIXA CORP ,  HENDRICKSON RONALD C ,  LODES MICHAEL J ,  HOUGHTON RAYMOND L

Inventor： HENDRICKSON RONALD C ,  LODES MICHAEL J ,  HOUGHTON RAYMOND L

IPC: G01N33/569 ,  A61K31/711 ,  A61K35/12 ,  A61K35/26 ,  A61K38/00 ,  A61K39/00 ,  A61K39/04 ,  A61K39/395 ,  A61K48/00 ,  A61P31/06 ,  A61P31/20 ,  A61P37/00 ,  A61P43/00 ,  C07K14/35 ,  C07K16/12 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/31 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  C12R1/32 ,  C12N5/06 ,  C12N15/11 ,  C12N15/63

CPC classification number: C07K14/35 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2035/124 ,  A61K2039/51 ,  A61K2039/5154 ,  C07K2319/00 ,  C12N2799/021

Abstract: Compounds and methods for the diagnosis and treatment of tuberculosis are disclosed. Compounds include the M. tuberculosis antigens Mtb-81 and Mtb-67.2, immunogenic portions thereof and polynucleotides that encode such portions. Such compositions may be used, for example, for the immunotherapy and serodiagnosis of M. tuberculosis infection.

Abstract translation: 公开了用于诊断和治疗结核病的化合物和方法。 化合物包括结核分枝杆菌抗原Mtb-81和Mtb-67.2，其免疫原性部分和编码这些部分的多核苷酸。 这样的组合物可以用于例如结核分枝杆菌感染的免疫治疗和血清诊断。

公开(公告)号：WO9633414A3

公开(公告)日：1996-11-21

申请号：PCT/US9605472

申请日：1996-04-19

Applicant: CORIXA CORP

Inventor： REED STEVEN G

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/44 ,  G01N33/569 ,  A61K39/005 ,  C12N1/21 ,  C12N15/12 ,  C12N15/85 ,  G01N33/543

CPC classification number: G01N33/56905 ,  A61K38/00 ,  A61K39/00 ,  C07K14/44 ,  Y10S435/975 ,  Y10S530/81 ,  Y10S530/822

Abstract: Compounds and methods are provided for diagnosing Leishmania infection. Disclosed compounds include polypeptides that contain at least an epitope of the Leishmania chagasi acidic ribosomal antigen LcP0, or a variant thereof. Such compounds are useful in a variety of immunoassays for detecting Leishmania infection and for identifying individuals with asymptomatic infections that are likely to progress to acute visceral leishmaniasis. The polypeptide compounds are further useful in vaccines and pharmaceutical compositions for preventing leishmaniasis.

公开(公告)号：WO0208267A9

公开(公告)日：2006-09-28

申请号：PCT/US0123121

申请日：2001-07-20

Applicant: CORIXA CORP ,  FLING STEVEN P ,  SKEIKY YASIR A W ,  PROBST PETER ,  BHATIA AJAY

Inventor： FLING STEVEN P ,  SKEIKY YASIR A W ,  PROBST PETER ,  BHATIA AJAY

IPC: G01N33/53 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/00 ,  A61K39/118 ,  A61K48/00 ,  A61P31/00 ,  A61P37/04 ,  A61P43/00 ,  C07K14/295 ,  C07K16/12 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/06 ,  C12N5/10 ,  C12N15/09 ,  C12N15/31 ,  C12Q1/06 ,  G01N33/566 ,  G01N33/569

CPC classification number: C07K14/295 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/51 ,  A61K2039/515 ,  A61K2039/5154 ,  A61K2039/53 ,  C07K2319/00

Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.

Abstract translation: 公开了用于诊断和治疗衣原体感染的化合物和方法。 提供的化合物包括含有衣原体抗原的至少一个抗原部分的多肽和编码这些多肽的DNA序列。 还提供了包含此类多肽或DNA序列的药物组合物和疫苗以及针对这些多肽的抗体。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的衣原体感染。

公开(公告)号：WO2006016997A2

公开(公告)日：2006-02-16

申请号：PCT/US2005022522

申请日：2005-06-24

Applicant: CORIXA CORP ,  JOHNSON DAVID A ,  PERSING DAVID H

Inventor： JOHNSON DAVID A ,  PERSING DAVID H

IPC: C07H5/02 ,  C07H11/04 ,  C07H13/04 ,  C07H15/04

CPC classification number: C07H5/02 ,  C07H11/04 ,  C07H13/04 ,  C07H15/04

Abstract: Compounds that are adjuvants and immunoeffectors are described and claimed. The compounds augment antibody production in immunized animals as well as stimulate cytokine production and activate macrophages. Compositions and methods for using the compounds as adjuvants and immunoeffectors are also disclosed.

Abstract translation: 描述并要求保护作为佐剂和免疫效应物的化合物。 这些化合物增强了免疫动物的抗体产生以及刺激细胞因子的产生并激活巨噬细胞。 还公开了使用这些化合物作为佐剂和免疫效应物的组合物和方法。

公开(公告)号：WO2005013899A3

公开(公告)日：2005-08-18

申请号：PCT/US2004023085

申请日：2004-07-15

Applicant: CORIXA CORP ,  HENDERSON ROBERT A ,  WANG TONGTONG ,  BANGUR CHAITANYA S ,  PECKHAM DAVID W ,  RETTER MARC W ,  FANGER GARY R

Inventor： HENDERSON ROBERT A ,  WANG TONGTONG ,  BANGUR CHAITANYA S ,  PECKHAM DAVID W ,  RETTER MARC W ,  FANGER GARY R

IPC: A61K20060101 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K39/40 ,  A61P35/00 ,  C07K1/00 ,  C07K14/47 ,  C07K14/82 ,  C07K16/30 ,  C12N5/08 ,  C12N15/12 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/574

CPC classification number: C07K16/3023 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/5154 ,  A61K2039/5158 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/82 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2319/00 ,  G01N33/57423

Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

公开(公告)号：WO03086175A8

公开(公告)日：2005-02-10

申请号：PCT/US0310945

申请日：2003-04-07

Applicant: CORIXA CORP ,  MERICLE BARBARA ,  FANGER GARY R ,  VEDVICK THOMAS S ,  CARTER DARRICK ,  WATANABE YOSHIHIRO ,  HENDERSON ROBERT A ,  KALOS MICHAEL D ,  SPIES GREGORY A ,  FOY TERESA M ,  FAN LIQUN ,  WANG TONGTONG ,  MCNABB ANDRIA ,  REED STEVEN G

Inventor： MERICLE BARBARA ,  FANGER GARY R ,  VEDVICK THOMAS S ,  CARTER DARRICK ,  WATANABE YOSHIHIRO ,  HENDERSON ROBERT A ,  KALOS MICHAEL D ,  SPIES GREGORY A ,  FOY TERESA M ,  FAN LIQUN ,  WANG TONGTONG ,  MCNABB ANDRIA ,  REED STEVEN G

IPC: G01N33/531 ,  A61K31/711 ,  A61K38/00 ,  A61K39/00 ,  A61K39/39 ,  A61K39/395 ,  A61K48/00 ,  A61P35/00 ,  A61P37/04 ,  A61P43/00 ,  C07K14/47 ,  C07K14/82 ,  C07K16/30 ,  C07K16/32 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/08 ,  C12Q1/68 ,  A01N43/04 ,  A01N63/00 ,  C07H21/02 ,  C12N5/00 ,  C12N15/00 ,  C12N15/63

CPC classification number: C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5154 ,  A61K2039/5158 ,  C07K14/4748 ,  C07K16/3023 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2319/00 ,  C12Q1/6809

Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

Abstract translation: 披露了用于治疗和诊断癌症，特别是肺癌的组合物和方法。 说明性组合物包含一种或多种肺肿瘤多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞和对表达此类多肽的细胞具有特异性的T细胞。 所公开的组合物可用于例如疾病，特别是肺癌的诊断，预防和/或治疗。

公开(公告)号：WO0125401A3

公开(公告)日：2005-02-03

申请号：PCT/US0027652

申请日：2000-10-06

Applicant: CORIXA CORP ,  SKEIKY YASIR ,  GUDERIAN JEFFREY

Inventor： SKEIKY YASIR ,  GUDERIAN JEFFREY

IPC: C12N15/09 ,  C07K14/35 ,  C07K14/47 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/02 ,  C12P21/04 ,  C07H21/04 ,  A01N63/00 ,  A61K38/00 ,  A61K39/00 ,  A61K39/02 ,  A61K39/04 ,  C07K1/00 ,  C12N15/00 ,  C12P1/04 ,  C12P21/06

CPC classification number: C07K14/35 ,  C07K14/4721 ,  C07K2319/00

Abstract: The present invention relates generally to nucleic acid and amino acid sequences of a fusion polypeptide comprising a Mycobacterium tuberculosis polypeptide, and a heterologous polypeptide of interest, expression vectors and host cells comprising such nucleic acids, and methods for producing such fusion polypeptides. In particular, the invention relates to materials and methods of using such M. tuberculosis sequence as a fusion partner to facilitate the stable and high yield expression of recombinant heterologous polypeptides of both eukaryotic and prokaryotic origin.

Abstract translation: 本发明一般涉及包含结核分枝杆菌多肽，感兴趣的异源多肽，表达载体和包含这种核酸的宿主细胞的融合多肽的核酸和氨基酸序列，以及用于产生这种融合多肽的方法。 特别地，本发明涉及使用这种结核分枝杆菌序列作为融合配偶体以促进真核和原核来源的重组异源多肽的稳定和高产量表达的材料和方法。

公开(公告)号：WO0198460A3

公开(公告)日：2004-10-28

申请号：PCT/US0119959

申请日：2001-06-20

Applicant: CORIXA CORP

Inventor： SKEIKY YASIR ,  REED STEVEN ,  ALDERSON MARK

IPC: C12N15/09 ,  A61K39/00 ,  A61K39/04 ,  A61K39/39 ,  A61P31/06 ,  C07K14/35 ,  C07K19/00 ,  A61K49/00 ,  A61K39/02 ,  A61K39/38

CPC classification number: C07K14/35 ,  A61K39/00 ,  A61K39/04 ,  A61K2039/53 ,  A61K2039/55505 ,  A61K2039/55566 ,  C07K2319/00

Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.

Abstract translation: 本发明涉及含有至少两种分枝杆菌属的组合物和融合蛋白。 抗原和编码这些组合物的核酸和融合蛋白。 本发明的组合物增加来自感染结核病的个体的血清的血清学敏感性，以及用于诊断，治疗和预防结核病感染的方法。

公开(公告)号：WO03037267A8

公开(公告)日：2003-12-24

申请号：PCT/US0234777

申请日：2002-10-28

Applicant: CORIXA CORP ,  HENDERSON ROBERT A ,  WANG TONGTONG ,  WATANABE YOSHIHIRO ,  KALOS MICHAEL D ,  SLEATH PAUL R ,  JOHNSON JEFFREY C ,  RETTER MARC W ,  DURHAM MARGARITA ,  CARTER DARRICK ,  FANGER GARY R ,  VEDVICK THOMAS S ,  BANGUR CHAITANYA S ,  MCNABB ANDRIA

Inventor： HENDERSON ROBERT A ,  WANG TONGTONG ,  WATANABE YOSHIHIRO ,  KALOS MICHAEL D ,  SLEATH PAUL R ,  JOHNSON JEFFREY C ,  RETTER MARC W ,  DURHAM MARGARITA ,  CARTER DARRICK ,  FANGER GARY R ,  VEDVICK THOMAS S ,  BANGUR CHAITANYA S ,  MCNABB ANDRIA

IPC: A61K38/00 ,  C07K14/47 ,  C12Q1/68 ,  A61K

CPC classification number: C07K14/4748 ,  A61K38/00 ,  A61K2039/5154 ,  A61K2039/5156 ,  C07K14/47 ,  C07K2319/00 ,  C12Q1/6886 ,  C12Q2600/158

Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

公开(公告)号：WO0241763A3

公开(公告)日：2003-10-02

申请号：PCT/US0150718

申请日：2001-10-18

Applicant: CORIXA CORP ,  JIANG YUQIU

Inventor： JIANG YUQIU

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07H21/02 ,  A01N43/04 ,  C07H21/04 ,  C12N5/00 ,  C12N15/00 ,  C12N15/63

CPC classification number: C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  A61K2039/515 ,  C07K2319/00

Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly colon cancer, are disclosed. Illustrative compositions comprise one or more colon tumor polypeptides, immunogenic portions thereof, polynuleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositiosn are usefel, for example, in the diagnosis, prevention and/or treatment of diseases, particularly colon cancer.

Abstract translation: 公开了用于治疗和诊断癌症，特别是结肠癌的组合物和方法。 说明性组合物包含一种或多种结肠肿瘤多肽，其免疫原性部分，编码这种多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及表达该多肽的细胞特异的T细胞。 所公开的组合物例如用于疾病，特别是结肠癌的诊断，预防和/或治疗中。