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    CALIBRATION OF IN VIVO BLOOD PRESSURE SENSORS
    31.
    发明申请
    CALIBRATION OF IN VIVO BLOOD PRESSURE SENSORS 审中-公开
    血液压力传感器校准

    公开(公告)号：WO2009051781A1

    公开(公告)日：2009-04-23

    申请号：PCT/US2008/011853

    申请日：2008-10-17

    Applicant: DATASCOPE INVESTMENT CORP. ,  WILLIAMS, Jonathan ,  DAFTARY, Shrenik ,  LESCHINSKY, Boris

    Inventor： WILLIAMS, Jonathan ,  DAFTARY, Shrenik ,  LESCHINSKY, Boris

    IPC: A61B5/0215

    CPC classification number: A61B5/02156 ,  A61M25/10185 ,  A61M2025/0002

    Abstract: A method for performing an in-vivo calibration of a blood pressure sensor 40 that is associated with an in-vivo balloon system. The method involves monitoring a patient's blood pressure by observing the system gas pressure while at the same time monitoring the patient's blood pressure through the sensor. The blood pressure measurements obtained by monitoring the system gas pressure are used as reference, or "true, " blood pressure measurements, and an "offset" is determined between the reference blood pressure measurements and the blood pressure measurements obtained through the sensor. The offset can be stored in a memory 42, which may also store sensor sensitivity data. The offset and/or sensitivity data may be used to adjust future measurements obtained from the sensor, thereby generating calibrated sensor measurements.

    Abstract translation: 一种用于进行与体内气球系统相关联的血压传感器40的体内校准的方法。 该方法包括通过观察系统气体压力来监测患者的血压，同时通过传感器监测患者的血压。 通过监测系统气体压力获得的血压测量用作参考或“真实”血压测量，并且在参考血压测量值与通过传感器获得的血压测量值之间确定“偏移”。 偏移可以存储在存储器42中，存储器42也可以存储传感器灵敏度数据。 偏移和/或灵敏度数据可用于调整从传感器获得的未来测量值，从而生成经校准的传感器测量值。

    MICROFLUIDIC DEVICE FOR MOLECULAR ANALYSIS
    34.
    发明申请
    MICROFLUIDIC DEVICE FOR MOLECULAR ANALYSIS 审中-公开
    用于分子分析的微流体装置

    公开(公告)号：WO03011768A3

    公开(公告)日：2003-05-30

    申请号：PCT/US0224316

    申请日：2002-08-01

    Applicant: DATASCOPE INVESTMENT CORP ,  NILSEN THOR W

    Inventor： NILSEN THOR W

    IPC: B01L3/00 ,  C12Q1/68 ,  C02F1/40 ,  C12M1/34 ,  C12M3/00 ,  G01N27/00 ,  G01N33/53

    CPC classification number: B01L3/502753 ,  B01L2200/10 ,  B01L2300/0681 ,  B01L2400/0421 ,  C12Q1/6816 ,  C12Q2565/629 ,  C12Q2565/607 ,  C12Q2565/125

    Abstract: An improved microfluidic device for the detection and analysis of desired chemical or biochemical components. The device allows molecular biological analysis and diagnosis using multistep reactions conducted on a small scale, with such reactions being conducted on or preferably within an electronic chip (12) containing biochemical components that enable the detection of desired materials in an applied sample. Preferably, the device includes a sample chamber (26) for lysis of sample cells using an applied AC field, a signal delivery chamber (46) wherein signal delivery molecules are bound to desired target molecules of interest, and/or electrodes (90) for detecting signal produced by the signal delivery molecules.

    Abstract translation: 用于检测和分析所需化学或生物化学成分的改进的微流体装置。 该装置允许使用小规模进行的多步反应进行分子生物学分析和诊断，其中这种反应在或优选地在含有能够检测所应用样品中所需材料的生物化学成分的电子芯片（12）内进行。 优选地，该装置包括用于使用所施加的AC场裂解样品池的样品室（26），信号传递室（46），其中信号传递分子与期望的目标分子结合，和/或电极（90），用于 检测由信号传递分子产生的信号。

    DOCKING STATION FOR A TRANSPORTABLE DEVICE
    35.
    发明申请
    DOCKING STATION FOR A TRANSPORTABLE DEVICE 审中-公开
    运输装置的锁定站

    公开(公告)号：WO2003024301A2

    公开(公告)日：2003-03-27

    申请号：PCT/US2002/029321

    申请日：2002-09-16

    Applicant: DATASCOPE INVESTMENT CORP. ,  KAUSHANSKY, Yefim ,  PACENKA, Edmund, G.

    Inventor： KAUSHANSKY, Yefim ,  PACENKA, Edmund, G.

    IPC: A61B

    CPC classification number: A61M1/1072 ,  A61M1/106 ,  A61M1/107 ,  A61M1/1074 ,  A61M1/125 ,  A61M2209/08

    Abstract: A mounting device (10) for securing transport patient connected equipment, specifically an intra-aortic balloon pump (IABP) (22), in the typically crowded medical transport vehicle. An engagement stud (20) on the IABP (22) slides into a spring-loaded latch (40) connected to a vehicle mounted base (11). The engagement stud configuration allows the user to engage the IABP (22) from any desired direction, i.e. slide the pump (22) from any of the four sides onto the mount (11). No effort is required from the user beyond the pushing motion for locking the IABP (22) onto the mount (11).

    Abstract translation: 一种用于在通常拥挤的医疗运输车辆中固定运输患者连接的设备，特别是主动脉内球囊泵（IABP）（22））的安装装置（10）。 IABP（22）上的接合柱（20）滑入连接到车载基座（11）的弹簧加载的闩锁（40）中。 接合螺柱构造允许使用者从任何所需方向接合IABP（22），即将泵（22）从四个侧面中的任一侧滑动到安装件（11）上。 不需要用户超出用于将IABP（22）锁定到安装件（11）上的推动运动。

    IMPROVED INTRA-AORTIC BALLOON CATHETER AND INSERTION SHEATH
    38.
    发明申请
    IMPROVED INTRA-AORTIC BALLOON CATHETER AND INSERTION SHEATH 审中-公开
    改进的内部气球导管和插入式护套

    公开(公告)号：WO0035358A9

    公开(公告)日：2002-08-29

    申请号：PCT/US9929487

    申请日：1999-12-13

    Applicant: DATASCOPE INVESTMENT CORP

    Inventor： LESCHINSKY BORIS

    IPC: A61F2/958 ,  A61M1/10 ,  A61M25/00 ,  A61M29/02 ,  A61B17/34 ,  A61M25/10

    CPC classification number: A61M29/02 ,  A61M1/1008 ,  A61M1/106 ,  A61M1/1072 ,  A61M1/125 ,  A61M25/0017

    Abstract: An improved intra-aortic balloon catheter system comprising an insertion sheath (20), having an expandable distal end (70), and a tapered balloon membrane (40) capable of being removed through said insertion sheath (20) upon completion of therapy. The outer diameter of the balloon membrane (40) in a wrapped state is smaller than the outer diameter of the outer tube (30).

    Abstract translation: 一种改进的主动脉内球囊导管系统，包括具有可扩展远端（70）的插入鞘（20）和能够在治疗完成时通过所述插入鞘（20）去除的锥形球囊膜（40）。 包裹状态的气囊膜（40）的外径小于外筒（30）的外径。

    METHODS FOR ASSAY AND DETECTION ON A MICROARRAY
    40.
    发明申请
    METHODS FOR ASSAY AND DETECTION ON A MICROARRAY 审中-公开
    微波测量和检测方法

    公开(公告)号：WO2001066555A1

    公开(公告)日：2001-09-13

    申请号：PCT/US2001/007477

    申请日：2001-03-08

    Applicant: DATASCOPE INVESTMENT CORP. ,  GETTS, Robert, C.

    Inventor： GETTS, Robert, C.

    IPC: C07H21/00

    CPC classification number: C12Q1/6837

    Abstract: Methods are provided for assay and detection on a microarray. The method of the present invention comprises incubating a mixture including: i) a first component comprising a cDNA reagent obtained from mRNA of a target sample, the cDNA having a capture sequence, and ii) a second component comprising a dendrimer having at least one first arm containing a label capable of emitting a detectable signal and at least one second arm having a second nucleotide sequence complementary to the capture sequence, at a first temperature and for a time sufficient to induce the first component to bind to the second component and form a prehybridized cDNA-dendrimer complex; contacting a microarray having thereon a plurality of features each containing a particular first nucleotide sequence with the mixture; and incubating the microarray and the prehybridized cDNA-dendrimer complex at a second temperature and for a time sufficient to induce prehybridized cDNA-dendrimer complex to bind to the first nucleotide sequence, wherein such binding results in the feature emitting the detectable signal whereby a hybridization pattern is generated on the microarray.

    Abstract translation: 提供了用于微阵列测定和检测的方法。 本发明的方法包括孵育混合物，其包括：i）包含从靶样品的mRNA获得的cDNA试剂的第一组分，具有捕获序列的cDNA，和ii）包含树枝状聚合物的第二组分，其具有至少一个第一 含有能够发射可检测信号的标记的臂，以及具有与捕获序列互补的第二核苷酸序列的至少一个第二臂，在第一温度和足以诱导第一组分与第二组分结合并形成 预杂交的cDNA-树状聚合物复合物; 使其上具有多个特征的微阵列与每个含有特定第一核苷酸序列的特征与所述混合物接触; 并在第二温度下孵育微阵列和预杂交的cDNA-树状聚合物复合物，并且足以诱导预杂交的cDNA-树状聚合物复合物结合第一核苷酸序列的时间，其中这种结合导致特征发射可检测信号，由此杂交模式 在微阵列上产生。

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