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51 条记录 (耗时 0.018 秒)

    METHODS FOR THE SYNTHESIS OF PYRIDOXAMINE
    31.
    发明申请
    METHODS FOR THE SYNTHESIS OF PYRIDOXAMINE 审中-公开
    吡哆醛合成方法

    公开(公告)号：WO2005077902A2

    公开(公告)日：2005-08-25

    申请号：PCT/US2005/003969

    申请日：2005-02-09

    申请人： BIOSTRATUM, INC. ,  KHALIFAH, Raja ,  KEILITZ, Roland ,  KOELLNER, Christoph

    发明人： KHALIFAH, Raja ,  KEILITZ, Roland ,  KOELLNER, Christoph

    IPC分类号： C07D213/66

    CPC分类号： C07D213/66 ,  C07D213/67 ,  C07D401/06 ,  C07D401/12

    摘要： The invention provides non-oxidative methods for the large scale manufacture of pyridoxamine (I) (4-aminomethyl-3-hydroxy-5-hydroxymethyl-2-methylpyridine): Formula (I), and salts thereof. The invention also provides intermediate compounds for the synthesis of pyridoxamine, as well as compositions and methods for the treatment and/or prevention of conditions associated with the formation of post-Amadori advanced glycation end-products.

    摘要翻译： 本发明提供了大规模生产吡哆胺（I）（4-氨基甲基-3-羟基-5-羟甲基-2-甲基吡啶）：式（I）及其盐的非氧化方法。 本发明还提供了用于合成吡哆胺的中间体化合物，以及用于治疗和/或预防与后阿马多后期糖基化终产物形成相关的病症的组合物和方法。

    MANGANESE(II) CHELATES
    36.
    发明申请
    MANGANESE(II) CHELATES 审中-公开
    马来西亚（二）烧烤

    公开(公告)号：WO1990003975A1

    公开(公告)日：1990-04-19

    申请号：PCT/EP1989001122

    申请日：1989-09-26

    申请人： SALUTAR, INC. ,  COCKBAIN, Julian, Roderick, Michaelson

    发明人： SALUTAR, INC. ,  COCKBAIN, Julian, Roderick, Michaelson ,  ROCKLAGE, Scott ,  CACHERIS, William ,  JAMIESON, Gene

    IPC分类号： C07F09/58

    CPC分类号： C07D213/66 ,  A61K49/06 ,  C07C229/16 ,  C07D257/02 ,  C07D273/00 ,  C07F9/65583

    摘要： A process is provided for the preparation of Mn(II) chelates for use as contrast agents in magnetic resonance imaging, said process comprising reacting insoluble manganese (II) oxide with an aqueous suspension comprising a molar equivalent or molar excess of an insoluble protonated chelating compound conveniently at a temperature of from 20 to 50°C. When the reaction is carried out with a protonated chelating agent in the absence of base, a precipitate of the protonated Mn(II) chelate is formed. A low osmolarity Mn(II) chelate solution can be formed from the precipitates by disssolving them in an aqueous solution of base. When the initial chelate forming reaction is carried out in a solution containing a molar equivalent or excess of base, a low osmolarity solution of the Mn(II) chelate is directly formed with most chelating agents. The Mn(II) chelate precipitates and low osmolarity solutions formed by the above processes are also aspects of this invention.

    COMPOSITIONS AND METHODS FOR THE TREATMENT OF DEPRESSION
    39.
    发明申请
    COMPOSITIONS AND METHODS FOR THE TREATMENT OF DEPRESSION 审中-公开
    用于治疗呕吐的组合物和方法

    公开(公告)号：WO2013167990A1

    公开(公告)日：2013-11-14

    申请号：PCT/IB2013/050850

    申请日：2013-02-01

    申请人： KANDULA, Mahesh

    发明人： KANDULA, Mahesh

    IPC分类号： C07C217/60 ,  A61K31/135 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/00 ,  A61P35/00

    CPC分类号： C07D339/04 ,  A61K47/48038 ,  A61K47/48061 ,  A61K47/542 ,  A61K47/545 ,  C07C219/08 ,  C07C2601/14 ,  C07D209/14 ,  C07D213/20 ,  C07D213/66 ,  C07D495/04

    摘要： The invention relates to the compounds of formula (I) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula (I), and methods for treating or preventing depression may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of major depressive disorder (MDD), anxiety, neurological diseases, general anxiety disorder, sodal phobia, panic disorder, vasomotor symptoms, diabetic neuropathy, epilepsy, bipolar disorder, migraine, schizophrenia, cancer, menopause, HIV and familial adenomatous polyposis.

    摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，以及其多晶型物，溶剂合物，对映体，立体异构体和水合物。 包含有效量的式（I）化合物的药物组合物，以及用于治疗或预防抑郁症的方法可以配制成口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射。 这些组合物可用于治疗重度抑郁症（MDD），焦虑症，神经性疾病，一般焦虑症，心律失常症，惊恐障碍，血管舒缩症状，糖尿病性神经病，癫痫，双相情感障碍，偏头痛，精神分裂症，癌症，绝经期，HIV 和家族性腺瘤性息肉病。