公开(公告)号：WO2012118508A1

公开(公告)日：2012-09-07

申请号：PCT/US2011/027023

申请日：2011-03-03

Applicant: EMPIRE TECHNOLOGY DEVELOPMENT LLC ,  LESCHINSKY, Boris

Inventor： LESCHINSKY, Boris

IPC: A61F2/24

CPC classification number: A61F2/958 ,  A61F2/2418 ,  A61F2/2433 ,  A61F2/966 ,  A61F2002/9583 ,  A61F2250/0059 ,  A61M2025/1095

Abstract: Technologies are generally described for percutaneous valve delivery systems with continuous blood flow, By providing a temporary perfusion channel in balloon-expandable stent and/or valve replacement systems, blood flow during the deployment of the stent or valve, when the inflation of the balloon may interrupt the blood flow, is ensured. The perfusion channel may be formed employing an elongated braided structure, which may be expanded radially and outwards upon being longitudinally compressed. One-way blood flow through the channel may be accomplished by providing a temporary check valve.

Abstract translation: 技术通常描述为具有持续血流的经皮瓣膜输送系统。通过在球囊扩张的支架和/或瓣膜置换系统中提供临时灌注通道，在展开支架或瓣膜期间的血液流动，当球囊膨胀时 中断血流，确保。 可以使用细长的编织结构来形成灌注通道，该结构可以在纵向压缩时径向和向外扩张。 可以通过提供临时止回阀来实现通过通道的单向血流。

公开(公告)号：WO2011005538A3

公开(公告)日：2011-03-03

申请号：PCT/US2010039529

申请日：2010-06-22

Applicant: LESCHINSKY BORIS

Inventor： LESCHINSKY BORIS

IPC: A61B5/022 ,  A61B5/02

CPC classification number: A61H9/0092 ,  A61B5/02208 ,  A61B5/02225 ,  A61B5/02233 ,  A61B17/12109 ,  A61B17/12136 ,  A61B17/135 ,  A61B17/1355 ,  A61B2017/00199 ,  A61H1/006 ,  A61H9/0078 ,  A61H2201/5035 ,  A61H2201/5038 ,  A61H2201/5071 ,  A61H2230/30

Abstract: Single- or dual-bladder devices for remote ischemic preconditioning and blood pressure monitoring are disclosed along with various oscillometry-based and other methods for detecting systolic and diastolic blood pressure while the ischemic preconditioning treatment is in progress. The devices and methods of the invention provide for delivery of ischemic preconditioning at the lowest effective cuff pressure while closely monitoring patient's hemodynamics. Advantageously, the device of the invention allows both ischemic preconditioning and blood pressure monitoring to be done on the same limb. Disposable battery-powered version of the device of the present invention is especially useful for emergency use with patients suffering from acute myocardial infarction, acute stroke, or acute trauma. Additional device configurations are described for use in a percutaneous intervention and vascular sealing settings.

Abstract translation: 公开了用于远程缺血预处理和血压监测的单或双膀胱装置以及用于在缺血预处理治疗正在进行时检测收缩压和舒张压的各种基于示波法和其他方法。 本发明的装置和方法提供了在最低有效袖带压力下递送缺血预处理，同时密切监测患者的血液动力学。 有利的是，本发明的装置允许在同一肢体上进行局部缺血预处理和血压监测。 本发明的装置的一次性电池供电形式对于患有急性心肌梗塞，急性中风或急性创伤的患者的紧急用途是特别有用的。 描述了用于经皮介入和血管密封设置的附加设备配置。

公开(公告)号：WO2011005538A2

公开(公告)日：2011-01-13

申请号：PCT/US2010/039529

申请日：2010-06-22

Applicant: LESCHINSKY, Boris

Inventor： LESCHINSKY, Boris

IPC: A61B5/022 ,  A61B5/02

CPC classification number: A61H9/0092 ,  A61B5/02208 ,  A61B5/02225 ,  A61B5/02233 ,  A61B17/12109 ,  A61B17/12136 ,  A61B17/135 ,  A61B17/1355 ,  A61B2017/00199 ,  A61H1/006 ,  A61H9/0078 ,  A61H2201/5035 ,  A61H2201/5038 ,  A61H2201/5071 ,  A61H2230/30

Abstract: Single- or dual-bladder devices for remote ischemic preconditioning and blood pressure monitoring are disclosed along with various oscillometry-based and other methods for detecting systolic and diastolic blood pressure while the ischemic preconditioning treatment is in progress. The devices and methods of the invention provide for delivery of ischemic preconditioning at the lowest effective cuff pressure while closely monitoring patient's hemodynamics. Advantageously, the device of the invention allows both ischemic preconditioning and blood pressure monitoring to be done on the same limb. Disposable battery-powered version of the device of the present invention is especially useful for emergency use with patients suffering from acute myocardial infarction, acute stroke, or acute trauma. Additional device configurations are described for use in a percutaneous intervention and vascular sealing settings.

Abstract translation: 公开了用于远端缺血预处理和血压监测的单膀胱或双膀胱装置以及在进行缺血预处理治疗期间用于检测收缩压和舒张压的各种基于示波器的方法。 本发明的装置和方法提供了在最低有效袖带压力下输送缺血预处理，同时密切监测患者的血液动力学。 有利地，本发明的装置允许在相同的肢体上进行缺血预处理和血压监测。 本发明装置的一次性电池供电版本对于急性心肌梗塞，急性中风或急性创伤患者的紧急使用特别有用。 描述了用于经皮干预和血管密封设置的附加装置配置。

公开(公告)号：WO2009051781A1

公开(公告)日：2009-04-23

申请号：PCT/US2008/011853

申请日：2008-10-17

Applicant: DATASCOPE INVESTMENT CORP. ,  WILLIAMS, Jonathan ,  DAFTARY, Shrenik ,  LESCHINSKY, Boris

Inventor： WILLIAMS, Jonathan ,  DAFTARY, Shrenik ,  LESCHINSKY, Boris

IPC: A61B5/0215

CPC classification number: A61B5/02156 ,  A61M25/10185 ,  A61M2025/0002

Abstract: A method for performing an in-vivo calibration of a blood pressure sensor 40 that is associated with an in-vivo balloon system. The method involves monitoring a patient's blood pressure by observing the system gas pressure while at the same time monitoring the patient's blood pressure through the sensor. The blood pressure measurements obtained by monitoring the system gas pressure are used as reference, or "true, " blood pressure measurements, and an "offset" is determined between the reference blood pressure measurements and the blood pressure measurements obtained through the sensor. The offset can be stored in a memory 42, which may also store sensor sensitivity data. The offset and/or sensitivity data may be used to adjust future measurements obtained from the sensor, thereby generating calibrated sensor measurements.

Abstract translation: 一种用于进行与体内气球系统相关联的血压传感器40的体内校准的方法。 该方法包括通过观察系统气体压力来监测患者的血压，同时通过传感器监测患者的血压。 通过监测系统气体压力获得的血压测量用作参考或“真实”血压测量，并且在参考血压测量值与通过传感器获得的血压测量值之间确定“偏移”。 偏移可以存储在存储器42中，存储器42也可以存储传感器灵敏度数据。 偏移和/或灵敏度数据可用于调整从传感器获得的未来测量值，从而生成经校准的传感器测量值。

公开(公告)号：WO2012094525A3

公开(公告)日：2013-01-10

申请号：PCT/US2012020369

申请日：2012-01-05

Applicant: THORATEC CORP ,  PENN STATE RES FOUND ,  CAMPBELL ROBERT L ,  FITZGERALD KEIF ,  HARRISON WILLIAM JAMES ,  LESCHINSKY BORIS ,  MALLISON THOMAS M ,  MCBRIDE MARK W ,  ROSLUND ADAM ,  WALTERS DANIEL A ,  YUEN PHYLLIS

Inventor： CAMPBELL ROBERT L ,  FITZGERALD KEIF ,  HARRISON WILLIAM JAMES ,  LESCHINSKY BORIS ,  MALLISON THOMAS M ,  MCBRIDE MARK W ,  ROSLUND ADAM ,  WALTERS DANIEL A ,  YUEN PHYLLIS

IPC: A61M25/01 ,  A61M1/10 ,  A61M25/088 ,  A61M29/02

CPC classification number: A61M25/04 ,  A61M1/1008 ,  A61M1/101 ,  A61M1/1012 ,  A61M1/1024 ,  A61M1/1034 ,  A61M1/122 ,  A61M1/125 ,  A61M2025/0024 ,  A61M2025/0096

Abstract: Disclosed herein are heart pumps that include a catheter assembly and that can be applied percutaneously. Some embodiments include a locking device that prevents components of the catheter assembly from being separated when in use. The catheter assembly can include an expandable tip. In some embodiments, the catheter assembly includes a housing having a wall structure, a portion of which can have a bulbous shape or can be deformable. In other embodiments, the housing can be configured to reduce fluttering or deflection of the housing and/or to maintain a gap between the housing and an impeller blade disposed therein.

Abstract translation: 本文公开了包括导管组件并且可以经皮应用的心脏泵。 一些实施例包括锁定装置，其防止导管组件的组件在使用时被分离。 导管组件可包括可扩张尖端。 在一些实施例中，导管组件包括具有壁结构的壳体，其一部分可具有球形形状或可变形。 在其他实施例中，壳体可以被配置为减少壳体的颤动或偏转和/或在壳体和设置在其中的叶轮叶片之间保持间隙。

公开(公告)号：WO2012094525A2

公开(公告)日：2012-07-12

申请号：PCT/US2012/020369

申请日：2012-01-05

Applicant: THORATEC CORPORATION ,  THE PENN STATE RESEARCH FOUNDATION ,  CAMPBELL, Robert, L. ,  FITZGERALD, Keif ,  HARRISON, William, James ,  LESCHINSKY, Boris ,  MALLISON, Thomas, M. ,  MCBRIDE, Mark, W. ,  ROSLUND, Adam ,  WALTERS, Daniel, A. ,  YUEN, Phyllis

Inventor： CAMPBELL, Robert, L. ,  FITZGERALD, Keif ,  HARRISON, William, James ,  LESCHINSKY, Boris ,  MALLISON, Thomas, M. ,  MCBRIDE, Mark, W. ,  ROSLUND, Adam ,  WALTERS, Daniel, A. ,  YUEN, Phyllis

IPC: A61M25/01 ,  A61M25/088 ,  A61M1/10 ,  A61M29/02

CPC classification number: A61M25/04 ,  A61M1/1008 ,  A61M1/101 ,  A61M1/1012 ,  A61M1/1024 ,  A61M1/1034 ,  A61M1/122 ,  A61M1/125 ,  A61M2025/0024 ,  A61M2025/0096

Abstract: Disclosed herein are heart pumps that include a catheter assembly and that can be applied percutaneously. Some embodiments include a locking device that prevents components of the catheter assembly from being separated when in use. The catheter assembly can include an expandable tip. In some embodiments, the catheter assembly includes a housing having a wall structure, a portion of which can have a bulbuous shape or can be deformable. In other embodiments, the housing can be configured to reduce fluttering or deflection of the housing and/or to maintain a gap between the housing and an impeller blade disposed therein.

Abstract translation: 本文公开了包括导管组件并且可以经皮应用的心脏泵。 一些实施例包括锁定装置，其防止导管组件的组件在使用时被分离。 导管组件可包括可扩张尖端。 在一些实施例中，导管组件包括具有壁结构的壳体，其一部分可具有球形形状或可变形。 在其他实施例中，壳体可以被配置为减少壳体的颤动或偏转和/或在壳体和设置在其中的叶轮叶片之间保持间隙。

公开(公告)号：WO2012087277A1

公开(公告)日：2012-06-28

申请号：PCT/US2010/061295

申请日：2010-12-20

Applicant: EMPIRE TECHNOLOGY DEVELOPMENT LLC ,  LESCHINSKY, Boris

Inventor： LESCHINSKY, Boris

IPC: A61B5/00

CPC classification number: A61B5/0215 ,  A61B5/01 ,  A61B5/6862 ,  A61B5/6876 ,  A61B6/12 ,  A61B8/0841 ,  A61F2/07

Abstract: Implantable apparatuses or biosensors for facilitating imaging-based diagnoses and methods thereof are disclosed. An implantable apparatus is configured to exhibit a form when subjected to a first physical parameter indicative of a first physiological state, and a second form when subjected to a second physical parameter indicative of a second physiological state.

Abstract translation: 公开了用于促进基于成像的诊断的可植入装置或生物传感器及其方法。 可植入装置被配置为当受到指示第一生理状态的第一物理参数时呈现形式，并且当受到指示第二生理状态的第二物理参数时呈现第二形式。

公开(公告)号：WO2007112033A3

公开(公告)日：2007-10-04

申请号：PCT/US2007/007313

申请日：2007-03-23

Applicant: THE PENN STATE RESEARCH FOUNDATION ,  DATASCOPE INVESTMENT CORP. ,  MCBRIDE, Mark, W. ,  BOGER, David, A. ,  CAMPBELL, Robert, L. ,  DILLON, Gregory, P. ,  HAMBRIC, Stephen, A. ,  KUNZ, Robert, F. ,  LESCHINSKY, Boris ,  MALLISON, Thomas, M. ,  RUNT, James, P. ,  WALSH, Justin, M.

Inventor： MCBRIDE, Mark, W. ,  BOGER, David, A. ,  CAMPBELL, Robert, L. ,  DILLON, Gregory, P. ,  HAMBRIC, Stephen, A. ,  KUNZ, Robert, F. ,  LESCHINSKY, Boris ,  MALLISON, Thomas, M. ,  RUNT, James, P. ,  WALSH, Justin, M.

IPC: A61M1/10

Abstract: An impeller includes a hub and at least one blade supported by the hub. The impeller has a stored configuration in which the blade is compressed so that its distal end moves towards the hub, and a deployed configuration in which the blade extends away from the hub. The impeller may be part of a pump for pumping fluids, such as blood within patients. A blood pump may include a cannula having a proximal portion with a fixed diameter, and a distal portion with an expandable diameter. The impeller may reside in the expandable portion of the cannula. The cannula may have a compressed diameter allowing percutaneous insertion into patients. Once at a desired location, the expandable portion of the cannula may be expanded and the impeller expanded to the deployed configuration. A flexible drive shaft may extend through the cannula for rotationally driving the impeller within the patient.

公开(公告)号：WO2002076545A3

公开(公告)日：2002-10-03

申请号：PCT/US2002/006749

申请日：2002-03-05

Applicant: DATASCOPE INVESTMENT CORP. ,  LESCHINSKY, Boris ,  LAKSIN, Olga ,  PETERS, George ,  SONG, Philip

Inventor： LESCHINSKY, Boris ,  LAKSIN, Olga ,  PETERS, George ,  SONG, Philip

IPC: A61M25/10

Abstract: An intra-aortic balloon catheter (1) having a gas lumen insert (100) disposed within its gas lumen (3) during insertion of the catheter (1) into the blood vessel of a patient. The gas lumen insert (100) facilitates insertion and helps prevent kinking of the catheter (1).

公开(公告)号：WO2007112033A2

公开(公告)日：2007-10-04

申请号：PCT/US2007007313

申请日：2007-03-23

Applicant: PENN STATE RES FOUND ,  DATASCOPE INVESTMENT CORP ,  MCBRIDE MARK W ,  BOGER DAVID A ,  CAMPBELL ROBERT L ,  DILLON GREGORY P ,  HAMBRIC STEPHEN A ,  KUNZ ROBERT F ,  LESCHINSKY BORIS ,  MALLISON THOMAS M ,  RUNT JAMES P ,  WALSH JUSTIN M

Inventor： MCBRIDE MARK W ,  BOGER DAVID A ,  CAMPBELL ROBERT L ,  DILLON GREGORY P ,  HAMBRIC STEPHEN A ,  KUNZ ROBERT F ,  LESCHINSKY BORIS ,  MALLISON THOMAS M ,  RUNT JAMES P ,  WALSH JUSTIN M

IPC: A61N1/362

CPC classification number: A61M1/1012 ,  A61M1/1008 ,  A61M1/101 ,  A61M1/1013 ,  A61M1/1017 ,  A61M1/102 ,  A61M1/1024 ,  A61M1/1034 ,  A61M1/122 ,  A61M1/125 ,  A61M2205/0266 ,  B33Y80/00 ,  F04D3/00 ,  F04D3/02 ,  F04D29/181 ,  F04D29/247 ,  F04D29/528 ,  F04D29/542 ,  F05B2240/311 ,  F05B2280/5001

Abstract: An impeller (605) includes a hub (610) and at least one blade (612) supported by the hub. The impeller has a stored configuration in which the blade is compressed so that its distal end moves towards the hub, and a deployed configuration in which the blade extends away from the hub. The impeller may be part of a pump for pumping fluids, such as pumping blood within a patient. A blood pump (600) may include a cannula (625) having a proximal portion (623) with a fixed diameter, and a distal portion (626) with an expandable diameter. The impeller may reside in the expandable portion of the cannula. The cannula may have a compressed diameter which allows it to be inserted percutaneously into a patient. Once at a desired location, the expandable portion of the cannula may be expanded and the impeller expanded to the deployed configuration. A flexible drive shaft (630) may extend through the cannula for rotationally driving the impeller within the patient's body.

Abstract translation: 叶轮（605）包括轮毂（610）和由轮毂支撑的至少一个叶片（612）。 叶轮具有存储构造，其中叶片被压缩，使得其远端朝向轮毂移动，以及展开构型，其中叶片远离轮毂延伸。 叶轮可以是用于泵送流体的泵的一部分，例如泵送患者体内的血液。 血液泵（600）可以包括具有固定直径的近端部分（623）和具有可扩张直径的远端部分（626）的套管（625）。 叶轮可以驻留在套管的可膨胀部分中。 套管可以具有压缩直径，其允许其经皮插入患者体内。 一旦在期望的位置，插管的可扩张部分可以膨胀并且叶轮膨胀到展开构型。 柔性驱动轴（630）可以延伸穿过套管以在患者体内旋转地驱动叶轮。